Engineered polyketides:Synergy between protein and host level engineering

作     者：Jesus F.Barajas Jacquelyn M.Blake-Hedges Constance B.Bailey Samuel Curran Jay.D.Keasling 

作者机构：Department of Energy Agile BioFoundryEmeryvilleCAUSA Department of ChemistryUniversity of CaliforniaBerkeleyBerkeleyCA 94720USA Joint BioEnergy InstituteEmeryvilleCA 94608USA Physical Biosciences DivisionLawrence Berkeley National LaboratoryBerkeleyCA 94720USA Comparative Biochemistry Graduate GroupUniversity of CaliforniaBerkeleyBerkeleyCA 94720USA QB3 InstituteUniversity of CaliforniaBerkeleyEmeryvilleCA 94608USA Department of Chemical&Biomolecular EngineeringDepartment of BioengineeringUniversity of CaliforniaBerkeleyBerkeleyCA 94720USA Novo Nordisk Foundation Center for BiosustainabilityTechnical University DenmarkDK2970 HorsholmDenmark 

出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)

年 卷 期：2017年第2卷第3期

页      面：147-166页

核心收录：

学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学] 

基　　金：This work was funded by the Joint BioEnergy Institute(JBEI),which is funded by the U.S.Department of Energy,Office of Science,Office of Biological and Environmental Research,under Contract DE-AC02-05CH11231 by the National Science Foundation under awards MCB-1442724,NSF-GRFP DGE-1106400 and CBET-1437775 as part of the Co-Optimization of Fuels&Engines(Co-Optima)project sponsored by the U.S.Department of Energy(DOE)Office of Energy Efficiency and Renewable Energy(EERE) Bioenergy Technologies and Vehicle Technologies Offices,and by the DOE Agile-Biofoundry(https://agilebiofoundry.org)supported by the U.S.Department of Energy,Energy Efficiency and Renewable Energy,Bioenergy Technologies Office,through contract DE-AC02-05CH11231 between Lawrence Berkeley National Laboratory and the U.S.Department of Energy.The United States Government retains and the publisher,by accepting the article for publication,acknowledges that the United States Government retains a nonexclusive,paid-up,irrevocable,world-wide license to publish or reproduce the published form of this manuscript,or allowothers to do so,for United States Government purposes.Additional funding was provided by the National Science Foundation Graduate Research Fellowship under Grant No.(DGE 1106400) 

主　　题：Polyketide Polyketide synthase Natural products Commodity chemical Metabolic engineering Synthetic biology 

摘      要：Metabolic engineering efforts toward rewiring metabolism of cells to produce new compounds often require the utilization of non-native enzymatic machinery that is capable of producing a broad range of chemical *** encompass one of the largest classes of chemically diverse natural *** thousands of known polyketides,modular polyketide synthases(PKSs)share a particularly attractive biosynthetic logic for generating chemical *** engineering of modular PKSs could open access to the deliberate production of both existing and novel *** this review,we discuss PKS engineering efforts applied at both the protein and cellular level for the generation of a diverse range of chemical structures,and we examine future applications of PKSs in the production of medicines,fuels and other industrially relevant chemicals.