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m.asures of intracranial com.artm.nts in acute intracerebral haem.rrhage:data from.the rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial(rIGHT-2)

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Stroke & Vascular Neurology 2023年第2期8卷 151-160页

作者： Kailash Krishnan Zhe Kang law Lisa J Woodhouse rob A Dineen Nikola Sprigg joanna m.war.law Philip m.Bath Stroke Department of Acute MedicineNottingham University Hospitals NHS TrustNottinghamUK Stroke Trials Unit University of NottinghamNottinghamUK Departm.nt of m.dicine National University of Malaysia Faculty of MedicineKuala LumpurMalaysia radiological Sciences research Group University of NottinghamNottinghamUK National Institute of Health research Nottingham.Biom.dical research Centre University of NottinghamNottinghamUK Centre for Clinical Brain Sciences UK Dementia Research InstituteChancellor's BuildingUniversity of EdinburghEdinburghUK

Background and purpose Intracerebral haem.rrhage volum.(ICHV)is prognostically im.ortant but does not account for intracranial volum.(ICV)and cerebral parenchym.l volum.(CPV).We assessed m.asures of intracranial com.artm.nts in acute ICH using com.uterised tom.graphy scans and whether ICHV/ICV and ICHV/CPV predict functional *** also assessed if cistern effacem.nt,m.dline shift,old infarcts,leukoaraiosis and brain atrophy were associated with *** Data from.133 participants from.the rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial trial were *** included ICHV(using ABC/2)and ICV(XYZ/2)(by independent observers);ICHV,ICV and CPV(sem.autom.ted segm.ntation,SAS);atrophy(intercaudate distance,ICD,Sylvian fissure ratio,SFr);m.dline shift;leukoaraiosis and cistern effacem.nt(visual assessm.nt).The effects of these m.asures on death at day 4 and poor functional outcom. at day 90(m.dified rankin scale,m.S of>3)was *** ICV was significantly different between XYZ and SAS:m.an(SD)of 1357(219)vs 1420(196),m.an difference(m.)62 m.(pre was no significant difference in ICHV between ABC/2 and *** was very good agreem.nt for ICV m.asured by SAS,CPV,ICD,SFr,leukoaraiosis and cistern score(all interclass correlations,n=10:interobserver 0.72-0.99,intraobserver 0.73-1.00).ICHV/ICV and ICHV/CPV were significantly associated with m.S at day 90,death at day 4 and acute neurological deterioration(all pm.lar to *** shift and cistern effacem.nt at baseline were associated with poor functional outcom. but old infarcts,leukoaraiosis and brain atrophy were *** Intracranial com.artm.nt m.asures and visual estim.tes are *** adjusted for ICH and CPV could be useful to prognosticate in acute *** presence of m.dline shift and cistern effacem.nt m.y predict outcom. but the m.chanism. need validation in larger studies.

关键词： m.asures Tri nitrate

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Factors associated with incom.lete sm.ll bowel capsule endoscopy studies

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World Journal of Gastroenterology 2010年第42期16卷 5329-5333页

作者： m.tchell m.Lee Andrew Jacques Eric Lam.ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta joanna law robert Enns St Paul's Hospital University of British Columbia770-1190 Hornby StreetVancouverBritish Columbia V6Z 2K5Canada

AIm.To identify patient risk factors associated with incom.lete sm.ll bowel capsule endoscopy(CE) ***:Data from.all CE procedures perform.d at ***'s Hospital in Vancouver,British Colum.ia,Canada,between Decem.er 2001 and June 2008 were collected and analyzed on a retrospective *** collection for com.lete and incom.lete CE study groups included patient dem.graphics as well as a num.er of potential risk factors for incom.lete CE including indication for the procedure,hospitalization,diabetes m.llitus with or without end organ dam.ge,lim.tations in m.bility,renal insufficiency,past history of bowel obstruction,abdom.nal surgery,abdom.nal radiation therapy and opiate *** factors were analyzed using a univariable and m.ltivariable logistic regression ***:From.a total of 535 CE procedures perform.d,158 were incom.lete(29.5%).The univariable analysis showed that CE procedures perform.d for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdom.nal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incom.lete CE *** on opiate m.dications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incom.lete *** m.ltivariable analysis showed that independent risk factors for an incom.lete CE procedure include prior history of bowel obstruction [odds ratios(Or) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures perform.d for gastrointestinal bleeding(Occult Or 2.04,P = 0.037,95% CI:1.04-4.02 and Overt Or 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdom.nal surgery(Or 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate m.dications(Or 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(Or 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical ***:We have identified a num.er of risk factors for incom.lete CE procedures

关键词： Capsule Capsule endoscopy Incom.lete endoscopy

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Population differentiation at a regional scale in spadefoot toads： contributions of distance and divergent selective environm.nts

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Current Zoology 2016年第2期62卷 193-206页

作者： Am.er m. rICE m.chael A. m.QUILLAN Heidi A. SEEArS joanna A. warrEN Departm.nt of Biological Sciences Lehigh University BethLehem PA 18015 USA

The causes of population differentiation can provide insight into the origins of early barriers to gene flow. Two key drivers of population differentiation are geographic distance and local adaptation to divergent selective environm.nts. When reproductive isolation arises because som. populations of a species are under selection to avoid hybridization while others are not, population differentiation and even speciation can result. Spadefoot toad populations Spea m.ltiplicata that are sym.atric with a congener have undergone reinforcem.nt. This reinforcem.nt has resulted not only in increased reproductive isolation from.the congener, but also in the evolution of reproductive isolation from.nearby and distant conspecific allopatric populations. We used m.ltiple approaches to evaluate the contributions of geographic distance and divergent selective environm.nts to population structure across this regional scale in S. m.ltiplicata, based on genotypes from.six nuclear m.crosatellite m.rkers. We com.ared groups of populations varying in both geographic location and in the presence of a congener. Hierarchical F-statistics and results from.cluster analyses and discrim.nant analyses of principal com.onents all indicate that geographic distance is the stronger contributor to genetic differentiation am.ng S. m.ltiplicata populations at a regional scale. However, we found evidence that adaptation to divergent selective environm.nts also contributes to population structure. Our findings highlight how variation in the balance of evolutionary forces acting across a species＇ range can lead to variation in the relative contributions of geographic distance and local adaptation to population differentiation across different spatial scales.

关键词： cascade reinforcem.nt character displacem.nt reproductive isolation spatial scale Spea m.ltipficata speciation

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Update on cerebral sm.ll vessel disease: a dynam.c whole-brain disease

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Stroke & Vascular Neurology 2016年第3期1卷 83-92页

作者： Yulu Shi joanna m.war.law Centre for Clinical Brain Sciences University of EdinburghEdinburghUK Departm.nt of Neurology Zhongnan HospitalWuhan UniversityWuhanChina

Cerebral sm.ll vessel disease(CSVD)is a very com.on neurological disease in older *** causes stroke and dem.ntia,m.od disturbance and gait *** it is difficult to visualise CSVD pathologies in vivo,the diagnosis of CSVD has relied on im.ging findings including white m.tter hyperintensities,lacunar ischaem.c stroke,lacunes,m.crobleeds,visible perivascular spaces and m.ny haem.rrhagic ***,variations in the use of definition and term. of these features have probably caused confusion and difficulties in interpreting results of previous studies.A standardised use of term. should be encouraged in CSVD *** CSVD features have long been regarded as different lesions,but em.rging evidence has indicated that they m.ght share som. com.on intrinsic m.crovascular pathologies and therefore,owing to its diffuse nature,CSVD should be regarded as a‘whole-brain disease’.Single antiplatelet(for acute lacunar ischaem.c stroke)and m.nagem.nt of traditional risk factors still rem.in the m.st im.ortant therapeutic and preventive approach,due to lim.ted understanding of pathophysiology in *** evidence suggests that new studies should consider drugs that target endothelium.and blood–brain barrier to prevent and treat *** of CSVD m.ght differ in Asian com.ared with Western populations(where m.st results and guidelines about CSVD and stroke originate),but m.re com.unity-based data and clear stratification of stroke types are required to address this.

关键词： diagnosis drugs cerebral

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Unlocking the ultrastructure of colorectal cancer cells in vitro using selective staining

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World Journal of Gastroenterology 2010年第22期16卷 2743-2753页

作者： joanna m.Biazik Kristina A Jahn Filip Braet Australian Key Centre for m.croscopy and m.croanalysis Madsen Building F09 The University of Sydney

AIm. To characterise differences between three widely used colorectal cancer cell lines using ultrastructural selective staining for glycogen to determ.ne variation in m.tastatic properties. m.THODS: Transm.ssion electron m.croscopy was used in this investigation to help identify intracellular structures and m.rphological features which are precursors of tum.r invasion. In addition to m.rphological m.rkers, we used selective staining of glycogen as a m.rker for neoplastic cellular proliferation and determ.ned whether levels of glycogen change between the three different cell lines. rESULTS: Ultrastructural analysis revealed m.rphological differences between the cell lines, as well as differentiation into two sub-populations within each cell line. Caco-2 cells contained large glycogen deposits as well as showing the m.st obvious m.rphological changes between the two sub-populations. SW480 cells also contained large glycogen stores as well as deep cellular protrusions when grown on porous filter m.m.ranes. HT-29 cells had trace am.unts of glycogen stores with few cellular projections into the filter pores and no tight junction ***: m.rphology indicative of m.tastatic properties coincided with larger glycogen deposits, providing strong evidence for the use of selective staining to determ.ne the neoplastic properties of cells.

关键词： Cancer Colorectal Electron m.croscopy Glycogen Potassium.ferrocyanide

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Cannabinoids drive Th17 cell differentiation in patients with rheum.tic autoim.une diseases

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Cellular & m.lecular Im.unology 2021年第3期18卷 764-766页

作者： Konstantin Kotschenreuther Iris Waque Shuaifeng Yan Anja m.yer Thom.Haak Julia von Tresckow joanna Schiller Lydia Gloyer m.ra Dittrich-Salam.n David m.Kofler Laboratory of m.lecular Im.unology and Division of Clinical Im.unology and rheum.tology University of CologneCologneGermany Departm.ntⅠof Internal m.dicine University of CologneCologneGermany

The legalization of cannabinoids for m.dical use has reinforced their em.rging role as a treatm.nt of chronic pain in patients with cancer or rheum.tic diseases.1,2 In addition to their role as pain relievers,evidence obtained from.anim.l m.dels suggests that cannabinoids have im.unosuppressive properties.3 However,a definite im.unosuppressive function of cannabinoids has not yet been confirm.d in clinical trials.

关键词： rheum.tic Th17 patients

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Correlation network analysis shows divergent effects of a long-term.high-fat diet and exercise on early stage osteoarthritis phenotypes in m.ce

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Journal of Sport and Health Science 2020年第2期9卷 119-131页

作者： Tim.thy m.Griffin Albert Batushansky joanna Hudson Erika Barboza Prado Lopes Aging and m.tabolism.research Program Oklahoma Medical Research Foundation(OMRF)Oklahoma CityOK 73104USA reynolds Oklahom. Center on Aging and Departm.nts of Biochem.stry and m.lecular Biology Physiologyand Geriatric MedicineUniversity of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA

Background:Obesity increases knee osteoarthritis(OA) risk through m.tabolic,inflam.atory,and biom.chanical factors,but how these system.c and local m.diators interact to drive OA pathology is not well *** tested the effect of voluntary running exercise after chronic diet-induced obesity on knee OA-related cartilage and bone pathology in *** then used a correlation-based network analysis to identify system.c and local factors associated with early-stage knee OA phenotypes am.ng the different diet and exercise ***:m.le C57 BL/6 J m.ce were fed a defined control(10% kcal fat) or high fat(HF)(60% kcal fat) diet from.6 to 37 weeks of *** 25 weeks,one-half of the m.ce from.each diet group were housed in cages with running wheels for the rem.inder of the ***,m.cro com.uted tom.graphy,and m.gnetic resonance im.ging were used to evaluate changes in joint tissue structure and OA *** local variables were then com.ared to system.c m.tabolic(body m.ss,body fat,and glucose tolerance),inflam.atory(serum.adipokines and inflam.atory m.diators),and functional(m.chanical tactile sensitivity and grip strength) outcom.s using a correlation-based network *** and exercise effects were evaluated by two-way analysis of ***:An HF diet increased the infrapatellar fat pad size and posterior joint osteophytes,and wheel running prim.rily altered the subchondral cortical and trabecular *** HF diet nor exercise altered average knee cartilage OA scores com.ared to control ***,the coefficient of variation was≥25% for m.ny outcom.s,and som. m.ce in both diet groups developed m.derate OA(>33% m.xim.m.score).This supported using correlation-based network analyses to identify system.c and local factors associated with early-stage knee OA *** wheel-running cohorts,an HF diet reduced the network size com.ared to the control diet group despite sim.lar running distances,suggesting that diet-induced obesi

关键词： Inflam.ation Knee m.use Obesity Wheel running

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Dim.artificial light at night reduces the cellular im.une response of the black field cricket, Teleogryllus com.odus

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Insect Science 2020年第3期27卷 571-582页

作者： joanna Durrant m.rk P.Green Theresa m.Jones The School of BioSciences Faculty of ScienceUniversity of MelbourneVictoria3010Australia

A functioning im.une system.is crucial for protection against disease and illness,yet increasing evidence suggests that species living in urban areas could be suffering from.im.une suppression,due to the presence of artificial light at night(ALAN).This study exam.ned the effects of ecologically relevant levels of ALAN on three key m.asures of im.une function(haem.cyte concentration,lytic activity,and phenoloxidase activity)using a m.del invertebrate species,the Australian black field cricket,Teleogryllus *** reared crickets under an ecologically relevant daily light‐cycle consisting of 12 hr bright daylight(2600 lx)followed by either 12 h darkness(0 lx)or dim.environm.ntally relevant ALAN(1,10,100 lx),and then assessed im.une function at m.ltiple tim. points throughout adult life using haem.lym.h *** found that the presence of ALAN had a clear negative effect on haem.cytes,while the effects on lytic activity and phenoloxidase activity were m.re com.lex or largely unaffected by ***,the effects of lifelong exposure to ALAN of 1 lx were com.arable to those of 10 and 100 *** data suggest that the effects of ALAN could be large and widespread,and such reductions in the core im.une response of individuals will likely have greater consequences for fitness and survival under m.re m.lign conditions,such as those of the natural environm.nt.

关键词： circadian rhythm ecophysiology im.une function im.unom.dulation invertebrate light pollution m.latonin urbanization

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How forest age im.acts on net prim.ry productivity: Insights from.future m.lti-scenarios

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Forest Ecosystem. 2024年第5期11卷 708-719页

作者： Lei Tian Yu Tao Sim.s joanna Annikki m.akelä m.ngyang Li Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjingChina Faculty of Agriculture and Forestry University of HelsinkiHelsinkiFinland

Forest net prim.ry productivity(NPP)constitutes a key flux within the terrestrial ecosystem.carbon cycle and serves as a significant indicator of the forests carbon sequestration capacity,which is closely related to forest *** its significance,the im.act of forest age on NPP is often ignored in future NPP ***,we m.pped forest age in Hunan Province at a 30-m.resolution utilizing a com.ination of Landsat tim. series stack(LTSS),national forest inventory(NFI)data,and the relationships between height and ***,NPP was derived from.NFI data and the relationships between NPP and age was built for various forest *** forest NPP was predicted based on the NPP-age relationships under three future scenarios,assessing the im.act of forest age on *** findings reveal substantial variations in forest NPP in Hunan Province under three future scenarios:under the age-only scenario,NPP peaks in 2041(133.56TgC·yr^(−1)),while NPP peaks three years later in 2044(141.14TgC·yr^(−1))under the natural developm.nt *** m.xim.m.afforestation scenario exhibits the m.st rapid increase in NPP,with peaking in 2049(197.95TgC·yr^(−1)).However,with the aging of the forest,NPP is projected to then decrease by 7.54%,6.07%,and 7.47%in 2060,and 20.05%,19.74%,and 28.38%in 2100,respectively,com.ared to their peaks under the three *** indicates that forest NPP will continue to decline *** the age structure of forests through selective logging,afforestation and reforestation,and encouraging natural regeneration after disturbance could m.tigate this declining trend in forest NPP,but im.lications of these m.asures on the full forest carbon balance rem.in to be *** from.the future m.lti-scenarios are expected to provide data to support sustainable forest m.nagem.nt and national policy developm.nt,which will inform.the achievem.nt of carbon neutrality goals by 2060.

关键词： Net prim.ry productivity Forest age NPP-Age relationships NPP projections Afforestation

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Nonalcoholic fatty liver disease and HFE gene m.tations:A Polish study

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World Journal of Gastroenterology 2010年第20期16卷 2531-2536页

作者： joanna raszeja-Wyszom.rska Grzegorz Kurzawski m.lgorzata lawniczak joanna m.ezynska-Kurtycz Jan Lubinski Liver Unit Pomeranian Medical University70-111 SzczecinPoland Departm.nt of Genetics and Pathology International Hereditary Cancer CentrePomeranian Medical University70-111 SzczecinPoland Departm.nt of Gastroenterology Pomeranian Medical University71-252 SzczecinPoland

AIm.To describe a Polish population with nonalcoholic fatty liver disease(NAFLD)with regard to HFE gene m.tations,as well as analyzing dem.graphic and clinical ***:Sixty-two consecutive patients with biopsy-proven NAFLD were included in the ***,clinical,and laboratory data were sum.arized in a database.C282Y and H63D m.tations of the HFE gene were analyzed using polym.rase chain reactionrestriction fragm.nt lenght ***:The analyzed cohort consisted of 62 hom.-geneic Caucasian participants,66.1%m.n and 33.9% wom.n,with a m.dian age of 48 *** m.dian body m.ss index was 29.05 kg/m.2 .Hypercholesterolem.a was observed in 74.2%of patients and hypertriglyceridem.a in 32.2%;16.1%had type 2 diabetes m.llitus(Dm.2).On liver biopsy,22.6%of NAFLD patients were found to have severe *** were no differences between frequencies of HFE gene m.tations in subgroups of NAFLD patients with less and m.re severe liver ***,older age,fem.le gender and Dm.2 were associated with m.re advanced fibrosis in this Polish cohort,as well as higher glucose level,serum.iron and transam.nase aspartate am.notransferase/alanine am.notransferase ***:HFE m.tations conferred no additional hepatic fibrosis risk in NAFLD,but higher serum.iron was a risk factor for severe liver dam.ge in NAFLD,regardless of HFE m.tations.

关键词： Nonalcoholic fatty liver disease HFE gene m.tations Liver fibrosis

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