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Comprehensive profiling of CTP-binding proteins using a biotinylated CTP affinity probe

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Chinese Chemical letters 2021年第11期32卷 3479-3482页

作者： Mengting pa Yunming liu Xiaofang Zheng Meijuan Zhou Changjun You Xiaoxia Dai State Key laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringMolecular Science and Biomedicine LaboratoryHunan Provincial Key Laboratory of Biomacromolecular Chemical BiologyHunan UniversityChangsha 410082China

recent studies have shown that CTP may act as a ligand to regulate the activity of its target proteins in many biological ***,proteome-wide identification of CTP-binding proteins remains ***,we employed a biotinylated CTP affinity probe coupled with stable isotope labeling by amino acids in cell culture(SIlAC)-based quantitative proteomics approach to capture,identify and quantify CTP-binding proteins in human *** performing two types of competitive SIlAC experiments with high *** concentrations of CTP probe(100 vs.10µmol/l)or with CTP probe in the presence of free CTP,we identified 90 potential CTP-binding proteins which are involved in a variety of biological processes,including protein folding,nucleotide binding and cell-cell ***,we developed a chemical proteomic method for uncovering the CTP-binding proteins in human cells,which could be widely applicable for profiling CTP-binding proteins in other biological samples.

关键词： CTP-binding proteins CTP affinity probe Mass spectrometry SIlAC Quantitative proteomics

A　CONSTITUTIVE　THEOrY　FOr　THE　rEYNOlDS－STrESS　ClOSUrES　IN　TUrBUlENCE　MODEllING

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Journal of Hydrodynamics 1996年第1期8卷 103-109页

作者： l. Y. Tao,(Department of Mechanical Engineering, University of Pittsburgh, pa15261,USA)G. Q. Chen(Centre for Environmental Sciences, Peking University, Beijing 100871,P. r. China)K. r. rajagopal(Department of Mechanical Engineering, University of Pittsbur

For the reynolds-stress closures in turbulence modelling, a constitutive theory is developed based on the principle of frame indifference and the theory of invariants. The present study sheds light on existing closure... 详细信息

关键词： turbulence modelling reynolds-Stress constitutive theory

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATlAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios l. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.l. Alberghi J. Albert P. Albicocco G.l. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.r. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo l. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan r. Astalos S. Atashi r.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.r. Bailey J.T. Baines l. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan r. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli l.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal l. Barak M. Barakat E.l. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATlAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATlAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATlAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATlAS JET QUArK GlUON TAGGING

Vestibular rehabilitation in cerebellar ataxia with neuropathy and vestibular areflexia syndrome(CANVAS)-A case report

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中华耳科学杂志:英文版 2023年第4期18卷 199-207页

作者： r.G.Harrell A.r.Cassidy B.N.Klatt P.Hovareshti S.l.Whitney School of Health and rehabilitation Sciences Department of Physical TherapyUniversity of PittsburghPittsburghPA15219USA rehabilitation Institute University of Pittsburgh Medical CenterPittsburghPA15219USA BlueHalo Intelligent AutomationRockvilleMD20855USA Department of Otolaryngology University of Pittsburgh Medical SchoolPittsburghPA15219USA The University of Pittsburgh Department of Physical Therapy100 Technology Dr.Pittsburgh PA 15219

Background and purpose:Cerebellar ataxia,neuropathy,and vestibular areflexia syndrome(CANVAS)is a neurodegenerative disease of the *** disease progression is slow,with up to 25%of people diagnosed needing to use a wheelchair after 15 years from *** symptoms arise from centrally-mediated ocular movement degradation and the reduced vestibular-ocular reflex functioning *** date,no report has shown an improvement in VOr gain or gait outcome measures in someone with CANVAS after a course of vestibular physical *** description:A 65-year-old male,patient X,first noticed symptoms in his fourth decade of life and was diagnosed with(CANVAS)in his seventh *** X reported numbness and tingling in his hands and feet,decreased ability to perform daily activities,and several ***:patient X completed a four-month course of vestibular physical therapy,including vestibular ocular reflex exercises,balance training,gait training,and the VestAid application for eye gaze compliance *** Vestaid application uses eyes and facial recognition software to record the percentage of time that the patient kept their eyes on the ***:After vestibular therapy,patient X had a clinically meaningful improvement in gait speed:from 1.02 m/s to 1.13 m/s and in the Functional Gait Assessment from 20/30 to 27/*** X's eye gaze compliance improved from a median of 43%(range 25e68%)to a median of 67%(58e83%).Discussion:This case study demonstrates that vestibular rehabilitation improved eye gaze compliance and functional outcomes in a person living with CANVAS.

关键词： vestibular neuropathy meaningful

Extraction of aluminium as aluminium sulphate from thermal power plant fly ashes

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Transactions of Nonferrous Metals Society of China 2017年第9期27卷 2082-2089页

作者： Seoul SANGITA Niva NAYAK Chitta ranjan pa Environment & Sustainability Department CSIR-Institute of Minerals & Materials Technology

Valuable metal extraction technology from thermal power plant fly ash is *** the present study,aluminium is extracted from fly ash as highly pure aluminium sulphate(>99.0%)by leaching with sulphuric acid,followed by pre-concentration and successive *** types of fly ashes from different sources,i.e.,Talcher Thermal Power Station(TTPS)and Vedanta Aluminium Company limited(VAl)were chosen for comparative study on the extraction of aluminium as aluminium *** product is characterized by powder X-ray diffraction(XrD),Fourier transform infrared spectroscopy(FTIr)and thermogravimetric analysis(TGA).Purity of aluminium sulphate was also investigated by inductively coupled plasma?optical emission spectrometry(ICP?OES).The extraction efficiency of aluminium depends on the varied solid-to-liquid ratio(fly ash:18mol/l H2SO4,g/ml)and particle size of fly ***-chemical analysis indicates that the obtained product is Al2(SO4)3·18H2O,having low iron content(0.08%).

关键词： fly ash sulphuric acid aluminium sulphate leaching solid-to-liquid ratio particle size

Sonicating bees demonstrate flexible pollen extraction without instrumental learning

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Current Zoology 2019年第4期65卷 425-436页

作者： Callin M. Switzer Avery l. russell Daniel r. papaj Stacey A. Combes robin Hopkins Department of Organismic and Evolutionary Biology Harvard University Cambridge MA USA Arnold Arboretum Harvard University Boston MA USA Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ USA Department of Neurobiology Physiology and Behavior University of California at Davis Davis CA USA Department of Biology and eScience Institute University of Washington Seattle WA USA Department of Biological Sciences University of Pittsburgh Pittsburgh PA USA

Pollen collection is necessary for bee survival and important for flowering plant reproduction, yet if and how pollen extraction motor routines are modified with experience is largely unknown. Here, we used an automated reward and monitoring system to evaluate modification in a common pollen-extraction routine, floral sonication. Through a series of laboratory experiments with the bumblebee, Bombus impatiens, we examined whether variation in sonication frequency and acceleration is due to instrumental learning based on rewards, a fixed behavioral response to rewards, and/or a mechanical constraint. We first investigated whether bees could learn to adjust their sonication frequency in response to pollen rewards given only for specified frequency ranges and found no evidenee of instrumental learning. However, we found that absenee versus receipt of a pollen reward did lead to a predictable behavioral resp on se, which depe nded on bee size. Fin ally, we found some evide nee of mechanical con straints, in that flower mass affected sonication acceleration (but not frequency) through an interaction with bee size. In generalz larger bees showed more flexibility in sonication frequency and acceleration, potentially reflecting a size-based constraint on the range over which smaller bees can modify frequency and accelerati on. Overall our results show that although bees did not display instrumental learning of sonication frequency, their sonication motor routine is nevertheless flexible.

关键词： Bombus impatiens buzz pollination foraging innate behavior learned behavior Solanum

下坡运动对大鼠骨骼肌肌浆网功能的影响(英文)

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中国康复医学杂志 2007年第12期22卷 1070-1074,1077页

作者：陈万 ruell pa Thompson MW Department of Fundamental Theories Shandong Sport UniversityJinan250063China School of Exercise & Sport Science Faculty of Health SciencesThe University of SydneySydney1825NSWAustralia

目的:观测研究下坡(离心)运动对大鼠骨骼肌肌浆网Ca2+-ATP酶活性,Ca2+摄取与释放在量与时程上的影响。此外,测定离子载体的刺激作用,即测定在含与不含(Ca2+离子载体)A23187时Ca2+-ATP酶活性的比值,用以评定囊泡的完整性。方法:成年雄性S... 详细信息

目的:观测研究下坡(离心)运动对大鼠骨骼肌肌浆网Ca2+-ATP酶活性,Ca2+摄取与释放在量与时程上的影响。此外,测定离子载体的刺激作用,即测定在含与不含(Ca2+离子载体)A23187时Ca2+-ATP酶活性的比值,用以评定囊泡的完整性。方法:成年雄性SD大鼠随机分为对照与离心运动组,离心运动的大鼠分别于运动后即刻,4,24,48,72和144h后取样(n=7).离心运动方式采用90min持续跑台下坡运动(-16°;15m/min)。取大鼠红股肌制备组织匀浆,测定肌浆网Ca2+-ATP酶活性,Ca2+摄取与释放。结果:与对照组[19.25±1.38nmol·min-1·(mg protein)-1]相比,肌浆网Ca2+摄取分别于运动后即刻和4h下降了29% and 36%(Pl·min-1·(mg protein)-1]相比,也分别于运动后即刻和4h下降了37% and 39%(P<0.05),24h持续降低(P<0.05).用含离子载体测定的肌浆网Ca2+-ATP酶活性运动后4h降低了31%(P<0.05),并于运动后24h仍然降低(P<0.05)。运动后,含与不含A23187时测定的Ca2+-ATP酶活性的比值未见显著性改变,表明该运动没有明显改变肌浆网膜的完整性。结论:一次性低强度,长时间下坡运动导致肌浆网功能长时间降低,运动后恢复期两天尚未完全恢复,亦可构成离心运动诱导的骨骼肌某些功能降低的基础。提示这些变化可能产生于离心收缩时肌节长度不匀一性所造成的张力应激。

关键词：离心运动:肌浆网 Ca^2+-ATP酶活性 Ca^2+摄取 Ca^2+释放

结合U-net与FPN的地震初至波拾取算法

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测绘地理信息 2024年第1期49卷 82-87页

作者：何彬周云耀吕永清中国地震局地震研究所湖北武汉430071 中国地震局地震大地测量重点实验室湖北武汉430071

精确识别初至波以及拾取地震初至波初至时间对于地震的精确定位、地震孕震机制的解释、地震预警等都具有很大的意义。单纯地依靠地震学专家进行分析会耗费大量的人力和时间。本文将U-net模型编码、解码语义分割的思想与特征图金字塔网络... 详细信息

精确识别初至波以及拾取地震初至波初至时间对于地震的精确定位、地震孕震机制的解释、地震预警等都具有很大的意义。单纯地依靠地震学专家进行分析会耗费大量的人力和时间。本文将U-net模型编码、解码语义分割的思想与特征图金字塔网络(feature pyramid networks,FPN)的思想结合,提出了一种新的初至波初至时间拾取算法,满足高精度识别与拾取初至波的需求。算法模型分为编码、解码两部分,编码部分分为四层,用于捕获特征,通过卷积核大小、步长等参数实现特征由低层级到高层级的抽象和提取。解码部分分为四层,通过对前一层进行反卷积上采样实现。最后,将编码、解码部分对应层级特征图组合,通过两层全连接神经网络实现最终结果输出。与传统算法相比,U-net FPN模型在对初至波初至时间的分类与定位上都有着显著提升。

关键词：初至波拾取 U-net FPN

Design of a Sliding Mode Control for a DC-to-DC Buck-Boost Converter

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Design of a Sliding Mode Control for a DC-to-DC Buck-Boost C...