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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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neural regeneration research 2025年第8期20卷 2218-2230页

作者： rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana r.n.Lemos Jeenu Mittal Khemraj Hirani Diabetes research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Hybrid Deep Learning-Based Adaptive Multiple Access Schemes Underwater Wireless networks

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Intelligent Automation & Soft Computing 2023年第2期35卷 2463-2477页

作者： D.Anitha r.A.karthika SrM Institute of Science and Technology KattankulathurChennai603203India Vels Institute of Science Technology&Advanced StudiesChennai600117India

Achieving sound communication systems in Under Water Acoustic(UWA)environment remains challenging for *** communication scheme is complex since these acoustic channels exhibit uneven characteristics such as long propagation delay and irregular Doppler *** development of machine and deep learning algorithms has reduced the burden of achieving reli-able and good communication schemes in the underwater acoustic *** paper proposes a novel intelligent selection method between the different modulation schemes such as Code Division Multiple Access(CDMA),Time Divi-sion Multiple Access(TDMA),and Orthogonal Frequency Division Multiplexing(OFDM)techniques using the hybrid combination of the convolutional neural net-works(Cnn)and ensemble single feedforward layers(SFL).The convolutional neural networks are used for channel feature extraction,and boosted ensembled feedforward layers are used for modulation selection based on the Cnn *** extensive experimentation is carried out and compared with other hybrid learning models and conventional *** results demonstrate that the performance of the proposed hybrid learning model has achieved nearly 98%accuracy and a 30%increase in BEr performance which outperformed the other learning models in achieving the communication schemes under dynamic underwater environments.

关键词： Code division multiple access time division multiple access convolutional neural networks feedforward layers

3D tomographic analysis of equatorial plasma bubble using GnSS-TEC data from Indonesian GnSS network

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Earth and Planetary Physics 2025年第1期9卷 127-136页

作者： Ihsan naufal Muafiry Prayitno Abadi Teguh n.Pratama Dyah r.Martiningrum Sri Ekawati Yuandhika GWismaya Febrylian FChabibi Gatot HPramono research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Dept.of Physics Faculty of ScienceUniversiti Teknologi MalaysiaJohor BahruMalaysia Dept.Earth Planet Sci. Hokkaido UniversitySapporoJapan School of Electrical Engineering Telkom UniversityBandungIndonesia

Equatorial Plasma Bubbles(EPBs)are ionospheric irregularities that take place near the magnetic *** most commonly occur after sunset during the equinox months,although they can also be observed during other *** phenomenon significantly disrupts radio wave signals essential to communication and navigation *** national network of Global navigation Satellite System(GnSS)receivers in Indonesia(>30°longitudinal range)provides an opportunity for detailed EPB *** explore this,we conducted preliminary 3D tomography of total electron content(TEC)data captured by GnSS receivers following a geomagnetic storm on December 3,2023,when at least four EPB clusters occurred in the Southeast Asian *** and extracted TEC depletion with a 120-minute running average were then used as inputs for a 3D tomography *** 2D spatial distribution consistently captured the four EPB clusters over *** tomography results were validated through a classical checkerboard test and comparisons with other ionospheric data sources,such as the Global Ionospheric Map(GIM)and International reference Ionosphere(IrI)*** of the results demonstrates the capability of the Indonesian GnSS network to measure peak ionospheric *** findings highlight the potential for future three-dimensional research of plasma bubbles in low-latitude regions using existing GnSS networks,with extensive longitudinal coverage.

关键词： EPB Indonesian GnSS network 3D tomography

Tuning the Microstructural and Magnetic Properties of ZnO nanopowders through the Simultaneous Doping of Mn and ni for Biomedical Applications

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Journal of Materials Science & Technology 2015年第11期31卷 1111-1117页

作者： K.karthika K.ravichandran Post Graduate & research Department of Physics AVVM Sri Pushpam College(Autonomous)

Undoped and Mn＋ni doped ZnO nanopowders were synthesized using a simple soft chemical route by varying the ni doping level （1, 3, 5 and 7 at.%） and keeping the Mn doping level （10 at.%） constant, X-ray diffraction studies reveal that the incorporated ni^2＋ ions form a secondary phase of cubic niO beyond the ni doping level of 3 at.%, which is also confirmed by Fourier transform infrared spectroscopy. The band gap of the nanopowders increases （from 3.32 to 3.44 eV） up to 3 at.% of ni doping and decreases with further doping. ZnO：Mn：ni nanopowders with 3 at.% of ni concentration exhibit good antibacterial efficiency. The variation in the size of the nanoparticles, as observed from the TEM images and hydroxyl radicals as evidenced from the photoluminescence results, clearly substantiate the discussion on the antibacterial efficiency of the synthesized nanopowders. Magnetic properties of the synthesized nanopowders were studied using a vibrating sample magnetometer, and the results showed that the doping of Mn and ni largely influences the magnetic properties of ZnO nanopowders.

关键词： ZnO nanopowders Soft chemical route Magnetic properties Antibacterial activity

Smart Fraud Detection in E-Transactions Using Synthetic Minority Oversampling and Binary Harris Hawks Optimization

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Computers, Materials & Continua 2023年第5期75卷 3171-3187页

作者： Chandana Gouri Tekkali karthika natarajan School of Computer Science and Engineering VIT-AP University522237Andhra PradeshIndia

Fraud Transactions are haunting the economy of many individuals with several factors across the *** research focuses on developing a mechanism by integrating various optimized machine-learning algorithms to ensure the security and integrity of digital *** research proposes a novel methodology through three ***,Synthetic Minority Oversampling Technique(SMOTE)is applied to get balanced ***,SMOTE is fed to the nature-inspired Meta Heuristic(MH)algorithm,namely Binary Harris Hawks Optimization(BinHHO),Binary Aquila Optimization(BAO),and Binary Grey Wolf Optimization(BGWO),for feature *** has performed well when compared with the other ***,features from BinHHO are fed to the supervised learning algorithms to classify the transactions such as fraud and *** efficiency of BinHHO is analyzed with other popular MH *** BinHHO has achieved the highest accuracy of 99.95%and demonstrates amore significant positive effect on the performance of the proposed model.

关键词： Metaheuristic algorithms K-nearest-neighbour binary aquila optimization binary grey wolf optimization BinHHO optimization support vector machine

Gas chromatographic method for the determination of hexaconazole residues in black tea

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 160-164页

作者： Chinnachamy karthika Paul James SACHIn United Planter's Association of South India (UPASI) Tea research Foundation Tea Research Institute Nirar Dam Branch Post Office (BPO) Valparai 642127 Coimbatore District Tamil Nadu India

A highly reliable, quantitative and sensitive analytical method for determining the residues of the fungicide, hexaconazole in black tea is described. The proposed method is based on liquid-liquid extraction followed by gas chromatographic determination, using nitrogen phosphorus detector (GC-nPD) for the identification and quantitation of hexaconazole. The most appropriate solvent mixture for extracting hexaconazole residues from black tea was n-hexane:acetone at 1:1 (v/v). The extract was cleaned up by adsorption column chromatography using activated florisil. Performance of the method was assessed by evaluating quality parameters such as recovery value, repeatability, reproducibility, linearity and limits of detection and quantitation. When the method was assessed for repeatability, the percentage of recovery ranged between 86% and 96% while the relative standard deviation was between 0.30% and 2.35%. In studies on reproducibility the recovery ranged from 81% to 85% and relative standard deviation from 1.68% to 5.13%, implying that the method was reliable. A field trial was conducted to verify the application of this method with real samples. results prove that the validated method was suitable for extracting hexaconazole residues.

关键词： Hexaconazole residues Black tea Florisil Gas chromatography-nitrogen phosphorus detector (GP-nPD)

nucleoside modified mrnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural regeneration research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Contribution of leaf growth on the disappearance of fungicides used on tea under south Indian agroclimatic conditions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第6期10卷 422-426页

作者： Chinnachamy karthika narayanan nair MUrALEEDHArAn United Planter's Association of South India (UPASI) Tea research Institute Tea Research Foundation Nirar Dam B.P.O United Planter's Association of South India (UPASI) Tea research Institute Tea Research FoundationNirar Dam B.P.O

The sprayed chemicals on tea leaves disappear over a period of time by the influence of rainfall elution, evaporation, growth dilution, and photodegradation. Influence of plant growth on the four fungicides (hexaconazole, propiconazole, tridemorph, and c) was studied to know the constructive loss of fungicides. The study shows that residues of fungicides sprayed on tea shoots got diluted by the growing process. The expansion of a leaf took 8 to 11 d and more than 50% of the fungicide residues were cleaned out during this leaf expansion period. Under south Indian agroclimatic condition, the fungicides are sprayed at an interval of 10 d, so it is safe that the tea is harvested on the 10th day of the application of fungicides.

关键词： Tea shoots Growth Dilution Fungicides residue loss

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural regeneration research 2025年第4期20卷 1031-1041页

作者： ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOr),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)