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Correction to:Arbovirus and seizures

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Acta Epileptologica 2020年第1期2卷 194-194页

After publication of this article[1],it is noticed the article contains an error:the section below should be placed between the section headings of‘Pathogenesis’and‘Activated glia’on page *** with the brain JEV’s neurotropism is a relevant factor of its *** is not synonymous with neurovirulence,but they can be associated with each other in some *** JEV typically replicates before it spreads to local lymph *** the liver,heart,kidney and other organs the blood-brain barrier(Fig.2).To cross the barrier,JEV replicates in endothelial cells inflammatory cells that carry the virus(Fig.3).

关键词： JEV section barrier

Development of photoreactive demineralized bone matrix 3D printing colloidal inks for bone tissue engineering

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regenerative Biomaterials 2023年第1期10卷 1604-1617页

作者： Katie J.hogan Hayriye Oztatlı Marissa r.Perez Sophia Si reyhan Umurhan Elysa Jui Ziwen Wang Emily Y.Jiang Sa r.Han Mani Diba K.Jane Grande-Allen Bora Garipcan Antonios G.Mikos Department of Bioengineering Rice UniversityMS-1426500 Main StreetHoustonTX 77030USA Baylor College of Medicine Medical Scientist Training Program HoustonTX 77030USA Institute of Biomedical Engineering Bo�gazic¸i University_Istanbul34684Turkey

Demineralized bone matrix(DBM)has been widely used clinically for dental,craniofacial and skeletal bone repair,as an osteoinductive and osteoconductive material.3D printing(3DP)enables the creation of bone tissue engineering scaffolds with complex geometries and *** methacryloylated gelatin nanoparticles(GNP-MAs)3DP inks have been developed,which display gel-like behavior for high print fidelity and are capable of post-printing photocrosslinking for control of scaffold swelling and ***,novel DBM nanoparticles(DBM-NPs,∼400 nm)were fabricated and characterized prior to incorporation in 3DP *** objectives of this study were to determine how these DBM-NPs would influence the printability of composite colloidal 3DP inks,assess the impact of ultraviolet(UV)crosslinking on 3DP scaffold swelling and degradation and evaluate the osteogenic potential of DBM-NP-containing composite colloidal *** addition of methacryloylated DBM-NPs(DBM-NP-MAs)to composite colloidal inks(100:0,95:5 and 75:25 GNP-MA:DBM-NP-MA)did not significantly impact the rheological properties associated with printability,such as viscosity and shear recovery or *** crosslinking with a UV dosage of 3 J/cm2 directly impacted the rate of 3DP scaffold swelling for all GNP-MA:DBM-NP-MA ratios with an∼40%greater increase in scaffold area and pore area in uncrosslinked versus photocrosslinked scaffolds over 21 days in phosphate-buffered saline(PBS).Likewise,degradation(hydrolytic and enzymatic)over 21 days for all DBM-NP-MA content groups was significantly decreased,∼45%less in PBS and collagenase-containing PBS,in UV-crosslinked versus uncrosslinked *** incorporation of DBM-NP-MAs into scaffolds decreased mass loss compared to GNP-MA-only scaffolds during collagenase *** in vitro osteogenic study with bone marrow-derived mesenchymal stem cells demonstrated osteoconductive properties of 3DP scaffolds for the DBM-NP-MA contents examine

关键词： demineralized bone matrix colloidal hydrogels 3D printing bone tissue engineering

Traumatic carotid-rosenthal fistula treated with Jostent Graftmaster

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World Journal of radiology 2014年第12期6卷 924-927页

作者： Hesham Allam r Charles Callison Daniel Scodary Aws Alawi Daniel W hogan Amer Alshekhlee Department of Neurology St.Louis University SSM Neurosciences Institute De Paul Health Center

Traumatic injuries of the carotid artery may result in severe morbidity and mortality. The most common location of carotid artery injury is the cavernous segment, which may result in fistulous connection to the cavernous sinus and ophthalmic veins, which in turn lead to pressure symptoms in the ipsilateral orbit. Unlike the commonly reported direct traumatic carotid-cavernous fistula, we describe an unusual case of a 38-year-old man presented with a traumatic brain injury led to a fistula connection between the cavernous carotid artery and the ipsilateral basal vein of rosenthal, with eventual drainage to the straight and transverse sinuses. The basal vein of rosenthal is usually formed from confluence of anterior and middle cerebral veins deep in the Sylvian fissure and drain the insular cortex and the cerebral peduncles to the vein of Galen. Immediate endovascular deployment of a covered stent in the cavernous carotid artery allowed sealing the laceration site. Three months follow up showed a non-focal neurological examination and healed carotid laceration over the covered stent.

关键词： Jostent Carotid artery Trauma Skull base Fracture

SOPHIE: Generative Neural Networks Separate Common and Specific Transcriptional responses

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 912-927页

作者： Alexandra J.Lee Dallas L.Mould Jake Crawford Dongbo Hu rani K.Powers Georgia Doing James C.Costello Deborah A.hogan Casey S.Greene Genomics and Computational Biology Graduate Program University of PennsylvaniaPhiladelphiaPA 19104USA Department of Microbiology and Immunology Geisel School of Medicine at DartmouthHanoverNH 03755USA Department of Systems Pharmacology and Translational Therapeutics University of PennsylvaniaPhiladelphiaPA 19104USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115USA Department of Pharmacology University of Colorado School of MedicineDenverCO 80045USA Center for Health AI University of Colorado School of MedicineDenverCO 80045USA Department of Biochemistry and Molecular Genetics University of Colorado School of MedicineDenverCO 80045USA

Genome-wide transcriptome profiling identifies genes that are prone to differential expression(DE)across contexts,as well as genes with changes specific to the experimental *** genes that are specifically changed in a context of interest from common differentially expressed genes(DEGs)allows more efficient prediction of which genes are specific to a given biological process under ***,common DEGs or pathways can only be identified through the laborious manual curation of experiments,an inordinately time-consuming *** we pioneer an approach,Specific cOntext Pattern Highlighting In Expression data(SOPHIE),for distinguishing between common and specific transcriptional patterns using a generative neural network to create a background set of experiments from which a null distribution of gene and pathway changes can be *** apply SOPHIE to diverse datasets including those from human,human cancer,and bacterial pathogen Pseudomonas *** identifies common DEGs in concordance with previously described,manually and systematically determined common *** molecular validation indicates that SOPHIE detects highly specific but low-magnitude biologically relevant transcriptional ***’s measure of specificity can complement log2 fold change values generated from traditional DE *** example,by filtering the set of DEGs,one can identify genes that are specifically relevant to the experimental condition of ***,these results can inform future research *** scripts used in these analyses are available at https://***/greenelab/*** can access https://***/greenelab/sophie to run SOPHIE on their own data.

关键词： Neural network Transcriptomics Software Differential expression analysis Machine learning

Underutilization of Living Donor Liver Transplantation in the United States: Bias against MELD 20 and Higher

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Journal of Clinical and Translational Hepatology 2016年第3期4卷 169-174页

作者： ryan B.Perumpail Eric r.Yoo George Cholankeril Lupe hogan Melodie Deis Waldo C.Concepcion C.Andrew Bonham Zobair M.Younossi robert J.Wong Aijaz Ahmed Division of Gastroenterology and Hepatology Stanford University School of Medicine Stanford CA USA Department of Medicine University of Illinois College of Medicine Chicago IL USA Division of Gastroenterology and Hepatology University of Tennessee Health Sciences Center Memphis TN USA Division of Surgery Division of Abdominal Transplantation Stanford University School of Medicine Stanford CA USA Department of Medicine Center for Liver Diseases Inova Fairfax HospitalFalls Church VA USA Division of Gastroenterology and Hepatology Alameda Health System Highland Hospital CampusOakland CA USA

Background and Aims:Utilization of living donor liver transplantation (LDLT) and its relationship with recipient Model for End-Stage Liver Disease (MELD) needs further evaluation in the United States (U.S.).We evaluated the association between recipient MELD score at the time of surgery and survival following ***:All *** LDLT recipients with MELDre evaluated using the 1995-2012 United Network for Organ Sharing *** following LDLTwas stratified into three MELD categories (MELDr methods and multivariate Cox proportional hazards ***:Overall,2,258 patients underwent *** to patients with MELDrall 5-year survival following LDLT was similar among patients with MELD 15-19 (80.9% vs.80.3%,p =0.77) and MELD 20-24 (81.2% vs.80.3%,p =0.73).When compared to patients with MELDre was no significant difference in long-term post-LDLT survival among those with MELD 15-19 (Hr:1.11,95% CI:0.85-1.45,p =0.45) and a non-significant trend towards lower survival in patients with MELD 20-24 (Hr:1.28,95%CI:0.91-1.81,p =0.16).Only 14% of LDLTs were performed in patients with MELD 20-24 and the remaining 86% in patients with MELDrutilized in patients with MELD 20 and higher.

关键词： Living donors Liver transplantation Waitlist Model for End-Stage Liver Disease(MELD)

Pharmacology : reviews & rationales /

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丛书名： Prentice Hall nursing reviews & rationales series

2005年

作者： hogan Mary Ann.

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关于孔眼的势分布

油气井测试 1989年第4期 136-142,118页

作者： D.W.Hilchie r.hogan 唐愉拉

应用电模拟确定了下套管射孔完井各种射孔模式时围绕孔眼的势分布,势分布是射孔穿透深度的函数。模拟了理想的射孔。另外,对径向流边界的位置还进行了确定,以使得边界的径向流假设不至于影响围绕着理想孔眼的势(压力)分布。流线垂直于... 详细信息

应用电模拟确定了下套管射孔完井各种射孔模式时围绕孔眼的势分布,势分布是射孔穿透深度的函数。模拟了理想的射孔。另外,对径向流边界的位置还进行了确定,以使得边界的径向流假设不至于影响围绕着理想孔眼的势(压力)分布。流线垂直于所测试的等势面。

关键词：射孔穿透深度下套管射孔完井径向流射孔技术裸眼完井压力恢复水泥环等势线深穿透

Handbook of Stem Cells

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丛书名： v. 1

2004年

作者： robert Lanza John Gearhart Brigid hogan Douglas Melton roger Pedersen James Thomson Michael West

ISBN: (数字)9780080533735

ISBN: (纸本)9780124366435

New discoveries in the field of stem cell research have frequently appeared in the news and in scientific literature. research in this area promises to lead to new therapies for cancer, heart disease, diabetes, and a wide variety of other diseases. This two-volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system. The editors of the Handbook of Stem Cells include: robert Lanza, Helen Blau, John Gearhart, Brigid hogan, Douglas Melton, Malcolm Moore, roger Pedersen, E. Donnall Thomas, James Thomson, Catherine Verfaillie, Irving Weissman, and Michael West. The Editorial Board includes: W. French Anderson, Peter Andrews, Anthony Atala, Jose Cibelli, Giulio Cossu, robert edwards, Martin Evans, Elaine Fuchs, Margaret Fuller, Fred Gage, richard Gardner, Margaret Goodell, ronald Green, William Haseltine, Joseph Itskovitz-Eldor, rudolf Jaenisch, Ihor Lemischka, Dame Anne McLaren, richard Mulligan, Stuart Orkin, Martin Pera, Benjamin reubinoff, Janet rossant, Hans Scholer, Austin Smith, Evan Snyder, Davor Solter, Alan Trounson, and Leonard Zon. This comprehensive set should be a much-needed addition to the library of students and researchers alike.

关键词： Stem cells.

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超导宇宙弦

世界科技研究与发展 1987年第9期 40-42页

作者： Craig hogan 郭凯声

由于近几年人们常常谈论超导超级对撞机、超级计算机与超对称性、超弦及宇宙弦等等,因此再听到一类新型的称为“超导宇宙弦”的假想天体时就不会感到很惊奇了。高能物理学家们认为宇宙中到处散布着种种想象的天体,“超导宇宙弦”这一超... 详细信息

由于近几年人们常常谈论超导超级对撞机、超级计算机与超对称性、超弦及宇宙弦等等,因此再听到一类新型的称为“超导宇宙弦”的假想天体时就不会感到很惊奇了。高能物理学家们认为宇宙中到处散布着种种想象的天体,“超导宇宙弦”这一超导物理与天文学的杂交产物就是这个日益壮大的天体队伍的最新成员。它那令人敬畏的名字使人想起它在最近的几篇论文(包括本期772页上 *** 与 *** 的论文)所提出的各种天体物

关键词：宇宙弦天体正电子轻子细丝