检索结果-南通市图书馆

Br.ef mater.al exposur. of r.ts to the xenobiotics dibutyl phthalate or.diethylstilbestr.l alter. adult-type Leydig cell development in male offspr.ng

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Jour.al of Andr.logy 2013年第2期15卷 261-268,I0009页

作者： r.char. Ivell Kee Heng Helen nicholson r.vinder.Anand-Ivell School of Molecular.and Biomedical Science University of Adelaide Adelaide 5005 Australia FBN Leibniz Institute of Far. Animal Biology Dummerstorf 18196 Germany Centr. for.r.pr.duction and Genomics Otago School of Medical Sciences University of Otago Dunedin 9054 New Zealand School of Phar.acy and Medical Sciences University of South Australia Adelaide 5000 Australia

Mater.al exposur. to estr.genic xenobiotics or.phthalates has been implicated in the distor.ion of ear.y male r.pr.ductive development, r.fer.ed to in humans as the testicular.dysgenesis syndr.me. It is not known, however. whether.such ear.y gestational and/or.lactational exposur. can influence the later.adult-type Leydig cell phenotype. In this study, Spr.gue-Dawley r.ts wer. exposed to dibutyl phthalate （DBP; fr.m gestational day （GD） 14.5 to postnatal day （PND） 6） or.diethylstilbestr.l （DES; fr.m GD14o5 to GD16.5） dur.ng a shor. gestationalllactational window, and male offspr.ng subsequently analysed for.var.ous postnatal testicular.par.meter.. All offspr.ng r.mained in good health thr.ughout the study. Mater.al xenobiotic tr.atment appear.d to modify specific Leydig cell gene expr.ssion in male offspr.ng, par.icular.y dur.ng the dynamic phase of mid-puber.y, with ser.m INSL3 concentr.tions showing that these compounds led to a faster.attainment of peak values, and a modest acceler.tion of the puber.al tr.jector.. Par. of this effect appear.d to be due to a tr.atment-specific impact on Leydig cell pr.lifer.tion dur.ng puber.y for.both xenobiotics. Taken together. these r.sults suppor. the notion that mater.al exposur. to cer.ain xenobiotics can also influence the development of the adult-type Leydig cell population, possibly thr.ugh an effect on the Leydig stem cell population.

关键词： diethylstilbestr.l (DES) INSL3 Leydig cells dibutyl phthalate (DBP) puber.y testis

Using occupancy models to deter.ine mammalian r.sponses to landscape changes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integr.tive Zoology 2009年第2期4卷 232-239页

作者： Jer.my M.nicholson Fr.nk T.VAN MANEN Depar.ment of For.str. Wildlifeand FisheriesUniversity of TennesseeKnoxvilleTennesseeUSA US Geological Sur.ey Southern Appalachian Research BranchUniversity of TennesseeKnoxvilleTennesseeUSA

Deter.ining impacts of anthr.pogenic landscape changes on wildlife populations is *** the challengesDeter.ining impacts of anthr.pogenic landscape changes on wildlife populations is *** the challenges of designing field studies to document conditions befor. and after.landscape changes occur.assessment of popula-of designing field studies to document conditions befor. and after.landscape changes occur.assessment of popula-tion r.sponses(*** in population density)often pr.vide poor.infer.nce because of sampling *** r.sponses(*** in population density)often pr.vide poor.infer.nce because of sampling *** of occupancy,however.only r.quir.s data on detection or.non-detection of a species and might pr.videEstimation of occupancy,however.only r.quir.s data on detection or.non-detection of a species and might pr.vide better.*** demonstr.te the utility of occupancy models,we used data fr.m an Amer.can black bear.Ur.usbetter.*** demonstr.te the utility of occupancy models,we used data fr.m an Amer.can black bear.Ur.us amer.canus Pallas)population in Nor.h Car.lina,USA to test our.r.sear.h hypothesis that documented declines inamer.canus Pallas)population in Nor.h Car.lina,USA to test our.r.sear.h hypothesis that documented declines in site occupancy of black bear. would be gr.ater.near.a new four.lane *** used multi-season occupancysite occupancy of black bear. would be gr.ater.near.a new four.lane *** used multi-season occupancy models to estimate site occupancy based on bear.visitation to sur.ey sites befor. and after.completion of the newmodels to estimate site occupancy based on bear.visitation to sur.ey sites befor. and after.completion of the new highway and as a function of distance to the *** occupancy declined fr.m 0.81 to 0.35 between the twohighway and as a function of distance to the *** occupancy declined fr.m 0.81 to 0.35 between the two s

关键词： landscape changes mammalian r.sponses occupancy models tr.nspor.ation infr.str.ctur. Ur.us amer.canus.

Molecular.Phenomic Appr.aches to Deconvolving the Systemic Effects of SAr.-CoV-2 Infection and Post-acute COVID-19 Syndr.me

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phenomics 2021年第4期1卷 143-150页

作者： Jer.my K.nicholson The Austr.lian National Phenome Center.and the Health Futur.s Institute Murdoch UniversityHarry Perkins BuildingRobert Warren DriveMurdoch PerthWA 6150Australia Institute of Global Health Innovation Imperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72NAUK

SAr. COV-2 infection causes acute and fr.quently sever. r.spir.tor. disease with associated multi-or.an damage and systemic distur.ances in many biochemical *** phenotyping pr.vides deep insights into the complex immunopathological pr.blems that dr.ve the r.sulting COVID-19 disease and is also a sour.e of novel metr.cs for.assess-ing patient r.cover..A multiplatfor. metabolic phenotyping appr.ach to studying the pathology and systemic metabolic sequelae of COVID-19 is consider.d her.,together.with a fr.mewor. for.assessing post-acute COVID-19 Syndr.me(PACS)that is a major.long-ter. health consequence for.many *** sudden emer.ence of the disease pr.sents a biological discover. challenge as we tr. to under.tand the pathological mechanisms of the disease and develop effective mitigation *** r.quir.s technologies to measur. objectively the extent and sub-phenotypes of the disease at the molecular.*** methods can r.veal metabolic sub-phenotypes and new biomar.er. that can be monitor.d dur.ng the acute disease phase and *** appr.ach is scalable and tr.nslatable to other.pathologies and pr.vides as an exem-plar.str.tegy for.the investigation of other.emer.ent zoonotic diseases with complex immunological dr.ver.,multi-system involvements and diver.e per.istent symptoms.

关键词： SAr. COV-2 COVID-19 Post-acute COVID-19 Syndr.me(PACS)lSpectr.scopy Metabolic Phenoconver.ion Phenor.ver.ion

Pr.per.ies of the multior.ital Hubbar. models for.the ir.n-based super.onductor.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fr.ntier. of physics 2011年第4期6卷 379-397页

作者： Elbio Dagotto Adr.ana Mor.o Andr.w nicholson Qinglong Luo Shuhua Liang Xiaotian Zhang Depar.ment of Physics and Astr.nomy The University of Tennessee Knoxville TN 37996 USA Mater.als Science and Technology Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA

A br.ef r.view of the main pr.per.ies of multior.ital Hubbar. models for.the Fe-based super.onductor. is pr.sented. The emphasis is on the r.sults obtained by our.gr.up at the Univer.ity of Tennessee and Oak r.dge National Labor.tor., Tennessee, USA, but r.sults by sever.l other.gr.ups ar. also discussed. The models studied her. have two, thr.e, and five or.itals, and they ar. analyzed using a var.ety of computational and mean-field appr.ximations. A ＂physical r.gion＂ wher. the pr.per.ies of the models ar. in qualitative agr.ement with neutr.n scatter.ng, photoemission, and tr.nspor. r.sults is r.vealed. A var.ety of inter.sting open questions ar. br.efly discussed such as： what ar. the dominant pair.ng tendencies in Hubbar. models？ Can pair.ng occur.in an inter.r.ital channel？ Ar. nesting effects of fundamental r.levance in the pnictides or.appr.aches based on local moments ar. mor. impor.ant？ What kind of magnetic states ar. found in the pr.sence of ir.n vacancies？ Can char.e str.pes exist in ir.n-based super.onductor.？ Why is tr.nspor. in the pnictides anisotr.pic？ The discussion of r.sults includes the descr.ption of these and other.open pr.blems in this fascinating ar.a of r.sear.h.

关键词： super.onductivity

Pr.gr.ss and pr.spects of engineer.d sequence-specific DNA modulating technologies for.the management of liver.diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wor.d Jour.al of Hepatology 2015年第6期7卷 859-873页

作者： Samantha A nicholson Buhle Moyo Patr.ck B Ar.uthnot Wits/SA Mr. Antivir.l Gene Ther.py r.sear.h Unit School of Pathology Health Sciences Faculty University of the Witwatersrand

Liver.diseases ar. one of the leading causes of mor.ality in the wor.d. The hepatic illnesses, which include inher.ted metabolic disor.er., hemophilias and vir.lhepatitides, ar. complex and cur.ently difficult to tr.at. The matur.tion of gene ther.py has her.lded new avenues for.developing effective inter.ention for.these diseases. DNA modification using gene ther.py is now possible and available technology may be exploited to achieve long ter. ther.peutic benefit. The ability to edit DNA sequences specifically is of par.mount impor.ance to advance gene ther.py for.application to liver.diseases. r.cent development of technologies that allow for.this has r.sulted in r.pid advancement of gene ther.py to tr.at sever.l chr.nic illnesses. Impr.vements in application of der.vatives of zinc finger.pr.teins(ZFPs), tr.nscr.ption activator.like effector.(TALEs), homing endonucleases(HEs) and cluster.d r.gular.y inter.paced palindr.mic r.peats(Cr.SPr. and Cr.SPr.associated(Cas) systems have been par.icular.y impor.ant. These sequence-specific technologies may be used to modify genes per.anently and also to alter.gene tr.nscr.ption for.ther.peutic pur.oses. This r.view descr.bes pr.gr.ss in development of ZFPs, TALEs, HEs and Cr.SPr.Cas for.application to tr.ating liver.diseases.

关键词： Gene ther.py Zinc finger. Tr.nscr.ptionactivator.like effector. Cluster.d r.gular.y inter.pacedshor. palindr.mic r.peats Homing endonucleases Liver.diseases

Tr.nsanal total mesor.ctal excision:a valid option for.r.ctal cancer.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wor.d Jour.al of Gastr.enter.logy 2015年第41期21卷 11700-11708页

作者： Nicolas C Buchs Gar. A nicholson Fr.der.c r.s Neil J Mor.ensen r.el Hompes Depar.ment of Color.ctal Sur.er. Churchill Hospital Oxford University Hospitals Division of Viscer.l Sur.er. Department of Surgery University Hospitals of Geneva Nuffield Depar.ment of Sur.ical Science University of Oxford John Radcliffe Hospital

Low anter.or.r.section can be a challenging oper.tion, especially in obese male patients and in par.icular.after.r.diother.py. Tr.nsanal total mesor.ctal excision(Ta TME) might offer.technical advantages over.lapar.scopic or.open appr.aches par.icular.y for.tumor. in the distal thir. of the r.ctum. The aim of this ar.icle is to r.view the cur.ent exper.ence with Ta TME. The limits and futur. developments ar. also explor.d. Although the exper.ence with Ta TME is still limited, it might be a pr.mising alter.ative to lapar.scopic TME, especially for.difficult cases wher. lapar.scopy is too demanding. The pr.liminar. data on complications and shor.-ter. oncological outcomes ar. good, but also emphasize the impor.ance of car.ful patient selection. Finally, ther. is a need for.lar.e-scale tr.als focusing on long-ter. outcomes and oncological safety befor. widespr.ad adoption can be r.commended.

关键词： Tr.nsanal Bottom up Tr.nsanal minimally invasive s

Evolved Algor.thm and Vibr.tion Stability for.Nonlinear.Distur.ed Secur.ty Systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sound & Vibr.tion 2019年第2期53卷 29-37页

作者： Tcw Chen Wr.y Mar.iott Ann nicholson Tim Chen Mar. Kmieckowiak Jcy Chen Depar.ment of Electr.cal and Computer.Engineer.ng North South UniversityDhaka-1229Bagladesh Depar.ment of Data Science Monash UniversityMelbourneVictoriaAustralia Dyson School of Design Engineer.ng Imperial College LondonSouth Kensington Campus London SW72AZUK Faculty of Engineer.ng King Abdulaziz UniversityJeddah 21589Saudi Arabia Faculty of Mathematics and Natur.l Sciences Albertus-Magnus-Platz50923 KolnGerman Industr.al Technology r.sear.h Institute 31057 HsinchuTaiwanDepartment of Artificial IntelligenceUniversity of MarylandMaryland 20742USA.

In this paper.a method sustaining system stability after.decomposition is *** on the stability cr.ter.on der.ved fr.m the ener.y function,a set of intelligent contr.ller. is synthesized which is used to maintain the stability of the *** sustainable stability pr.blem can be r.for.ulated as a Linear.Matr.x Inequalities(LMI)*** key to guar.nteeing the stability of the system as a whole is to find a common symmetr.cally positive definite matr.x for.all ***,the Evolved Bat Algor.thm(EBA)is employed to r.place the pole assignment method and the conventional mathematical methods for.solving the *** EBA is utilized to find feasible solutions in ter.s of the ener.y *** exper.mental r.sults show that the EBA is capable of pr.viding pr.per.solutions,which satisfy the sustainability and stability cr.ter.a,after.a shor. per.od of r.cur.ive computing.

关键词： Fuzzy ener.y equation swar. intelligence evolved bat algor.thm

Pr.gester.ne r.ceptor. A and B differ.ntially modulate cor.icotr.pin-r.leasing hor.one gene expr.ssion thr.ugh a cAMP r.gulator. element

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

第二军医大学学报 2005年第4期26卷 435-435页

作者： Smith r.nicholson r. Depar.ment of Physiology Second Military Medical UniversityShanghai 200433 ChinaDepartment of Physiology Second Military Medical UniversityShanghai 200433 China

Cor.icotr.phin-r.leasing hor.one (Cr.) plays a major.r.le in mechanisms contr.lling human pr.gnancy and par.ur.tion. Gene r.gulation by pr.gester.ne may be a key point in the contr.l of placental Cr. pr.duction. Studies in pr.mar. placental cells show that antagonism of pr.gester.ne activity or.pr.duction by r.486 or.tr.lostane leads to an incr.ase in Cr. pr.moter.activity. This effect can be r.ver.ed by the addition of pr.gester.ne. Over.xpr.ssion of pr.gester.ne r.ceptor.A (Pr.A) or.glucocor.icoid r.ceptor.r.sulted in a decr.ase in Cr. pr.moter.activity following pr.gester.ne tr.atment, wher.as an incr.ase in pr.moter.activity was obser.ed with over.xpr.ssed Pr.B. Studies including mutation of the cAMP r.gulator. element (Cr.) confir. this site to be essential for.the pr.gester.ne-mediated effects. In summar., our.r.sults demonstr.te that pr.gester.ne r.gulates Cr. gene tr.nscr.ption via a Cr. in the Cr. pr.moter.and that Pr.A and Pr.B exhibit differ.nt actions in the r.gulation of Cr. gene expr.ssion.

关键词：黄体酮激素释放激素因子 cAMP

The Pliocene-r.cent Euphr.tes r.ver.system:Sediment facies and ar.hitectur. as an analogue for.subsur.ace r.ser.oir.

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ener.y Geoscience 2020年第3期1卷 174-193页

作者： Dor.ik Stow Uisdean nicholson Samantha Kear.ey Dominic Tatum Andy Gar.iner.Amer.Ghabr. Mahmoud Jaweesh EGIS-IGE Heriot-Watt UniversityEdinburghEH144ASUK Glasgow Inter.ational College 56 Dumbarton RoadGlasgowG116NUUK Depar.ment of Geology and Petr.leum Explor.tion Engineer.ng Faculty of Petroleum EngineeringSyrian Private UniversityDamascusSyria School of Geogr.phy University of BirminghamBirminghamB152TTUK

The Tigr.s-Euphr.tes is a continental-scale fluvial system,ar.und 2800 km in length,which dr.ins over.1 million km2 of *** system or.ginated in the Late Miocene and developed into the pr.ncipal axial dr.inage system of the r.gion,which follows br.ad r.gional str.ctur.l featur.s of the Mesopotamian For.land *** pr.ser.ation and outcr.pping of the Pliocene and Quater.ar. Euphr.tes deposits yield a viable local analogue for.subsur.ace fluvial r.ser.oir. in the r.gion,and for.other.fluvial systems that have developed in for.land basin *** paper.documents the fir.t detailed study of the sedimentar. char.cter.stics of these Pliocene and Quater.ar. fluvial deposits along the middle r.aches of the pr.sent-day Euphr.tes in *** Euphr.tes fluvial system developed fr.m small and pr.bably shor.-lived isolated cut-and-fill channels in the Pliocene,char.cter.sed by abundant debr.te and slump facies,thr.ugh to a br.ad meander.ng system at *** Quater.ar. deposits r.pr.sent a br.ided to meander.ng system that was mor. ener.etic than that of the moder. day *** Quater.ar. facies include a dominance of gr.vels,pebbly sands and sands as channel associations,coupled with sands,muds and paleosols r.pr.senting channel abandonment,over.ank and cr.vasse-splay *** widths,wher. obser.ed,r.nge fr.m 50 to 500 m,and minimum fill thicknesses r.nge fr.m 3 to 7 *** combined channel-fill for.stacked channels is up to 25 m *** cor.elation of channel elements over.at least 1 km of section indicates that r.pid and extensive later.l migr.tion has *** splay lobes can be identified in the over.ank deposits,with a width of 30e60 m and sand thickness of 0.5e1.5 *** geometr.,natur. and dimensions of these ar.hitectur.l elements pr.vide a useful analogue for.subsur.ace *** high-ener.y channel facies of the Quater.ar. system show ver. good r.ser.oir.attr.butes,with good cor.elation and *** the bed-

关键词： Euphr.tes r.ver Fluvial facies Fluvial ar.hitectur. r.ser.oir.analogue