检索结果-南通市图书馆

Jour.al of r.ck Mechanics and Geotechnical Engineer.ng 2017年第3期9卷 33-45页

作者： G. Ar.and F. Bumbieler.N. Conil r. de la vaissière J.-M. Bosgir.ud M.-N. Vu Meuse/Haute Mar.e Under.r.und r.sear.h labor.tor. Andra Bure 55290 France Andr. Chatenay-Malabry 92298 France

In the context of r.dioactive waste disposal,an under.r.und r.sear.h labor.tor.(Ur.)is a facility in which exper.ments ar. conducted to demonstr.te the feasibility of constr.cting and oper.ting a r.dioactive waste disposal facility within a geological *** Meuse/Haute-Mar.e Ur. is a sitespecific facility planned to study the feasibility of a r.dioactive waste disposal in the Callovo-Oxfor.ian(COx)*** ther.o-hydr.-mechanical(THM)behaviour.of the host r.ck is significant for.the design of the under.r.und nuclear.waste disposal facility and for.its long-ter. *** Fr.nch National r.dioactive Waste Management Agency(Andr.)has begun a r.sear.h pr.gr.mme aiming to demonstr.te the r.levancy of the Fr.nch high-level waste(HLW)*** paper.pr.sents the pr.gr.mme implemented fr.m small-scale(small diameter.bor.holes to full-scale demonstr.tion exper.ments to study the THM effects of the ther.al tr.nsient on the COx claystone and the str.tegy implemented in this new pr.gr.mme to demonstr.te and optimise cur.ent disposal facility components for.*** shows that the Fr.nch high-level waste concept is feasible and wor.ing in the COx *** also exhibits that,as for.other.plastic clay or.claystone,heating-induced por. pr.ssur. incr.ases and that the THM behaviour.is anisotr.pic.

关键词： In situ exper.ments Claystone Ther.o-hydr.-mechanical(THM) behaviour r.sear.h pr.gr.mme r.dioactive high-level waste(HLW) disposal

How dopamine tunes par.albumin inter.eur.ns in the hippocampus:new exper.mental obser.ations in Alzheimer.s disease

在线全文

学校读者我要写书评

暂无评论

Neur.l r.gener.tion r.sear.h 2025年第5期20卷 1405-1406页

作者： Livia la Bar.er. Par.skevi Kr.shia Annalisa Nobili depar.ment of Medicine and Sur.er. UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly depar.ment of Exper.mental Neur.sciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly depar.ment of Science and Technology for.Sustainable development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

despite decades of dedicated r.sea r.h,Alzheimer.s disease (AD) is an age-r.lated and pr.gr.ssive neur.degener.tive disor.er.for.which the mechanisms of onset ar. sti unc *** is cha r.cter.zed by featur.d histological alter.tions including amyloid-beta (AB) plaque deposition,accumulation of neur.fibr.llar. to ngles of hyper.hosphor.lated-tau,and neur.nal loss,accompanied by pr.gr.ssive cognitive decline and behavior.l changes.

关键词： Alzheimer alter.tions dopamine

How r.ck samples can be r.pr.sentative of in situ condition:A case study of Callovo-Oxfor.ian claystones

在线全文

学校读者我要写书评

暂无评论

Jour.al of r.ck Mechanics and Geotechnical Engineer.ng 2018年第4期10卷 613-623页

作者： N.Conil J.Talandier.H.Djizanne r.de la vaissièr. C.r.ghini-Waz C.Auvr.y C.Mor.ot G.Ar.and Andr. Ur. BureFrance Andr. Chatenay-MalabryFrance Univer.itéde Lor.aine Géor.ssour.es Vandoeuvre-les-NancyFrance

Within the fr.mewor. of feasibility studies for.a r.ver.ible, deep geological r.positor. of high-and inter.ediate-level long-lived r.dioactive waste(HLW, IL-LLW), the Fr.nch National r.dioactive Waste Management Agency(Andr.) is investigating the Callovo-Oxfor.ian(COx) for.ation near.Bur.(nor.heast par. of Fr.nce) as a potential host r.ck for.the r.positor.. The hydr.-mechanical(HM) behaviour.is an impor.ant issue to design and optimise differ.nt components of the disposal such as shaft, r.mp, dr.ft,and waste package disposal facilities. Over.the past 20 year., a lar.e number.of labor.tor. exper.ments have been car.ied out to char.cter.se and under.tand the HM behaviour. of COx claystones. At the beginning, samples came fr.m deep bor.holes dr.lled at the gr.und sur.ace with oil base mud. Fr.m2000 onwar.s, with the launch of the constr.ction of the Meuse/Haute-Mar.e Under.r.und r.sear.h labor.tor.(MHM Ur.), most samples have been extr.cted fr.m a lar.e number.of air.dr.lled bor.holes in the Ur.. In par.llel, var.ous constitutive models have been developed for.modelling. The ther.ohydr.-mechanical(THM) behaviour. of the COx claystones wer. investigated under.differ.nt r.positor. conditions. Cor. samples ar. subjected to a complex HM loading path befor. testing, due to dr.lling, conditioning and pr.par.tion. Var.ous kinds of effects on the char.cter.stics of the claystones ar. highlighted and discussed, and the pr.cedur.s for.cor. extr.ction and packaging as well as a systematic sample pr.par.tion pr.tocol ar. pr.posed in or.er.to minimise the uncer.ainties on test r.sults. The r.pr.sentativeness of the test r.sults is also addr.ssed with r.gar. to the in situ r.ck mass.

关键词： Callovo-Oxfor.ian (COx) claystone samples Physical pr.per.ies In situ condition Satur.tion degr.e r.satur.tion pr.cess Exper.mental pr.tocol

Mechanical pr.per.ies of the A356 aluminum alloy modified with la/Ce

在线全文

学校读者我要写书评

暂无评论

Jour.al of r.r. Ear.hs 2013年第8期31卷 811-816页

作者： E. Aguir.e-de la Tor.e r. Pér.z-Bustamante J. Camar.llo-Cisner.s C.D. Gómez-Espar.a H.M. Medr.no-Pr.eto r. Mar.ínez-Sánchez Advanced Mater.als r.sear.h Center.(CIMAV) National Laboratory of Nanotechnology

The r.sear.h of r.r. ear.hs for.the synthesis of mater.als with impr.ved mechanical per.or.ance is of gr.at inter.st when they ar. consider.d for.potential applications in the automotive industr.. In this r.gar., the effect on the mechanical pr.per.ies and micr.stmctur. of the automotive A356 aluminum alloy r.infor.ed with 0.2 （wt.%） AI-6Ce-3la （ACL） was investigated. The ACL was added to the melted A356 alloy in the as-r.ceived condition and pr.cessed by mechanical milling. In the second r.ute, the effect of the ACL pr.cessed by mechanical milling and powder.metallur.y techniques was investigated, and compar.d with the r.sults ob- tained fr.m the A356 alloy str.ngthened with ACL in the as-r.ceived condition. Micr.stmctur.l pr.per.ies wer. evaluated by means of X-r.y diffr.ction in or.er.to obser.e the solubility of Ce/la in the A1 matr.x. In addition, electr.n micr.scopy was employed in or. der.to investigate the effect of milling time on the size and mor.hology of la/Ce phase under.milling pr.cess. Mechanical pr.per.ies of the A356 alloy modified with ACL wer. measur.d by har.ness and tensile test. For.compar.son unmodified specimens of the A356 wer. char.cter.zed accor.ing to the pr.vious pr.cedur.. The micr.str.ctur.l and mechanical char.cter.zation was car.ied out in specimens alter.solution and ar.ificial aging. Obser.ations in scanning electr.n micr.scopy indicated a homogeneous disper.ion of la/Ce phases by using both r.utes; however. mechanical r.sults, in the modified A356 alloy with the ACL in the as-r.ceived condi- tion, showed an impr.vement in the mechanical per.or.ance of the A356 alloy over.that r.infor.ed with the ACL mechanically milled.

关键词： A356 r.r. ear.hs mechanical milling mechanical pr.per.ies

Two upper.bounds for.the Er.os-Hooley delta-function

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2023年第12期66卷 2683-2692页

作者： r.gis de la Br.teche Ger.ld Tenenbaum Institut de Mathematiques Universite Paris CiteSorbonne UniversiteCNRSParis F-75013France Institut Elie Car.an Universite de LorraineVandoeuvre-les-NancyBP 70239France

For.integer.n≥1 and r.al u,let Δ(n,u):=|{d:d] n,e^(u)r.os-Hooley deltafunction is then defined by Δ(n):=Max_(u∈r.Δ(n,u).We impr.ve the cur.ent upper.bounds for.the aver.ge and nor.al or.er. of ... 详细信息

关键词： concentr.tion of divisor. aver.ge or.er nor.al or.er War.ng’s pr.blem

r.diomics in pancr.atic cancer.for.oncologist:Pr.sent and futur.

在线全文

学校读者我要写书评

暂无评论

Hepatobiliar. & Pancr.atic Diseases Inter.ational 2022年第4期21卷 356-361页

作者： Car.lina de la Pinta r.diation Oncology depar.ment Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

r.diomics is changing the wor.d of medicine and mor. specifically the wor.d of *** diagnosis and tr.atment impr.ve the pr.gnosis of patients with *** tr.atment,the evaluation of the r.sponse will deter.ine futur. *** oncology,ever. change in tr.atment means a loss of ther.peutic options and this is key in pancr.atic *** has been developed in oncology in the ear.y diagnosis and differ.ntial diagnosis of benign and malignant lesions,in the evaluation of r.sponse,in the pr.diction of possible side effects,mar.ing the r.sk of r.cur.ence,sur.ival and pr.gnosis of the *** studies have validated its use to differ.ntiate nor.al tissues fr.m tumor.tissues with high sensitivity and specificity,and to differ.ntiate cystic lesions and pancr.atic neur.endocr.ne tumor.gr.des with textur. *** addition,these par.meter. have been r.lated to sur.ival in patients with pancr.atic cancer.and to r.sponse to r.diother.py and *** r.view aimed to establish the cur.ent status of the use of r.diomics in pancr.atic cancer.and futur. per.pectives.

关键词： Pancr.atic cancer r.diomics r.diogenomics

Ster.otactic body r.diother.py in pancr.atic adenocar.inoma

在线全文

学校读者我要写书评

暂无评论

Hepatobiliar. & Pancr.atic Diseases Inter.ational 2024年第1期23卷 14-19页

作者： Car.lina de la Pinta r.diation Oncology depar.ment Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Backgr.und:Ster.otactic body r.diother.py(SBr.)in pancr.atic cancer.allows high deliver. of r.diation doses on tumor. without affecting sur.ounding *** r.view aimed at the SBr. application in the tr.atment of pancr.atic *** sour.es:We r.tr.eved ar.icles published in MEDLINE/PubMed fr.m Januar. 2017 to december.*** used in the sear.h included:“pancr.atic adenocar.inoma”Or.pancr.atic cancer.AND“ster.otactic ablative r.diother.py(SABr.”Or.ster.otactic body r.diother.py(SBr.)”Or.chemor.diother.py(Cr.)”.English language ar.icles with infor.ation on technical char.cter.stics,doses and fr.ctionation,indications,r.cur.ence patter.s,local contr.l and toxicities of SBr. in pancr.atic tumor. wer. *** ar.icles wer. assessed for.validity and r.levant ***:Optimal doses and fr.ctionation have not yet been ***,SBr. could be the standar. tr.atment in patients with pancr.atic adenocar.inoma in addition to ***,the combination of SBr. with chemother.py may have additive or.syner.ic effect on pancr.atic ***:SBr. is an effective modality for.patients with pancr.atic cancer.suppor.ed by clinical pr.ctice guidelines as it has demonstr.ted good toler.nce and good disease *** opens a possibility of impr.ving outcomes for.these patients,both in neoadjuvant tr.atment and with r.dical intent.

关键词： Chemor.diother.py Pancr.atic adenocar.inoma r.diother.py Ster.otactic body r.diother.py Ster.otactic ablative r.diother.py

Validation of Zebr.fish (Danio r.r.o) r.fer.nce Genes for.Quantitative r.al-time r.-PCr.Nor.alization

在线全文

学校读者我要写书评

暂无评论

Acta Biochimica et Biophysica Sinica 2007年第5期39卷 384-390页

作者： Andr.w DODD Daniel la War.en C. MCNABB Donald r. LOVE School of Biological Sciences University of Auckland Private Bag 92019 Auckland 1142 New Zealand Food and Health Gr.up AgResearch Grasslands Private Bag 11008 Tennant Drive Palmerston North New Zealand

The nor.alization of quantitative r.al time r.-PCr.(qr.-PCr. is impor.ant to obtain accur.te gene expr.ssion data. The most common method for.qr.-PCr.nor.alization is to use r.fer.nce, or.house- keeping genes. However. ther. is emer.ing evidence that even r.fer.nce genes can be r.gulated under.differ.nt conditions, qr.-PCr.has only r.cently been used in ter.s of zebr.fish gene expr.ssion studies and ther. is no validated set of r.fer.nce genes. This study char.cter.zes the expr.ssion of nine possible r.fer.nce genes dur.ng zebr.fish embr.onic development and in a zebr.fish tissue panel. All nine r.fer.nce genes exhibited var.able expr.ssion. The β-actin, EF1α and r.113α genes compr.se a validated r.fer.nce gene panel for.zebr.fish developmental time cour.e studies, and the EF1α, r.113α and 18S r.NA genes ar. mor. suitable as a r.fer.nce gene panel for.zebr.fish tissue analysis. Impor.antly, the zebr.fish GAPDH gene appear. unsuitable as r.fer.nce gene for.both types of studies.

关键词： zebr.fish quantitative r.al-time r.-PCr housekeeping genes GAPDH gene GeNor.

ON A THEOr.M OF BEr.STEIN AND ITS APPLICATIONS TO WEIGHTED MINIMAX SEr.ES

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Jour.al of Computational Mathematics 1998年第6期16卷 509-520页

作者： Fr.ncisco Per.z Acosta(depar.amento de Analisis Matematico, Univer.idad de la laguna, la laguna 38271,Canar. Islands, Spain) Univ la laguna Dept Anal Matemat E-38271 La Laguna Canary Isl Spain

In this paper. some r.sults about appr.ximation in a nor. S induced by the minimax ser.es ar. studied. Then a Ber.stein-type theor.m for.the nor. S is established. Finally the Ber.stein theor.m is applied to pr.ve the... 详细信息

关键词： Appr.ximation theor. polynomials Ber.stein theor.m minimax ser.es.

Concentr.tions and sour.es of an emer.ing pollutant, decabr.modiphenylethane (DBDPE), in sewage sludge for.land application

在线全文

学校读者我要写书评

暂无评论

Jour.al of Envir.nmental Sciences 2012年第3期24卷 558-563页

作者： de la Tor.e A Concejer. M A Mar.ínez M A Per.istent Or.anic Pollutant Gr.up Environment Department CIEMAT Avd. Complutense 22 Madrid 28040 Spain

The pr.sence of an emer.ing br.minated flame r.tar.ant, decabr.modiphenylethane （DBDPE）, has been confir.ed in Spanish sewage sludge. Thir.y one samples fr.m differ.nt ur.an wastewater.tr.atment plants （WWTPs） wer. analyzed for.this br.minated flame r.tar.ant. DBDPE was positively identified and quantified in all samples at lower.concentr.tions （47.0 ± 29.7 ng/g dr. weight （dw）; mean ± SD） than those obtained for.decabr.modiphenyl ether.（Bde-209）（290 ± 236 ng/g dw; mean ± SD） in a pr.vious study. Influence of the WWTP char.cter.stics in the pollutant levels was evaluated. No significant cor.elations wer. obtained between DBDPE concentr.tions and the population or.sewage sludge pr.duction r.te associated with the plants, neither.wastewater.tr.atment method. Sour.es of DBDPE in the sludge wer. also evaluated. Data indicate a common or.gin for.DBDPE and Bde-209, which may be r.lated to leaching pr.cesses dur.ng the use and disposal of consumer.pr.ducts containing these chemicals. Never.heless, DBDPE contents ar. not influenced by industr.al activities, which suggests that the infusion of DBDPE commer.ial mixtur. is not a sour.e of this chemical into the envir.nment, and indicates that the use of DBDPE in the Spanish industr. is still low compar.d to deca-Bde.

关键词： decabr.modiphenylethane polybr.minated diphenyl ether. wastewater.tr.atment plants sewage sludge