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机械通气新生儿和婴幼儿持续静脉滴注可乐宁随机对照研究

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中国小儿急救医学 2014年第7期21卷 422-422页

作者： Hünseler.C Balling G r.hlig C 方伯梁首都医科大学附属北京儿童医院

目的评估持续静脉滴注可乐宁1μg/（kg·h）对机械通气新生儿和婴幼儿芬太尼及咪达唑仑需求的影响。设计前瞻性双盲随机对照多中心试验。网址:Contr.lled ***/ISr.TN77772144。场所 28家德国三级儿童/新生儿重症监护病房。对象机械通气... 详细信息

目的评估持续静脉滴注可乐宁1μg/（kg·h）对机械通气新生儿和婴幼儿芬太尼及咪达唑仑需求的影响。设计前瞻性双盲随机对照多中心试验。网址:Contr.lled ***/ISr.TN77772144。场所 28家德国三级儿童/新生儿重症监护病房。对象机械通气新生儿和婴幼儿。分层研究:I层（1;8 d）,Ⅱ层（29;20 d）,Ⅲ层（121 d;岁）。干预措施气管插管后第4天予患儿可乐宁1μg/（kg·h）或安慰剂治疗。调整芬太尼和咪达唑仑用量以达到既定的镇痛镇静目标（Har.wig评分）。测量指标和主要结果随机入组219例婴幼儿;212例静点研究用药,机械通气原因69.7%为术后监护,30.3%为其他原因。主要研究终点:全体研究对象于静点研究用药后72 h内的芬太尼和咪达唑仑用量（主要观察期）。对全体研究对象行验证分析示芬太尼和咪达唑仑用量没有区别。按年龄分层分析示,I层患儿（n=112）可乐宁组芬太尼[可乐宁组:（2.1±1.8）μg/（kg·h）,安慰剂组:（3.2±3.1）μg/（kg·h）;p=0.032]及咪达唑仑[可乐宁组:（113.0±100.1）μg/（kg·h）,安慰剂组:（180.2±204.0）μg/（kg·h）;p=0.03]用量显著低于对照组。Ⅱ层（n=43）及Ⅲ层（n=46）患儿组间药物用量差异无统计学意义。Ⅰ层患儿可乐宁组镇静.戒断评分显著低于对照组（p

关键词：可乐宁静脉输注镇痛镇静新生儿婴幼儿

Classification, diagnosis, and management of conjunctival lymphoma

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Eye and Vision 2019年第1期6卷 175-190页

作者： r.becca E.Tanenbaum Anat Galor.Sander.r.Dubovy Car.l L.Kar. Depar.ment of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900 NW 17th St.MiamiMiamiFL 33136USA

Lymphoma is a malignant lymphopr.lifer.tive tumor.that can involve the *** 5–15%of all extr.nodal lymphomas ar. found in the ocular.adnexal r.gion,with appr.ximately 25%of those involving the ***-eight per.ent of conjunctival lymphomas ar.se fr.m *** most common subtype of conjunctival lymphoma is extr.nodal mar.inal zone lymphoma(80%),followed by follicular.lymphoma(8%),diffuse lar.e B-cell lymphoma(3%)and mantle cell lymphoma(3%).Natur.l killer.and T cells(NK/T)ar. r.r. causes of *** most conjunctival lymphomas ar. localized to the ocular.adnexa at the time of pr.sentation,systemic examination and management ar. of key impor.ance in the long-ter. car. of the *** r.view outlines the classification,etiology,pr.sentation,diagnosis,and management of conjunctival *** novel use of high r.solution optical coher.nce tomogr.phy,both as a diagnostic tool and as a means for.ongoing evaluation dur.ng tr.atment,is *** options discussed include exter.al beam r.diation,chemother.py,immunother.py,antibiotic ther.py,and combination *** investigation of the etiology and pathogenesis of conjunctival lymphoma is expected to r.veal oppor.unities for.innovative and individualized ther.peutic *** between multiple disciplines is key in the advancement of the field.

关键词： Conjunctiva Conjunctival tumor Extr.nodal mar.inal zone lymphoma Lymphoma Optical coher.nce tomogr.phy Salmon patch

多参数Mr.检测服用环丙沙星后健康男性跟腱中的糖胺聚糖变化:初步观察

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国际医学放射学杂志 2015年第4期 382-382页

作者： V.Jur.s Y.Winhofer.p.Szomolanyi J.Vosshenr.ch B.hager p.Wolf 赵效新 Mr.Centr. of Excellence Department of Biomedical Imaging and Image-Guided Therapy 7F Internal Medicine III and Medical University of ViennaInstitute of Measurement Science

摘要目的判断定量Mr.技术[Mr.成像、糖胺聚糖(GAG)化学交换饱和转移(CEST)和T2*mapping]可否用于标记跟腱摄取环丙沙星后的生化改变。材料与方法研究经过

关键词：环丙沙星 GAG 跟腱糖胺聚糖 Mr.

pseudopemphigoid as caused by topical dr.gs and pemphigus disease

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Wor.d Jour.al of Ophthalmology 2015年第1期5卷 1-15页

作者： Laur. C Huang James r.Wong Javier.Alonso-Llamazar.s Car.os H Nousar. Victor.L per.z Guiller.o Amescua Car.l L Kar. Anat Galor Depar.ment of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineMiamiFL 33136United States Depar.ment of Der.atology and Cutaneous Sur.er. Miami Veterans Administration Medical CenterMiamiFL 33136United States Institute for.Immunofluor.scence Pompano BeachFL 33069United States Amer.path/Quest South Flor.da Pompano BeachFL 33069United States Depar.ment of Der.atology and Cutaneous Sur.er. University of Miami Miller School of MedicineMiamiFL 33136United States Depar.ment of Ophthalmology Miami Veterans Administration Medical CenterMiamiFL 33136United States

pseudopemphigoid can cause a chr.nic cicatr.cial conjunctivitis that is clinically identical to the manifestations seen in mucous membr.ne pemphigoid, a disor.er.with a common clinical phenotype and multiple autoimmune links. For.the pur.ose of this r.view, we will descr.be pseudopemphigoid as caused by topical dr.gs, the most common etiology with ocular.manifestations, and as caused by the pemphigus disease, a mor. r.r. etiology. Specifically, we will discuss the ophthalmological featur.s of dr.g-induced cicatr.cial conjunctivitis, pemphigus vulgar.s, and par.neoplastic pemphigus. Other.etiologies of pseudopemphigoid exist that will not be descr.bed in this r.view including autoimmune or.inflammator. conditions such as lichen planus, sar.oidosis, gr.nulomatosis with polyangiitis(Wegener.s gr.nulomatosis), er.thema multifor.e(minor. major. and Stevens-Johnson syndr.me), bullous pemphigoid, skin-dominated linear.IgA bullous der.atosis, and skin-dominated epider.olysis bullosa acquisita. pr.mpt diagnosis of the under.ying etiology in pseudopemphigoid is par.mount to the patient's outcome as cer.ain diseases ar. associated with a mor. sever. clinical cour.e, incr.ased ocular.involvement, and differ.ntial r.sponse to tr.atment. A completehistor. and ocular.examination may find ear.y cicatr.cial changes in the conjunctiva that ar. impor.ant to note and evaluate to avoid pr.gr.ssion to mor. sever. disease manifestations. When such cicatr.cial changes ar. noted, pr.per.diagnostic techniques ar. needed to help elucidate a diagnosis. Lastly, collabor.tion between ophthalmologists and subspecialists such as der.atologists, pathologists, immunologists, and other. involved in the car. of the patient is needed to ensur. optimal management of disease.

关键词： pseudopemphigoid Mucous membr.ne pemphigoid Cicatr.cial conjunctivitis pemphigus vulgar.s par.neoplastic pemphigus Dr.g-induced conjunctival cicatr.zation

Inter.ction of Diet/Lifestyle Inter.ention and TCF7L2 Genotype on Glycemic Contr.l and Adiposity among Over.eight or.Obese Adults:Big Data fr.m Seven r.ndomized Contr.lled Tr.als Wor.dwide

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Health Data Science 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yor.ko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio r.s Liana C.Del Gobbo Jor.i Salas-Salvadó Miguel A.Mar.ínez-González Jan polak Mar.ku Laakso Ar.e Astr.p Dominique Langin Jor. hager Gabby Hul Tor.en Hansen Oluf peder.en Jean-Michel Opper. Wim H.M.Sar.s peter.Ar.er.Montser.at Cofán Sujatha r.jar.m Jaakko Tuomilehto Jaana Lindstr.m Vanessa D.de Mello Alena Stancacova Matti Uusitupa Mathilde Svendstr.p Thor.ild I.A.Sør.nsen Chr.stopher.D.Gar.ner.Joan Sabaté Dolor.s Cor.lla J.Alfr.do Mar.inez Lu Qi Depar.ment of Epidemiology&Biostatistics School of Public HealthPeking UniversityChina Depar.ment of Global Health School of Public HealthPeking UniversityChina Key Labor.tor. of Molecular.Car.iovascular.Sciences Ministr. of Education China Global Health Institute peking Univer.ity China Depar.ment of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Depar.ment of Nutr.tion Harvard T.H.Chan School of Public HealthBostonMAUSA Depar.ment of Endocr.nology&Nutr.tion Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain CIBEr.Fisiopatologia de la Obesidad y Nutr.ción(CIBEr.bn) Instituto de Salud Carlos III(ISCIII)MadridSpain Stanfor. pr.vention r.sear.h Center Stanford UniversityStanford CAUSA Human Nutr.tion Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain Univer.ity of Navar.a Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Depar.ment for.the Study of Obesity and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Depar.ment of Medicine University of Eastern FinlandKuopioFinland Univer.ity of Copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut National de la Santéet de la r.cher.he Médicale(Inser.) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance NestléInstitute of Health Sciences LausanneSwitzerland Depar.ment of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sor.onne Univer.ité Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** str.ngest locus which associated with type 2 diabetes(T2D)by the common var.ant r.7903146 is the tr.nscr.ption factor.7-like 2 gene(TCF7L2).We aimed to quantify the inter.ction of diet/lifestyle inter.entions and the genetic effect of TCF7L2 r.7903146 on glycemic tr.its,body weight,or.waist cir.umfer.nce in over.eight or.obese adults in sever.l r.ndomized contr.lled tr.als(r.Ts).*** October.2016 to May 2018,a lar.e collabor.tive analysis was per.or.ed by pooling individualpar.icipant data fr.m 7 *** r.Ts r.por.ed changes in glycemic contr.l and adiposity of the var.ant r.7903146 after.dietar./lifestyle-r.lated inter.entions in over.eight or.obese *** tr.atment inter.ction models which used the genetic effect encoded by the allele dose and common covar.ates wer. applicable to individual par.icipant data in all *** the joint analysis,a total of 7 eligible r.Ts wer. included(n=4,114).Impor.antly,we obser.ed a significant effect modification of diet/lifestyle-r.lated inter.entions on the TCF7L2 var.ant r.7903146 and changes in fasting *** with the contr.l gr.up,diet/lifestyle inter.entions wer. r.lated to lower.fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for.heter.geneity and over.ll effect:I^(2)=45:1%,pp=0:028)per.one copy of the TCF7L2 T r.sk ***,r.gar.less of genetic r.sk,diet/lifestyle inter.entions wer. associated with lower.waist ***,ther. was no significant change for.diet/lifestyle inter.entions in other.glycemic contr.l and adiposity tr.its per.one copy of TCF7L2 r.sk *** findings suggest that car.ying the TCF7L2 T r.sk allele may have a modestly gr.ater.benefit for.specific diet/lifestyle inter.entions to impr.ve the contr.l of fasting glucose in over.eight or.obese adults.

关键词： TCF7L2 weight finding