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Multibr.nched-Based Fluor.nated Mater.als:Tailor.Made Design of ^(19)F‑Mr. Pr.bes

Accounts of Mater.als r.sear.h 2023年第1期4卷 71-85页

作者： Beatr.ce lucia bona.Olga Koshkina Cr.stina Chir.zzi Valentina Dichiar.nte Pier.ngelo Metr.ngolo Fr.ncesca Baldelli Bombelli Supr.BioNanolab Department of ChemistryMaterials and Chemical Engineering“Giulio Natta”Politecnico di MilanoMilan 20131Italy Sustainable Polymer.Chemistr. Gr.up Department of Molecules and MaterialsMesa+Institute for NanotechnologyUniversity of TwenteTwente 7522 NBThe Netherlands

CONSPECTUS: Futur. medicine is pr.mar.ly aiming at the development of novel appr.achesfor.an ear.y diagnosis of diseases and a per.onalized ther.py for.patients. For.achieving theseobjectives, a key r.le is played by medical imaging. Among available noninvasive imagingtechniques, Fluor.ne-19 (^(19)F) Magnetic r.sonance Imaging (Mr.) is emer.ing as a power.ulquantitative detection modality for.clinical use both for.molecular.imaging and for.cell *** str.ngth of using ^(19)F-Mr. is mainly r.lated to the lack of endogenous or.anic fluor.ne intissues, with no backgr.und, enabling the visualization of fluor.nated tr.cer. as hot-spot images,adding secondar. independent infor.ation to the anatomical featur.s pr.vided by thegr.yscale ^(1)H-Mr.. The main challenge for.^(19)F-Mr. clinical application is the intr.nsic r.ducedsensitivity of Mr.. To impr.ve sensitivity, undoubtedly the use of a high field Mr. scanner.andcr.ogenic r.diofr.quency pr.bes is advantageous, but ther. is a clear.need of developingincr.asingly effective fluor.nated *** ideal tr.cer.should bear.as many as possible magnetically equivalent fluor.ne atoms andshow optimal magnetic r.sonance r.laxivity pr.per.ies (i.e., T_(1) and T_(2)), which enable r.duced acquisition time with the possibility toapply fast imaging methods. Mor.over. it should be biocompatible with r.duced tendency to bioaccumulate in tissues, which is oneof the main dr.wbacks in using per.luor.car.ons (PFCs), together.with their.difficulty to be chemically modified with functionalgr.ups. In fact, PFCs such as per.luor.octyl br.mide (PFOB), per.luor.-15-cr.wn-5-ether.(PFCE), and linear.per.luor.polyether.(PFPE) ar. cur.ently the most used tr.cer. in ^(19)F-Mr. pr.clinical and clinical studies, with the above-mentioned limitations. In thisr.gar., molecules bear.ng shor. br.nched fluor.nated chains gained a lot of attention for.their.high number.of equivalent fluor.nesand expected capability of r.ducing bioaccumulation concer.

关键词： fluor.ne Pr.be scanner

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In vitr. establishment of shoot mer.stems of Ilex par.guar.ensis and identification of endophytic bacter.a

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Jour.al of For.str. r.sear.h 2019年第5期30卷 1765-1777页

作者： Jessica de Cassia Tomasi Juliana Degenhar.t-Goldbach r.nata lucia Gr.nennvaldt Ger.ana Davila dos Santos Vania Apar.cida Vicente luziane Fr.nciscon Cleusa bona.Mar.uer.te Quoir.n Depar.ment of Cr.p Pr.duction and Pr.tection Federal University of Parana1540 Rua dos Funciona′riosCuritibaPR 80035-060Brazil Br.zilian Agr.cultur.l r.sear.h Cor.or.tion(EMBr.PA)For.str. ColomboPRBrazil Depar.ment of Basic Pathology Federal University of ParanaCuritibaBrazil Depar.ment of Botany Federal University of ParanaCuritibaBrazil

Yer.a mate(Ilex par.guar.ensis ***.-Hil.)is a species of gr.at economic,social and envir.nmental impor.ance for.the souther. r.gions of Br.zil,Ur.guay and *** the most diver.e pr.ducts ar. obtained fr.m mate leaves,including mate *** objective of this study was to establish shoot mer.stem cultur.s(mer.stematic dome and a few pr.mor.ia)of elite clones and identify the endophytic bacter.a pr.sent in the *** tested the effect of clones(F1,F2,A03 and A07),cultur. media(MS,1/2MS,1/4MS and WPM),cytokinins(kinetin,BA and 2iP),activated char.oal(1,2 and 3 g l^-1),and disinfecting agent(sodium hypochlor.te and mer.ur.c chlor.de)on in vitr. establishment.F1 and F2 clones wer. the most r.sponsive for.shoot mer.stem in vitr. *** medium supplemented with 8.8 lM 2iP,0.2 lM NAA and 3 g l^-1 activated char.oal was the most suitable for.the in vitr. establishment of the F1 *** phytotoxic effect of the disinfectant was obser.ed and some mer.stems *** isolated endophytic bacter.um was identified for.the fir.t time in yer.a mate as Agr.bacter.um *** conclude,we wer. able to establish in vitr. cultur. of yer.a mate using mer.stems as explants but the tissues wer. not fr.e of endophytic micr.or.anisms which could inter.er. with explant r.sponse.

关键词： Yer.a mate Tissue cultur. 2iP Activated char.oal Endophytic bacter.a Agr.bacter.um lar.ymoor.i Oxidation

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lapar.scopic diagnosis of pleur.l mesothelioma pr.senting with pseudoachalasia

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Wor.d Jour.al of Gastr.enter.logy 2009年第28期15卷 3569-3572页

作者： Gr.ta Saino Davide bona.Mar.o Nencioni Bar.ar. r.bino luigi bona.ina Depar.ment of Sur.er. Universityof Milano School of Medicine IRCCS Policlinico San DonatoVia Morandi 30 20097 San Donato Milanese (Milano) Italy

Pseudoachalasia due to pleur.l mesothelioma is an extr.mely r.r. condition. A 70-year.old woman pr.sented with pr.gr.ssive dysphagia for.solid and liquids and a mild weight loss. A bar.um swallow study r.vealed an esophageal dilatation and a smoothly nar.owed esophagogastr.c junction. An esophageal manometr. showed absence of per.stalsis. Endoscopy demonstr.ted an extr.nsic stenosis of the distal esophagus with negative biopsies. A mar.ed thickening of the distal esophagus and a r.ght-sided pleur.l effusion wer. evident at computed tomogr.phy （CT） scan, but cytological examination of the thor.cic fluid was negative. Endoscopic ultr.sound showed the disappear.nce of the distal esophageal wall str.tification and thickening of the esophageal wall. The patient under.ent an explor.tive lapar.scopy. Biopsies of the esophageal muscle wer. consistent with the diagnosis of epithelioid type pleur.l mesothelioma. An esophageal stent was placed for.palliation of dysphagia. The patient died four.months after.the diagnosis. This is the fir.t r.por.ed case of pleur.l mesothelioma diagnosed thr.ugh lapar.scopy.

关键词： Dysphagia Achalasia Pseudoachalasia Mesothelioma lapar.scopy

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long-ter. r.sults of endosur.ical and open sur.ical appr.ach for.Zenker.diver.iculum

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Wor.d Jour.al of Gastr.enter.logy 2007年第18期13卷 2586-2589页

作者： luigi bona.ina Davide bona.Medhanie Abr.ham Gr.ta Saino Emmanuele Abate Univer.ity of Milano Department of Medical and Surgical Sciences Section of General Surgery I.R.C.C.S Policlinico San Donato Italy

AIM: To assess the effectiveness of minimally invasive ver.us tr.ditional open sur.ical appr.ach in the tr.atment of Zenker.diver.iculum. METHODS: Between 1976 and 2006, 297 patients under.ent tr.nsor.l stapling (n = 181) or.stapled diver.iculectomy and cr.cophar.ngeal myotomy (n = 116). Subjective and objective evaluations of the outcome of the two pr.cedur.s wer. made at 1 and 6 mo after.oper.tion, and then ever. year. long-ter. follow-up data wer. available for.a subgr.up of patients at a minimum of 5 and 10 year.. r.SUlTS: The oper.tive time and hospital stay wer. mar.edly r.duced in patients under.oing the endosur.ical appr.ach. Over.ll, 92% of patients under.oing the endosur.ical appr.ach and 94% of those under.oing the open appr.ach wer. symptom-fr.e or.wer. significantly impr.ved after.a median follow-up of 27 and 48 mo, r.spectively. At a minimum follow-up of 5 and 10 year., most patients wer. asymptomatic after.both pr.cedur.s, except for.those individuals under.oing an endosur.ical pr.cedur. for.a small diver.iculum (lUSION: Both oper.tions r.lieve the outflow obstr.ction at the phar.ngoesophageal junction, indicating that cr.cophar.ngeal myotomy has an impor.ant ther.peutic r.le in this disease independent of the r.section of the pouch and of the sur.ical appr.ach. Diver.icula smaller.than 3 cm r.pr.sent a for.al contr.indication to the endosur.ical appr.ach because the common wall is too shor. to accommodate one car.r.dge of staples and to allow complete division of the sphincter.

关键词： Esophagus Zenker.diver.iculum Cr.cophar.ngealmyotomy Diver.iculectomy Dysphagia Aspir.tionpneumonia

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lapar.scopic r.section for.incidentally detected Meckel diver.iculum

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Wor.d Jour.al of Gastr.enter.logy 2008年第31期14卷 4961-4963页

作者： Davide bona.luigi Stefano Schipani Mar.o Nencioni Bar.ar. r.bino luigi bona.ina Depar.ment of Sur.er. IRCCS Policlinico San Donato University of Milan Milano 20137 Italy Pathology Unit Istituto Clinico Sant’Ambrogio Milano 20137 Italy

The management of Meckel diver.iculum found un-expectedly dur.ng an abdominal oper.tion r.mains contr.ver.ial. Most published r.por.s have included only patients under.oing diver.iculectomy or.bowel r.section thr.ugh lapar.tomy. We r.por. a case of a car.inoid tumor.in a Meckel’s diver.iculum which was incidentally detected and r.moved dur.ng lapar.scopic inguinal her.ia r.pair. Although ther. is no compelling evidence in the liter.tur. to r.commend pr.phylactic diver.iculectomy, lapar.scopic stapled r.section r.pr.-sents a viable and safe appr.ach in healthy individuals under.oing elective sur.er. for.other.pur.oses.

关键词： lapar.scopy Incidental findings Meckel's diver.iculum Car.inoid tumor

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Pr.valence and pr.gnostic value of car.iac tr.ponin in elder.y patients hospitalized for.COVID-19

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Jour.al of Ger.atr.c Car.iology 2021年第5期18卷 338-345页

作者： Vincenzo De Mar.o Antonio Di Biagio r.ber.a Della bona.Antonio Vena Eleonor. Ar.oscello Har.sha Emir.ona Sar. Mor. Maur. Giacomini Gior.io Da r.n Paolo Pelosi Matteo Bassetti Pietr. Amer. Italo Por.o GECOVID study gr.up Car.iovascular.Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Depar.ment of Inter.al Medicine University of GenovaGenovaItaly Infectious Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Depar.ment of Health Sciences University of GenovaGenovaItaly Emer.ency Depar.ment IRCCS Ospedale Policlinico San MartinoGenovaItaly Depar.ment of Infor.atics BioengineeringRobotics and System EngineeringUniversity of GenovaGenovaItaly labor.tor. Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Anesthesia and Intensive Car. Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Depar.ment of Sur.ical Sciences and Integr.ted Diagnostics University of GenovaGenovaItaly

BACKGr.UND Incr.ases in car.iac tr.ponin(cTn)in cor.navir.s disease 2019(COVID19)have been associated with wor.e ***,data about the significance of cTn in elder.y subjects with COVID19 ar. *** Fr.m a r.gistr. of consecutive patients with COVID19 admitted to a hub hospital in Italy fr.m 25/02/2020 to 03/07/2020,we selected those≥60 year.ld and with cTnI measur.d within thr.e days fr.m the molecular.diagnosis of SAr.CoV2 *** available,a second cTnI value within 48 h was also *** r.lationship between incr.ased cTnI and allcause inhospital mor.ality was evaluated by a Cox r.gr.ssion model and r.str.cted cubic spline functions with thr.e *** Of 343 included patients(median age:75.0(68.0−83.0)year.,34.7%men),88(25.7%)had cTnI above the upper.efer.nce limit(0.046μg/l).Patients with incr.ased cTnI had mor. comor.idities,gr.ater.impair.d r.spir.tor. exchange and higher.inflammator. mar.er. on admission than those with nor.al ***,they died mor.(73.9%vs.37.3%,Pr.15(6−25)days of *** association of elevated cTnI with mor.ality was confir.ed by the adjusted Cox r.gr.ssion model(Hr.1.61,95%CI:1.06−2.52,P=0.039)and was linear.until 0.3μg/l,with a subsequent *** 191(55.7%)patients with a second cTnI measur.ment,49(25.7%)had an incr.asing tr.nd,which was not associated with mor.ality(univar.ate Hr.1.39,95%CI:0.87−2.22,P=0.265).CONClUSIONS In elder.y COVID19 patients,an initial incr.ase in cTn is common and pr.dicts a higher.r.sk of *** cTn testing may not confer.additional pr.gnostic infor.ation.

关键词： patients mor.ality admitted

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Color.ctal Cancer. for.the r.cent 20 year. in Kor.a

Colorectal Cancers for the Recent 20 years in Korea

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第六次全国大肠癌会议暨中日韩大肠癌会议

作者： bona.H. lee Min Kyoon lim Depts of Gener.l Sur.er. Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea Depts of Gener.l Sur.er. Hallym University Hangang Sacred Heart Hospital Seoul 150-020 Korea

＜正＞The incidence of color.ctal cancer.Cr.） has been mar.edly incr.ased fr.m 4.9％ of all sites in 1975 to 8.2％ in 1995（5,312 Cr. patients of 64,761 total cancer.patients）. The gastr.c cancer.is the most fr.quent cancer.and 24％ of total cancer., but the incidence of gastr.c cancer.has not been incr.asing. The nation-wide over.ll incidence

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Multivar.ate Optimization of Volatile Compounds Extr.ction in Char.onnay Wine by Headspace-Solid Phase Micr. Extr.ction and Gas Chr.matogr.phy Coupled with Tandem Mass Spectr.metr.

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Amer.can Jour.al of Analytical Chemistr. 2016年第10期7卷 712-723页

作者： Sabr.na de bona.Sar.or.Mar.a Sganzer.a José Teixeir. Filho Helena Teixeir. Godoy Food Analysis labor.tor. Department of Food Science Faculty of Food Engineering University of Campinas (UNICAMP) Campinas Brazil Facvest Univer.ity (UNIFACVEST) Lages Brazil Hydr.logy labor.tor. Faculty of Agricultural Engeneering University of Campinas (UNICAMP) Campinas Brazil

A method for.optimization of extr.ction of volatile compounds in Char.onnay wine was developed using headspace-solid phase micr.extr.ction (HS-SPME) and gas chr.matogr.phy coupled with tr.ple quadr.pole tandem mass spectr.metr. (GC-MS/MS). Optimization of the HS-SPME conditions, temper.tur. (T, °C) and extr.-ction time (t, minutes), was car.ied out using a 22 factor.al centr.l composite r.ta- tional design (CCr.). Total ar.a of chr.matogr.phic peaks of nineteen compounds was monitor.d in or.er.to identify the best r.sponse and the data was collected on multiple r.action monitor.ng (Mr.) mode. The mathematical model that descr.bes the r.sponse sur.ace for.the CCr. was validated using the analysis of var.ance (ANO VA) with 95% of confidence level. This model showed a lack of fit based on mean squar. pur. er.or.r.tios for.each r.sponse, in which Fcalculated was 2.23 higher.than Ftabulated. Even though the models cannot be r.gor.usly used to make quantitative pr.dictions, the coefficients of the model, especially the linear.ones, ar. useful for.under.tanding systematic behaviour.of the r.sponse values as a function of the factor.levels. Multivar.ate statistical design can be used in optimization of HS-SPME extr.ction par.meter. with r.duced number.of exper.ments and can be useful in sampling method of volatile compounds of Char.onnay wines analysis by CG-MS/MS. The optimal condition achieved in this method was 30°C and 45 minutes of extr.ction.

关键词： Char.onnay GC-MS/MS HS-SPME Multivar.ate Optimization Volatile Compounds

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Cover.d nitinol stents for.the tr.atment of esophageal str.ctur.s and leaks

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Wor.d Jour.al of Gastr.enter.logy 2010年第18期16卷 2260-2264页

作者： Davide bona.letizia laface luigi bona.ina Emmanuele Abate Moshe Schaffer.Ippazio Ugenti Stefano Siboni r.sar.a Car.inola Depar.ment of Medical and Sur.ical Sciences Division of General SurgeryIRCCS Policlinico San DonatoUniversity of Milan Medical School

AIM:To compar. 2 differ.nt types of cover.d esophageal nitinol stents(Ultr.flex and Choostent) in ter.s of efficacy,complications,and long-ter. ***:A r.tr.spective r.view of a consecutive ser.es of 65 patients who under.ent endoscopic placement of an Ultr.flex stent(n = 33) or.a Choostent(n = 32) fr.m June 2001 to October.2009 was ***:Stent placement was successful in all patients without hospital *** significant differ.nces in patient discomfor. and complications wer. obser.ed between the Ultr.flex stent and Choostent *** median follow-up time was 6 mo(inter.uar.ile r.nge 3-16 mo).Endoscopic r.inter.ention was r.quir.d in 9 patients(14%) because of stent migr.tion or.food *** significant differ.nce in the r.te of r.inter.ention between the 2 gr.ups was obser.ed(P = 0.8).The mean dysphagia scor. 1 mo after.stent placement was 1.9 ± 0.3 for.the Ultr.flex stent and 2.1 ± 0.4 for.the Choostent(P = 0.6).At 1-mo follow-up endoscopy,the cover.membr.ne of the stent appear.d to be damaged mor. fr.quently in the Choostent gr.up(P = 0.34).r.moval of the Choostent was possible up to 8 wk without ***:Ultr.flex and Choostent pr.ved to be equally r.liable for.palliation of dysphagia and *** of the Choostent was easy and safe under.mild sedation.

关键词： Dysphagia Esophageal neoplasms Endoscopy Palliative car. Sur.ical anastomosis Str.ctur. Neoadjuvant ther.py Self-expanding metal stents

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Disper.ive soliton solutions for.shallow water.wave system and modified Benjamin-bona.Mahony equations via applications of mathematical methods

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Jour.al of Ocean Engineer.ng and Science 2021年第1期6卷 85-98页

作者： Asghar.Ali Aly r.Seadawy Mathematics Depar.ment University of EducationLahorePakistan Mathematics Depar.ment Faculty of ScienceTaibah UniversityAl-Madinah Al-MunawarahSaudi Arabia

We have utilized thr.e novel methods,called gener.lized dir.ct algebr.ic,modified F-expansion and impr.ved simple equation methods to constr.ct tr.veling wave solutions of the system of shallow water.wave equations and modified Benjamin-bona.Mahony *** substituting par.icular.values of the par.meter.,differ.nt solitar. wave solutions ar. der.ved fr.m the exact tr.veling wave *** is shown that these employed methods ar. mor. power.ul tools for.nonlinear.wave equations.

关键词： System of shallow water.wave equations Modified Benjamin-bona.Mahony equation Gener.lized dir.ct algebr.ic method Impr.ved simple equation method Modified F-expansion method Tr.veling wave solutions Solitar. wave solutions

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