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revealing the regulation Effect of Surface Charge at Aromatic Interface to Dynamic Conformational Changes of α-Synuclein at Early Aggregation Stage

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Chinese Journal of Chemistry 2024年第16期42卷 1867-1876页

作者： Yuqi Zhang lie Wu Xiue Jiang State Key laboratoryof Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun Jilin 130022China Schoolof Applied Chemistry and Engineering University of Science and Technology of ChinaHefei Anhui 230026China research Center for Analytical Science College of ChemistryNankai UniversityTianjin 300071China

The aggregation ofα-synuclein(α-syn)is strongly influenced by membrane interfaces,but the mechanism of transition from monomers to oligomers at early aggregation stage is not ***,we investigate the adsorption and structure changes ofα-syn on oppositely charged aromatic interfaces through in-situ surface-enhanced infrared absorption(SEIrA)spectroscopy and nano-Ir *** results show that the synergy of electrostatic and hydrophobic interactions leads to a“fast-slow”two-step aggregation pathway on negatively charged *** adsorption induces the formation of an extended helix structure and subsequently partial helix unwinding in NAC region,which enables the hydrophobic stacking between nearby NAC *** antipar.llel β-sheet rich aggregates are gradually emerging as further interactions of monomers with the fast formed“first layer”.Monomers electrostatically adsorb on positively charged interface by C-terminus with NAC region and N-terminus stretched in solvent,which serve as an aggregation core and induce further adsorption and gradual formation of aggregates with C-terminus *** results demonstrate the modulation of surface charge and synergy of electrostatic and hydrophobic interactions on the interaction modes and aggregation pathways,which provide insights into dynamic conformation changes ofα-syn at early aggregation stage and imply the important r.le of spatial-tempor.l heterogeneity of membranes inα-synucleinopathies.

关键词： α-Synuclein Interface Early aggregation Ir spectroscopy Surface analysis Analytical methods Proteins Dynamic monitoring

Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding rNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation

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Journal of Integrative Medicine 2024年第2期22卷 188-198页

作者： Meng li Yang Zhou Hui Zhu lie-ming Xu Jian Ping Institute of liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Preventive Treatment Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437 China Department of Gastroenter.logy Suzhou Traditional Chinese Medicine HospitalSuzhou 215000Jiangsu ProvinceChina Shanghai Key laboratory of Traditional Chinese Medicine Shanghai 201203China Key laboratory of liver and Kidney Diseases(Ministry of Education) Shanghai 201203China

Objective:This study explores the mechanism of action of Danhongqing formula(DHQ),a compoundbased Chinese medicine formula,in the treatment of cholestatic liver ***:In vivo experiments were conducted using 8-week-old multidrug resistance protein 2 knockout(Mdr2-/-)mice as an animal model of cholestatic liver *** was administered or.lly for 8 weeks,and its impact on cholestatic liver fibrosis was evaluated by assessing liver function,liver histopathology,and the expression of liver fibrosis-r.lated ***-time polymerase chain reaction,Western blot,immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding rNA H19(H19)and signal transducer and activator of transcription 3(STAT3)phosphor.lation in the liver tissue of Mdr2-/-*** addition,cholangiocytes and hepatic stellate cells(HSCs)were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and H19 *** overexpressing H19 were constructed,and a conditioned medium containing H19 was collected to measure its effects on STAT3 protein expression and cell *** intervention effect of DHQ on these processes was also *** overexpressing H19 were constructed to measure the impact of H19 on cell activation and assess the intervention effect of ***:DHQ alleviated liver injury,ductular reaction,and fibrosis in Mdr2-/-mice,and inhibited H19expression,STAT3 expression and STAT3 *** formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of H19,inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium,and decreased the expression of activation markers in *** overexpression of H19 in a human HSC line confirmed that H19 promoted STAT3 phosphor.lation and HSC activation,and DHQ was able to successfully inhibit these ***:DHQ effectively alleviated spontaneous cholestatic liver fibrosis in Md

关键词： liver cirrhosis biliary long non-coding rNA H19 Danhongqing formula Cholangiocyte Hepatic stellate cells STAT3 transcription factor

localization and mapping algorithm based on lidar-IMU-Camera fusion

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Journal of Intelligent and Connected Vehicles

Journal of Intelligent and Connected Vehicles 2024年第2期7卷 97-107页

作者： Yibing Zhao Yuhe liang Zhenqiang Ma lie Guo Hexin Zhang School of Mechanical Engineering Dalian University of TechnologyDalian 116024China Department of the Built Environment Technology University of EindhovenEindhoven 5600MBthe Netherlands

Positioning and mapping technology is a difficult and hot topic in autonomous driving environment sensing *** a complex traffic environment,the signal of the Global Navigation Satellite System(GNSS)will be blocked,leading to inaccurate vehicle *** ensure the security of automatic electric campus vehicles,this study is based on the lightweight and Ground-Optimized lidar Odometry and Mapping on Variable Terrain(lEGO-lOAM)algorithm with a monocular vision system *** algorithm framework based on lidar-IMU-Camera(lidar means light detection and ranging)fusion was proposed.A lightweight monocular vision odometer model was used,and the lEGO-lOAM system was employed to initialize monocular *** visual odometer information was taken as the initial value of the laser *** the back-end opti9mization phase error state,the Kalman filtering fusion algorithm was employed to fuse the visual odometer and lEGO-lOAM system for *** visual word bag model was applied to perform loopback *** the test results into account,the laser radar.loopback detection was further optimized,reducing the accumulated positioning *** real car experiment results showed that our algorithm could improve the mapping quality and positioning accuracy in the campus *** lidar-IMU-Camera algorithm framework was verified on the Hong Kong city dataset *** with the lEGO-lOAM algorithm,the results show that the proposed algorithm can effectively reduce map drift,improve map resolution,and output more accurate driving trajectory information.

关键词： lightweight and Ground-Optimized lidar Odometry and Mapping on Variable Terrain(lEGO-lOAM) monocular vision system error state Kalman filter odometer

Clinical effect of spleen aminopeptide on improving liver function damage and immune function in children with infant hepatitis syndrome

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1742-1748页

作者： Xiao-Qing Fang Tian Gan lie-Min Wang Department of Pediatrics General Hospital of Central Theater Command of PLAWuhan 430061Hubei ProvinceChina Department of Pharmacy The First People’s Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina Department of Neonatal Central Hospital of EnshiEnshi 445000Hubei ProvinceChina

BACKGrOUND Infant hepatitis syndrome(IHS)is a clinical syndrome in infants less than one year of age with gener.lized skin jaundice,abnormal liver function,and hepato-megaly due to various etiologies such as *** To investigate the effect of IHS patients,after treatment with arsphenamine-based peptides,on patients'liver function damage and immune *** Of 110 patients with IHS treated in our hospital from January 2019 to January 2021 were grouped according to the randomized residual grouping method,with 5 cases in each group shed due to transfer,***,50 cases remained in each *** contr.l group was treated with reduced glutathione,and the treat-ment group was treated with sesquiterpene peptide based on the contr.l *** and compare the differences in indicators after *** The comparison of serum total bilirubin,direct bilirubin,and serum alanine transferase after treatment was significantly different and lower in the treatment group than in the contr.l group(Prison of CD4+,CD3+,CD4+/CD8+after treatment was significantly different and higher in the treatment group than in the contr.l group,and the comparison was statist-ically significant(Plication of the two groups showed that the rash,cough and sputum,elevated platelets,and gastrointestinal reactions in the treatment group were significantly lower than those in the contr.l group,and the differences were statistically significant by test(PlUSION The comparative study of IHS treated with arsphenamine combined with reduced glutathione is more effective.

关键词： Infant hepatitis syndrome Splenamin reduced glutathione liver function Immune function Complication

Fracture sealing performance of granular.lost circulation materials at elevated temperature:A theoretical and coupled CFD-DEM simulation study

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Petr.leum Science 2024年第1期21卷 567-581页

作者： Chong lin Qi-Cong Xu lie-Xiang Han Gao li Hai He Hong-ling Zhou Ji-Ping She CCDC Dr.lling&Production Technology research Institute Guanghan618300SichuanChina State Key laboratory of Oil and Gas reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina College of Materials Science and Engineering Chongqing UniversityChongqing400044China State Key lab of Oil and Gas reservoir Geology and Exploitation(Chengdu University of Technology) Chengdu610059SichuanChina College of Energy Chengdu University of TechnologyChengdu610059SichuanChina

lost circulation is a common downhole problem of dr.lling in geothermal and high-temperature,high-pressure(HTHP)*** circulation material(lCM)is a regular preventive and remedial measure for.lost ***,conventional lCMs seem ineffective in high-temperature *** may be due to the changes in the mechanical properties of lCMs and their sealing performance under high-temperature *** understand how high temperature affects the fracture sealing performance of lCMs,we developed a coupled computational fluid dynamics-discrete element method(CFD-DEM)model to simulate the behavior of granular.lCMs in *** summarized the literature on the effects of high temperature on the mechanical properties of lCMs and the rheological properties of dr.lling *** conducted sensitivity analyses to investigate how changing lCM slurry properties affected the fracture sealing efficiency at increasing *** results show that high temperature reduces the size,strength,and friction coefficient of lCMs as well as the dr.lling fluid ***,softer,and less frictional lCM particles have lower bridging probability and slower bridging *** particles tend to form dual-particle bridges rather than single-particle *** result in a deeper,tighter,but unstable sealing *** dr.lling fluid viscosity leads to faster and shallower sealing zones.

关键词： Geothermal well dr.lling HTHP formationlost circulation material CFD-DEM Fracture sealing

Effect of cylinder wall parameters on the final packing density of mono-disperse spheres subject to three-dimensional vibrations Author.links open overlay panel

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Particuology 2024年第8期91卷 211-225页

作者： Jack r.Grogan Andrei l.Nicuşan Christopher r.K.Windows-Yule School of Chemical Engineering The University of BirminghamEdgbastonBirminghamB152TTUK

Achieving densely packed particles is desirable within the industries of ceramics,pharmaceuticals,defence and additive *** this work,we use the discrete element method(DEM)to determine the effect of wall parameters on the final packing density of mono-disperse spheres subject to 4 varying three-dimensional vibration and fill *** focus specifically on the impact of the container wall parameters on the particles'final packing *** on from the validation of the DEM simulation the particle-wall coefficient of restitution,the particle-wall coefficient of r.lling friction and the particle-wall coefficient of sliding friction were varied individually and the effect on the final packing density *** r.latively low particle-particle friction glass beads,the effect of these wall properties had no discernible effect on the final packing density *** on from these findings the particle-wall properties were varied at the extreme values of particle-particle coefficient of r.lling friction and particle-particle coefficient of sliding *** a particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of restitution resulted in a minor increase in the final packing density of particles though this was not statistically *** a particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of r.lling friction resulted in a minor decrease in the final packing density of the particles though again not to a degree where the trend can,with complete certainty,be distinguished from the random error across the ***,when the particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of sliding friction resulted in a significant decrease in the final packing density of *** decrease was attributed to the propagation of force chains throughout the *** significant decrease in final packing density with

关键词： Vibropacking Packing Densification Vibration Discrete element method Friction Wall friction restitution

Par.llel Driving with Big Models and Foundation Intelligence in Cyber-hysical-ocial Spaces

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research 2024年第2期2024卷 1-17页

作者： Xiao Wang Jun Huang Yonglin Tian Chen Sun lie Yang Shanhe lou Chen lv Changyin Sun Fei-Yue Wang School of Artificial Intelligence Anhui UniversityHefeiChina Macao University of Science and Technology MacaoChina State Key laboratory for Management and Contr.l of Complex Systems Institute of AutomationChinese Academy of SciencesBeijingChina MVSlab Department of Mechanical and Mechatronics EngineeringUniversity of Waterloo200 University Ave WestWaterlooON N2L3G1Canada School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingaporeSingapore

recent years have witnessed numerous technical breakthroughs in connected and autonomous vehicles (CAVs). On the one hand, these breakthroughs have significantly advanced the development of intelligent transportation systems (ITSs);on the other hand, these new traffic participants introduce more complex and uncertain elements to ITSs from the social space. Digital twins (DTs) provide real-time, data-driven, precise modeling for constructing the digital mapping of physical-world ITSs. Meanwhile, the metaverse integrates emerging technologies such as virtual reality/mixed reality, artificial intelligence, and DTs to model and explore how to realize improved sustainability, increased efficiency, and enhanced safety. More recently, as a leading effort toward gener.l artificial intelligence, the concept of foundation model was proposed and has achieved significant success, showing great potential to lay the cornerstone for diverse artificial intelligence applications across different domains. In this article, we explore the big models embodied foundation intelligence for par.llel driving in cyber-physical-social spaces, which integrate metaverse and DTs to construct a par.llel training space for CAVs, and present a comprehensive elucidation of the crucial characteristics and operational mechanisms. Beyond providing the infrastructure and foundation intelligence of big models for par.llel driving, this article also discusses future trends and potential research directions, and the ?S?goals of par.llel driving.

关键词： breakthrough integrate corners

Insights into in-situ imbibition behavior of fracturing fluid in propped shale fractures based on nuclear magnetic resonance:A case study from longmaxi Formation shale,Sichuan Basin,China

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Petr.leum Science 2024年第1期21卷 410-429页

作者： Jing-Jing Guo Kai-Xiang Di lie-Hui Zhang Yu-long Zhao Hui-Ying Tang rui-Han Zhang Ye Tian National Key laboratory of Oil and Gas reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina

Shale gas is an important component of unconventional oil and gas *** the imbibition behavior is helpful to optimize flowback parameters and enhance gas *** imbibition studies have focused on shale matrix,and the pressure conditions discussed were mostly *** initial imbibition behavior begins from propped fractures to matrix,but there are few studies working on explaining the imbibition behavior in propped fractures or the phenomenon of many shale wells exhibit higher productivity after a“soaking”***,propped fracture samples were designed for imbibition and migration *** order to accurately study the mechanism and main influencing factors of fracturing fluid imbibition and migration in propped and unpropped shale fractures under high temperature and high pressure,a series of experiments based on nuclear magnetic resonance(NMr)were carried *** showed that NMr T_(2) spectra of all samples exhibited a bimodal *** final imbibition volume of fracturing fluid was positively r.lated to pressure and fracture *** imbibition effect of fracturing fluid was more evident in matrix pores under high *** the migration during soaking stage,the fracturing fluid gradually migrated from large pores to small pores and gradually displaced the shale gas from the matrix,thus allowing the water blocking in propped fractures to self-unlock to some *** permeability decreased in the imbibition stage,while it recovered in the migration stage to some extent.

关键词： Forced imbibition Migration Soaking NMr T_(2)spectra Propped fracture Permeability recovery

Pure-high-even-order dispersion bound solitons complexes in ultra-fast fiber.lasers

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light(Science & Applications) 2024年第5期13卷 957-972页

作者： Ying Han Bo Gao Honglin Wen Chunyang Ma Jiayu Huo Yingying li luyao Zhou Qi li Ge Wu lie liu College of Communication Engineering Jilin UniversityChangchun 130012China. research Center of Circuits and Systems Peng Cheng LaboratoryShenzhen 518055China. International Collaborative laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China. College of Electronic Science and Engineering Jilin UniversityChangchun 130012China

Tempor.l solitons have been the focus of much research due to their fascinating physical *** solitons can form bound states,which are fundamentally crucial modes in fiber.laser and present striking analogies with their matter molecules counterparts,which means they have potential applications in large-capacity transmission and alloptical information *** traditionally,second-order dispersion has been the dominant dispersion for conventional solitons,recent experimental and theoretical research has shown that pure-high-even-order dispersion(PHEOD)solitons with energy-width scaling can arise from the interaction of arbitrary negative-even-order dispersion and Kerr *** these advancements,research on the bound states of PHEOD solitons is currently *** this study,we obtained PHEOD bound solitons in a fiber.laser using an intra-cavity spectr.l pulse shaper for high-order dispersion ***,we experimentally demonstrate the existence of PHEOD solitons and PHEOD bound solitons with pure-quartic,-sextic,-octic,and-decic *** simulations corroborate these experimental ***,vibrating phase PHEOD bound soliton pairs,sliding phase PHEOD bound soliton pairs,and hybrid phase PHEOD bound tri-soliton are discovered and *** results broaden the fundamental understanding of solitons and show the universality of multi-soliton patterns.

关键词： dispersion solitons soliton