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脑震宁颗粒对三重脑震荡模型大鼠额颞叶皮质区线粒体生物合成的影响

肿瘤病因学研究与中西医结合肿瘤综合诊疗交流研讨会

作者： Mingqing Tang~1,William Xu~2,qizhao wang~1,Ruian Xu~(1*) 1 Engineering Research Center of Molecular Med icine,Ministry of Education,362021,China & Institute of Molecular Medicine,Huaqiao University,Fujian,362021,China 2 Faculty of Science,University of New South Wales,2052,Australia

Lung cancer,the leading cause of mortality in both men and women in the United States,is largely diagnosed at its advanced stages that there are no effective therapeutic *** tobacco smoking is the well established cause of lung cancer,the underlying mechanism for lung tumorigenesis remains poorly *** important event in tumor development appears to be the epigenetic alterations,especially the change of DNA methylation patterns,which induce the most tumor suppressor gene *** one scenario,DNA methyltransferase(DNMT) that is responsible for DNA methylation accounts for the major epigenetic maintenance and *** another scenario,DNMT itself is regulated by the environment carcinogens(smoke),epigenetic and genetic *** not only plays a pivotal role in lung tumorigenesis,but also is a promising molecular bio-marker for early lung cancer diagnosis and *** the elucidation of the DNMT and its related epigenetic regulation in lung cancer is of great importance,which may expedite the overcome of lung cancer.

关键词： Lung cancer Epigenetic regulation DNA methylation DNMT Gene silence Epigenetic therapy

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中国实验方剂学杂志 2024年第14期30卷 107-113页

作者：魏楠楠武立雅王恬恬刘骐肇张唯依王永辉高丽赵乐山西中医药大学山西晋中030619

目的:基于线粒体能量代谢,从生物合成角度探究脑震宁颗粒对脑震荡后综合征模型大鼠的记忆功能和神经元的影响。方法:SPF级Wistar大鼠,采用自由落体撞击法构建三重脑震荡模型(MCC),依据模型评价标准将造模成功大鼠分为模型组,吡拉西坦组(... 详细信息

目的:基于线粒体能量代谢,从生物合成角度探究脑震宁颗粒对脑震荡后综合征模型大鼠的记忆功能和神经元的影响。方法:SPF级Wistar大鼠,采用自由落体撞击法构建三重脑震荡模型(MCC),依据模型评价标准将造模成功大鼠分为模型组,吡拉西坦组(0.324 g·kg^(-1)),脑震宁低、中、高剂量组(2.25、4.5、9 g·kg^(-1)),另设正常组,按剂量进行灌胃治疗,正常组和模型组给予等体积生理盐水,每天1次,连续14 d。观察大鼠给药前后的一般状态;采用旷场实验和新物体识别实验检测大鼠的运动和记忆能力;采用苏木素-伊红(HE)染色观察大鼠皮层组织神经元的病理改变;采用蛋白免疫印迹法(Western blot)和实时荧光定量聚合酶链式反应(Real-time PCR)检测大鼠组织过氧化物酶体增殖物激活受体γ-共激活因子-1α(PGC-1α)、核呼吸因子1(NRF-1)、线粒体转录因子(TFAM)的蛋白和mRNA表达。结果:与正常组比较,模型组大鼠精神焦虑狂躁,被毛萎黄脏乱,摄食量减少;旷场实验中模型大鼠的运动总路程、中央格进入次数和直立次数显著降低(P<0.01),静止时间显著升高(P<0.01);新物体识别指数显著下降(P<0.01);皮层组织神经元数量减少,分布稀疏,核仁畸形、破裂,形态不规则;皮层组织PGC-1α、NRF-1、TFAM的蛋白表达水平均显著降低(P<0.01);皮层组织PGC-1α、NRF-1、TFAM的mRNA表达水平均显著降低(P<0.01)。与模型组比较,吡拉西坦组和脑震宁各剂量组大鼠精神状态和被毛颜色改善,食欲增加,活动逐渐正常;旷场实验中大鼠的运动总路程、中央格进入次数和直立次数明显增高(P<0.05,P<0.01),静止时间明显降低(P<0.05,P<0.01);新物体识别指数明显上升(P<0.05,P<0.01);皮层组织神经元数量增多,排列较为紧密,核大而圆,部分细胞形态不规则,胞浆浑浊;吡拉西坦组和脑震宁中剂量组皮层组织PGC-1α、NRF-1和TFAM蛋白表达显著升高(P<0.01),脑震宁低剂量组大鼠皮层组织NRF-1和TFAM蛋白表达显著升高(P<0.01),脑震宁高剂量组大鼠皮层组织PGC-1α和TFAM蛋白表达显著升高(P<0.01);吡拉西坦组和脑震宁各剂量组皮层组织PGC-1α、NRF-1、TFAM mRNA表达水平明显升高(P<0.05,P<0.01)。结论:脑震宁颗粒可以改善MCC大鼠的运动探索和记忆学习状况,修复神经元损伤,保护神经功能,其作用机制可能与促进大脑皮层神经元的线粒体生物合成有关。

关键词：脑震荡后综合征线粒体能量代谢生物合成脑震宁颗粒皮层

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低龄儿童龋相关口腔微生物特点分析

上海口腔医学 2024年第1期33卷 59-63页

作者：黄骏韩轩马其钊邹静口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院儿童口腔科四川成都610041 天津医科大学口腔医学院儿童口腔科天津300070

目的:通过16S r RNA高通量测序技术探索有龋儿童口腔微生物的结构特点。方法 :纳入30名全身健康的3~5岁儿童为研究对象,根据乳牙龋失补牙面指数分为无龋组(caries free, CF组,15名)和低龄儿童龋组(early childhood caries,ECC组,15名),... 详细信息

目的:通过16S r RNA高通量测序技术探索有龋儿童口腔微生物的结构特点。方法 :纳入30名全身健康的3~5岁儿童为研究对象,根据乳牙龋失补牙面指数分为无龋组(caries free, CF组,15名)和低龄儿童龋组(early childhood caries,ECC组,15名),采集2组儿童的唾液及牙菌斑样本,在Illumina Miseq测序平台高通量测序,并通过生物信息学分析方法,采用SPSS 23.0软件包,对样本微生物群落结构及多样性进行差异性分析。结果:ECC组微生物多样性显著低于CF组。在门水平,放线菌门(Actinobateria)在ECC组唾液样本中丰度较高;厚壁菌门(Firmicutes)在CF组菌斑样本中丰度较高。在属水平,劳特普罗菌属(Lautropia)在CF组唾液样本中丰度较高,心杆菌属(Cardiobacterium)、孪生球菌属(Gemella)和颗粒链球菌属(Granulicatella)在CF组菌斑样本中丰度较高;罗氏菌属(Rothia)在ECC组唾液样本中丰度较高,棒状杆菌属(Corynebacterium)在ECC组菌斑样本中丰度较高。结论:无龋与有龋儿童唾液和菌斑微生物群落种类和组成存在显著差异;特定微生物与ECC的发生相关,对特定微生物的筛选,有助于对ECC进行早期预测及防治。

关键词：低龄儿童龋牙菌斑唾液高通量测序

Direct observations of reaction zone structure in shock-induced ignition of methane air mixture

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Chinese Science Bulletin 2009年第13期54卷 2247-2255页

作者： wang GaoFeng MA ChengBiao wang BaoYuan LIN qizhao Department of Thermal Science and Energy Engineering University of Science and Technology of China Hefei 230027 China

Ignition of methane/air mixture by the passage of a shock wave is an important issue for understanding more details ofits gaseous *** experiments of shock-induced ignition of stoichiometric methane/air mixture were conducted on a shock tube *** reaction zone structure in weak and strong ignition cases were investigated by digital chemiluminescence imaging and planar laser induced fluorescence(PLIF) *** to smaller gradients in induced time in weak ignition,which provided more time to nonlinear chemical reaction process,the results show that the reaction structures are highly nonuniform in those weak ignition cases,which become more regular while induced shock waves become *** strong ignition case,it gives a typical detonation *** characteristics of reaction zone released by single-pulsed OH PLIF technique agreed well with other experimental measurements in this paper and were also in accord with the conclusions of previous *** successful implementation of the PLIF system has explored a new high temporally and spatially resolved method for the study ofinteraction between shock wave and gaseous matter in shock tube.

关键词：反应区结构空气混合物平面激光诱导荧光点火甲烷化学反应过程诱导时间气相爆轰

Molecular mechanisms of inhibiting glucosyltransferases for biofilm formation in Streptococcus mutans

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International Journal of Oral Science 2021年第3期13卷 243-250页

作者： Qiong Zhang qizhao Ma Yan wang Hui Wu Jing Zou State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases and Department of Pediatric DentistryWest China Hospital of StomatologySichuan UniversityChengduChina Department of Integrative Biomedical and Diagnostic Sciences Oregon Health and Science University School of DentistryPortlandORUSA

Glucosyltransferases(Gtfs)play critical roles in the etiology and pathogenesis of Streptococcus mutans(***)-mediated dental caries including early childhood *** enhance the biofilm formation and promotes colonization of cariogenic bacteria by generating biofilm extracellular polysaccharides(EPSs),the key virulence property in the cariogenic ***,Gtfs have become an appealing target for effective therapeutic interventions that inhibit cariogenic ***,targeting Gtfs selectively impairs the *** virulence without affecting *** existence or the existence of other species in the oral *** the past decade,numerous Gtfs inhibitory molecules have been identified,mainly including natural and synthetic compounds and their derivatives,antibodies,and metal *** therapeutic agents exert their inhibitory role in inhibiting the expression gtf genes and the activities and secretion of Gtfs enzymes with a wide range of sensitivity and *** molecular mechanisms of inhibiting Gtfs will contribute to instructing drug combination strategies,which is more effective for inhibiting Gtfs than one drug or class of *** review highlights our current understanding of Gtfs activities and their potential utility,and discusses challenges and opportunities for future exploration of Gtfs as a therapeutic target.

关键词： inhibiting mechanisms instru

移动边缘计算中基于混合人工蜂群算法的计算卸载策略

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南京信息工程大学学报 2024年第4期16卷 520-527页

作者：沈正林吴涛周启钊陈曦成都信息工程大学计算机学院成都610225 西南民族大学计算机科学与技术学院成都610225

计算卸载是移动边缘计算(Mobile Edge Computing,MEC)中的关键技术.针对多用户多MEC服务器场景中计算卸载策略的不足,本文提出一种混合人工蜂群算法(Artificial Reverse Sine-Cosine,ARSC).首先,使用反向学习策略初始化种群,优化种群的... 详细信息

计算卸载是移动边缘计算(Mobile Edge Computing,MEC)中的关键技术.针对多用户多MEC服务器场景中计算卸载策略的不足,本文提出一种混合人工蜂群算法(Artificial Reverse Sine-Cosine,ARSC).首先,使用反向学习策略初始化种群,优化种群的初始解;然后,在雇佣蜂阶段利用正余弦算法的全局最优引导信息,提升算法的局部搜索能力;最后,为了平衡算法的全局搜索能力和局部搜索能力,引入动态感知因子对算法的步长因子进行改进.仿真实验结果表明,相比基于粒子群算法的卸载策略、基于人工蜂群算法的卸载策略,ARSC策略在系统时延、系统能耗、收敛性等指标上均有所改善.

关键词：移动边缘计算计算卸载人工蜂群算法正余弦算法多用户多MEC

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Round-the-clock water harvesting from dry air using a metal-organic framework

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Chinese Journal of Chemical Engineering 2022年第9期35卷 170-177页

作者： Jianhui Li Yi wang Yang Chen qizhao Xiong Jiangfeng Yang Libo Li Jinping Li College of Chemistry and Chemical Engineering Shanxi Key Laboratory of Gas Energy Efficient and Clean UtilizationTaiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Coal Science and Technology Ministry of Education and Shanxi ProvinceTaiyuan University of TechnologyTaiyuan 030024China

Harvesting water from the atmosphere is an important process to solve the extreme lack of water resources in arid regions. Adsorption-based atmospheric water harvesting(AWH) takes advantage of solar thermal energy to harvest water from air. This technique is particularly suitable for arid regions characterized by low humidity and an abundance of sunshine. Nonetheless, under low humidity conditions, AWH is highly dependent on water-adsorbing materials exhibiting excellent performance. In this work, a metal–organic framework(MOF), namely [Zn_(2)(bpy)(btec)(H_(2)O)_(2)]·2H_(2)O, also denoted as MWH-1, was investigated for application in water harvesting under low humidity conditions(200 cm^(3)·cm^(-3);RH = 10%, uptake >250 cm^(3)·cm^(-3)). This ensured effective water harvesting at high temperatures during the day. In situ powder X-ray diffraction and Fourier-transform infrared analyses confirmed the sensitive water adsorption process of MWH-1a. The X-ray single-crystal study further demonstrated that single-crystal structures could be completely restored following water ***-1 showed good structural stability and enabled water harvesting under low humidity and high temperature conditions. Thus, it has the potential for application in round-the-clock water harvesting in extremely arid regions.

关键词： MOFs Atmospheric water harvesting Extremely low humidity Single-crystal restoration Round-the-clock

Investigation of the roles of lignin in biomass-based hydrogel for efficient desalination

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Frontiers of Chemical Science and Engineering 2023年第7期17卷 954-965页

作者： qizhao Shao Lan Sun Xinzhou Wu Dafeng Zheng School of Chemistry and Chemical Engineering Guangdong Engineering Research Center for Green Fine ChemicalsSouth China University of TechnologyGuangzhou 510640China

The shortage of freshwater has become a global challenge,and solar-driven interfacial evaporation for desalination is a promising way to alleviate the *** develop highly efficient and environmentally friendly photothermal evaporator,the hydroxyethyl cellulose(HEC)/alkaline lignin(AL)/graphene oxide(GO)hydrogels(CLGs)with remarkable evaporative performance were successfully fabricated by a facile solgel method using biomass *** influence of AL content on the physicochemical properties of the evaporator was *** increasing content of AL improves the mechanical properties,saturated water content and crosslink density of the *** designed materials exhibit outstanding thermal insulation capacity(the thermal conductivity of less than 0.05 W·m^(–1)·K^(-1))and high light absorption capacity of more than 97%.The solar evaporation efficiency and water evaporation rate of the HEC/64 wt%of AL/GO hydrogels(CLG4)achieve 92.1%and 2.55 kg·m^(–2)·h^(-1) under 1 sun,*** salt resistance test results reveal that the evaporation rate of the CLG4 can still reach 2.44 kg·m^(–2)·h^(–1) in 3.5 wt% NaCl *** solar evaporation rate of the CLG4 can maintain in the range of 2.45–2.59 kg·m^(–2)·h^(–) in five *** low-cost lignin-based photothermal evaporator offers a sustainable strategy for desalination.

关键词： lignin photothermal cellulose desalination hydrogel

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天然氢气藏地质特征、形成分布与资源前景

天然气地球科学 2024年第6期35卷 1113-1122页

作者：魏琪钊朱如凯杨智吴松涛成大伟刘翰林王小妮蒋文琦范雨辰中国石油勘探开发研究院北京100083

天然氢作为一种新发现的、地质成因的、可再生清洁氢,或将改变未来的氢气能源格局。基于对国内外天然氢勘探和利用现状、研究进展等调研,取得以下4点认识:①美国、俄罗斯、法国、澳大利亚等多个国家已在天然氢气藏勘探研究中取得积极进... 详细信息

天然氢作为一种新发现的、地质成因的、可再生清洁氢,或将改变未来的氢气能源格局。基于对国内外天然氢勘探和利用现状、研究进展等调研,取得以下4点认识:①美国、俄罗斯、法国、澳大利亚等多个国家已在天然氢气藏勘探研究中取得积极进展,中国仍处于未起步阶段;②天然氢气藏具有5个地质特征,即氢源分布广泛、断层裂缝是氢主要运移通道、游离氢决定资源量大小、资源甜点区埋深浅及氢气藏属于动态成藏系统;③天然氢有深层脱气、蛇纹石化、水的裂解等多种成因机制,天然氢气藏主要分布在陆上火成岩区、金伯利岩、矿体、蒸发岩、油气田、裂谷带岩体和前寒武纪基底7个区域;(4)现有的氢生成量估算值(254±91)×10^(9)m^(3)/a远低于实际,天然氢有望成为全球清洁氢的主要来源。此外,围绕天然氢学科建立和中国天然氢领域发展面临的理论技术问题提出了相关建议和方向。

关键词：氢气天然氢气藏清洁氢勘探现状地质特征形成机制资源潜力