DNMT and Its Related Epigenetic Regulation in Lung Tumorigenesis

作     者：Mingqing Tang~1,William Xu~2,Qizhao Wang~1,Ruian Xu~(1*) 1 Engineering Research Center of Molecular Med icine,Ministry of Education,362021,China & Institute of Molecular Medicine,Huaqiao University,Fujian,362021,China 2 Faculty of Science,University of New South Wales,2052,Australia 

会议名称：《肿瘤病因学研究与中西医结合肿瘤综合诊疗交流研讨会》

会议日期：2009年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National 863 2008AA02Z135 to Y D and RA XU Fujian Provincial Nature Science Foundation 2007J105 to RA XU and Xiamen City Science and Technology Grant to RA XU 

关 键 词：Lung cancer Epigenetic regulation DNA methylation DNMT Gene silence Epigenetic therapy 

摘      要：Lung cancer,the leading cause of mortality in both men and women in the United States,is largely diagnosed at its advanced stages that there are no effective therapeutic *** tobacco smoking is the well established cause of lung cancer,the underlying mechanism for lung tumorigenesis remains poorly *** important event in tumor development appears to be the epigenetic alterations,especially the change of DNA methylation patterns,which induce the most tumor suppressor gene *** one scenario,DNA methyltransferase(DNMT) that is responsible for DNA methylation accounts for the major epigenetic maintenance and *** another scenario,DNMT itself is regulated by the environment carcinogens(smoke),epigenetic and genetic *** not only plays a pivotal role in lung tumorigenesis,but also is a promising molecular bio-marker for early lung cancer diagnosis and *** the elucidation of the DNMT and its related epigenetic regulation in lung cancer is of great importance,which may expedite the overcome of lung cancer.