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Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity

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Neuroscience Bulletin 2023年第9期39卷 1454-1458页

作者： Mengying Jiang qiwu xu Can Yang Dan Li Ji-Wei Liu Yuxian Zhang Yong-Chuan Zhu Zhi-Qi Xiong Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai200030China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai201210China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China

Dear Editor,The X-linked gene cyclin-dependent kinase-like 5(CDKL5)encodes a serine/threonine kinase that is associated with CDKL5-deficiency disorder(CDD),a severe developmental and epileptic encephalopathy characterized by early-onset seizures,gross developmental delay,and motor disabilities[1].The expression of CDKL5 is highly enriched in the brain and is significantly induced during postnatal development[2].

关键词： seizures enriched CDK

Microsurgery of intramedullary cervical cord tumor

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中华医学杂志(英文版) 1996年第10期109卷 761-761页

作者： xu qiwu Bao Weimin Mao Renling Department of Neurosurgery Institute of Neurology Shanghai Medical University Shanghai 200040

OBJECTIVE To evaluate whether intramedullary tumor of the cervical spinal cord is amenable to aggressive surgery and to clarify surgical timing and important points for tumor *** AND METHODS Fifty-eight patients with intramedullary tumor of the cervical spinal cord were examined by magnetic resonance imaging and treated by microsurgery in Huashan Hospital between May 1988 and December 1994. The results were analysed by F or Chi square *** Tumors were totally resected in 50 cases (86.2%), subtotally resected in 7 and partially resected in 1. Forty-five (77.6%) patients had their neurological status improved postoperatively. Most patients with moderate neurological deficit can recover remarkably after total tumor removal. Laser surgery is especially helpful for treating *** Intramedullary tumor of the cervical spinal cord is amenable to total tumor removal. Operation is suitable when a patient presents moderate neurological deficit. Proficient surgical technique and standards for total tumor resection are essential for goodRESULTS . Preoperative radiotherapy contributes to difficult surgery and poor prognosis, and is not recommended.

关键词： SPINAL-CORD EPENDYMOMAS CHILDREN

Diagnosis and treatment of intramedullary hemangioblastoma of cervical spinal cord

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Chinese Medical Journal 2002年第7期115卷 1010-1013,146-147页

作者：徐启武鲍伟民庞力复旦大学附属华山医院神经外科上海200040

OBJECTIVE: To investigate the diagnosis and surgical techniques of intramedullary hemangioblastoma of the cervical spinal cord. METHODS: MR imaging and the methods and results of surgery were analyzed in 21 patients. RESULTS: The tumors were divided into three types on MR imaging. Syringeal type, where the tumor varied in size and was accompanied by syringobulbia and syringomyelia; Cystic type, where the tumor presented as a cyst with a small mural node; and Solid type, where the tumor was revealed as a huge solid mass. All tumors were totally removed and diagnosis was confirmed by histological study. Post-operative neurological status was improved in 20 patients and aggravated in 1. CONCLUSIONS: The localization and the nature diagnosis of the tumor can be made by cervical MR imaging. Operative methods vary with tumor types. It is the most important that the tumor is dissected along the right interface and removed after devascularization.

关键词： Adolescent Adult Cervical Vertebrae Female Hemangioblastoma Humans Magnetic Resonance Imaging Male Middle Aged Spinal Cord Neoplasms

基于聚合二次模态分解及Informer的短期负荷预测

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电网技术 2024年第6期48卷 2574-2583,I0087-I0091页

作者：石卓见冉启武徐福聪陕西理工大学电气工程学院陕西省汉中市723000 国网福建省电力有限公司福建省福州市350003

针对区域级负荷的非平稳性及长序列预测精度低的问题,该文提出了一种基于聚合二次模态分解及Informer的短期负荷预测方法。首先,运用改进完全集合经验模态分解(improved complete ensemble empirical mode decomposition with adaptive ... 详细信息

针对区域级负荷的非平稳性及长序列预测精度低的问题,该文提出了一种基于聚合二次模态分解及Informer的短期负荷预测方法。首先,运用改进完全集合经验模态分解(improved complete ensemble empirical mode decomposition with adaptive noise,ICEEMDAN)对负荷序列进行初步分解,削弱原始序列的随机性与波动性;其次,根据子序列的样本熵计算结果进行聚合,并通过比较不同的聚合方式选出最优重构方案;然后,利用变分模态分解对高复杂度的合作模态函数进行二次分解;充分考虑到电价、气象等因素对负荷的影响,采用随机森林(random forest,RF)算法进行相关性分析,从而为每个子序列构建不同的高耦合度特征矩阵并输入Informer进行建模,并通过其多层次编码及稀疏多头自注意力机制等方式提高对负荷序列的预测效率;最后采用巴塞罗那区域级负荷数据集进行实例验证,结果显示所提框架有效解决了模态分解过程中的模态混叠以及高频分量问题,并且其长序列预测均方根误差相比其他经典深度学习模型最高降低了65.28%。

关键词：短期负荷预测二次分解样本熵聚合方式比较 Informer 随机森林算法长序列预测

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二元机翼非线性气动弹性自适应控制

西北工业大学学报 2015年第5期33卷 775-780页

作者：许行之高亚奎章卫国王峰许奇武西北工业大学自动化学院陕西西安710072 北京万源工业有限公司北京100176

研究了带有前后缘控制面的二元机翼气动弹性颤振主动控制问题。采用多项式非线性模型建立气动弹性动态方程,然后考虑俯仰方向阻尼和刚度存在参数不确定性的情况下,利用Lyapunov稳定性理论设计了具有全局稳定的反馈线性化自适应和结构化... 详细信息

研究了带有前后缘控制面的二元机翼气动弹性颤振主动控制问题。采用多项式非线性模型建立气动弹性动态方程,然后考虑俯仰方向阻尼和刚度存在参数不确定性的情况下,利用Lyapunov稳定性理论设计了具有全局稳定的反馈线性化自适应和结构化模型参考自适应(SMRAC)控制律。仿真结果显示,在控制面偏转存在限制时,所设计的控制律可以有效地实现颤振的抑制,考虑阻尼不确定性对于颤振抑制具有减小收敛时间的作用,但对于系统响应特性占据主导作用的是刚度不确定性。

关键词：自适应控制系统非线性气动弹性二元机翼参数不确定性

THE APPLICATION OF HE-NE LASER NEEDLE TO REHABILITATION OF BRAIN INJURY

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World Journal of Acupuncture-Moxibustion 1992年第1期2卷 14-16页

作者： Gu Guozhu Jiang Chengchuan Li Chengchuang Fang Youan xu qiwu, Institute of Neurology, Shanghai Medical University, Shanghai, China

20 cases of brain injury were treated for rehabilitation by He-Ne laser irradia-tion and observed on nailfold microcirculation. The optical fiber was pointed directly to the respec-tive acupoint. The selected acupoints were: Baihui (DU20), Fengfu (DU16), Fengchi (GB20),Taiyang (EX-HN5) and Hegu (LI4); each one received 4 minutes and totally 20 minutes foronce. Treatment was continued for 10 days. The immediate analgesic effect of laser reached 82.2%. The velocity in blood flow of 84.4%patients increased (P<0.01). In consequence, analgesic effect correlated closely with the velocityin the blood flow. It showed that the effect of laser therapy was superior to that of palliative treat-ment.

关键词： minutes rehabilitation palliative analgesic acupoint totally pointed immediate consequence LASER

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脊髓髓内血管母细胞瘤1例报告与文献复习

中国微侵袭神经外科杂志 2010年第11期15卷 497-500页

作者：徐启武冷冰复旦大学附属华山医院神经外科上海200040

目的总结脊髓髓内血管母细胞瘤的诊治经验。方法回顾性分析1例脊髓髓内血管母细胞瘤病人的临床资料和493例文献报告病例的相关资料。结果行超选择性栓塞后获肿瘤全切除。随访1年,神经系统功能明显改善。结论脊髓血管DSA可定位、定性诊... 详细信息

目的总结脊髓髓内血管母细胞瘤的诊治经验。方法回顾性分析1例脊髓髓内血管母细胞瘤病人的临床资料和493例文献报告病例的相关资料。结果行超选择性栓塞后获肿瘤全切除。随访1年,神经系统功能明显改善。结论脊髓血管DSA可定位、定性诊断脊髓髓内血管母细胞瘤,并能发现多发病灶,对制订治疗方案有益。如应用得当,术前超选择性栓塞是低风险的,其可减少术中出血,缩短手术时间,减轻手术伤残,增加肿瘤全切除机会。脊髓髓内血管母细胞瘤的最佳治疗,是在最少出血状态下手术全切除肿瘤。

关键词：血管母细胞瘤栓塞,治疗性妊娠神经外科手术

Residual stress and radial stress gradient in polycrystalline diamond compacts

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金刚石与磨料磨具工程 2008年第S1期28卷 88-91,96页

作者： xu Guoping~(1,2),Yin Zhimin~1,Chen qiwu~2,xu Gen~1 (1.School of Materials Science & Engineering,Central South University,Changsha 410083,Hunan,China) (2.Changsha research institute of mining and metallurgy,Changsha 410012,Hunan,China)

The differential thermal expansion of the polycrystalline diamond layer and the tungsten carbide substrate results in large residual stresses as PDC cutters cooling after *** residual stresses on the top surface of the diamond layer of PDC were measured at five points along the radial direction of PDC using X-ray Diffraction Residual Stress Instrument,thus the stresses and their radial distribution were *** results show that the stresses on the diamond surface are compressive,the biggest stress appears at the central point(about 1200 MPa),and that from the center to the edge of PDC,the magnitude of the stress decreases. A finite element analysis(FEA) was made to check the validity of the testing *** FEA modeling results were found to correlate well with the measured *** leading to the deviation between XRD experimental measurements and the calculations of residual stress by FEA were also analyzed.

关键词： Polycrystalline diamond Residual stress XRD FEA

椎管内复发肿瘤的诊断和手术治疗(附28例报告)

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中国神经精神疾病杂志 2000年第3期26卷 135-136页

作者：于佶徐启武闻金坤上海医科大学华山医院神经外科 200040 扬州苏北人民医院神经外科

目的　研究复发椎管内肿瘤的临床诊断和手术治疗特点。方法　对 2 8例复发椎管内肿瘤进行回顾性分析 ,所有患者均用MR诊断并再次行手术治疗。结果　 2 8例复发椎管内肿瘤诊断明确 ;出院时 ,症状体征改善或消失者 2 1例 ,无变化 6例 ,加... 详细信息

目的　研究复发椎管内肿瘤的临床诊断和手术治疗特点。方法　对 2 8例复发椎管内肿瘤进行回顾性分析 ,所有患者均用MR诊断并再次行手术治疗。结果　 2 8例复发椎管内肿瘤诊断明确 ;出院时 ,症状体征改善或消失者 2 1例 ,无变化 6例 ,加重 1例。 18例随访 2个月至 9年 ,症状体征继续改善者 15例 ,无变化 2例 ,死亡 1例。结论　根据临床表现及MR检查即能明确诊断复发椎管内肿瘤 ;只要提高手术技能。

关键词：椎管内肿瘤肿瘤复发诊断外科手术病例报告