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Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure

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Chinese Journal of Integrative Medicine 2024年第5期30卷 458-467页

作者： HU Yu-xuan qiu Sheng-lei SHANG ju-ju WANG Zi LAI Xiao-lei Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China

Although there have been significant advances in the treatment of heart failure in recent years,chronic heart failure remains a leading cause of cardiovascular disease-related *** studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart ***,most of the drugs that increase cardiac energy are still in the theoretical or testing *** research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate *** this review,we summarized the mechanisms by which botanical drugs(the active ingredients/formulas/Chinese patent medicines)improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptors(PPARs)and other related *** the same time,some potential protective effects of botanical drugs on myocardium,such as alleviating oxidative stress and dysbiosis signaling,caused by metabolic disorders,were briefly discussed.

关键词： botanical drugs chronic heart failure myocardial metabolism pharmacological effects review

Constraining the Earth-mass Primordial Black Hole Mergers Model of the Non-repeating FRBs Using the First CHIME/FRB Catalog

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Research in Astronomy and Astrophysics 2024年第9期24卷 76-82页

作者： Min Meng qiu-ju Huang Can-Min Deng Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

In this paper,we upgrade the constraints for the Earth-mass primordial black hole mergers model based on the first Canadian Hydrogen Intensity Mapping Experiment(CHIME)/fast radio burst(FRB)*** the null hypothesis that the observed non-repeating FRBs originate from Earth-mass primordial black hole mergers,we find that how the charges were distributed in the primordial black hole population is well described by a double powerlaw function with typical charge value of law function with typical charge value of q_(c)/10^(-5)=1.60_(-0.28)^(+0.28),where the power-law index α_(1)=2.33_(-0.18)^(+0.15) for q

关键词： black hole physics (stars:)gamma ray burst:general (cosmology:)dark matter

Towards the universal defense for query-based audio adversarial attacks on speech recognition system

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Cybersecurity 2024年第1期7卷 53-70页

作者： Feng guo Zheng Sun Yuxuan Chen Lei ju School of Cyber Science and Technology Shandong UniversityQingdaoChina Quancheng Laboratory QCLJinanChina

Recently,studies show that deep learning-based automatic speech recognition(ASR)systems are vulnerable to adversarial examples(AEs),which add a small amount of noise to the original audio *** AE attacks pose new challenges to deep learning security and have raised significant concerns about deploying ASR systems and *** existing defense methods are either limited in application or only defend on results,but not on *** this work,we propose a novel method to infer the adversary intent and discover audio adversarial examples based on the AEs generation *** insight of this method is based on the observation:many existing audio AE attacks utilize query-based methods,which means the adversary must send continuous and similar queries to target ASR models during the audio AE generation *** by this observation,We propose a memory mechanism by adopting audio fingerprint technology to analyze the similarity of the current query with a certain length of memory ***,we can identify when a sequence of queries appears to be suspectable to generate audio *** extensive evaluation on four state-of-the-art audio AE attacks,we demonstrate that on average our defense identify the adversary’s intent with over 90%*** careful regard for robustness evaluations,we also analyze our proposed defense and its strength to withstand two adaptive ***,our scheme is available out-of-the-box and directly compatible with any ensemble of ASR defense models to uncover audio AE attacks effectively without model retraining.

关键词： Adversarial attacks Defense Memory mechanism Query-based

A Local Macroscopic Conservative(LoMaC)Low Rank Tensor Method with the Discontinuous Galerkin Method for the Vlasov Dynamics

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Communications on Applied Mathematics and Computation 2024年第1期6卷 550-575页

作者： Wei guo Jannatul Ferdous Ema Jing-Mei qiu Department of Mathematics and Statistics Texas Tech UniversityLubbockTX70409USA Department of Mathematical Sciences University of DelawareNewarkDE19716USA

In this paper,we propose a novel Local Macroscopic Conservative(LoMaC)low rank tensor method with discontinuous Galerkin(DG)discretization for the physical and phase spaces for simulating the Vlasov-Poisson(VP)*** LoMaC property refers to the exact local conservation of macroscopic mass,momentum,and energy at the discrete *** recently developed LoMaC low rank tensor algorithm(arXiv:2207.00518)simultaneously evolves the macroscopic conservation laws of mass,momentum,and energy using the kinetic flux vector splitting;then the LoMaC property is realized by projecting the low rank kinetic solution onto a subspace that shares the same macroscopic *** paper is a generalization of our previous work,but with DG discretization to take advantage of its compactness and flexibility in handling boundary conditions and its superior accuracy in the long *** algorithm is developed in a similar fashion as that for a finite difference scheme,by observing that the DG method can be viewed equivalently in a nodal *** the nodal DG method,assuming a tensorized computational grid,one will be able to(i)derive differentiation matrices for different nodal points based on a DG upwind discretization of transport terms,and(ii)define a weighted inner product space based on the nodal DG grid *** algorithm can be extended to the high dimensional problems by hierarchical Tucker(HT)decomposition of solution tensors and a corresponding conservative projection *** a similar spirit,the algorithm can be extended to DG methods on nodal points of an unstructured mesh,or to other types of discretization,e.g.,the spectral method in velocity *** numerical results are performed to showcase the efficacy of the method.

关键词： Hierarchical Tucker(HT)decomposition Conservative SVD Energy conservation Discontinuous Galerkin(DG)method

Exact Box-Constrained Economic Operating Region for Power Grids Considering Renewable Energy Sources

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 514-523页

作者： Huating Xu Bin Feng Chutong Wang Chuangxin guo Jian qiu Mingyang Sun College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Department of Control Science and Engineering Zhejiang UniversityHangzhou 310027China

The growing integration of renewable energy sources manifests as an effective strategy for reducing carbon emissions. This paper strives to efficiently approximate the set of optimal scheduling plans(OSPs) to enhance the performance of the steady-state adaptive cruise method(SACM) of power grid, improving the ability of dealing with operational uncertainties. Initially, we provide a mathematical definition of the exact boxconstrained economic operating region(EBC-EOR) for the power grid and its dispatchable components. Following this, we introduce an EBC-EOR formulation algorithm and the corresponding bi-level optimization models designed to explore the economic operating boundaries. In addition, we propose an enhanced big-M method to expedite the computation of the EBCEOR. Finally, the effectiveness of the EBC-EOR formulation, its economic attributes, correlation with the scheduling plan underpinned by model predictive control, and the significant improvement in computational efficiency(over twelvefold) are verified through case studies conducted on two test systems..

关键词： Exact box-constrained economic operating region(EBC-EOR) big-M method intelligent scheduling steady-state adaptive cruise uncertainty renewable energy source

Synthesis of granulated Li_(1.33)Mn_(1.67)O_(4) via two antisolvent methods for lithium adsorption from gas-produced water

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Chinese Journal of Chemical Engineering 2024年第5期69卷 34-46页

作者： jun qiu Lu-Ri Bao Wei guo Ying Yang Shu-Ying Sun National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China

Gas-produced water is an accompanying wastewater in the natural gas extraction process,and it is a potential liquid lithium resource that contains a considerable amount of *** study investigated the feasibility of using manganese-based ion sieves to adsorb and extract lithium from gas-produced *** we focused on the applicability of two different granulation methods,extrusion and droplet,in gas-produced water *** types of H_(1.33)Mn_(1.67)O_(4) particles were prepared by the extrusion method(EHMO)and the droplet method(DHMO).The porosity of DHMO was much higher than that of EHMO,and the adsorption performance of DHMO increased with the decrease of binder *** prepared with a binder concentration of 0.14 g·ml^(-1)exhibited the best adsorption performance in gas-produced water,and the Li^(+)adsorption capacity could reach 25.14 mg·g^(-1).In gas-produced water,the adsorption equilibrium of DHMO only took 9 h,and the adsorption process conformed to the Langmuir model and pseudo-second-order kinetic *** pore diffusion model(PDM)could well describe its adsorption ***,DHMO showed a great selectivity to Li^(+),and the selectivity order of DHMO in gas-produced water was Li^(+)>Ba^(2+)>>Mg^(2+),Ca^(2+),Sr^(2+)>>Na^(+)>>K^(+).After 20 cycles,the Li^(+)adsorption capacity was still higher than 17.30 mg·g^(-1),and the rate of manganese dissolution was less than 1%.

关键词： Gas-produced water Granulation Li_(1.33)Mn_(1.67)O_(4)

Ag-doped Ti_(3)C_(2)T_(x) sensor:A promising candidate for lowconcentration H_(2)S gas sensing

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High Voltage 2024年第3期9卷 537-545页

作者： Fuping Zeng Xiaoxuan Feng Xiaoyue Chen Hao qiu Yiming Yan Qiang Yao ju Tang School of Electrical Engineering and Automation Wuhan UniversityWuhanChina Hubei Key Laboratory of Power Equipment&System Security for Integrated Energy Resources WuhanChina State Grid Chengdu Electric Power Supply Company ChengduChina State Grid Chongqing Electric Power Research Institute ChongqingChina State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingChina

Trace hydrogen sulphide(H_(2)S)could reflect the severity of insulation faults in gas-insulated switchgear(GIS),therefore,accurate and fast detection of low-concentration H_(2)S is important for on-line monitoring,fault diagnosis,and state evaluation in ***-Ti_(3)C_(2)T_(x) chemiresistive-type sensors were fabricated via drop-coating with self-reduction synthesised Ag-doped Ti_(3)C_(2)T_(x).The as-prepared sensors exhibited an excel-lent sensitivity and selectivity to H_(2)S with an extremely low detection of limit of 18.57 parts per billion(ppb)at 25℃(room temperature).The response of Ag-Ti_(3)C_(2)T_(x) sensor to 10 parts per million(ppm)H_(2)S was enhanced~12 times than that of the pristine Ti_(3)C_(2)T_(x) *** compositing of Ti_(3)C_(2)T_(x) with Ag nanoparticles(NPs)enabled the fast response/recovery time for H_(2)S *** analysis found that the enhanced H_(2)S sensing performances could be attributed to chemical sensitisation,adsorbed oxygen species regulation and high Brunauer–Emmett–Teller(BET)surface *** study paves the way for Ag-Ti_(3)C_(2)T_(x) as room-temperature sensing materials to detect low-concentration H_(2)S in GIS.

关键词： insulation diagnosis attributed

Simultaneous removal of 1,2-dichlorobenzene and furan over Mn-Ce-Fe oxide catalyst:Catalytic activity and product analysis

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Journal of Rare Earths 2024年第5期42卷 972-979,I0006页

作者： juan qiu Minghui Tang Yaqi Peng Xuanhao guo Shengyong Lu Jianhua Yan Taizhou Institute of Zhejiang University Taizhou 318000China State Key Laboratory for Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China

The Mn-Ce-Fe mixed oxide(MCFe)was prepared by co-precipitation and the catalytic performance was tested by using 1,2-dichlorobenzene(1,2-DCB)and furan as model molecules of PCDD/*** effect of O_(2)concentration,SO_(2) and NO on the catalytic activity was *** 270℃,the MCFe oxide catalyst presents significant simultaneous removal efficiency of 75.25%and 100%for 1,2-DCB and furan,***-Emmett-Teller(BET)method(BET),X-ray diffraction(XRD),scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectroscopy(FTIR),H_2-temperature programmed reduction(H_(2)-TPR),NH_(3)-temperature programmed desorption(NH_3-TPD)and O_(2)-TPD were used to characterize the catalysts before and after the *** tests suggest that the oxidation behavior of furan occurred prior to that of 1,*** to the intermediate products detected by gas chromatography-mass spectrometry(GC-MS),the by-products include chlorinated hydrocarbons,long-chain hydrocarbons,ketone,*** catalytic oxidation reaction paths are proposed.

关键词： 1 2-dichlorobenzene Furan Catalytic oxidation Product analysis Rare earths

Multi-scale analyses of phase transformation mechanisms and hardness in linear friction welded Ti17(a+β)/Ti17(β)dissimilar titanium alloy joint

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Chinese Journal of Aeronautics 2024年第1期37卷 312-324页

作者： Zhenguo guo Tiejun MA Xiawei YANG ju LI Wenya LI Achilles VAIRIS State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesNorthwestern Polytechnical UniversityXi’an 710072China Aeronautical Key Laboratory for Welding and Joining Technologies AVIC Manufacturing Technology InstituteBeijing 100024China Mechanical Engineering Department University of West AtticaAthens 12241Greece

The Ti17(a+β)-Ti17(β)dual alloy-dual property blisk produced using Linear Friction Welding(LFW)is considered as high-performance component in advanced ***,up to now,microstructure evolution and relationship between microstructure and micro mechanical properties of LFWed Ti17(a+β)/Ti17(β)dissimilar joint have not been thoroughly *** this work,complex analyses of the phase transformation mechanisms of the joint are conducted,and phase transformations in individual zones are correlated to their microhardness and *** reveal that a dissolution occurs under high temperatures encountered during LFW,which reduces microhardness of the joint to that of Ti17(a+β)and Ti17(β).In ThermoMechanically Affected Zone of Ti17(a+β)(TMAZ-(a+β))side joint,a large number of nanocrystalline a phases form with different *** microstructure strengthens significantly by fine grains which balances partial softening effect of a dissolution,and increases nanohardness of a phase and microhardness of TMAZ-(a+β).Superlattice metastableβphase precipitates from metastableβin Weld Zone(WZ)during quick cooling following welding,because of short-range diffusion migration of solute atoms,especiallyβstabilizing elements Mo and *** precipitation of the superlattice metastableβphase results in precipitation strengthening,which in turn increases nanohardness of metastableβand microhardness in WZ.

关键词： Linear friction welding Ti17 titanium alloy Phase transformation Microhardness Nanohardness