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Effect of various functional groups on biodiesel synthesis from soybean oils by acidic ionic liquids

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Chinese Chemical Letters 2012年第10期23卷 1107-1110页

作者： Ming Ming Fan Jing Jie Zhou qiu ju han Ping Bo Zhang The Key Laboratory of Food Colloids and Biotechnology Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China

Preparation of biodiesel from soybean oils catalyzed by five acidic ionic liquids with three cationic functional groups was investigated. The improvement of the catalytic activities was affected by various functional groups including pyridine group, N- methylimidazole group, triethylamine group. Among them [C4SO3Hpy]HSO4 with pyridine group showed better catalytic activity with the biodiesel yield of 94.5%, and still yielded more than 90% after six successive uses. The possible mechanism was also discussed by two reaction paths in detail.

关键词： Biodiesel Acidic ionic liquid Soybean oils Transesterification

Innate and adaptive immune escape mechanisms of hepatitis B virus

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World Journal of Gastroenterology 2022年第9期28卷 881-896页

作者： Hua-jun Zhao Yi-Fei Hu qiu-ju han Jian Zhang Institute of Immunopharmaceutical Sciences School of Pharmaceutical SciencesShandong UniversityJinan 250012Shandong ProvinceChina

Chronic hepatitis B virus(HBV)infection is an international health problem with extremely high mortality and morbidity *** current clinical chronic hepatitis B(CHB)treatment strategies can partly inhibit and eliminate HBV,viral breakthrough may result due to non-adherence to treatment,the emergence of viral resistance,and a long treatment *** CHB infection arises as a consequence of complex interactions between the virus and the host innate and adaptive immune ***,understanding the immune escape mechanisms involved in persistent HBV infection is important for designing novel CHB treatment strategies to clear HBV and achieve long-lasting immune *** review details the immunological and biological characteristics and escape mechanisms of HBV and the novel immune-based therapies that are currently used for treating HBV.

关键词： Hepatitis B virus Innate immunity Adaptive immunity Immune tolerance Therapeutic strategy

Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells

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World Journal of Gastroenterology 2021年第24期27卷 3581-3594页

作者： qiu-ju han Yong-Liang Mu Hua-jun Zhao Rong-Rong Zhao Quan-juan Guo Yu-hang Su Jian Zhang Institute of Immunopharmaceutical Sciences School of Pharmaceutical SciencesShandong UniversityJinan 250012Shandong ProvinceChina Department of Emergency Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Fasudil,as a Ras homology family member A(RhoA)kinase inhibitor,is used to improve brain microcirculation and promote nerve regeneration *** evidence shows that Rho-kinase inhibition could improve liver *** To evaluate the anti-fibrotic effects of Fasudil in a mouse model of liver fibrosis induced by thioacetamide(TAA).METHODS C57BL/6 mice were administered TAA once every 3 d for 12 *** 1 wk after induction with TAA,Fasudil was intraperitoneally injected once a day for 3 wk,followed by hematoxylin and eosin staining,sirius red staining,western blotting,and quantitative polymerase chain reaction(qPCR),and immune cell activation was assayed by fluorescence-activated cell ***,the effects of Fasudil on hepatic stellate cells and natural killer(NK)cells were assayed in *** First,we found that TAA-induced liver injury was protected,and the positive area of sirius red staining and type I collagen deposition were significantly decreased by Fasudil ***,western blot and qPCR assays showed that the levels of alpha smooth muscle actin(α-SMA),matrix metalloproteinase 2(MMP-2),MMP-9,and transforming growth factor beta 1(TGF-β1)were inhibited by ***,flow cytometry analysis revealed that NK cells were activated by Fasudil treatment in vivo and in ***,Fasudil directly promoted the apoptosis and inhibited the proliferation of hepatic stellate cells by decreasingα-SMA and TGF-β*** Fasudil inhibits liver fibrosis by activating NK cells and blocking hepatic stellate cell activation,thereby providing a feasible solution for the clinical treatment of liver fibrosis.

关键词： Liver fibrosis Natural killer cells Fasudil Hepatic stellate cells

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

国产和进口苜蓿对生鲜乳生产的影响及经济效益分析

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中国畜牧杂志 2016年第18期52卷 6-11页

作者：仇菊韩娟梁克红刘鹏秦玉昌农业部食物与营养发展研究所北京100081 中国农业科学院北京畜牧兽医研究所北京100193

本试验就国产和进口苜蓿对奶牛健康及生鲜乳品质、奶牛养殖场及苜蓿种植户经济效益的影响进行分析,旨在为奶牛饲养和苜蓿种植提供科学依据。试验选用15头奶牛,分为对照组、在日粮中分别添加30%国产苜蓿以及进口苜蓿组,饲喂60 d后进行指... 详细信息

本试验就国产和进口苜蓿对奶牛健康及生鲜乳品质、奶牛养殖场及苜蓿种植户经济效益的影响进行分析,旨在为奶牛饲养和苜蓿种植提供科学依据。试验选用15头奶牛,分为对照组、在日粮中分别添加30%国产苜蓿以及进口苜蓿组,饲喂60 d后进行指标测定,并结合调研数据进行分析。结果显示:国产和进口苜蓿在保持奶牛健康状况的前提下,提高了产奶量及生鲜乳的品质;国产和进口苜蓿可使每头奶牛每天分别增收9.21元和1.54元;在大庆市2个苜蓿主产区县的种植纯收益相比于玉米分别增加了239元和179元。表明不仅养殖场饲喂国产苜蓿比进口的经济效益好,而且农户种植苜蓿较种植玉米具有更好的经济价值。

关键词：苜蓿营养成分奶牛健康生鲜乳品质经济效益

Impacts of Platform’s Omnichannel Coupons on Multichannel Suppliers

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Journal of Systems Science and Systems Engineering 2023年第1期32卷 71-99页

作者： Yue Zhang Xiaojian Hu ju Zhao ju qiu School of Management Hefei University of TechnologyHefei230009China Key Laboratory of Process Optimization and Intelligent Decision-Making Ministry of EducationHefei230009China

While coupons that can be redeemed only in online channels have been issued by e-commerce platforms for decades, a new type of platform’s coupons, i.e., omnichannel coupons, which can be redeemed in both online and store channels, is gaining popularity with the rise of the omnichannel retail mode. It is interesting to explore the conditions under which omnichannel coupons are more advantageous to platforms and multichannel suppliers that sell products through platforms and physical stores. Two game models are developed in two cases where an e-commerce platform offers single channel coupons or omnichannel coupons for a multichannel supplier. Two scenarios are considered: one in which a consumer’s valuation of a product that fits his or her need is homogeneous and another in which the valuation is heterogeneous. Equilibrium outcomes show that under the homogeneous scenario, the product price and coupon face value in both coupon modes increase with the product’s fit probability when the cross-selling revenue is high, while decrease with the product’s fit probability when the cross-selling revenue is low. However, under the heterogeneous scenario, the price in both modes increases with the product’s fit probability only when the supplier’s loss from returns is low and the cross-selling revenue is high, and the coupon face value always decreases with the product’s fit probability. Compared with single channel coupons, omnichannel coupons may lead to a higher product price under certain conditions. Furthermore, omnichannel coupons can lead to higher total demand and benefit both the platform and the supplier if and only if the product’s fit probability is low and the supplier’s loss from returns is high. An extension shows that the platform’s preference for omnichannel coupons is weakened when the supplier offers a partial refund policy.

关键词： Omnichannel coupon promotion e-commerce platform game theory

Preparation of ZnO Nanoparticles from Zn-containing Rotary Hearth Furnace Dust

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Journal of Wuhan University of Technology(Materials Science) 2022年第1期37卷 32-37页

作者： YAO Haiwei MA han MAO Rui qiu Jiayong CHEN Chunyu ju Dianchun School of Metallurgy and Materials Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600China Shagang Iron&Steel Research Institute of Jiangsu Province Zhangjiagang 215625China

To solve the problem of the low added value Zn-containing rotary hearth furnace(RHF)dust,two deep eutectic solvents(DESs)were employed,such as choline chloride-urea(ChCl-urea)and choline chloride-oxalic acid dihydrate(CC-OA)solvent and Zn-containing RHF dust(water-washed)as the research ***,we prepared ZnO nanoparticles using two DESs or their combination,namely,ChCl-urea(Method A),CC-OA(Method B),first CC-OA and then ChCl-urea(Method B-A)and first ChCl-urea and then CCOA(Method A-B),*** effects of these methods on the properties of as-obtained precursors and ZnO nanoparticles were investigated in *** results indicated that the precursor obtained by Method A was Zn_(4)CO_(3)(OH)_(6)·H_(2)O,and those by Methods B,B-A,and A-B were all ZnC_(2)O_(4)·2H_(2)***,the decomposition steps of the last three methods were *** ZnO contents of 95.486%,99.768%,99.733%,and 99.76%were obtained by Methods A,B,B-A,and A-B,*** A,B,and B-A led to the formation of spherical and agglomerated ZnO nanoparticles with normal size distributions,where Method B showed the best distribution with an average diameter 25 *** ZnO nanoparticles obtained by the Method A-B did not possess good properties.

关键词： rotary hearth furnace Zn-containing dust deep eutectic solvent ZnO nanoparticle

Semiclassical Calculations of Recurrence Spectra for Lithium Atoms in Parallel Electric and Magnetic Fields

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Chinese Physics Letters 2002年第1期19卷 29-31页

作者： Lin Sheng-Lu, Zhang qiu-ju Department of Physics Shandong Normal University Ji\'nan 250014

By using the region-splitting consistent and iterative method, we calculate the recurrence spectra of lithium atoms in parallel strong external electric and magnetic fields, and obtain the novel resonance structure in the photoabsorption spectrum above the ionization threshold with a constant scaled electric field at (F↑-)= 0.036, and a scaled energy at ε= 0.58 and ε= 0.006, respectively. The results are compared with those of hydrogen obtained by using standard closed orbit theory. It is demonstrated that the core-scattered effects exhibited in combination recurrence play a great role

关键词： Electric fields

农产品中微量营养素含量下降原因综合分析与应对策略

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中国食物与营养 2016年第12期22卷 35-38页

作者：刘鹏朱大洲梁克红仇菊韩娟王靖卢林纲农业部食物与营养发展研究所北京100081

近年来,我国农产品综合生产能力稳步提高,食物供需基本平衡,居民营养状况明显改善,但仍存在营养不足与营养过剩问题,尤其是因微量元素缺乏导致的"隐性饥饿"及营养性慢性疾病呈高发态势。自20世纪60年代"绿色革命"以来,农作物栽培技术和... 详细信息

近年来,我国农产品综合生产能力稳步提高,食物供需基本平衡,居民营养状况明显改善,但仍存在营养不足与营养过剩问题,尤其是因微量元素缺乏导致的"隐性饥饿"及营养性慢性疾病呈高发态势。自20世纪60年代"绿色革命"以来,农作物栽培技术和育种技术的进步使农产品产量增加,而许多研究表明,单位体积农作物产品中部分营养素,尤其是微量营养素含量有下降趋势,对农作物中微量营养素形成了"稀释效应",导致单位体积营养素含量的下降。本文综述了国内外关于农产品微量营养素含量变化的研究进展,提出深入开展农作物营养品质分析研究、建立对主要农产品微量营养素含量监测体系、从食物生产源头入手提升农作物营养品质,为增进国民营养健康提供优质的食用农产品等政策建议。

关键词：绿色革命隐性饥饿微量营养素稀释效应营养品质