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真实世界研究及其在临床护理中的研究前景

中华现代护理杂志 2024年第11期30卷 1535-1540页

作者：陈阳李庆印北京协和医学院、中国医学科学院阜外医院护理部北京100037

基于真实世界研究发展历程、定义、设计类型和在医疗卫生领域的应用现状,探索真实世界研究在我国临床护理研究的现状以及应用前景,以期启发护理科研工作者基于真实世界研究理念,挖掘真实护理现状,为临床护理高质量发展形成相关的实践指... 详细信息

基于真实世界研究发展历程、定义、设计类型和在医疗卫生领域的应用现状,探索真实世界研究在我国临床护理研究的现状以及应用前景,以期启发护理科研工作者基于真实世界研究理念,挖掘真实护理现状,为临床护理高质量发展形成相关的实践指南、技术规范等提供现实依据,从而提高患者护理服务质量。

关键词：综述真实世界研究护理

中国≥45岁人群健康体检服务利用情况:一项基于CHARLS2018的全国横断面调查

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中国全科医学 2024年第10期27卷 1179-1185页

作者：高川李庆印柯丹丹周俞余张宇扬何仲中国医学科学院阜外医院护理研究室北京市100037 北京协和医学院人文和社会科学学院北京市100005 中国医学科学院北京协和医院北京市100005

背景居民门诊和住院的医疗卫生服务利用情况及影响因素的研究已经十分成熟,然而分析我国居民预防性就医及健康体检服务利用情况的相关研究却较少。目的了解我国≥45岁人群健康体检服务利用情况,并分析其影响因素。方法利用2018年《中国... 详细信息

背景居民门诊和住院的医疗卫生服务利用情况及影响因素的研究已经十分成熟,然而分析我国居民预防性就医及健康体检服务利用情况的相关研究却较少。目的了解我国≥45岁人群健康体检服务利用情况,并分析其影响因素。方法利用2018年《中国健康与养老追踪调查》(CHARLS)的数据,选取≥45岁人群,统计其2015—2018年参加体检率和体检项目数。采用零膨胀负二项回归(Zinb)模型,分析居民参加体检项目数的影响因素。结果本研究共纳入17203例居民,平均年龄(62.4±10.0)岁,参加体检率为47.73%(8211/17203)。体检参加率排名前三位的分别是新疆维吾尔自治区(96.47%)、上海市(83.67%)和北京市(82.05%),排名后三位的分别为辽宁省(35.41%)、青海省(36.55%)和福建省(36.94%)。8211例参加过常规体检的人群平均年龄(64.1±9.9)岁,人均参加体检项目中位数为9(5,12)项。体检项目数排名前三位的分别为北京市(14项)、上海市(14项)和新疆维吾尔自治区(13项),排名后三位的分别为甘肃省(7项)、安徽省(7项)和辽宁省(7.5项)。非参数检验显示,城镇居民体检项目数高于农村(10项与8项),东部高于中部(10项与8项)、西部(10项与9项)及东北部(10项与8项),西部高于中部(9项与8项)(P<0.001)。Zinb模型显示,经济区域(中部、西部、东北部)、居住地类型(城镇地区)、性别(女性)、年龄(60岁及以上)、文化程度(初中及以上)、健康状况(共患病)和基本医疗保险类型(职工医疗保险)是居民参加体检项目数的影响因素(P<0.001)。按照城镇和农村进行亚组分析,结果显示经济区域(中部、西部、东北部)、年龄(60岁及以上)、文化程度(初中及以上)是城镇和农村居民参加体检项目数的共同影响因素(P<0.05)。除此之外,对于城镇地区居民而言,已婚是其参加体检项目数的影响因素(P<0.001);对于农村地区居民而言,男性、共病、具有职工医疗保险是其参加体检项目数的影响因素(P<0.001)。结论我国≥45岁人群健康体检服务利用率较低,城镇地区、东部地区健康体检服务更多,年龄和文化程度是居民利用健康体检服务的影响因素,婚姻状况是城镇地区居民利用健康体检服务的影响因素,性别、健康状态和基本医疗保险类型是农村地区居民利用健康体检服务的影响因素。未来应进一步提高居民健康体检服务的利用率,并分城乡和地域制定不同的政策措施。

关键词：中年人老年人体格检查预防卫生服务健康体检影响因素分析

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肌骨超声在附着点炎评估中的应用进展

临床超声医学杂志 2024年第7期26卷 611-615页

作者：钟琳马蓉李清音杨裕佳四川大学华西医院超声科成都市610041

附着点炎在健康成人及风湿免疫性疾病人群中发病率均较高,且其与部分风湿免疫性疾病患者的疾病活动度、生活质量均有一定的关系。目前已有较多共识建议关注风湿免疫性疾病患者附着点炎,并进一步强调了附着点的临床作用。肌骨超声作为目... 详细信息

附着点炎在健康成人及风湿免疫性疾病人群中发病率均较高,且其与部分风湿免疫性疾病患者的疾病活动度、生活质量均有一定的关系。目前已有较多共识建议关注风湿免疫性疾病患者附着点炎,并进一步强调了附着点的临床作用。肌骨超声作为目前评估外周附着点的首选影像学检查方法,为研究附着点炎开发了较多超声评分系统,但均存在一定不足。本文就附着点炎的评估方法、肌骨超声评估附着点炎的应用现状等进行综述,并对未来附着点炎超声评估研究进行了合理的展望。

关键词：肌骨超声附着点炎风湿免疫性疾病

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基于知识图谱的多源信息融合事故处理系统

山东理工大学学报（自然科学版） 2024年第3期38卷 28-34页

作者：罗顺财李庆印魏福禄周昕山东理工大学交通与车辆工程学院山东淄博255049

目前交通事故处理存在效率低、保险申请复杂、缺乏统一的事故数据共享平台等一系列问题。本文设计了一个基于知识图谱的多源信息融合事故处理系统,将智能问答模块运用于交通事故处理中,系统可服务于警察、保险、医疗和当事人四个角色的... 详细信息

目前交通事故处理存在效率低、保险申请复杂、缺乏统一的事故数据共享平台等一系列问题。本文设计了一个基于知识图谱的多源信息融合事故处理系统,将智能问答模块运用于交通事故处理中,系统可服务于警察、保险、医疗和当事人四个角色的人员,根据交通事故处理流程赋予权限,设计交通事故处理知识图谱,并采用模块化的方式进行开发。利用BERT-BiLSTM-CRF模型构建问答模块,针对问答模块的医疗问答、赔偿推荐功能,通过相应的数据进行训练,采用召回率R、精准率P、F1三种评价指标,选择评价结果最好的模型导入系统后端构建智能问答模块。在系统推广使用中,用户对医疗问答功能非常满意,事故当事人采用推荐赔偿价格的比例超过80%。

关键词：交通事故知识图谱 BERT-BiLSTM-CRF模型智能问答

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Flow Direction Level Traffic Flow Prediction Based on a GCN-LSTM Combined Model

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Intelligent Automation & Soft Computing 2023年第8期37卷 2001-2018页

作者： Fulu Wei Xin li Yongqing Guo Zhenyu Wang qingyin li Xueshi Ma Department of Transportation Engineering Shandong University of TechnologyZibo255000China Center for Urban Transportation Research University of South FloridaTampa33620USA Road Traffic Safety Comprehensive Management Office Traffic Police Detachment of Zibo Public Security BureauZibo255000China

Traffic flow prediction plays an important role in intelligent transportation systems and is of great significance in the applications of traffic control and urban *** to the complexity of road traffic flow data,traffic flow prediction has been one of the challenging tasks to fully exploit the spatiotemporal characteristics of roads to improve prediction *** this study,a combined flow direction level traffic flow prediction graph convolutional network(GCN)and long short-term memory(LSTM)model based on spatiotemporal characteristics is ***,a GCN model is employed to capture the topological structure of the data graph and extract the spatial features of road ***,due to the capability to handle long-term dependencies,the longterm memory is used to predict the time series of traffic flow and extract the time *** proposed model is evaluated using real-world data,which are obtained from the intersection of liuquan Road and Zhongrun Avenue in the Zibo High-Tech Zone of *** results show that the developed combined GCNLSTM flow direction level traffic flow prediction model can perform better than the single models of the LSTM model and GCN model,and the combined ARIMA-LSTM model in traffic flow has a strong spatiotemporal correlation.

关键词： Flow direction level traffic flow forecasting spatiotemporal characteristics graph convolutional network short-and long-termmemory network

Morphology design of microporous organic polymers and their potential applications:an overview

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Science China Chemistry 2017年第8期60卷 1056-1066页

作者： qingyin li shumaila razzaque shangbin jin bien tan key laboratory of material chemistry for energy conversion and storage ministry of educationhubei key laboratory of material chemistry and service failureschool of chemistry and chemical engineeringhuazhong university of science and technologyWuhan 430074China

Microporous organic polymers(MOPs) have attracted considerable research interest because of their well-defined porosity,high surface area, lightweight nature, and tunable surface chemistry. The morphology of MOPs are demonstrated to play a significant role in various applications although limited examples manifesting the importance of the MOP morphology in numerous applications have been reported. This review summarizes the recent progress in the design of MOPs using different techniques, including hard and soft template and direct synthesis methods. In addition, their applications, which possibly attribute to their shape, are discussed. Furthermore, the advantages and disadvantages of different methods are discussed, as well as their development and future challenges.

关键词： microporous organic polymers morphology control different dimensional structure

Effectivenss of electroacupuncture for skeletal muscle pain in Parkinson's disease:a Clinical randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第2期44卷 388-395页

作者： WANG Shaosong SUN Jingqing FENG qingyin li Bin WANG Xin YUAN Fan CUI Yingxue Department of acupuncture Beijing Hospital of Traditional Chinese MedicineBeijing 100010China

OBJECTIVE:To explore the effect of electroacupuncture on skeletal muscle pain in Parkinson's disease(PD).METHODS:A single-center randomized controlled trial was conducted with sixty patients with Parkinson's disease with skeletal muscle pain were randomly divided into electroacupuncture group and sham acupuncture control group with 30 patients *** electric acupuncture group was treated with electric acupuncture,while the control group was treated with Park needle *** groups were treated 5 times a week for a total of 4 weeks,and both groups completed 20 ***'s Parkinson's Pain Scale(KPPS)and visual analog scale(VAS)were used before and after treatment to evaluate the pain degree of *** shear wave elastography(SWE)and modified Ashworth score(MAS)were used to evaluate the changes of muscle ***'s comprehensive Score Scale(MDS-UPDRS,including UPDRS Ⅱ and UPDRS Ⅲ)was used to evaluate exercise *** Depression Scale(HAMD)score was used to evaluate the emotional changes of *** correlation analysis was used to explore the correlation between pain degree and muscle tone,exercise ability and ***:During the study,one case fell off in the control group,and 30 cases were eventually included in the analysis and treatment group and 29 cases in the control *** treatment,Young's modulus of biceps and quadriceps and shear wave velocity of biceps were decreased in electroacupuncture group compared with before treatment,while KPPS score,VAS score,UPDRS Ⅱ,UPDRS Ⅲ and modified Ashworth score were decreased,with statistical significance(P0.05).After treatment,KPPS score,VAS score,UPDRS Ⅱ and UPDRS Ⅲ,MAS,HAMD score,Young's modulus of biceps and shear wave velocity in electroacupuncture group were significantly lower than those in control group(P<0.05).Spearman correlation analysis showed that KPPS score was positively correl

关键词： Parkinson disease muscle skeletal pain electroacupuncture muscle tention mood disorders randomized controlled trial

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左心室辅助装置植入患者术后护理专家共识

中华护理杂志 2024年第14期59卷 1687-1690页

作者：国家心血管病专家委员会护理专业委员会马艳吴荣张辰李庆印黄雨佳赵明晶付强李永刚王佳妮不详国家心血管病中心、中国医学科学院阜外医院手供一体中心北京市100037 国家心血管病中心、中国医学科学院阜外医院成人外科恢复室一区北京市100037 国家心血管病中心、中国医学科学院阜外医院护理部北京市100037 国家心血管病中心、中国医学科学院阜外医院心脏康复中心北京市100037 国家心血管病中心、中国医学科学院阜外医院内科重症病区北京市100037

目的形成左心室辅助装置植入患者术后护理专家共识(以下简称“共识”),推动护士规范、安全的为左心室辅助装置植入患者实施术后护理。方法全面回顾国内外左心室辅助装置植入患者护理相关指南、专家共识、系统评价、原始研究等文献及相... 详细信息

目的形成左心室辅助装置植入患者术后护理专家共识(以下简称“共识”),推动护士规范、安全的为左心室辅助装置植入患者实施术后护理。方法全面回顾国内外左心室辅助装置植入患者护理相关指南、专家共识、系统评价、原始研究等文献及相关疾病诊疗方案等,形成“共识”初稿,通过2轮专家函询和1轮线上专家会议,对各条目进行调整、修改,形成“共识”终稿。结果函询专家应答率为93.75%,2轮函询专家权威系数分别为0.927和0.920,各指标重要性评分均>3.5分,变异系数均<0.25。2轮函询的肯德尔和谐系数分别为0.402和0.407(P<0.01)。通过专家函询及专家会议,形成的终版“共识”涵盖血流动力学监测、左心室辅助装置功能监测、凝血功能监测、经皮缆线的固定及切口护理、运动康复、健康教育、出院前考核7个主题。结论构建的“共识”具有科学性、严谨性和权威性。“共识”内容覆盖左心室辅助装置植入患者术后护理的各个环节,可为左心室辅助装置植入患者术后护理提供参考及指导。

关键词：心力衰竭左心室辅助装置术后护理专家共识

miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma

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BIOCELL 2024年第4期48卷 581-590页

作者： liJUAN ZHANG qingyin MENG li ZHUANG QUAN GONG XIANDA HUANG XUEQIN li SHIJUAN li GUOQIN WANG XICAI WANG Department of Rehabilitation and Palliative Medicine The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Department of Pathology The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Emergency Department(Outpatient Chemotherapy Center) The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Department of Cancer BioTreatment Center The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina Department of Cancer Institute The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalKunmingChina

Background:Lung adenocarcinoma is a very pervasive histological form of lung cancers,and inhibiting metastasis is crucial for effective *** this investigation,we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain(PHTF2)in dictating the aggressiveness and metastasis of lung ***:We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal *** experiments including cell count kit(CCK)-8 growth assay,apoptosis analysis,migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma ***,we examined tumorigenesis and metastasis in a nude mouse ***:MiR-30a-5p exhibited downregulation pattern in lung adenocarcinoma *** of miR-30a-5p mimic in lung adenocarcinoma cells resulted in the suppression of malignant ***,the administration of miR-30a-5p mimic also curbed tumorigenesis and metastasis of lung adenocarcinoma cells in animal ***,PHTF2 was found to be a molecular target of *** PHTF2 counteracted the tumor-suppressive effect of the miR-30a-5p ***:miR-30a-5p functions as a tumor-suppressive molecule while PHTF2 acts as an oncogenic factor in the development and metastasis of lung ***,targeting miR-30a-5p and PHTF2 could be developed into a promising therapeutic approach for inhibiting metastasis in lung adenocarcinoma.

关键词： Lung cancer Malignant phenotype Tumor formation Tumor suppressor Oncogene