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Corrosion Behavior of MgZnCa Bulk Amorphous Alloys Fabricated by Spark Plasma Sintering

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Acta Metallurgica Sinica(English Letters) 2016年第9期29卷 793-799页

作者： Feng-xiang Qin Chuan Ji Zhen-Hua Dan guo-Qiang Xie Hao Wang Shin-Ichi Yamaura Mitsuo Niinomi Yang-De Li School of Materials Science and Engineering Nanjing University of Science and Technology Institute for Materials Research Tohoku University College of Materials Science and Engineering Nanjing TECH University WPI-AIMR Tohoku University Dongguan Eontech Co. Ltd

Centimeter-sized Mg65Zn30Ca5 bulk amorphous alloys were fabricated by the spark plasma sintering process from the amorphous powders with a size smaller than 5 la m prepared by ball-milling. The sintered Mg65Zn30Ca5 samples were in an amorphous state when the spark plasma sintering was performed at a temperature of 383 K under a pressure of 600 MPa. The data of polarization curves presented that the sintered Mg65Zn30Ca5 bulk amorphous alloys exhibited higher corrosion resistance than pure Mg and AZ31B alloy owing to high content of Zn and homogeneous structure. A calcium phosphate compound layer was formed on the sintered Mg65Zn30Ca5 bulk amorphous sample after immersion in Hanks＇ solution, which is effective in improving corrosion resistance and bioactivity. The sintered MgZnCa bulk amorphous alloys with large dimensions broaden the potential application of bulk amorphous alloys in the biomedical fields.

关键词： Mg Bulk amorphous alloys Spark plasma sintering Corrosion behavior Biomedical applications

Renal blood perfusion in GK rats using targeted contrast enhanced ultrasonography

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 656-661页

作者： Bo Liu Liang Feng Li-Ping Gu Chao-qing Wang Xing-Hua Li Yi-Min Jiang Wei-Mei Li qing-Zhi guo Fang Ma Xinxiang Medical College Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Objective: To explore application of targeted contrast enhanced ultrasonography in diagnosis of early stage vascular endothelial injury and diabetic nephropathy. Methods: Targeted Sono VueTM microbubble was prepared by attaching anti-TM monoclonal antibody to the surface of ordinary micro-bubble Sono Vue by biotin-avidin bridge method and ultrasonic instrument was used to evaluate the developing situation of targeted microbubble in vitro. Twenty 12-week-old male GK rats and 20 Wistar rats were enrolled in this study, and were randomly divided into targeted angiography group and ordinary angiography group. Targeted microbubbles Sono VueTM or general microbubble Sono Vue were rapidly injected to the rats via tail vein; the developing situation of the two contrast agents in rats kidneys was dynamically observed. Time intensity curve was used to analyse rat kidney perfusion characteristics in different groups. Results: Targeted ultrasound microbubble Sono Vue-TM was successfully constructed, and it could be used to develop an external image. Targeted microbubbles Sono Vue-TM enabled clear development of experimental rat kidney. Time intensity curve shapes of rat kidney of the two groups showed as single apex with steep ascending and slowly descending branch. Compared with the control group, the rising slope of the GK rat renal cortex, medulla in targeted angiography group increased(P<0.05); the peak intensity of medulla increased(P<0.05), and the total area under the curve of medulla increased(P<0.05). Compared with control group, the ascending branch of the GK rat in renal cortex, medulla in ordinary angiography group increased(P<0.05). The peak intensity of the curve increased(P<0.05), and the total area under the curve increased(P<0.05). Compared with the ordinary angiography group, the peak of GK rat medullacurve in targeted angiography group intensity increased(P<0.05), and the total area under the curve increased(P<0.05). Conclusions: Targeted microbubbles Sono Vu

关键词： Targeted microbubble contrast agent Contrast enhanced ultrasonography Thrombomodulin GK rats

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GPS相位模糊度固定对钟差解算的影响研究

华中科技大学学报（自然科学版） 2023年第3期51卷 108-113页

作者：郭向华中科技大学精密重力测量国家重大科技基础设施湖北武汉430074 华中科技大学物理学院引力中心湖北武汉430074

分析了全球定位系统(GPS)载波相位模糊度固定对接收机钟差解算的影响,并利用GRACE-FO实测数据基于不固定模糊度、固定单差模糊度和固定双差模糊度三种方法解算了三组钟差,最后通过与官方产品比较和重叠弧段比较两种方法进行了质量评估.... 详细信息

分析了全球定位系统(GPS)载波相位模糊度固定对接收机钟差解算的影响,并利用GRACE-FO实测数据基于不固定模糊度、固定单差模糊度和固定双差模糊度三种方法解算了三组钟差,最后通过与官方产品比较和重叠弧段比较两种方法进行了质量评估.结果显示:固定单差模糊度和固定双差模糊度所解算的相对钟差与官方产品差异的标准差(17.2和13.2 ps)比不固定模糊度(32.8 ps)分别减小了48%和60%;重叠弧段差异标准差(2.3和0.7 ps)比不固定模糊度(11.4 ps)分别减小了80%和94%,比官方产品(3.6 ps)分别减小了36%和81%.以上结果表明固定GPS相位模糊度可显著改善相对钟差精度.

关键词：全球定位系统(GPS) 重力恢复与气候实验(GRACE) 模糊度固定接收机钟差卫星重力

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含铍废渣陶瓷的制备及其性能研究

湘潭大学学报（自然科学版） 2024年第3期46卷 119-130页

作者：肖业勇戴友芝赵媛媛刘雅妮付广义曾志彦郭庆郭婧湘潭大学环境与资源学院湖南湘潭411105 湖南省环境保护科学研究院水污染控制技术湖南省重点实验室湖南长沙410004 五矿铍业股份有限公司湖南衡阳421510

为实现含铍废渣的资源化利用,以含铍废渣为原料之一,二氧化硅、氧化铝和氧化镁为骨料,利用硅酸盐水泥作为黏合剂,辅以氧化钙、粉煤灰和二氧化钛组合成复合添加剂采用直接凝固注模成型法制备了含铍高性能陶瓷.探究了添加剂配比和煅烧条... 详细信息

为实现含铍废渣的资源化利用,以含铍废渣为原料之一,二氧化硅、氧化铝和氧化镁为骨料,利用硅酸盐水泥作为黏合剂,辅以氧化钙、粉煤灰和二氧化钛组合成复合添加剂采用直接凝固注模成型法制备了含铍高性能陶瓷.探究了添加剂配比和煅烧条件对铍浸出浓度的影响,并研究了不同陈化时间、保温时间和煅烧温度下制备的烧结试样的微观结构、强度、密度和耐热性能.研究结果表明骨料、铍渣、硅酸盐水泥和复合添加剂(其中氧化钙、粉煤灰和二氧化钛质量比为5∶5∶1)质量比值为60.8∶4∶6∶11时,所得含铍陶瓷样品铍浸出浓度低于国标限值,调整制备参数后可低至0.0107 mg·L^(-1),且具有较好抗压强度和耐热性.最佳制备条件为陈化8 h、在1200℃下保温煅烧4 h.该技术可为铍渣的综合利用提供一条有效的途径.

关键词：含铍废渣含铍陶瓷浸出毒性危险废物利用

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基于复杂工程问题的工程训练课程探索与实践

铸造工程 2024年第1期48卷 78-81页

作者：杨旭郑耀辉梁峰杨静项坤郭海萍沈阳航空航天大学工程训练中心辽宁沈阳110136

分析工程教育专业认证下工程训练的不足,探索工程训练实践教学的改进方法,并以物料夹取装置为例构建了实践教学模式。该模式以实践能力、创新能力培养为主导,以综合创新项目为载体,融合双元制指导教师团队,重构工程训练实践教学体系,创... 详细信息

分析工程教育专业认证下工程训练的不足,探索工程训练实践教学的改进方法,并以物料夹取装置为例构建了实践教学模式。该模式以实践能力、创新能力培养为主导,以综合创新项目为载体,融合双元制指导教师团队,重构工程训练实践教学体系,创建“三联项目库”驱动各模块间交叉融合,着力培养学生应用所学知识解决复杂工程问题能力,并在解决问题过程中有所收获。

关键词：工程训练专业认证项目库交叉融合铸造

One pot synthesis of dibenzodiazepinones via CuI catalysis in ethylene glycol

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Chinese Chemical Letters 2013年第9期24卷 825-828页

作者： qing-Yang Zhang Xiao-Jian Wang Yu-Lin Tian Jian-guo Qi Chun Li Da-Li Yin State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences

A one pot protocol for the synthesis of dibenzodiazepinones was developed. The substituted ethyl 2- halobenzoates are cross-coupled with o-phenylenediamine utilizing a ligand-free, Cul catalyzed system, which spontaneously undergo an intramolecular N-acylation in ethylene glycol to give the corresponding products in high yields. This synthetic protocol provides a concise and efficient access to a wide variety of dibenzodiazepinone, including biologically active molecules.

关键词： One pot Copper Cyclization Dibenzodiazepinone

Sanguinarine Attenuates Lipopolysaccharide-induced Inflammation and Apoptosis by Inhibiting the TLR4/NF-KB Pathway in H9c2 Cardiomyocytes

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Current Medical Science 2018年第2期38卷 204-211页

作者： Yan-yan MENG Yuan LIU Zhe-fu HU Yao ZHANG Jian NI Zhen-guo MA Hai-han LIAO qing-qing WU Qi-zhu TANG Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China Cardiovascular Research Institute Wuhan University Wuhan 430060 China Hubei Key Laboratory of Cardiology Wuhan 430060 China

The inflammatory response is involved in the pathogenesis of the most common types of heart disease. Sanguinarine （SAN） has various pharmacological properties such as anti-inflammatory, antioxidant, antibacterial, antitumor, and immune-enhancing properties. However, few studies have investigated the effects of SAN on lipopolysaceharide （LPS）-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes. Therefore, in this study, H9c2 cells were co-treated with SAN and LPS, and the mRNA levels of pro-inflammation markers and the apoptosis rate were measured to clarify the effect of SAN on cardiac inflammation. The underlying mechanism was further investigated by detecting the activation of Toll-like receptor （TLR）4/nuclear faetor-κB （NF-κB） signaling pathways. As a result, increased mRNA expression of interleukin （IL）-1β, IL-6, and TNFα induced by LPS was attenuated after SAN treatment; LPS-induced apoptosis ofHge2 cardiomyocytes and cleaved-caspase 8, 9, 3 were all significantly reduced by SAN. Further experiments showed that the beneficial effect of SAN on blocking the inflammation and apoptosis of H9c2 cardiomyocytes induced by LPS was associated with suppression of the TLR4/NF-κB signaling pathway. It was suggested that SAN suppressed the LPS-induced inflammation and apoptosis of H9c2 cardiomyocytes, which may be mediated by inhibition of the TLR4/NF-κB signaling pathway. Thus, SAN may be a feasible therapy to treat sepsis patients with cardiac dysfunction.

关键词： lipopolysaccharides sanguinarine inflammation H9c2 cardiac cells apoptosis

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勘测项目生产管理信息系统设计与实现

城市勘测 2024年第4期 20-22,26页

作者：肖可可何涛涛周翔陈旭帅温玉维郭义中国能源建设集团湖南省电力设计院有限公司湖南长沙410007

针对勘测项目管理过程中存在的问题,结合日常管理业务工作流程,分析系统建设需求,详细阐述了系统的总体架构、数据库设计、功能设计和安全设计,并在此基础上开发了适用于企业勘测项目生产管理的信息系统,提升勘测项目管理的信息化水平... 详细信息

针对勘测项目管理过程中存在的问题,结合日常管理业务工作流程,分析系统建设需求,详细阐述了系统的总体架构、数据库设计、功能设计和安全设计,并在此基础上开发了适用于企业勘测项目生产管理的信息系统,提升勘测项目管理的信息化水平和能力,深化精细管理,切实提高生产效率和管理水平,促进企业可持续性发展。

关键词：勘测项目生产管理 GIS 开源框架

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气动调节阀定位控制算法的研究进展

阀门 2024年第7期 909-912页

作者：俞伟方芳俞建国李向英万贤浙江伯特利科技股份有限公司浙江温州325105

气动调节阀作为工业自动化系统中的关键执行元件,其定位控制精度对于生产效率和系统安全具有重要意义。在气动调节阀定位控制领域,已有多种控制算法被提出并应用,如PID控制、模糊控制、神经网络控制等,这些算法在特定条件下取得了一定... 详细信息

气动调节阀作为工业自动化系统中的关键执行元件,其定位控制精度对于生产效率和系统安全具有重要意义。在气动调节阀定位控制领域,已有多种控制算法被提出并应用,如PID控制、模糊控制、神经网络控制等,这些算法在特定条件下取得了一定的控制效果,但仍存在一些不足,如气动系统的非线性、不确定性以及外部干扰等因素给定位控制带来了挑战。因此,本文过深入分析近年来国内外高校和研究机构在气动阀门定位控制算法方面的研究,对PID算法、预测控制算法、模糊控制算法等控制算法进行分析和总结,并在此基础上进行展望。

关键词：气动调节阀定位控制算法