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Chordin-like 2 influences the differentiation fate of retinal pigment epithelium cells by dynamically regulating BMP pathway

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 711-720页

作者： Duo Li Song-tao Yuan Xin-Yi Xie Han shen qing-Huai Liu Yong Yao Department of Ophthalmology the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxiJiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina

AIM:To explore the functions of Chordin-like 2,which is encoded by CHRDL2,in the process of retinal pigmented epithelium(RPE)differentiation and damage ***:The fetal RPE cells(f RPE)was obtained from aborted fetus which obeyed medical ***-time quantitative polymerase chain reaction was used to measure expression quantity of CHRDL2 and other functional genes *** down and overexpression was used to analyze the functions about Chordin-like ***-linked immunosorbent assay(ELISA)was used to detect the secretion of bone morphogenetic proteins 4(BMP4).Flow cytometry was used to analyze cell *** morphology was observed by phase contrast microscope(PCM).RESULTS:In normal RPE cells,CHRDL2 was firstly upregulated and followed a downregulation but eventually,it was expressed higher than the cells which undergone epithelial-mesenchymal transition(EMT).After knocking down CHRDL2,the secretion of BMP4 was decreased,RPErelated genes(OTX2,MITF,RPE65)were downregulated while EMT-related genes(SNAI1,VIM)were ***,the expression of these related genes after overexpression of CHRDL2 had contrary ***-like 2 also regulated the cell cycle by regulating BMP *** CHRDL2 was knocked down,more f RPE cells stayed in S phase of cell cycle,while adding BMP4 reduced the proportion of the cells in S ***,overexpression of CHRDL2 increased more BMP4 secretion,this effect decreased the number of cells in S phase,but exogenous BMP inhibitor also could change this *** last,in the process of RPE cells differentiation,adding BMP4 at early stage could intervene normal RPE *** with BMP4,inhibiting BMP pathway had no significant negative effect at early stage,but suppressed differentiation at late ***:BMP pathway can be activated in a correct temporal order,otherwise,the cells have incorrect differentiation *** Chordin-like 2 plays a role in dynamic regulation of BMP

关键词： retinal pigmented epithelium differentiation epithelial-mesenchymal transition BMP pathway cell proliferation

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A New Approach for Preparing Effective Inhibition Film on Copper Based on Self-assembled Process

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Chinese Chemical Letters 2003年第3期14卷 308-311页

作者： Chun tao shen Hao CHEN DepartmentofChemistry ShandongUniversityJinan250100 StateKeylaboratoryforCorrosionandProtection Shenyang110015

A new method for preparing effective inhibition film on copper has been developed. Phenylthiourea (PT) was first absorbed to copper surface to form a monolayer. 1-Dodecanethiol (DT) was then assembled on the surface for modification. Finally, AC voltage was loaded on copper covered the mixed film to improve it further. After these processes, an effective inhibition film was gained because of its high charge transfer resistance and low corrosion current density shown in electrochemical impedance spectra and polarization. The inhibition efficiency was more than 97%.

关键词： Self-assembly phenylthiourea (PT) 1-dodecanethiol (DT) AC voltage.

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A QUANTUM MULTI-AGENT BASED NEURAL NETWORK MODEL FOR FAILURE PREDICTION

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Journal of Systems Science and Systems Engineering 2016年第2期25卷 210-228页

作者： Wei Wu Min Liu qing Liu Weiming shen School of Electronic and Information Engineering Tongji University Shanghai 201804 China The Key Laboratory of Embedded System and Service Computing Ministry of EducationTongji University Shanghai 200092 China

An effective prognostic program is crucial to the predictive maintenance of complex equipment since it can improve productivity, prolong equipment life, and enhance system safety. This paper proposes a novel technique for accurate failure prognosis based on back propagation neural network and quantum multi-agent algorithm. Inspired by the extensive research of quantum computing theory and multi-agent systems, the technique employs a quantum multi-agent strategy, with the main characteristics of quantum agent representation and several operations including fitness evaluation, cooperation, crossover and mutation, for parameters optimization of neural network to avoid the deficiencies such as slow convergence and liability of getting stuck to local minima. To validate the feasibility of the proposed approach, several numerical approximation experiments were firstly designed, after which real vibrational data of bearings from the Laboratory of Cincinnati University were analyzed and used to assess the health condition for a given future point. The results were rather encouraging and indicated that the presented forecasting method has the potential to be utilized as an estimation tool for failure prediction in industrial machinery.

关键词： Failure prediction complex equipment quantum-inspired multi-agent algorithm back propagation neural network

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Improve Computer Visualization of Architecture Based on the Bayesian Network

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Computers, Materials & Continua 2019年第2期58卷 307-318页

作者： tao shen Yukari Nagai Chan Gao Knowledge Science Japan Advanced Institute of Science and TechnologyNomi CityIshikawa 923-1292Japan Architecture Department Huzhou UniversityHuzhouZhejiang313000China

Computer visualization has marvelous effects when it is applied in various fields,especially in architectural *** an emerging force in the innovation industry,architects and design agencies have already demonstrated the value of architectural visual products in actual application *** on the digital image technology,virtual presentation of future scenes simulates architecture design,architectural renderings and multimedia ***,it can help design agencies transform the theoretical design concept into a lively and realistic visual which can provide the audience with a clearer understanding of the engineering and construction ***,it is challenging for designers to produce satisfactory renderings due to the frequent fault data during *** this paper,we use the 3Ds MAX as the operating platform and we present an algorithm based on the Bayesian network to construct a vector representation of the fault *** this basis,a case study of 3D Max’application has also been presented.

关键词： 3Ds MAX architectural visualization application geometric reconstruction Bayes.

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Optimal Building Frame Column Design Based on the Genetic Algorithm

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Computers, Materials & Continua 2019年第3期58卷 641-651页

Building structure is like the skeleton of the building,it bears the effects of various forces and forms a supporting system,which is the material basis on which the building *** building structure design is a vital part in architecture design,architects often explore novel applications of their technologies for building structure ***,such searches relied on experiences,expertise or gut *** this paper,a new design method for the optimal building frame column design based on the genetic algorithm is *** of all,in order to construct the optimal model of the building frame column,building units are divided into three categories in general:building bottom,main building and building ***,the genetic algorithm is introduced to optimize the building frame *** the meantime,a PGA-Skeleton based concurrent genetic algorithm design plan is proposed to improve the optimization efficiency of the genetic ***,effectiveness of the mentioned algorithm is verified through the simulation experiment.

关键词： Structure optimization genetic algorithm concurrent computation conceptual design simulation experiment.

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Global Existence of Solutions for Stochastic Impulsive Differential Equations

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Acta Mathematica Sinica,English Series 2011年第4期27卷 773-780页

作者： Li Juan shen Ji tao SUN Department of Mathematics Tongji University Shanghai 200092 P. R. China Department of Mathematics Luoyang Normal University Luoyang 471022 P. R. China

In this paper we obtain some results on the global existence of solution to It5 stochastic impulsive differential equations in u（[0,∞）,Rn）which denotes the family of Rn-valued stochastic processes x satisfying supt∈[0,∞）E｜x（t）｜2〈∞ under non-Lipschitz coefficients. The Schaefer fixed point theorem is employed to achieve the desired result. An example is provided to illustrate the obtained results.

关键词： Stochastic differential equations impulse global existence

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Driving mechanisms of nitrogen transport and transformation in lacustrine wetlands

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Science China Earth Sciences 2016年第3期59卷 464-476页

作者： ZHAO Shan ZHOU Nian qing shen Xin Ping Department of Hydraulic Engineering Tongji UniversityKey Laboratory of Yangtze River Water Environment Ministry of Education Shanghai 200092 China School of Civil and Environmental Engineering Georgia Institute of Technology Atlanta Georgia 30332 USA Dongting Lake Water Resources Administration Bureau of Hunan Province Changsha 410007 China

As an essential component of proteins and genetic material for all organisms, nitrogen(N) is one of the major limiting factors that control the dynamics, biodiversity and functioning of lacustrine wetlands, in which intensified N biogeochemical activities take place. Reactive N loaded into wetland ecosystems has been doubled due to various human activities, including industrial, agricultural activities and urbanization. The main driving mechanisms of N transport and transformation in lacustrine wetlands are categorized to pushing forces and pulling forces in this study. Geomorphology, wetland age, N concentrations, and temperature are the main pushing forces(passive forces); whereas water table variation, oxygen concentration, other elements availability, oxidation-reduction potential(Eh) and p H, and microorganisms are the predominant pulling forces(active forces). The direction and kinetic energy of reactions are determined by pulling forces and then are stimulated by pushing forces. These two types of forces are analyzed and discussed separately. Based on the analysis of driving mechanisms, possible solutions to wetland N pollutions are proposed at individual, regional and global scales, respectively. Additional research needs are addressed to obtain a thorough understanding of N transport and transformations in wetlands and to reduce detrimental impacts of excessive N on such fragile ecosystems.

关键词： Nitrogen Driving mechanisms Transport and transformation Excessive loading Lacustrine wetlands

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Singlet-triplet gaps in substituted carbenes predicted from block-correlated coupled cluster method

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Science China Chemistry 2008年第12期51卷 1197-1202页

作者： shen Jun FANG tao LI Shuhua Key Laboratory of Mesoscopic Chemistry of Ministry of Education Institute of Theoretical and Computational ChemistrySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China

The block correlated coupled cluster (BCCC) method, with the complete active-space self-consistent-field (CASSCF) reference function, has been applied to investigating the singlet-triplet gaps in several substituted carbenes including four halocarbenes (CHCl, CF2, CCl2, and CBr2) and two hydroxycar-benes (CHOH and C(OH)2). A comparison of our results with the experimental data and other theoretical estimates shows that the present approach can provide quantitative descriptions for all the studied carbenes. It is demonstrated that the CAS-BCCC method is a promising theoretical tool for calculating the electronic structures of diradicals.

关键词： block correlated coupled cluster method carbene singlet-triplet gap diradicals

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Downtown Retailing Development Under Suburbanization——A Case Study of Beijing

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Chinese Geographical Science 2007年第1期17卷 1-9页

作者： CHAI Yanwei shen Jie LONG tao Department of Urban and Regional Planning Peking University Beijing 100871 China

The role of retailing has diminished in the center of cities of Western countries since its heyday in the 1920s. This trend was caused by violent transformations in the economic, social and locational contexts which involve resi- dential suburbanization, as well as new forms of commercial development out of town. As far as transforming China is concerned, the downtown retailing center has also come to turning point of development in the context of suburbaniza- tion. Based on the survey of Beijing residents’ shopping behavior, the present research tends to making clear the actual change and development problem of downtown retailing center. Combining with the macro retailing environment, re- lated influencing factors are further discussed too. Study results show that downtown retailing still plays an important part in resident’s shopping activity. However, with rapid urban sprawl, retailing in urban center has been greatly threatened by booming out-of-town commerce. In the course of such spatial change, the suburbanization of resident, the prevalence of new commercial forms and the change of consumers’ life style all have exerted their own pressure on downtown retailing. But for the special socioeconomic background of development and the support of government policy, it will still keep its vitality of retailing for a long period of time.

关键词： downtown retailing center consumer behavior suburbanization questionnaire survey Beijing

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电膜萃取技术提取生物检材中滥用药物的研究进展

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分析测试学报 2025年第1期44卷 25-33页

作者：高同飞董壮壮沈先涛黄垂秀华中科技大学同济医学院法医学系湖北武汉430030 华中科技大学同济医学院公共卫生学院教育部环境与健康重点实验室湖北武汉430030

电膜萃取技术(EME)是一种绿色高效的新型样品前处理技术,因其选择性好、净化能力强等优点,近年来被广泛应用于食品分析、环境分析、药物分析以及法医毒物分析领域。该文总结了近五年EME在滥用药物提取中的研究进展,重点总结了EME从不同... 详细信息

电膜萃取技术(EME)是一种绿色高效的新型样品前处理技术,因其选择性好、净化能力强等优点,近年来被广泛应用于食品分析、环境分析、药物分析以及法医毒物分析领域。该文总结了近五年EME在滥用药物提取中的研究进展,重点总结了EME从不同生物检材(如血液、尿液、唾液、毛发和组织等)中提取富集滥用药物的应用情况,特别关注了其对于毒品、新精神活性物质(NPS)以及临床类滥用药物的分离性能。同时,也探讨了EME应用于法医学领域面临的挑战,并展望了其未来的发展方向。

关键词：电膜萃取法医毒物分析样品前处理滥用药物毛发唾液

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