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Journal of Iron and Steel Research International 2023年第6期30卷 1211-1221页

作者： qing-hua xie Pei-yuan Ni Toshihiro Tanaka Mikael Ersson Ying Li Key Laboratory of Ecological Metallurgy of Multi-metal Intergrown Ores of Ministry of Education School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina Liaoning Key Laboratory of Metallurgical Sensor Materials and Technology School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina Graduate School of Engineering Osaka UniversityOsaka 565-0871Japan Department of Materials Science and Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden

Flow field,heat transfer and inclusion behavior in a 700 mm round bloom mold under the effect of a swirling flow submerged entry nozzle(SEN)were investigated with the aim to enhance the casting *** results indicate that the impinging flow phenomenon,which is commonly observed in conventional single-port SEN casting,was completely suppressed by the swirling flow SEN coming from a novel swirling flow generator design in *** from the SEN port moved towards the mold wall in 360 direction,leading to a uniform temperature distribution in the *** to a conventional single-port SEN casting,the steel super-heat was decreased by about 5 K at the mold center,and the temperature was increased by around 3.5 K near the *** addition,the removal ratio of inclusions to the mold top surface in the swirling flow SEN casting was found to be ***,the removal ratio of spherical inclusions with diameters of 1,10,50 and 100μm was increased by 18.2%,18.5%,22.6% and 42.7%,***,the ratio was raised by 18.2%,20.8%,21.5% and 44.1%for non-spherical inclusions,respectively.

关键词： Large round bloom Swirling flow submerged entry nozzle casting Flow field Heat transfer Inclusion behavior

Prognostic significance of identification of traditional Chinese medicine syndromes in colorectal cancer

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Traditional Medicine Research 2023年第10期8卷 1-10页

作者： Guo-Hang huang Yu-Qi Liang qing-hua xie Yuan-Hao Hu Zheng-Lin Liu Qi-Sheng Zhong Jun-Wei Chen Yan-Hai Lyu Quan-Feng Zhang Dang-Fang Gu Yong-Qiang Wu Jun-Yu Ke The Rehabilitation Medicine Department The Third Affiliated Hospital of Sun Yan-Sen UniversityGuangzhou 510630China The Second Clinical College Guangzhou University of Chinese MedicineGuangzhou 510006China Animal Experiment Center Guangzhou University of Chinese MedicineGuangzhou 510006China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006China The First Clinical Medical College Guangzhou University of Traditional Chinese MedicineGuangzhou 510006China Department of Surgery II Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou 525200China The Basic Medical College Guangzhou University of Chinese MedicineGuangzhou 510006China

Background:Traditional Chinese medicine(TCM)syndrome is the basic unit of TCM treatment,which help clinicians assess the disease progression and treatment preoperative of tumor ***,the prognostic significance of TCM syndrome is still *** study aims to detect the differences in overall survival between different TCM syndrome and further develop a new nomogram with TCM syndrome for predicting overall survival in colorectal ***:A total of 324 patients with colorectal cancer were enrolled and categorized into three groups based on TCM syndrome:deficiency,excess,and *** prognosis of colorectal cancer patients with different TCM syndromes was evaluated using Kaplan-Meier analysis and Cox regression ***:The proportion of advanced stage and lymph metastasis in the patients with deficiency syndrome was higher,and the overall survival was shorter than other ***,the TCM syndrome(P<0.001),tumor invasion depth(P<0.001),lymph metastasis(P=0.018),organic metastasis(P=0.005)and tumor node metastasis(TNM)stage(P=0.029)were the independent prognostic ***,a new nomogram with TCM syndrome was established and assessed.324 colorectal cancer patients were randomly divided into training(n=215)and validation cohorts(n=109).A nomogram incorporating preoperative TCM syndrome,gender,age,T,N,and M status was developed,which had good discrimination and ***:Taken together,our results indicated that TCM syndrome could assess the prognosis of colorectal *** nomogram incorporating TCM syndromes and tumor information is helpful for risk stratification and prognostic predictions in colorectal cancer preoperatively.

关键词： colorectal cancer traditional Chinese medicine syndromes overall survival prognosis nomogram

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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幽门螺杆菌BALB/c小鼠适应性菌株的驯化及模型建立

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世界华人消化杂志 2007年第12期15卷 1338-1341页

作者：郭刚刘开云解庆华张卫军邹全明第三军医大学临床微生物学及免疫学教研室重庆市400038

目的:通过体内连续传代获得幽门螺杆菌(Hpylori)的BALB/c小鼠适应性定植菌株并建立稳定的感染模型.方法:以H pylori蒙古沙鼠适应株GS_(10)连续传代感染BALB/c小鼠,每次感染20只,感染后4 wk进行微生物学检查(分离培养、直接涂片染色镜检... 详细信息

目的:通过体内连续传代获得幽门螺杆菌(Hpylori)的BALB/c小鼠适应性定植菌株并建立稳定的感染模型.方法:以H pylori蒙古沙鼠适应株GS_(10)连续传代感染BALB/c小鼠,每次感染20只,感染后4 wk进行微生物学检查(分离培养、直接涂片染色镜检、快速尿素酶试验、PCR鉴定),观察H pylori的定植情况,计算每批动物的感染率,直至感染率稳定在80%以上,然后对已稳定感染的小鼠胃黏膜组织进行H pylori定量培养及病理学检查.结果:随着H pylori菌株GS_(10)在BALB/c小鼠内的连续传代,感染率逐渐升高.GS_(10)株初次感染率仅为11.1%,传代至第6代(BS_6株)以后,感染率稳定在80%以上;BALB/c小鼠适应株BS_8感染小鼠后4 wk在胃窦、胃体和胃底的定植密度(CFU/g组织)的常数对数均值分别为5.32±0.88,4.14±1.05和1.05±2.25,与SS1的定植密度相比,相差不显著(P>0.05).感染鼠病理学检查在胃窦黏膜上皮细胞间及固有层中发现大量炎症细胞浸润;在胃窦及幽门部上皮细胞表层黏液、胃腺窝中见到大量H pylori存在.结论:经过连续传代感染,驯化出一株高定植力和感染率的Hpylori BALB/c小鼠适应株,并成功建立稳定的H pylori小鼠感染模型.

关键词：幽门螺杆菌动物模型 BALB/c小鼠感染适应性菌株

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 29-35页

作者： Shi-Qiong Zhou Peng Wan Seng Zhang Yuan Ren Hong-Tao Li qing-hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor *** it metastasizes to the liver,treatment options become particularly limited and *** treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves ***,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on *** study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic *** To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic *** Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer *** in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable *** in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight *** June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy *** The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy *** incidence of severe adverse events did not differ sign

关键词： Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma

Identification of MyD88 as a novel target of miR-155,involved in negative regulation of Helicobacter pylori-induced inflammation

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Identification of MyD88 as a novel target of miR-155,involve...

重庆微生物学会第九届会员代表大会暨学术年会

作者： Bin Tang,Bin Xiao,Zhen Liu,Na Li,En-Dong Zhu,Bo-Sheng Li,qing-hua xie,Yuan Zhuang,Quan-Ming Zou~*,Xu-Hu Mao~* (Department of Clinical Microbiology and Immunology,College of Medical Laboratory Science,Third Military Medical University,Chongqing 400038,China.)

MicroRNA-155(miR-155) has been implicated as a central regulator of the immune system. We have previously reported that miR-155 negatively regulates Helicobacter pylori(***)-induced inflammation,but the molecular mechanism of miR-155 regulating the inflammation is not fully clear. Here,we identified myeloid differentiation protein 88(MyD88) as a target gene of miR-155 by using prediction *** post-transcriptional suppression of MyD88 expression by miR-155 was confirmed by Luciferase reporter assays and western ***,the results of RNAi indicated that miR-155 was able to negatively regulate ***-induced proinflammatory cytokines via targeting of *** together,we identified MyD88 as a novel target of miR-155,involved in negative regulation of *** -induced inflammation.

关键词： Helicobacter pylori miR-155 MyD88 inflammation

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保安湖生态因子场格局分析

水生生物学报 2004年第6期28卷 581-586页

作者：马凯蔡庆华谢志才刘瑞秋黎道丰中国科学院水生生物研究所

利用实地调查和实验分析数据构建保安湖理化因子GIS数据库 ,以此模拟保安湖生态因子场 ,并通过栅格统计获得保安湖水环境的整体特征。得到的 15个生态因子场非常直观地展示出各项理化因子在全湖分布范围内的浓度分布情况 ,体现了保安湖... 详细信息

利用实地调查和实验分析数据构建保安湖理化因子GIS数据库 ,以此模拟保安湖生态因子场 ,并通过栅格统计获得保安湖水环境的整体特征。得到的 15个生态因子场非常直观地展示出各项理化因子在全湖分布范围内的浓度分布情况 ,体现了保安湖水环境强烈的空间异质性。栅格统计结果则显示该湖整体而言 ,其营养状况目前已相当高。

关键词：保安湖生态因子场栅格统计生物类群

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Putative zeatin O-glucosyltransferase OscZOG1 regulates root and shoot development and formation of agronomic traits in rice

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Journal of Integrative Plant Biology 2016年第7期58卷 627-641页

作者： Xiao-Ling Shang Rong-Rong xie hua Tian,qing-Long Wang and Fang-qing Guo Rong-Rong xie hua Tian qing-Long Wang Fang-qing Guo The National Key Laboratory of Plant Molecular Genetics and National Center of Plant Gene Research(shanghai) Institute of Plant Physiology&EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China.

As a ubiquitous reaction, glucosylation controls the bioactivity of cytokinins in plant growth and development. Here we show that genetic manipulation of zeatin-O- glucosylation regulates the formation of important agronomic traits in rice by manipulating the expression of OscZOG1 gene, encoding a putative zeatin O-glucosyltransferase. We found that OscZOG~ was preferentially expressed in shoot and root meristematic tissues and nascent organs. The growth of lateral roots was stimulated in the overexpression lines, but inhibited in RNA interference lines. In shoots, knockdown of OscZOG1 expression by RNA interference significantly im- proved tillering, panicle branching, grain number per panicle and seed size, which are important agronomic traits for grain yield. In contrast, constitutive expression of OscZOG1 leads to negative effects on the formation of the grain-yielding traits with a marked increase in the accumulation levels of cis-zeatin O-glucoside （cZOG） in the transgenic rice plants. In this study,our findings demonstrate the feasibility of improving the critical yield-determinant agronomic traits, including tiller number, panicle branches, total grain number per panicle and grain weight by downregulating the expression level of OscZOG1. Our results suggest that modulating the levels of cytokinin glucosylation can function as a fine-tuning switch in regulating the formation of agronomic traits in rice.

关键词： Cis-zeatin O-glucoside (cZOG) cytokinin glucosylation grain-yield traits lateral root panicle development rice

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Towards an Accurate and Robust Roe-Type Scheme for All Mach Number Flows

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Advances in Applied Mathematics and Mechanics 2019年第1期11卷 132-167页

作者： Wenjia xie Ye Zhang qing Chang hua Li College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073HunanChina

We propose an accurate and robust Roe-type scheme applied to the compressible Euler system at all Mach *** study the occurrence of unstable modes during the shock wave computation,a shock instability analysis of several Roe-type schemes is carried *** analysis approach allows to propose a simple and effective modification to eliminate shock instability of the Roe method for hypersonic flows.A desirable feature of this modification is that it does not resort to any additional numerical dissipation on linear degenerate waves to suppress the shock *** an all Mach correction strategy,the modified Roe-type scheme is further extended to solve flow problems at all Mach *** results that are obtained for various test cases indicate that the new scheme has a good performance in terms of accuracy and robustness.

关键词： Roe scheme low Mach number numerical shock instability