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Development and validation of a deep learning model to screen hypokalemia from electrocardiogram in emergency patients

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Chinese Medical Journal 2021年第19期134卷 2333-2339页

作者： Chen-Xi Wang Yi-Chu Zhang Qi-Lin Kong Zu-Xiang wu Ping-Ping Yang Cai-hua Zhu Shou-Lin Chen Tao wu qing-hua wu Qi Chen Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang University School of MedicineNanchangJiangxi 330006China Department of Anesthesiology The Second Affiliated Hospital of Nanchang UniversityNanchang University School of MedicineNanchangJiangxi 330006China

Background:A deep learning model(DLM)that enables non-invasive hypokalemia screening from an electrocardiogram(ECG)may improve the detection of this life-threatening *** study aimed to develop and evaluate the performance of a DLM for the detection of hypokalemia from the ECGs of emergency ***:We used a total of 9908 ECG data from emergency patients who were admitted at the Second Affiliated Hospital of Nanchang University,Jiangxi,China,from September 2017 to October *** DLM was trained using 12 ECG leads(lead Ⅰ,Ⅱ,Ⅲ,aVR,aVL,aVF,and V1–6)to detect patients with serum potassium concentrations<3.5 mmol/L and was validated using retrospective data from the Jiangling branch of the Second Affiliated Hospital of Nanchang *** blood draw was completed within 10 min before and after the ECG examination,and there was no new or ongoing infusion during this ***:We used 6904 ECGs and 1726 ECGs as development and internal validation data sets,*** addition,1278 ECGs from the Jiangling branch of the Second Affiliated Hospital of Nanchang University were used as external validation data *** 12 ECG leads(leads Ⅰ,Ⅱ,Ⅲ,aVR,aVL,aVF,and V1–6),the area under the receiver operating characteristic curve(AUC)of the DLM was 0.80(95%confidence interval[CI]:0.77–0.82)for the internal validation data *** an optimal operating point yielded a sensitivity of 71.4%and a specificity of 77.1%.Using the same 12 ECG leads,the external validation data set resulted in an AUC for the DLM of 0.77(95%CI:0.75–0.79).Using an optimal operating point yielded a sensitivity of 70.0%and a specificity of 69.1%.Conclusions:In this study,using 12 ECG leads,a DLM detected hypokalemia in emergency patients with an AUC of 0.77 to *** intelligence could be used to analyze an ECG to quickly screen for hypokalemia.

关键词： Deep learning Hypokalemia Electrocardiogram Artificial intelligence

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Treatment of chronic heart failure in the 21st century: A new era of biomedical engineering has come

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Chronic Diseases and Translational Medicine 2019年第2期5卷 75-88页

作者： Chun-Song Hu qing-hua wu Da-Yi Hu Tengiz Tkebuchava Jiangxi Academy of Medical Science Hospital of Nanchang University Nanchang University Nanchang Jiangxi 330006 China Institute of Cardiovascular Diseases Nanchang University Nanchang Jiangxi 330006 China Department of Cardiology People's Hospital of Peking University Beijing 100044 China Department of Cardiology Tongji University School of Medicine Shanghai 200032 China Boston TransTec LLC Boston MA 02459 USA

Chronic heart failure (CHF) is a challenging burden on public health. Therapeutic strategies for CHF have developed rapidly in the past decades from conventional medical therapy, which mainly includes administration of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and aldosterone antagonists, to biomedical engineering methods, which include interventional engineering, such as percutaneous balloon mitral valvotomy, percutaneous coronary intervention, catheter ablation, biventricular pacing or cardiac resynchronization therapy (CRT) and CRT-defibrillator use, and implantable cardioverter defibrillator use;mechanical engineering, such as left ventricular assistant device use, internal artery balloon counteq^ulsation, cardiac support device use, and total artificial heart implantation;surgical engineering, such as coronary artery bypass graft, valve replacement or repair of rheumatic or congenital heart diseases, and heart transplantation (HT);regenerate engineering, which includes gene therapy, stem cell transplantation, and tissue engineering;and rehabilitating engineering, which includes exercise training, low-salt diet, nursing, psychological interventions, health education, and external counterpulsation/enhanced external counterpulsation in the outpatient department. These biomedical engineering therapies have greatly improved the symptoms of CHF and life expectancy. To date, pharmacotherapy, which is based on evidence-based medicine, large-scale, multi-center, randomized controlled clinical trials, is still a major treatment option for CHF;the current interventional and mechanical device engineering treatment for advanced CHF is not enough owing to its individual status. In place of HT or the use of a total artificial heart, stem cell technology and gene therapy in regenerate engineering for CHF are very promising. However, each therapy has its advantages and disadvantages, and it is currently possible to select better the

关键词： Chronic heart failure Biomedical engineering Treatment

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A mutation of Aspergillus niger for hyper-production of citric acid from corn meal hydrolysate in a bioreactor

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第11期15卷 1006-1010页

作者： Wei HU Jing LIU Ji-hong CHEN Shu-yang WANG Dong LU qing-hua wu Wen-jian LI Institute of Modern Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Key laboratory of Microbial Resources Exploition and Application

The properties of the screened mutants for hyper-production of citric acid induced by carbon （12C6＋） ion beams and X-ray irradiation were investigated in our current study. Among these mutants, mutant H4002 screened from 12C6＋ ion irradiation had a higher yield of citric acid production than the parental strain in a 250-ml shaking flash. These expanded submerged experiments in a bioreactor were also carried out for mutant H4002. The results showed that （177.7-196.0） g/L citric acid was accumulated by H4002 through exploiting corn meal hydrolysate （containing initial 200.0-235.7 g/L sugar） with the productivity of （2.96-3.27） g/（L.h）. This was especially true when the initial sugar concentration was 210 g/L, and the best economical citric acid production reached （187.5±0.7） g/L with a productivity of 3.13 g/（L.h）. It was observed that mutant H4002 can utilize low-cost corn meal as a feedstock to efficiently produce citric acid. These results imply that the H4002 strain has the industrial production potentiality for citric acid and offers strong competition for the citric acid industry.

关键词： Mutation Citric acid Corn meal hydrolysate Aspergillus niger

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Novel strategies halt cardiovascular, diabetes, and cancer strips

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Chronic Diseases and Translational Medicine 2017年第3期3卷 159-164页

作者： Chun-Song Hu qing-hua wu Da-Yi Hu Tengiz Tkebuchava Department of Cardiovascular Medicine Nanchang University Nanchang 330006 China Cardiovascular Center Peking University People's Hospital Beijing 100044 China Boston TransTec LLC Boston MA 02459 USA

In this article, we introduce briefly several strategies for preventing atherosclerotic cardiovascular disease and promoting healthcare for non-communicable diseases (NCDs). These novel strategies include four core elements of health-sleep, emotion, exercise, and diet-and consist of SEED intervention (SEEDi) and E(e)SEEDi due to supplementation of the environment as a core element, and Hu's healthy lifestyles intervention (HHLi) which originates from E(e)SEED-BasED healthy lifestyles. They are suitable for the early evaluation of risk factors, and play a key role in the prevention and management of human NCDs when combined with the RT-ABCDEF strategy and the Grade 210 prevention, which include obesity-OSA-hypertension syndrome and C-type hypertension, especially in halting cardiovascular, diabetes and cancer (CDC) strips we first discovered. After successful clinical practice, we may expect our novel strategies for controlling these chronic diseases according to the conception of mass prevention and treatment.

关键词： Cardiovascular disease Noncommunicable disease Prevention Treatment Healthy lifestyles

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Investigation of Mechanism of Premature Ovarian Failure Regulation by Kidney-tonifying Herbs and Liver-clearing Herbs in Dingjing Decoction

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Chinese Herbal Medicines 2015年第4期7卷 328-333页

作者： Xiu-feng Wang Lei Zhang qing-hua wu Jian-xin Min Na Ma Lai-cheng Luo Basic School of Guangdong Pharmaceutical University Basic Medical School of Jiangxi University of Traditional Chinese Medicine

Objective To investigate the mechanisms through which kidney-tonifying herbs（KTHs） and liver-clearing herbs（LCHs） in Dingjing Decoction（DJD） regulate premature ovarian failure（POF）. Methods One hundred and fifty Sprague-Dawley rats were randomly divided into five groups such as control, model, KTHs, LCHs, and DJD groups. POF-related biological molecules were examined. Factor analysis was performed to investigate the regulatory networks and key biomolecules involved in mediating POF after treatment with KTHs and LCHs. Results The master regulatory factors in the reproductive endocrine network associated with KTHs intervention included four molecules in the pituitary-ovarian axis, cortisol（CORT） in the target gland of pituitary-adrenal axis, and some molecules in the hypothalamus. In contrast, the master regulatory factors associated with LCHs intervention included four molecules in the pituitary-ovarian axis and some molecules in the hypothalamus; No biomolecules in the pituitary-adrenal axis were involved in the LCH-mediated ***-releasing hormone（Gn RH）, which was identified as a common biological molecule in the hypothalamus, was involved in regulating the reproductive endocrine network in association with KTHs intervention. Conclusion KTHs directly regulates biological molecules in the pituitary-adrenal axis and indirectly regulates those in the pituitary-adrenal axis through the hypothalamus, while the LCHs only exert its effects indirectly. Gn RH is the key biological molecule associated with KTHs intervention.

关键词： corticotropin-releasing hormone Dingjing Decoction factor analysis kidney-tonifying herbs liver-clearing herbs signaling mechanism premature ovarian failure pituitaryadrenal axis

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表面活性剂对树形银纳米结构影响的蒙特-卡洛模拟（英文）

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物理化学学报 2016年第10期32卷 2518-2522页

作者：王元元徐群星谢华清吴子华邢姣娇上海第二工业大学环境与材料工程学院上海201209

采用偏压受限扩散聚集模型研究溶液中银树形纳米结构的生长。模拟中,在二维正方形格子中引入了等腰直角三角形粒子进行模拟,同时运用不同的粘贴概率来描述表面活性剂的效果。模拟结果表明树形纳米结构随着偏压的增大而变得更密。表面活... 详细信息

采用偏压受限扩散聚集模型研究溶液中银树形纳米结构的生长。模拟中,在二维正方形格子中引入了等腰直角三角形粒子进行模拟,同时运用不同的粘贴概率来描述表面活性剂的效果。模拟结果表明树形纳米结构随着偏压的增大而变得更密。表面活性剂的加入使得树形纳米结构变得更加对称和规则。更进一步,当表面活性剂的效果足够强且外加偏压很小的时候,银纳米颗粒聚集成了银纳米片。模拟结果有利于定性解释相关的实验结果。

关键词：蒙特-卡洛模拟树形银纳米结构表面活性剂

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian wu Tao wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Novel Strategies Halt Cardiovascular-Diabetes-Cancer Strips

Novel Strategies Halt Cardiovascular-Diabetes-Cancer Strips

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江西省第六次中西医结合心血管学术交流会

作者：胡春松 qing-hua wu Jun-Yan Hong Douglas W.Losordo Sheng-Shou Hu Dayi Hu 南昌大学专家门诊部

＜正＞Summary We found there were cardiovascular-diabetes-cancers（CDC） strips from evidence-based available literatures on clinical trials and analyzed related *** we’ ve already developed new strategies in our previous works for the prevention of coronary heart disease,cardiovascular events and healthcare,etc. These novel strategies,which including SEED（sleep,emotion,exercise and diet） intervention（SEEDi）,E（e）SEED（environment + SEED） intervention（E（e）SEEDi） and even Hu’ s healthy lifestyles（E（e）SEED-BasED ones） intervention（HHLi）,also called " Chinese vaccine" or " hero for human health（HHH）",as the core elements of "Grade 210 prevention",play an important role in the prevention and management of human chronic diseases when combined with RT-ABCDEF strategy,for example, OOH syndrome,especially in halting CDC strips we discovered.

关键词： cardiovascular disease diabetes cancer E(e)SEED-BasED healthy lifestyles

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai Fu Geping Yin Liguang Wang Yongmin wu hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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