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The Correlation Between Decreased Ornithine Level and Alleviation of Rheumatoid Arthritis Patients Assessed by a Randomized,Placebo-Controlled,Double-Blind Clinical Trial of Sinomenine

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Engineering 2022年第9期16卷 93-99页

作者： Ying Shi Hu-Dan Pan Jian-Lin Wu qing-hua zou Xin-Yi Xie Hong-Gang Li hua Zhou Xi-qing Bian Wen-Fei Leng Can-Jian Wang Ya-Feng Wang Yong-Fei Fang Liang Liu Department of Rheumatology The Southwest Hospital of Army Military Medical UniversityChongqing 400038China State Key Laboratory of Dampness Syndrome Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine&Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao 999078China People’s Hospital of Changshou Chongqing Chongqing 401220China Traditional Chinese Medicine Hospital Dianjiang Chongqing Chongqing 408300China Medical Management Center World Federation of Chinese Medicine SocietiesBeijing 100101China

Sinomenine(SIN)is commonly used as part of rheumatoid arthritis(RA)therapy in China,but there is still no published evidence of the efficacy of SIN *** work investigates the efficacy and safety of SIN in treating RA patients and analyzes the correlation between ornithine level and the alleviation of disease activity in RA *** this 24 week,randomized,placebo-controlled,double-blind clinical trial,people with mild to moderate RA were randomly assigned(1:1:1,stratified by hospital)to receive SIN(120 mg,twice daily),methotrexate(MTX)(10 mg per week),or SIN+MTX *** primary outcome was the proportion of patients who achieved a 50%improvement in the American College of Rheumatology(ACR50)criteria at week 24 and who showed improvement according to the clinical disease activity index(CDAI).In this prospective subgroup analysis,we also assessed whether the 24-week alterations of disease activity in the treatment group were significantly correlated to the levels of blood *** the 135 enrolled participants,38,39,and 36 patients were treated with SIN,MTX,and SIN+MTX,*** the SIN-treated group,52.63%of patients achieved ACR50 after 24-weeks of treatment,which was comparable to the results in the MTX-treated and SIN+MTX-treated *** and gastrointestinal disorders were the main adverse events;however,the ratio of patients suffering from hepatic disorder in the SIN group(1/38)was much lower than that in the MTX(10/39)and SIN+MTX(8/36)groups.A total of 221 serum samples were collected at the four follow-up time points in the three treatments,and the levels of ornithine,citrulline,and arginine were obtained through ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF/MS).The serum ornithine level decreased after the 24-week treatment along with a decrease in disease activity,and may reflect therapeutic responses with a sensitivity value of 80%.In conclusion,SIN revealed a comparabl

关键词： Rheumatoid arthritis Sinomenine Efficacy Safety Inflammatory biomarker

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Comparative proteomic analysis of Vibrio cholerae O139, O22, O155 and El Tor biotype epidemic strains

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Journal of Microbiology and Immunology 2005年第2期3卷 83-88页

作者： qing hua zou Bo QINC LI JIAN ZHONG ZHANG National Institute for Communicable Disease Control arid Prevention Chinese Center for Disease Control and Prevention Beijing P.R. China

The purposes of this study are to compare the proteome of Vibrio cholerae O139 strains with that of O22, O155 and El Tot biotype epidemic strains, and to identifv whether O139 strains have a close relation with the latter. Proteins of two V. cholerae serogroup O139 strains, two El Tor biotype epidemic strains, one O22 strain, and one O155 strain were separated by two-dimensional gel electrophoresis （2-DE） ; the silver stained 2-DE gels were scanned with （ligital lmageScanner and analyzed with lmageMaster 2D Elite 3.10 software. Similarities of protein maps between these strains were analyzed. The two O139 strains had 86% proteins in common; the two El Tor biotype epidemie strains showed 84% proteins in common; O139 strains shared 67 % , 47 % and 45 % proteins with El Tor biotype epidemic strains, O22 and O 155 strains respectively. Although the proteome of O 139 strains have close similarity to that of El Tor biotype epidemic strains, great disparities exist. O139 strains may not originate from El Tor biotype directly, and a transition strain may exist.

关键词： Vibrio cholerae Two-dimensional gel electrophoresis

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Proteome Analysis of Neisseria meningitidis Serogroup Strains C Associated with Outbreaks in China

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Biomedical and Environmental Sciences 2010年第4期23卷 251-258页

作者： YUAN HU ZHU-JUN SHAO XIAO-MEI YAN BO-qing LI FEI ZHAO DI XIAO JUN REN MING-huaN ZHENG CHUN-XIANG FAN LI-hua HE LI XU YI-XIN GU HAI JIANG FENG-hua GUO ZHEN-WEI DAI HONG-YU REN MEI-JUAN LU XIA CHEN qing-hua zou FAN-LIANG MENG JIAN-ZHONG ZHANG National Institute for Communicable Disease Control and Prevention China CDC P O Box 5 Changping Beijing 102206 China Anhui Provincial Center for Disease Control and Prevention Hefei 230061 Anhui China

Objective During 2003-2005, an outbreak of meningitis due to Neisseria meningitidis serogroup C occurred in China. With the aim to find strain clues result in the final epidemics, the ancestral strain 053442, a clinical isolate, and a carrier strain 053426 with different gene type were analyzed. Methods Clinical strain 053442 and carrier strain 053426 were cultured on GC agar plates under the same condition. Two-dimensional electrophoresis was performed using the pH 3–10 nonlinear IPG strips of 24 cm length, and all the protein spots were identified by matrix-assisted laser desorption/ionization time of flight spectrometry. Results 502 and 380 protein spots were identified in 053426 and 053442 respectively, relating to 266 and 202 different genes covering a wide range of cellular functions. The express volume and number of proteins involved in energy metabolism, protein synthesis and amino acid biosynthesis in 053426 were higher than in 053442. Virulence factor Opa, Opc and a series of proteins involved in pilus assembly and retraction were identified in 053442, which appear to be of primary importance in colonization and invasion of human cells. Compared to 053442, virulence protein species were less in 053426, with lower express volumes too. No Opa and Opc were detected in 053426. Conclusion The different protein expression profiles of the clinical strain 053442 and carrier strain 053426 in the present study provide some clues of the different pathogenicity of the two strains, which may account for result in the final epidemics.

关键词： Neisseria meningitidis Reference map Two-dimensional gel electrophoresis MALDI-TOF/TOF-MS

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行为变换与自动武器创新

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上海交通大学学报 2002年第9期36卷 1231-1236页

作者：梁庆华邹慧君冯涛郭为忠上海交通大学机械与动力工程学院上海200030

行为变换是机构执行系统创新的重要方法与手段 .提出了行为变换的 4种方法 ,即行为合并、行为分割、行为分解和行为分位 ,建立了行为变换的规则体系 ,并以行为变换在自动武器创新设计中应用为引线。

关键词：行为合并行为结构行为变换自动武器创新设计行为分割执行机构系统结构变换

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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi qing Yifei Chen Jilian zou Meiling Jia Qian Wang Runda Jiang Lihua huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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转染试剂及幽门螺杆菌对AGS细胞形态的影响

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世界华人消化杂志 2006年第4期14卷 382-386页

作者：邹清华曾浔孟凡亮何利华张建中中国疾病预防控制中心传染病预防控制所北京市102206

目的:探讨不同的转染试剂对AGS细胞形态的影响,观察这些转染试剂能否像幽门螺杆菌那样引起AGS细胞蜂鸟状改变．方法:用多聚阳离子转染试剂(多聚乙酰亚胺、梭华-Sofast)和改良的脂类转染试剂 (Effectene Transfection Reagent)分别转染A... 详细信息

目的:探讨不同的转染试剂对AGS细胞形态的影响,观察这些转染试剂能否像幽门螺杆菌那样引起AGS细胞蜂鸟状改变．方法:用多聚阳离子转染试剂(多聚乙酰亚胺、梭华-Sofast)和改良的脂类转染试剂 (Effectene Transfection Reagent)分别转染AGS 细胞,观察细胞形态的变化．用幽门螺杆菌 26695菌株攻击AGS细胞,观察细胞形态的变化并与经转染试剂作用的细胞进行形态比较．结果:幽门螺杆菌攻击后4 h能引起AGS细胞发生蜂鸟状改变．两种多聚阳离子转染试剂也均能引起AGS细胞发生蜂鸟状改变,与幽门螺杆菌引起的细胞形态改变相似,大部分细胞拉长,并且不受是否转染DNA的影响．此种变化在转染4 h时便出现,与试剂剂量的增加呈正相关．当PEI的剂量为10 μL时,细胞出现凋亡,15μL时凋亡加重．改良的脂类转染试剂对 AGS细胞的形态未产生影响．结论:在研究引起AGS细胞形态改变的因素时,不宜选择多聚阳离子转染试剂;多聚阳离子引起的AGS细胞形态改变与幽门螺杆菌引起的AGS细胞形态改变之间是否存在关系值得进一步研究．

关键词：转染试剂幽门螺杆菌 AGS细胞形态

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高乙氧基乙基纤维素合成实验研究

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涂料工业 2004年第12期34卷 8-11页

作者：李洪青邹华生刘会冲华南理工大学化工与能源学院广州510640 广东风华高新科技集团有限公司肇庆526020

采用正交实验的方法,以醚化剂本身为稀释剂,探讨了高乙氧基含量乙基纤维素二步法合成的工艺条件,并采用红外光谱、核磁共振氢谱对产品结构进行了表征。以1 mol纤维素为基准,优选出最佳工艺条件为:氢氧化钠溶液浓度50％,氢氧化钠用量16.2... 详细信息

采用正交实验的方法,以醚化剂本身为稀释剂,探讨了高乙氧基含量乙基纤维素二步法合成的工艺条件,并采用红外光谱、核磁共振氢谱对产品结构进行了表征。以1 mol纤维素为基准,优选出最佳工艺条件为:氢氧化钠溶液浓度50％,氢氧化钠用量16.2 mol,碱化温度32℃,碱化时间3 h,氯乙烷用量为40 mol,醚化温度140℃,醚化时间12 h,该条件下,乙氧基含量可高达45.8％。

关键词：乙氧基醚化合成实验乙基纤维素乙烷氢氧化钠二步法核磁共振氢谱表征红外光谱

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高取代度乙基纤维素的一步法合成机理及研究

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涂料工业 2005年第7期35卷 16-20页

作者：李洪青邹华生肖磊廖晓燕刘会冲华南理工大学化工与能源学院广州510640 广东风华高新科技集团有限公司肇庆526020

采用正交试验方法,以甲苯为稀释剂,探讨了高取代度乙基纤维素一步法合成的反应机理及工艺条件,并采用红外光谱、核磁共振氢谱对产物分子结构进行了鉴定表征。以27g纤维素为基准,优选出一步法合成最佳工艺条件为甲苯用量180g,氢氧化钠溶... 详细信息

采用正交试验方法,以甲苯为稀释剂,探讨了高取代度乙基纤维素一步法合成的反应机理及工艺条件,并采用红外光谱、核磁共振氢谱对产物分子结构进行了鉴定表征。以27g纤维素为基准,优选出一步法合成最佳工艺条件为甲苯用量180g,氢氧化钠溶液质量浓度60%,氯乙烷用量477.5g,反应温度140℃,反应时间13h,该条件下,乙氧基含量(质量分数)可达44.8%。

关键词：乙基纤维素高取代度合成机理一步法合成正交试验方法核磁共振氢谱最佳工艺条件氢氧化钠溶液反应机理红外光谱分子结构质量浓度反应温度反应时间质量分数稀释剂氯乙烷乙氧基甲苯用量产物

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Genome-wide characterization and expression analysis of WRKY family genes during development and resistance to Colletotrichum fructicola in cultivated strawberry(Fragaria×ananassa Duch.)

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Journal of Integrative Agriculture 2022年第6期21卷 1658-1672页

作者： zou Xiao-hua DONG Chao LIU Hai-ting GAO qing-hua Shanghai Key Laboratory of Protected Horticultural Technology Forestry and Fruit Tree Research InstituteShanghai Academy of Agricultural Sciences(SAAS)Shanghai 201403P.R.China

Based on the recently published whole-genome sequence of cultivated strawberry ’Camarosa’, in this study, 222FaWRKY genes were identified in the ’Camarosa’ genome. Phylogenetic analysis showed that the 222 FaWRKY candidate genes were classified into three groups, of which 41 were in group Ⅰ, 142 were in group Ⅱ, and 39 were in group Ⅲ. The 222 FaWRKY genes were evenly distributed among the seven chromosomes. The exon–intron structures and motifs of the WRKY genes had evolutionary diversity in different cultivated strawberry genomes. Regarding differential expression, the expression of FaWRKY133 was relatively high in leaves, while FaWRKY63 was specifically expressed in roots. FaWRKY207, 59, 46, 182, 156, 58, 39, 62 and 115 were up-regulated during achene development from the green to red fruit transition. FaWRK181, 166 and 211 were highly expressed in receptacles at the ripe fruit stage. One interesting finding was that Fa WRKY179 and 205 were significantly repressed after Colletotrichum fructicola inoculation in both ’Benihoppe’ and ’Sweet Charlie’ compared with Mock. The data reported here provide a foundation for further comparative genomics and analyses of the distinct expression patterns of FaWRKY genes in various tissues and in response to C. fructicola inoculation.

关键词： Fragaria×ananassa FaWRKY Colletotrichum fructicola structure evolution

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