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Influence of Interfacial Enantiomeric Grafting on Melt Rheology and Crystallization of Polylactide/Cellulose Nanocrystals Composites

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Chinese Journal of Polymer Science 2022年第1期40卷 93-106页

作者： hua-Gao Fang Kang-Jie Yang Qi-Zheng Xie Xu Chen Sheng-Li wu Yun-Sheng Ding Department of Polymer Science and Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China Anhui Province Key Laboratory of Advanced Functional Materials and Devices Hefei 230009China Anhui Institute for Food and Drug Control Hefei230051China

Incorporating the surface-grafted cellulose nanocrystals(CNCs)with enantiomeric polylactide(PLLA or PDLA)is an effective and sustainable way to modify PLLA,but their difference in promoting matrix crystallization is still *** this study,the CNCs with identical content and length of PLLA and PDLA(CNC-g-L and CNC-g-D)were prepared and blended with *** rheological properties of PLLA/CNC-gD are greatly improved,indicating that the stereocomplexation can significantly improve the interfacial strength as compared with the conventional van der Waals force in PLLA/***,the matrix crystallizes at a higher rate in PLLA/CNC-g-L than PLLA/***/CNC-g-L15 reaches its half crystallinity in 8.26 min while a longer period of 13.41 min is required for PLLA/*** observation reveals that the superior crystallization behavior in PLLA/CNC-g-L is originated from its higher nucleation efficiency and faster growth *** formation of low content of sc-PLA at the interface can restrict the diffusion of PLLA but contribute less to generate crystalline nuclei,which synergistically leads to the retarded crystallization kinetics in PLLA/*** the mechanism of different interfacial enantiomeric grafting on the melt rheology and crystallization of PLLA is of great significance for the development of high-performance polylactide materials.

关键词： Cellulose nanocrystal Polylactide nanocomposite Interfacial stereocomplexation Crystallization Rheology

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ON THE EXPLICIT COMPACT SCHEMES II: EXTENSION OF THE STCE/CE METHOD ON NONSTAGGERED GRIDS ON THE EXPLICIT COMPACT SCHEMES II: EXTENSION OF THE STCE/CE METHOD ON NONSTAGGERED GRIDS

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Journal of Computational Mathematics 2000年第5期18卷 467-480页

作者： hua-zhong Tang , hua-mu wu (State Key Laboratory of Scientific and Engineering Computing, Institute of Computational Mathematics, Chinese Academy of Sciences, Beijing 100080, China) 中科院计算数学所科学与工程计算国家重点实验室北京 100080

This paper continues to construct and study the explicit compact (EC) schemes for conservation laws. First, we axtend STCE/SE method on non-staggered grid, which has same well resolution as one in [1], and just requires half of the computational works. Then, we consider some constructions of the EC schemes for two-dimensional conservation laws, and some 1D and 2D numerical experiments are also given.

关键词： Conservation laws Compact scheme Shock-Capturing method Euler equations.

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腹腔镜胃袖状切除术治疗肥胖合并2型糖尿病及脂肪胰的临床研究

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中华普外科手术学杂志（电子版） 2024年第5期18卷 554-557页

作者：李猛姜腊董磊吴情贾犇黎皖北煤电集团总医院胃肠外科安徽宿州234000 皖北煤电集团总医院中心实验室安徽宿州234000 安徽医科大学第二附属医院胃肠外科合肥230601

目的:探究腹腔镜胃袖状切除术(LSG)治疗肥胖合并2型糖尿病及脂肪胰的临床效果。方法:回顾性分析2021年1月至2022年10月行LSG治疗的63例肥胖合并2型糖尿病及脂肪胰患者临床资料,分析手术前后减重效果、代谢指标及胰腺功能指标变化情况,... 详细信息

目的:探究腹腔镜胃袖状切除术(LSG)治疗肥胖合并2型糖尿病及脂肪胰的临床效果。方法:回顾性分析2021年1月至2022年10月行LSG治疗的63例肥胖合并2型糖尿病及脂肪胰患者临床资料,分析手术前后减重效果、代谢指标及胰腺功能指标变化情况,统计术后12个月患者2型糖尿病、脂肪胰及其他合并症缓解情况。采用SPSS 25.0分析数据。物理指标、血糖和血脂代谢指标等计量资料以(x±s)表示,采用配对样本t检验;合并症情况等计数资料以[例(%)]表示。P<0.05为差异有统计学意义。结果:与术前比较,术后6个月、12个月患者体重、体重指数(BMI)、多余体重减轻百分比(EWL%)、腰围、臀围、收缩压、舒张压等物理指标及空腹血糖(FPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)等血糖、血脂代谢指标呈下降趋势,且术后12个月各指标水平显著低于术后6个月(P<0.05);与术前比较,术后6个月、12个月患者胰岛素抵抗指数(Homa-IR)明显降低,胰岛β细胞功能(Homa-β)水平明显升高,且术后12个月Homa-IR显著低于术后6个月,术后12个月Homa-β水平明显高于术后6月(P<0.05)。至术后12个月,2型糖尿病的缓解率为71.4%,合并症脂肪胰、高血压、高血脂症缓解率分别达到了82.5%、77.8%、81.8%。结论:LSG治疗肥胖合并2型糖尿病及脂肪胰安全有效,可达到明显的减重效果,同时可改善血糖、血脂等代谢情况及胰腺功能,且术后多数患者可达到糖尿病缓解和脂肪胰缓解。

关键词：腹腔镜胃袖状切除术肥胖 2型糖尿病脂肪胰

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A chitosan-mediated inhalable nanovaccine against SARS-CoV-2

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Nano Research 2022年第5期15卷 4191-4200页

作者： Shao-hua Zhuo Jun-Jun wu Lang Zhao Wen-Hao Li Yu-Fen Zhao Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China Beijing Institute for Brain Disorders Beijing 100069China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Institute of Drug Discovery Technology Ningbo UniversityNingbo 315221China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),with several antigenic variants,has grown into a global challenge,and the rapid establishment of an immune barrier is crucial to achieving long-term control of the *** has led to a great demand for easy preparation and scalable vaccines,especially in low-income ***,we present an inhalable nanovaccine comprising chitosan and SARS-CoV-2 spike *** chitosan-mediated nanovaccine enabled a strong spike-specific antibody immune response and augmented local mucosal immunity in bronchoalveolar lavage and lungs,which might be capable of protecting the host from infection without systemic *** addition,the enhanced adaptive immunity stimulated by chitosan showed potential protection against ***,inhalation of the nanovaccine induced a comparable antibody response compared to intramuscular *** inhalable nanovaccine against SARS-CoV-2 offers a convenient and compliant strategy to reduce the use of needles and the need for medical staff.

关键词： severe acute respiratory syndrome coronavirus 2(SASR-CoV-2) inhalation nanovaccine chitosan

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Charlson comorbidity index helps predict the risk of mortality for patients with type 2 diabetic nephropathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第1期15卷 58-66页

作者： You-qun huaNG Rong GOU Yong-shu DIAO qing-hua YIN Wen-xing FAN Ya-ping LIANG Yi CHEN Min wu Li ZANG Ling LI Jing ZANG Lu CHENG Ping FU Fang LIU Division of Nephrology West China Hospital of Sichuan University Chengdu 610041 China

Our intent is to examine the predictive role of Charlson comorbidity index （CCI） on mortality of patients with type 2 diabetic nephropathy （DN）. Based on the CCI score, the severity of comorbidity was categorized into three grades： mild, with CCI scores of 1-2; moderate, with CCI scores of 3-4; and severe, with CCI scores 〉5. Factors influencing mortality and differences between groups stratified by CCI were determined by logistical regression analysis and one-way analysis of variance （ANOVA）. The impact of CCI on mortality was assessed by the Kaplan- Meier analysis. A total of 533 patients with type 2 DN were enrolled in this study, all of them had comorbidity （CCI score 〉1）, and 44.7% （238/533） died. The mortality increased with CCI scores： 21.0% （50/238） patients with CCI scores of 1-2, 56.7% （135/238） patients with CCI scores of 3-4, and 22.3% （53/238） patients with CCI scores 〉5. Logistical regression analysis showed that CCI scores, hemoglobin, and serum albumin were the potential predictors of mortality （P〈0.05）. One-way ANOVA analysis showed that DN patients with higher CCI scores had lower levels of hemoglobulin, higher levels of serum creatinine, and higher mortality rates than those with lower CCI scores. The Kaplan-Meier curves showed that survival time decreased when the CCI scores and mortality rates went up. In con- clusion, CCI provides a simple, readily applicable, and valid method for classifying comorbidities and predicting the mortality of type 2 DN. An increased awareness of the potential comorbidities in type 2 DN patients may provide insights into this complicated disease and improve the outcomes by identifying and treating patients earlier and more effectively.

关键词： Diabetic nephropathy (DN) Charlson comorbidity index (CCI) Mortality

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Reconstruction of nerve root sheaths for sacral extradural spinal meningeal cysts with spinal nerve root fibers

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Science China(Life Sciences) 2013年第11期56卷 1007-1013页

作者： SUN JianJun WANG ZhenYu LI ZhenDong wu HaiBo YEN RuYu ZHENG Mei CHANG qing LIU Isabelle Yisha Department of Neurosurgery Peking University Third Hospital Peking University Department of Neuroradiology Peking University Third Hospital Department of General Surgery Peking University Third Hospital Department of Neurology Peking University Third Hospital Department of Pathology Peking University Third Hospital Department of Head & Neck Surgery UCLA Medical CenterLos Angeles CA 90095 USA

This study analyzed the clinical characteristics and outcomes of sacral extradural spinal meningeal cysts with spinal nerve root fibers treated by reconstruction of the nerve root *** relationships between the cysts and spinal nerve root fibers were examined microscopically,the cysts were partially excised,and the defects were oversewn to reconstruct the nerve root *** Improved Japanese Orthopedic Association(IJOA)scoring system was used to evaluate preoperative and postoperative neurological ***-eight patients were included in this study,with a mean age of 41.4±15.57 *** mean IJOA score was 18.8±1.32 preoperatively and 19.6±0.65 postoperatively,which was a significant difference(t=–3.77,P=0.001).These results indicate a significant improvement in neurological function after *** most significant improvement in neurological function was sensation(z=–2.86,P=0.004),followed by bowel/bladder function(z=–2.31,P=0.02).

关键词： sacral canal spinal meningeal cysts reconstructed nerve root sheath spinal nerve root fibers clinical outcomes

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短凯伦藻高效溶藻菌Pseudoalteromonas shioyasakiensis SE3的分离、鉴定及溶藻作用研究

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海洋与湖沼 2024年第4期55卷 896-904页

作者：姚玉芳吴在兴袁涌铨贺立燕曹西华宋秀贤俞志明中国科学院海洋研究所、海洋生态与环境科学重点实验室山东青岛266071 青岛海洋科技中心、海洋生态与环境科学功能实验室山东青岛266237 中国科学院大学北京100049

微生物防控法以其生态调控功能和环境友好特征成为赤潮治理领域备受关注的一种方法。从短凯伦藻(Karenia brevis)藻际微生物中筛选出一株高效溶藻菌,研究了其对短凯伦藻的溶藻特性、溶藻作用方式及机制。经16S rDNA鉴定,该溶藻菌属于假... 详细信息

微生物防控法以其生态调控功能和环境友好特征成为赤潮治理领域备受关注的一种方法。从短凯伦藻(Karenia brevis)藻际微生物中筛选出一株高效溶藻菌,研究了其对短凯伦藻的溶藻特性、溶藻作用方式及机制。经16S rDNA鉴定,该溶藻菌属于假交替单胞菌属细菌Pseudoalteromonas shioyasakiensis SE3。结果表明,菌株SE3的溶藻效果不受细菌生长阶段的影响,主要受细菌数量的影响,当细菌密度为1.2×107 cells/mL时,在6 h即能达到100%的溶藻率。基于扫描与透射电镜等研究发现,菌株SE3主要以与藻细胞直接接触的作用方式溶藻,菌株SE3首先破坏短凯伦藻膜结构,侵入藻细胞内部,导致藻细胞的死亡。上述研究结果为利用藻际细菌防控赤潮提供了重要参考。

关键词：赤潮治理微生物方法溶藻细菌假交替单胞菌溶藻机制

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Choice and Changes of Contraceptive Methods after Primiparous Delivery in Shanghai

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Journal of Reproduction and Contraception 1999年第1期10卷 40-48页

作者： XUELi(薛丽) YUAN Wei(袁伟) LOU Chao-hua(楼超华) wu Jun-qing(武俊青) FANG Ke-juan(方可娟) GAO Er-sheng(高尔生) ShanghaiInstituteofPlannedParenthoodResearch Shanghai200032China

Totally, 3 701 prim iparousw om en in Shanghaiw ere follow ed up for 15 m onths after delivery to assess their initialand subsequent changes in choice of contraceptive m ethods. Results show ed that 15 m onths after delivery, 95.46of w om en had al- ready used a contraceptive m ethod. The leading firstchoice of contraceptive m ethods am ong urban w om en w asthe condom (50.72) or IUD(29.09), w hile the leading firstchoice am ong ruralw om en w asIUD(56.65) or the condom (30.60). Within 15 m onths after delivery, w om en w hose first choice had been the condom tended to sw itch usually to an IUD. Butfew er w om en w hosefirstm ethod w asan IUD sw itched to other m ethods. Atthe 15th m onth follow -up, 94.54of w om en w ere all using a m ethod, w ith 60.76of urban w om en and 71.07of rural w om en using IUDs. Multinom inal logistic regression analysis suggests that w om en's characteristics influ- ence the choice of m ethods. Urban, w ell-educated w om en w ere m ore likely to choose condom and rhythm , and lesslikely to chooseOC. Older w om en tended to use condom and rhythm m ore often than younger w om en. Breastfeeding w om en w ere lesslikely to use OC. Wom en w ho received recom m endations regarding postpartum contraception from fam ily planning w orkers w ere m ore likely to use IUD. It w as concluded that fam ily planning w orkers should increase w om en's aw areness of the advantages and disadvantagesof differentm ethods, dispelmythsand rum orsaboutsom em ethodsand improve w om en'sknow ledge of inform ed choice.

关键词： Contraceptive m ethod choice Contraceptive m ethod switching Multi- nom inallogistic regression

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辅助燃煤机组AGC调节的熔盐电加热器动态性能研究

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热力发电 2024年第4期53卷 84-91页

作者：马汀山张国龙居文平常东锋王伟雒青张建元耿如意兀鹏越高效灵活煤电及碳捕集利用封存全国重点实验室北京102209 西安热工研究院有限公司陕西西安710054 西安西热节能技术有限公司陕西西安710054

燃煤机组耦合熔盐电加热器系统可大幅提升其调频调峰能力。基于Modelica语言建立了熔盐电加热器的动态模型并完成了试验验证,揭示了熔盐电加热器在熔盐流量扰动和机组自动发电控制(AGC)负荷扰动下的动态特性。基于其动态特性提出了“前... 详细信息

燃煤机组耦合熔盐电加热器系统可大幅提升其调频调峰能力。基于Modelica语言建立了熔盐电加热器的动态模型并完成了试验验证,揭示了熔盐电加热器在熔盐流量扰动和机组自动发电控制(AGC)负荷扰动下的动态特性。基于其动态特性提出了“前馈+PID”调节的温度控制方法,计算分析了熔盐电加热器辅助燃煤机组AGC调节时的电负荷变化特性和热力参数变化特性。研究结果表明,配置10 MW熔盐电加热器可使660 MW燃煤机组AGC变负荷速率提升340%,且所提控制方法能够维持电加热器热力参数的稳定。

关键词：燃煤机组熔盐储热电加热器动态特性 AGC调节

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基于空间分析的森林公园对游憩者健康的影响研究

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西北林学院学报 2024年第3期39卷 248-256页

作者：朱晋立陈千山吴舒扬王琬青郑燊玥董建文郑宇福建农林大学风景园林与艺术学院福建福州350002 闽江学院福建福州350108

以福州国家森林公园为例,结合AHP法、问卷调查法与GIS空间分析法量化评价景观元素、空间特征与健康效益评估状况,利用相关性分析与Johnson-Neyman技术解析三者之间的影响,并对空间特征的调节效应与调节阈值进行评估,揭示其作用逻辑和影... 详细信息

以福州国家森林公园为例,结合AHP法、问卷调查法与GIS空间分析法量化评价景观元素、空间特征与健康效益评估状况,利用相关性分析与Johnson-Neyman技术解析三者之间的影响,并对空间特征的调节效应与调节阈值进行评估,揭示其作用逻辑和影响边界。结果表明:1)森林公园景观元素对健康效益评估具有显著影响,植被(0.1213)、自然互动体验(0.0962)、动物(0.0914)是重要指标;2)绿视率、植被覆盖度、归一化植被指数、空间可达性、空间围合度与健康效益评估存在显著相关性,但不同要素之间的影响关系具有差异性;3)森林公园景观元素对健康效益评估产生影响的过程中,空间特征对于局部路径存在显著调节作用,绿视率、植被覆盖度、归一化植被指数和空间围合度的正向调节效应阈值分别为34.489、0.2316、0.1911、0.664。结合森林公园评价和空间特征分析,通过相关性分析与调节效应检验,解析了森林公园景观元素、空间特征与健康效益评估的影响,为健康导向的森林公园景观规划设计提供参考借鉴与实践价值。

关键词：森林公园景观元素空间特征健康效益调节效应福州

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