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The Effect and Mechanism of Fructus lycii on Improvement of Exercise Fatigue Using a Network Pharmacological Approach with in vitro Experimental Verification

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Biomedical and Environmental Sciences 2024年第1期37卷 42-53页

作者： JI Xiao ning LIU zhao Ping ZHANG Chao Zheng CHEN Min LIANG Jiang LU Jiang ZHANG Lei National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China China National Center for Food Safety Risk Assessment Beijing 100022China Chinese Center for Disease Control and Prevention Beijing 102206China

Objective This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise *** A network pharmacological approach was used to explore potential mechanisms of action of Fructus *** muscle C2C12 cells and immunofluorescence were employed to verify the effect and mechanism of the representative components in Fructus lycii predicted by network pharmacological *** Six potential active components,namely quercetin,β-sitosterol,stigmasterol,7-Omethylluteolin-6-C-beta-glucoside_qt,atropine,and glycitein,were identified to have potency in improving exercise fatigue via multiple pathways,such as the PI3K-Akt,neuroactive ligand-receptor interaction,IL-17,TNF,and MAPK signaling *** immunofluorescence results indicated that quercetin,a significant active component in Fructus lycii,increased the mean staining area of 2-NBDG,TMRM,and MitoTracker,and decreased the area of CellRox compared to the ***,the protein expression levels of p-38 MAPK,p-MAPK,p-JNK,p-PI3K,and p-AKT markedly increased after quercetin *** Fructus lycii might alleviate exercise fatigue through multiple components and *** these,quercetin appears to improve exercise fatigue by enhancing energy metabolism and reducing oxidative *** PI3K-AKT and MAPK signaling pathways also appear to play a role in this process.

关键词： Fructus lycii Exercise fatigue Network pharmacology

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Semitransparent Organic Solar Cells with Superior Thermal/Light Stability and Balanced Efficiency and Transmittance

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Energy & Environmental Materials 2024年第4期7卷 215-222页

作者： Zhipeng Yin Huan zhao Yang Liu Xunwen Xiao Yong Zhang Huahang Lai ning Li Hai-Qiao Wang School of Materials Science and Engineering Ningbo Tech University State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and Devices School of Materials Science and Engineering South China University of Technology ningbo University of Technology ningbo Institute of Technology Beihang University Hangna Nanofabrication Equipment Co. Ltd.

Semitransparent organic solar cells show attractive potential in the application of building-integrated photovoltaics,agrivoltaics,floating photovoltaics,and wearable electronics,as their multiple functionalities of e... 详细信息

关键词： organic solar cell semitransparent thermal/light stability

Electrochemical protein biosensors for disease marker detection:progress and opportunities

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Microsystems & Nanoengineering 2024年第3期10卷 1-20页

作者： Lanpeng Guo Yunong zhao qing Huang Jing Huang Yanbing Tao Jianjun Chen Hua-Yao Li Huan Liu School of Integrated Circuits Wuhan National Laboratory for OptoelectronicsOptics Valley LaboratoryHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Integrated CircuitsAnhui UniversityHefei 230601China School of Optoelectronic Materials and Technology Jianghan UniversityWuhan 430056China Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology1277 Jiefang AvenueWuhan 430022China Wenzhou Institute of Advanced Manufacturing Technology Huazhong University of Science and TechnologyWenzhou 325000China

The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor *** are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic *** protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in ***,the active centers of protein biomarkers are surrounded by a peptide matrix,which hinders charge transfer and results in insufficient sensor ***,electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein *** this review,we summarize recent reports of electrochemical biosensors for protein biomarker *** highlight the latest research on electrochemical protein biosensors for the detection of cancer,viral infectious diseases,inflammation,and other *** corresponding sensitive materials,transducer structures,and detection principles associated with such biosensors are also addressed ***,we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

关键词： diagnosis specificity Electrochemical

Improvement of impact properties of Al-Si-Mg alloy via solution treatment and joint modification with Sr and La

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Rare Metals 2024年第7期43卷 3301-3313页

作者： Xiong-Ling Zheng Shao-Xiang Li Jia-Le Ma qing-Yan Xu Hai-Dong zhao Zhi-Qiang Han Key Laboratory for Advanced Materials Processing Technology Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China National Engineering Research Center of Near-Net Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510641China

An effort to obtain superior impact properties for Al-7Si-0.35 Mg alloy is presented,where modification with 0.02 wt% Sr and 0.1 wt% La as well as solution treatment was jointly *** samples were solution treated at 535℃ for 15 min to 12 *** microstructure,fracture mechanism,and their correlation with the impact properties of the alloy were studied in detail mainly through optical microscopy(OM),scanning electron microscopy(SEM) and oscillography impact *** results show that the addition of Sr and La refined the eutectic Si particles significantly from~ 2.05 μm(modified with Sr alone) to~ 0.75 μm in as-cast microstructure,leading to a very homogeneous distribution of spheroidized Si particles in the alloy solution treated at 535℃ for 8 *** alloy exhibits excellent impact toughness up to 75 J·cm^(-2),which is much higher than the maximum impact toughness of the alloys modified by Sr alone(~ 46 J·cm^(-2)).The major reason for this remarkable increase in the impact property is the dramatic increase in crack initiation *** dispersoid-free zones(DFZs)near the eutectic regions mainly consist of the ductile Al-matrix,which exhibits excellent *** ductile Al-matrix of the DFZs hinders the crack propagation,resulting in a significant increase in crack propagation energy.

关键词： Aluminum alloys Modification Solution treatment Microstructure Impact properties Fracture mechanism

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Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing

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National Science Review 2024年第2期11卷 196-206页

作者： Man Luo Qin Wang Gang zhao Wei Jiang Cici Zeng qingao Zhang Ruyu Yang Wang Dong Yunxi zhao Guozhen Zhang Jun Jiang Yucai Wang qing Zhu Key Laboratory of Precision and Intelligent Chemistry School of Chemistry and Materials Science University of Science and Technology of China Department of Radiology The First Affiliated Hospital of University of Science and Technology of China Division of Life Sciences and Medicine University of Science and Technology of China Shenzhen Senior High School Institute of Intelligent Innovation Henan Academy of Sciences

Hydrogen therapy shows great promise as a versatile treatment method for diseases associated with the overexpression of reactive oxygen and nitrogen species（RONS）. However, developing an advanced hydrogen therapy platform that integrates controllable hydrogen release, efficient RONS elimination, and biodegradability remains a giant technical challenge. In this study, we demonstrate for the first time that the tungsten bronze phase H0.53WO3（HWO） is an exceptionally ideal hydrogen carrier, with salient features including temperature-dependent highly-reductive atomic hydrogen release and broad-spectrum RONS scavenging capability distinct from that of molecular hydrogen. Moreover, its unique p H-responsive biodegradability ensures post-therapeutic clearance at pathological sites. Treatment with HWO of diabetic wounds in an animal model indicates that the solid-state atomic H promotes vascular formation by activating M2-type macrophage polarization and anti-inflammatory cytokine production, resulting in acceleration of chronic wound healing. Our findings significantly expand the basic categories of hydrogen therapeutic materials and pave the way for investigating more physical forms of hydrogen species as efficient RONS scavengers for clinical disease treatment.

关键词： atomic hydrogen RONS scavenger inflammatory regulation diabetic wound healing hydrogen therapy

Unresolved Excess Accumulation of Myelin-Derived Cholesterol Contributes to Scar Formation after Spinal Cord Injury

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Research 2024年第1期2023卷 17-32页

作者： Bolin Zheng Yijing He Shuai Yin Xu Zhu qing zhao Huiyi Yang zhaojie wang Rongrong Zhu Liming Cheng Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration Ministry of EducationDepartment of OrthopedicsTongji HospitalSchool of MedicineTongji UniversityShanghai 200092China Frontier Science Center for Stem Cell Research School of Life Science and TechnologyTongji UniversityShanghai 200092China Clinical Center for Brain and Spinal Cord Research Tongji UniversityShanghai 200092China

Spinal cord injury triggers complex pathological cascades,resulting in destructive tissue damage and incomplete tissue *** formation is generally considered a barrier for regeneration in the central nervous ***,the intrinsic mechanism of scar formation after spinal cord injury has not been fully ***,we report that excess cholesterol accumulates in phagocytes and is inefficiently removed from spinal cord lesions in young adult ***,we observed that excessive cholesterol also accumulates in injured peripheral nerves but is subsequently removed by reverse ***,preventing reverse cholesterol transport leads to macrophage accumulation and fibrosis in injured peripheral ***,the neonatal mouse spinal cord lesions are devoid of myelin-derived lipids and can heal without excess cholesterol *** found that transplantation of myelin into neonatal lesions disrupts healing with excessive cholesterol accumulation,persistent macrophage activation,and *** internalization suppresses macrophage apoptosis mediated by CD5L expression,indicating that myelin-derived cholesterol plays a critical role in impaired wound *** together,our data suggest that the central nervous system lacks an efficient approach for cholesterol clearance,resulting in excessive accumulation of myelin-derived cholesterol,thereby inducing scar formation after injury.

关键词： healing Spinal impaired

Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI Hua-feng YANG Zi-qiang HAN Jun-jun LI He-fang JIN zhao-qing CHEN Wei-qing CHEN Fei-hua GONG Mou-chun Department of General Surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(SY)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(PD-1)antibody(Anti-mPD-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(PD-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mPD-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mPD-1(P<0.01),accompanied by an inactivation of PD-1/PD-L1 axis,which were extremely further enhanced by SY(P<0.05 or P<0.01).Increased fluorescence intensity,elevated percentage of CD3+CD8+T cells,facilitated release of inflammatory cytokines,inactivated PD-1/PD-L1 axis,and increased CCL5/CXCL10 secretion were observed in Anti-mPD-1 treated mice(P<0.01),which were markedly enhanced by SY(P<0.05 or P<0.01).Furthermore,the enhanced effects of SY on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the PD-1/PD-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mPD-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(P<0.01).Conclusion SY inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

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'Stars' Shine over Beijing

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Women of China 1994年第7期 46-47页

作者： WEN qing zhao ning

WITHIN the past decade Beijingers have become familiar with the star system that ranks the city’s hotels. And the rapid economic development of Beijing has transformed it into a city with the most hotels in the world. Beijing now boasts 183 star-ranked hotels and 50,000 guest rooms affiliated with about 200 other hotels which cater to foreign travelers. But these numbers seem low when one considers the current economic boom in China. Development of more high-grade hotels in Beijing

关键词： World Stars Shine over Beijing

Comparative study on interaction between rare earth oxide refractories and rare earth treated steel

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Journal of Iron and Steel Research International 2024年第6期31卷 1493-1501页

作者： Ze Meng Guang-qiang Li Cheng Yuan Yi-jiang zhao qing Zheng Bin Zeng Yu Liu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina Technical Center Lianyuan Iron and Steel Co.Ltd.Loudi417009HunanChina

Refractories have an important effect on the cleanliness of molten *** interaction between CeAlO_(3) refractories and Ce treated steel was explored and compared with that between Al_(2)O_(3) refractories and Ce treated *** results show that the Ce content in steel decreases sharply after contact with Al_(2)O_(3) refractories and the pick-up of dissolved Al *** with the test of Al_(2)O_(3) refractories,the loss of Ce content is less in the test of CeAlO_(3) refractory,and the total oxygen content and dissolved Al content in steel increase *** dense and continuous Ce_(2)O_(2)S interface layer is observed at the CeAlO_(3) refractories/steel interface,which can serve as the metallurgical isolation layer and hinder the further interaction between refractories and ***,the higher steel cleanliness and less penetration of refractories by molten steel are obtained in the test of CeAlO_(3) *** CeAlO_(3) refractories show a promising prospect in the production of clean Ce treated steel.

关键词： CeAlO_(3)refractory Steel Cleanliness Interaction Rare earth