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Intensified warming suppressed the snowmelt in the Tibetan Plateau

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Advances in Climate Change Research 2024年第3期15卷 452-463页

作者： Xiang li Peng CUI Xue-qin ZHANG Fang ZHANG Key Lab of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China China‒Pakistan Joint Research Center on Earth Sciences Chinese Academy of Sciences and Higher Education CommissionIslamabad 45320Pakistan

Understanding how hydrological factors interrelate is crucial when examining the impact of climate warming on ***,these connections are often overlooked,leading to an unclear relationship between temperature and *** study investigates the complex interplay between temperature and snowmelt in the Tibetan Plateau from 1961 to 2020,focusing on how extreme high-temperature events affect the frequency of extreme *** a structural equation model,we detected three temperature-related factors that predominantly influenced snowmelt and extreme *** annual average temperature was found to have a significant indirect impact on snowmelt,mediated by changes in snowfall,snow depth and snow *** contrast,high-temperature days(daily maximum temperatures exceeding the 90th percentile)and heat waves(at least three consecutive high-temperature days)negatively affected extreme snowmelt directly or *** direct effect of increasing extreme temperature events was associated with an earlier onset of high-temperature periods,which accelerated snowmelt and shortened the duration of extreme snowmelt ***,the reduction in snow cover owing to warming emerged as a main factor suppressing snowmelt and extreme snowmelt *** also revealed spatiotemporal variations in the temperature‒snowmelt relationship that highly depended on changes in snowmelt *** study elucidated why warming suppresses snowmelt and extreme snowmelt events in the Tibetan Plateau,highlighting the mediating roles of snow-related and phenological *** findings will provide scientific support for climate simulation and water management policymaking in alpine regions worldwide.

关键词： Climate change Extreme temperature Snowmelt Structural equation model Tibetan Plateau

Cancer organoids:A platform in basic and translational research

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Genes & Diseases 2024年第2期11卷 614-632页

作者： Xin Ma qin Wang Guozheng li Hui li Shouping Xu Da Pang Department of Breast Surgery Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China Sino-Russian Medical Research Center Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China Heilongjiang Academy of Medical Sciences HarbinHeilongjiang 150086China Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China) College of Pharmacy of Harbin Medical UniversityHarbinHeilongjiang 150086China

An accumulation of previous work has established organoids as good preclinical models of human tumors,facilitating translation from basic research to clinical *** are changing the paradigm of preclinical cancer research because they can recapitulate the heterogeneity and pathophysiology of human cancers and more closely approximate the complex tissue environment and structure found in clinical tumors than in vitro cell lines and animal ***,the potential applications of cancer organoids remain to be comprehensively *** the review,we firstly describe what is currently known about cancer organoid culture and then discuss in depth the basic mechanisms,including tumorigenesis and tumor metastasis,and describe recent advances in patient-derived tumor organoids(PDOs)for drug screening and immunological ***,the present challenges faced by organoid technology in clinical practice and its prospects are *** review highlights that organoids may offer a novel therapeutic strategy for cancer research.

关键词： Drug assays Immunotherapy Mechanism research Organoids Precision medicine

A Novel Divide and Conquer Solution for Long-term Video Salient Object Detection

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Machine Intelligence Research 2024年第4期21卷 684-703页

作者： Yun-Xiao li Cheng-li-Zhao Chen Shuai li Ai-Min Hao Hong qin State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China College of Computer Science and Technology China University of Petroleum(East China)Qingdao 266580China Department of Computer Science Stony Brook UniversityNew York 11794USA

Recently,a new research trend in our video salient object detection(VSOD)research community has focused on enhancing the detection results via model self-fine-tuning using sparsely mined high-quality keyframes from the given *** such a learning scheme is generally effective,it has a critical limitation,i.e.,the model learned on sparse frames only possesses weak generalization *** situation could become worse on“long”videos since they tend to have intensive scene ***,in such videos,the keyframe information from a longer time span is less relevant to the previous,which could also cause learning conflict and deteriorate the model ***,the learning scheme is usually incapable of handling complex pattern *** solve this problem,we propose a divide-and-conquer framework,which can convert a complex problem domain into multiple simple ***,we devise a novel background consistency analysis(BCA)which effectively divides the mined frames into disjoint *** for each group,we assign an individual deep model on it to capture its key attribute during the fine-tuning *** the testing phase,we design a model-matching strategy,which could dynamically select the best-matched model from those fine-tuned ones to handle the given testing *** experiments show that our method can adapt severe background appearance variation coupling with object movement and obtain robust saliency detection compared with the previous scheme and the state-of-the-art methods.

关键词： Video salient object detection background consistency analysis weakly supervised learning long-term information background shift.

Enhanced Sensing Mechanism Based on Shifting an Exceptional Point

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Research 2024年第3期6卷 285-292页

作者： Xuan Mao Guo-qing qin Hao Zhang Bo-Yang Wang Dan Long Gui-qin.li Gui-Lu Long Department of Physics State Key Laboratory of Low-Dimensional Quantum PhysicsTsinghua UniversityBeijing 100084China Beijing Institute of Radio Measurement The Second Academy of China Aerospace Science and Industry Corporation(CASIC)Beijing 100854China Purple Mountain Laboratories Nanjing 21111China Frontier Science Center for Quantum Information Beijing 100084China Beijing Academy of Quantum Information Sciences Beijing 100193China

Non-Hermitian systems associated with exceptional points (EPs) are expected to demonstrate a giant response enhancement for various sensors. The widely investigated enhancement mechanism based on diverging from an EP should destroy the EP and further limits its applications for multiple sensing scenarios in a time sequence. To break the above limit, here, we proposed a new enhanced sensing mechanism based on shifting an EP. Different from the mechanism of diverging from an EP, our scheme is an EP nondemolition and the giant enhancement of response is acquired by a slight shift of the EP along the parameter axis induced by perturbation. The new sensing mechanism can promise the most effective response enhancement for all sensors in the case of multiple sensing in a time sequence. To verify our sensing mechanism, we construct a mass sensor and a gyroscope with concrete physical implementations. Our work will deepen the understanding of EP-based sensing and inspire designing various high-sensitivity sensors in different physical systems.

关键词： mechanism shifting exceptional

Long-term complete response to anti-programmed-death-1 monotherapy in a patient with relapsed and refractory ovarian adenocarcinoma: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1967-1973页

作者： Guang-Di Zhou qin.li Affiliated to Shanghai Jiao Tong University School of Medicine Xinhua HospitalShanghai 200092China Department of Obstetrics and Gynecology Shanghai Changhai HospitalShanghai 200433China

BACKGROUND Ovarian cancer is the most common malignant tumor of the female reproductive system,and the survival rate of patients with relapsed and refractory ovarian cancer is very *** SUMMARY Here,we report a case of high-grade serous papillary adenocarcinoma of the ovary that was successfully treated with *** surgery and adjuvant chemotherapy for the 56-year-old patient were successful;however,her tumor *** second-line chemotherapy,targeted agents,and other treatments were ineffective,as the tumor continued to recur and ***-programmed cell death-1(PD-1)monotherapy(tislelizumab)completely alleviated the tumor,and the multiple metastatic tumors *** date,the patient has used anti-PD-1 for 32 months,experiencing no disease progression and maintaining good health without additional *** This case suggests that anti-PD-1 immunotherapy may have long-term positive effects on outcomes in some refractory recurrent solid *** research is needed to identify patients most likely to respond to anti-PD-1 therapy.

关键词： Anti-programmed cell death-1 Tislelizumab Ovarian cancer Relapsed cancer treatment Immunotherapy Case report

Extrusion-base d 3D-printe d“rolle d-up”composite scaffolds with hierarchical pore structure for bone growth and repair

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Journal of Materials Science & Technology 2024年第4期171卷 222-234页

作者： Yufan li li Chen Yijing Stehle Mingyue lin Chenxin Wang Rui Zhang Min Huang Yubao li qin Zou Research Center for Nano Biomaterials Analytical&Testing CenterSichuan UniversityChengdu 610064China Analytical&Testing Center Sichuan UniversityChengdu 610064China Department of mechanical engineering Union College807 Union St.SchenectadyNY 12308USA Sichuan Institute of Atomic Energy Chengdu 610101China

Three-dimensional(3D)bioprinting,specifically direct ink writing(DIW)capable of printing biologically active substances such as growth factors or drugs under low-temperature conditions,is an emerging di-rection in bone tissue ***,limited by the bio-ink mobility and the poor resolution of this printing technology,the lateral pores of current crisscross-stacked scaffolds printed through DIW tend to clog and are inimical to bone ***,it is critical to develop DIW printed biologi-cal scaffold structure with high mechanical strength,porosity,and biocompatibility ***,patterned polylactic acid(PLA)/polycaprolactone(PCL)/nano-hydroxyapatite(n-HA)based scaffold was printed through DIW technological and rolled-up for properties characterization,cytocompatibility test,and bone repair *** result not only shows that the hexagonal patterned scaffolds are me-chanically strong with porosity,but also demonstrated that the hierarchical pore structure formed during rolled-up has the potential to address the clogging problem and stimulates bone growth and repair.

关键词： Direct ink writing(DIW) Bone repair scaffold,Micro-CT Bio composites

A strategy for mechanically integrating robust hydrogeltissue hybrid to promote the anti-calcification and endothelialization of bioprosthetic heart valve

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Regenerative Biomaterials 2024年第2期3卷 123-136页

作者： Haoshuang Wu Nuoya Chen Tiantian Zheng li li Mengyue Hu Yumei qin Gaoyang Guo li Yang Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China Institute of Clinical Pathology West China Hospital of Sichuan UniversityChengdu 610041China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065China

Bioprosthetic heart valve(BHV)replacement has been the predo-minant treatment for severe heart valve diseases over *** clinically available BHVs are crosslinked by glutaraldehyde(GLUT),while the high toxicity of residual GLUT could initiate calcification,severe thrombosis,and delayed ***,we construed a mechanically integrating robust hydrogel-tissue hybrid to improve the performance of *** particular,recombinant humanized coilagen type Ⅲ(rhCOLⅢ),which was precisely customized with anti-coagulant and pro-endothelialization bioactivity,was first incorporated into the polyvinyl alcohol(PVA)-based hydrogel via hydrogen bond ***,tannic acid was introduced to enhance the mechanicalperfo of PVA-based hvdrogel and interfacial bonding between the hydrogel layer and bio-derived tissue due to the strong affinity for a wide range of *** vitro and in vivo experimental results confirmed that the GLUT-crosslinked BHVs modified by the robust PVA-based hydrogel embedded rhCOliI and TA possessed long-term anti-coagulant,accelerated endothelialization,mild inflammatory response and anti-calcification ***,our mechanically integrating robust hydrogel-tissue hybrid strategy showed the potential to enhance the service function and prolong the service life of the BHVs after implantation.

关键词： bioprosthetic heart valves recombinant humanized collagen typeⅢ endothelialization anti-calcification anti-coagulation

Resilience-driven cooperative reconfiguration strategy for unmanned weapon system-of-systems

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Journal of Systems Engineering and Electronics 2024年第4期35卷 932-944页

作者： SUN qin.li Hongxu ZENG Yifan ZHANG Yingchao School of Systems Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China

As the unmanned weap system-of systems(UWSoS)becomes complex,the inevitable uncertain interference gradu-ally increases,which leads to a strong emphasis on the resilience of ***,this paper presents a resilience-driven cooperative reconfiguration strategy to enhance the resilience of ***,a unified resilience-driven coopera-tive reconfiguration strategy framework is designed to guide the UWSoS resilience ***,a cooperative reconfiguration strategy algorithm is proposed to identify the optimal cooperative reconfiguration sequence,combining the cooperative pair resilience contribution index(CPRCI)and coop-erative pair importance index(CPII).At last,the effectiveness and superiority of the proposed algorithm are demonstrated through various attack scenario simulations that include differ-ent attack modes and *** analysis results can pro-vide a reference for decision-makers to manage UWSoS.

关键词： resilience strategy unmanned weapon system-of-systems(UWSoS) cooperative reconfiguration unmanned con-frontation

Nano-effect enhanced cooperative luminescence of Yb^(3+) clusters in bulk materials

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Journal of Rare Earths 2024年第3期42卷 473-478,I0002页

作者： Daguang li Jiahao Cui Yanhui Dong Hao Cui Dan Zhao Weiping qin State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun130012China

In order to improve the multi-ion cooperative transition, we proposed and exploited a novel nanoscale effect, namely the nanoshell effect in bulk materials. Based on the effect, an optimal material structure was designed by coating the surfaces of Ca F_(2):Yb^(3+)micron size particles with ZrO_(2). An about 2 times higher intensity of cooperative luminescence is observed upon laser excitation at 980 nm. Dynamical analysis exhibits that the novel effect plays a key role in improving the performance of cooperative transitions. Our results also suggest that the nanoshell effect in bulk materials is likely to be significant in some special cases, which have not been reported yet in the literature.

关键词： Yb^(3+)cluster ZrO_(2) Nanoshell Enhancement Cooperative luminescence Rare earths