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Dual peroxisome proliferator-activated receptorα/δagonists:Hope for the treatment of alcohol-associated liver disease?

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World Journal of Gastroenterology 2024年第37期30卷 4163-4167页

作者： xin-yang Zhang qin-Jun-Jie Chen Feng Zhu Min Li Dan Shang Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Vascular Surgery Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061Hubei ProvinceChina

In this letter,we review the article“Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease”.We focus specifically on the detrimental effects of alcohol-associated liver disease(ALD)on human *** its insidious onset and increasing incidence,increasing awareness of ALD can contribute to reducing the prevalence of liver *** comprises a spectrum of several different disorders,including liver steatosis,steatohepatitis,fibrosis,cirrhosis,and hepatocellular *** pathogenesis of ALD is exceedingly *** studies have shown that peroxisome proliferator-activated receptors(PPARs)regulate lipid metabolism,glucose homeostasis and inflammatory responses within the ***,their dysfunction is a major contributor to the progression of *** is an oral,dual PPARαandδ*** effectiveness of elafibranor in the treatment of ALD remains *** this letter,we emphasize the harm of ALD and the burden it places on ***,we summarize the clinical management of all stages of ALD and present new insights into its pathogenesis and potential therapeutic ***,we discuss the mechanisms of action of PPARαandδagonists,the significance of their antifibrotic effects on ALD and future research directions.

关键词： Alcohol-associated liver disease Fibrosis Antifibrotic effect Elafibranor Peroxisome proliferator-activated receptor

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A generative adversarial network-based unified model integrating bias correction and downscaling for global SST

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Atmospheric and Oceanic Science Letters 2024年第1期17卷 45-52页

作者： Shijin Yuan xin Feng Bin Mu Bo qin xin Wang Yuxuan Chen School of Software Engineering Tongji UniversityShanghaiChina

本文提出了一种基于生成对抗网络的全球海表面温度(sea surface temperature,SST)偏差订正及降尺度整合模型.该模型的生成器使用偏差订正模块将数值模式预测结果进行校正,再用可复用的共享降尺度模块将订正后的数据分辨率逐次提高.该模... 详细信息

本文提出了一种基于生成对抗网络的全球海表面温度(sea surface temperature,SST)偏差订正及降尺度整合模型.该模型的生成器使用偏差订正模块将数值模式预测结果进行校正,再用可复用的共享降尺度模块将订正后的数据分辨率逐次提高.该模型的判别器可鉴别偏差订正及降尺度结果的质量,以此为标准进行对抗训练。同时,在对抗损失函数中含有物理引导的动力学惩罚项以提高模型的性能.本研究基于分辨率为1°的GFDL SPEAR模式的SST预测结果,选择遥感系统(Remote Sensing System)的观测资料作为真值,面向月尺度ENSO与IOD事件以及天尺度海洋热浪事件开展了验证试验:模型在将分辨率提高到0.0625°×0.0625°的同时将预测误差减少约90.3%,突破了观测数据分辨率的限制,且与观测结果的结构相似性高达96.46%.

关键词：偏差订正降尺度海表面温度生成对抗网络物理引导的神经网络

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A highly reduced Mo_(74) polyoxometalate featuring high proton conductivity accessed by building block strategy

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Science China Chemistry 2024年第3期67卷 862-868页

作者： Shi-Yi Liu Xue-xin Li Wei-Chao Chen Kui-Zhan Shao xin-Long Wang Chao qin Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Highly reduced polyoxometalates(POMs) are predicted to be used as rather high energy density materials;however,it still suffers from the limited cluster species and reduction *** we demonstrate that it is possible to employ the building block strategy to generate a highly reduced polyoxomolybdate(C_(2)H_(8)N)_(14)(NH_(4))_(4)H_(14)[Mo_(48)-ⅤMo_(26)ⅥO_(202)(OH)_(12)(SO_(4))_(6)]·46H_(2)O(Mo_(74)).The fundamental Mo-based{Mo_x}(x=4,5,and 6) building blocks,which are templated by tetra-coordinated anions{MoO_(4)}or{SO_(4)},not only lay foundation for the formation of Mo_(74) featuring an unprecedented reduction ratio of 65%,but also give rise to SBBs-mediated(secondary building blocks) supramolecular dense packing interactions among the isolated Mo_(74) clusters that are favorable for proton ***,high proton conductivity(2.04×10^(-2)S cm^(-1)) had been realized at 50℃ and 90% relative humidity,revealing one of the well-known POMs-based crystalline proton conducting *** result highlights that this building block approach possesses great potential in producing highly reduced POM systems that can achieve controllable reduced ratio and desirable properties.

关键词： polyoxometalate building block molybdenum highly reduced state proton conduction

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To explore the pathogenesis of anterior resection syndrome by magnetic resonance imaging rectal defecography

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 529-538页

作者： Ling-Hou Meng Xian-Wei Mo Bing-Yu yang Hai-Quan qin qing-Zhou Song xin-xin He Qiang Li Zheng Wang Chang-Lin Mo Guo-Hai yang Department of Gastrointestinal Surgery Guangxi Clinical Research Center for Colorectal CancerGuangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal and Anal Surgery Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiology Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina First Department of Chemotherapy Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over 90%of rectal cancer patients develop low anterior resection syndrome(LARS)after sphincter-preserving *** current globally recognized evaluation method has many drawbacks and its subjectivity is too strong,which hinders the research and treatment of *** To evaluate the anorectal function after colorectal cancer surgery by quantifying the index of magnetic resonance imaging(MRI)defecography,and pathogenesis of *** We evaluated 34 patients using the standard LARS score,and a new LARS evaluation index was established using the dynamic images of MRI defecography to verify the LARS *** In the LARS score model,there were 10(29.41%)mild and 24(70.58%)severe cases of *** comparison of defecation rate between the two groups was 29.36±14.17%versus 46.83±18.62%(P=0.004);and MRI-rectal compliance(MRI-RC)score was 3.63±1.96 versus 7.0±3.21(P=0.001).Severe and mild LARS had significant differences using the two evaluation *** was a significant negative correlation between LARS and MRI-RC score(P<0.001),and they had a negative correlation with defecation rate(P=0.028).CONCLUSION MRI defecography and standard LARS score can both be used as an evaluation index to study the pathogenesis of LARS.

关键词： Anterior resection syndrome Colorectal cancer Diagnostic evaluation system Magnetic resonance imaging defecography Pathogenesis

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High-Performanceα-Diimine Nickel Complexes for Facile Access of PE Elastomers with Exceptional Material Properties

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Chinese Journal of Polymer Science 2024年第5期42卷 620-635,I0008页

作者： Li-Dong qin xin-Yu Wang Qaiser Mahmood Zhi-xin Yu Yi-Zhou Wang Song Zou Tong-Ling Liang Wen-Hua Sun School of Pharmaceutical Sciences Changchun University of Chinese MedicineChangchun130117China Chemistry and Chemical Engineering Guangdong Laboratory Shantou515031China Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Science Institute of ChemistryChinese Academy of SciencesBeijing100190China

For practicable elastomeric polyethylene,achieving high catalyst thermal stability and activity,along with precise control of polymer properties such as branching density,molecular weights,and distribution,is crucial but *** this study,two sets of symmetricalα-diimine nickel complexes,each comprising four nickel bromide or chloride complexes,were synthesized and investigated their performance for ethylene polymerization under various reaction *** activation with either Et2AlCl or MMAO cocatalysts,these complexes displayed not only high activity but also generated high molecular weight polyethylenes with controlled polydispersity and a substantial number of *** catalyst with the least steric hindrance displayed the remarkable high activity(up to 1.2×10^(7) g·mol^(-1)·h^(-1)).Notably,nickel bromides demonstrated higher activity compared to their chloride *** investigation into the effect of reaction temperature on catalytic performance revealed that NiBrMe-MMAO system displayed high thermal stability(activity up to 2.51×10^(6) g·mol^(-1)·h^(-1) at 100℃)and consistently yielded high polymer molecular weights with narrow polydispersity over a broad temperature range of 30-100℃.Of significant note,mechanical analysis of the resulting polyethylene demonstrated excellent ultimate tensile strength and high strain at ***,the polyethylene sample prepared at 100℃exhibited ultimate tensile strength up to 10 MPa with 1863%maximum strain at break and a strain recovery of up to 54.9%after ten cycles at a fixed strain of 300%,indicating excellent material properties of prepared thermoplastic polyethylene elastomers(TPE).

关键词： Thermoplastic polyethylene elastomers α-Diimine nickel pre-catalysts Ethylene polymerization Mechanical properties Highly branched polyethylene

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Effect of thermo-mechanical treatment on microstructure and mechanical properties of wire-arc additively manufactured Al-Cu alloy

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Journal of Central South University 2024年第7期31卷 2181-2193页

作者： ZHANG Tao qin Zhen-yang GONG Hai WU Yun-xin CHEN xin Light Alloy Research Institute Central South UniversityChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China Welding and Additive Manufacturing Centre Cranfield UniversityBedfordMK430ALUK

Wire-arc additive manufacture(WAAM)has great potential for manufacturing of Al-Cu ***,inferior mechanical properties of WAAM deposited material restrict its industrial ***-layer cold rolling and thermo-mechanical heat treatment(T8)with pre-stretching deformation between solution and aging treatment were adopted in this *** effects on hardness,mechanical properties and microstructure were analyzed and compared to the conventional heat treatment(T6).The results show that cold rolling increases the hardness and strengths,which further increase with T8 *** ultimate tensile strength(UTS)of 513 MPa and yield stress(YS)of 413 MPa can be obtained in the inter-layer cold-rolled sample with T8 treatment,which is much higher than that in the as-deposited *** cold-rolled samples show higher elongation than that of as-deposited ones due to significant elimination of porosity in cold rolling;while both the T6 and T8 treatments decrease the *** cold rolling and pre-stretching deformation both contribute to the formation of dense and dispersive precipitatedθ′phases,which inhibits the dislocation movement and enhances the strengths;as a result,T8 treatment shows better strengthening effect than the T6 *** strengthening mechanism was analyzed and it was mainly related to work hardening and precipitation strengthening.

关键词： wire-arc additive manufacture inter-layer cold rolling thermal-mechanical treatment microstructure mechanical properties strengthening mechanism

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Structure,ligands,and roles of GPR126/ADGRG6 in the development and diseases

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Genes & Diseases 2024年第1期11卷 294-305页

作者： Qi Li Anran Huo Mengqi Li Jiali Wang Qiao Yin Lumiao Chen xin Chu Yuan qin Yuwan Qi yang Li Hengxiang Cui Qifei Cong Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases Soochow UniversitySuzhouJiangsu215123China Department of Neurology and Clinical Research Center of Neurological Disease The Second Affliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Nephrology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Emergency Center The Second Affiliated Hospital of Nantong UniversityNantongJiangsu226001China Department of Neurology Huzhou Central HospitalThe Affiliated Huzhou HospitalZhejiang University School of MedicineHuzhouZhejiang 313000China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China

Adhesion G protein-coupled receptors(aGPCRs)are the second largest diverse group within the GPCR superfamily,which play critical roles in many physiological and patho-logical processes through cell-cell and cell-extracellular matrix *** adhesion GPCR Adgrg6,also known as GPR126,is one of the better-characterized ***126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and *** studies have extended our understanding of GPR126-mediated roles during develop-ment and in human *** this review,we highlighted these recent advances in GPR126 in expression profile,molecular structure,ligand-receptor interactions,and associated physiological and pathological functions in development and diseases.

关键词： Adhesion G protein-coupled receptor Function GPR126/Adgrg6 Ligand Structure

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Spatiotemporal characteristics of seed rain and soil seed bank of artificial Caragana korshinskii Kom. forest in the Tengger Desert, China

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Journal of Arid Land 2024年第4期16卷 550-566页

作者： SHEN Jianxiang WANG xin WANG Lei WANG Jiahui QU Wenjie ZHANG Xue CHANG Xuanxuan yang xinguo CHEN Lin qin Weichun ZHANG Bo NIU Jinshuai College of Ecological Environment Ningxia UniversityYinchuan 750021China Key Laboratory of Restoration and Reconstruction of Degraded Ecosystems in Northwest China Ministry of EducationNingxia UniversityYinchuan 750021China College of Agriculture Ningxia UniversityYinchuan 750021China

Vegetation restoration and reconstruction are effective approaches to desertification control and achieving social and economic sustainability in desert ***,the self-succession ability of native plants during the later periods of vegetation restoration remains ***,this study was conducted to bridge the knowledge gap by investigating the regeneration dynamics of artificial forest under natural *** information of seed rain and soil seed bank was collected and quantified from an artificial Caragana korshinskii *** in the Tengger Desert,*** germination tests were conducted in a laboratory *** analysis of species quantity and diversity in seed rain and soil seed bank was conducted to assess the impact of different durations of sand fixation(60,40,and 20 a)on the progress of vegetation restoration and ecological conditions in artificial *** *** results showed that the top three dominant plant species in seed rain were Echinops gmelinii Turcz.,Eragrostis minor Host.,and Agropyron mongolicum Keng.,and the top three dominant plant species in soil seed bank were ***,Chloris virgata Sw.,and *** restoration period increased,the density of seed rain and soil seed bank increased first and then *** for species richness,as restoration period increased,it gradually increased in seed rain but decreased in soil seed *** was a positive correlation between seed rain density and soil seed bank density among all the three restoration *** species similarity between seed rain or soil seed bank and aboveground vegetation decreased with the extension of restoration *** shape of the seeds,specifically those with external appendages such as spines and crown hair,clearly had an effect on their dispersal,then resulting in lower seed density in soil seed *** addition,precipitation was a crucial factor in promoting rapid germination,also resulting in lower seed density in soi

关键词： ecological restoration soil seed bank seed rain artificial forest vegetation desertification Caragana korshinskii Tengger Desert

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Co_(3)S_(4)-pyrolysis lotus fiber flexible textile as a hybrid electrocatalyst for overall water splitting

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Journal of Energy Chemistry 2024年第2期89卷 336-344,I0008页

作者： Qiulan Zhou Zhen Liu Xuxu Wang Yaqian Li xin qin Lijuan Guo Liwei Zhou Weijian Xu Academician Workstation Changsha Medical UniversityChangsha 410219HunanChina College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082HunanChina College of Environmental Science and Engineering Hunan UniversityChangsha 410082HunanChina School of Basic Medicine Changsha Medical UniversityChangsha 410219HunanChina

Electrocatalytic overall water splitting(OWS),a pivotal approach in addressing the global energy crisis,aims to produce hydrogen and ***,most of the catalysts in powder form are adhesively bounding to the electrodes,resulting in catalyst detachment by bubble generation and other uncertain interference,and eventually reducing the OWS *** surmount this challenge,we synthesized a hybrid material of Co_(3)S_(4)-pyrolysis lotus fiber(labeled as Co_(3)S_(4)-p LF)textile by hydrothermal and hightemperature pyrolysis processes for electrocatalytic *** to the natural LF textile exposing the uniformly distributed functional groups(AOH,ANH_(2),etc.)to anchor Co_(3)S_(4)nanoparticles with hierarchical porous structure and outstanding hydrophily,the hybrid Co_(3)S_(4)-p LF catalyst shows low overpotentials at 10 m A cm^(-2)(η_(10,HER)=100 m Vη_(10,OER)=240 mV)alongside prolonged operational stability during electrocatalytic *** calculations reveal that the electron transfer from p LF to Co_(3)S_(4)in the hybrid Co_(3)S_(4)-p LF is beneficial to the electrocatalytic *** work will shed light on the development of nature-inspired carbon-based materials in hybrid electrocatalysts for OWS.

关键词： Overall water splitting Hybrid electrocatalyst Textile Lotus fiber Co_(3)S_(4)nanoparticles

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Chiral Pair Density Waves with Residual Fermi Arcs in RbV3Sb5

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Chinese Physics Letters 2024年第9期41卷 88-92页

作者： Xiao-Yu Yan Hanbin Deng Tianyu yang Guowei Liu Wei Song Hu Miao Zhijun Tu Hechang Lei Shuo Wang Ben-Chuan Lin Hailang qin Jia-xin Yin Department of Physics Southern University of Science and TechnologyShenzhen 518055China Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Beijing Key Laboratory of Optoelectronic Functional Materials MicroNano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area Shenzhen 518055China

The chiral 2×2 charge order has been reported and confirmed in the kagome superconductor RbV3Sb5,while its interplay with superconductivity remains elusive owing to its lowest superconducting transition temperature Tc of about 0.85K in the AV3Sb5 family(A=K,Rb,Cs)that severely challenges electronic spectroscopic ***,utilizing dilution-refrigerator-based scanning tunneling microscopy down to 30 mK,we observe chiral 2×2 pair density waves with residual Fermi arcs in *** find a superconducting gap of 150eV with substantial residual in-gap *** spatial distribution of this gap exhibits chiral 2×2 modulations,signaling a chiral pair density wave(PDW).Our quasi-particle interference imaging of the zero-energy residual states further reveals arc-like *** discuss the relation of the gap modulations with the residual Fermi arcs under the space-momentum correspondence between PDW and Bogoliubov Fermi states.

关键词： Fermi chiral utilizing

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