Dual peroxisome proliferator-activated receptorα/δagonists:Hope for the treatment of alcohol-associated liver disease?
作者机构：Department of Vascular SurgeryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Hepatobiliary SurgeryUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Vascular SurgeryHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061Hubei ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2024年第30卷第37期
页 面：4163-4167页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by National Natural Science Foundation of China,No.82172754 and No.81874208 Natural Science Foundation Project of Hubei Province,No.2021CFB562
主 题：Alcohol-associated liver disease Fibrosis Antifibrotic effect Elafibranor Peroxisome proliferator-activated receptor
摘 要：In this letter,we review the article“Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease.We focus specifically on the detrimental effects of alcohol-associated liver disease(ALD)on human *** its insidious onset and increasing incidence,increasing awareness of ALD can contribute to reducing the prevalence of liver *** comprises a spectrum of several different disorders,including liver steatosis,steatohepatitis,fibrosis,cirrhosis,and hepatocellular *** pathogenesis of ALD is exceedingly *** studies have shown that peroxisome proliferator-activated receptors(PPARs)regulate lipid metabolism,glucose homeostasis and inflammatory responses within the ***,their dysfunction is a major contributor to the progression of *** is an oral,dual PPARαandδ*** effectiveness of elafibranor in the treatment of ALD remains *** this letter,we emphasize the harm of ALD and the burden it places on ***,we summarize the clinical management of all stages of ALD and present new insights into its pathogenesis and potential therapeutic ***,we discuss the mechanisms of action of PPARαandδagonists,the significance of their antifibrotic effects on ALD and future research directions.
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