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In vitro degradation of MAO/PLA coating on Mg-1.21Li-1.12Ca-1.0Y alloy

Frontiers of Materials Science 2014年第4期8卷 343-353页

作者： Rong-Chang ZENG Wei-Chen QI Ying-Wei SONG qin-kun he Hong-Zhi CUI En-Hou HAN College of Materials Science and Engineering Shandong University of Science and Technology Qingdao 266590 China State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology Qingdao 266590 China National Engineering Center for Corrosion Control Institute of Metals Research Chinese Academy of Sciences Shenyang 110016 China

Magnesium and its alloys are promising biomaterials due to their biocompatibility and osteoinduction. The plasticity and corrosion resistance of commercial magnesium alloys cannot meet the requirements for degradable biomaterials completely at present. Particularly, the alkalinity in the microenvironment surrounding the degradation, implants, resulting from the arises a major concern. Micro arc oxidation （MAO） and poly（lactic acid）（PLA） composite （MAO/PLA）coating on biomedical Mg- 1.21Li-1.12Ca-1.0Y alloy was prepared to manipulate pH variation in an appropriate range. Surface morphologies were discerned using SEM EMPA. AM corrosion resistance was evaluated via electrochemical Polarization and impedance and hydrogen volumetric method. The results demonstrated that the MAO coating predomlnantly consisted of MgO, Mg2SiO4 and YzO3. The composite coating markedly improved the corrosion resistance of the alloy. The rise in solution pH for the MAO/PLA coating was tailored to a favorable range of 7.5-7.8 The neutrallzation caused by the alkalinity of MAO and Mg substrate and acidification of PLA was probed. The reSult designates that MAOI PLA composite coating on Mg-1.21Li-1.12Ca-1.0Y alloys may be a promising biomedical coating.

关键词： magnesium alloy micro.arc oxidation (MAO) poly(lactic acid)(PLA) biomaterial degradation

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen qin Xuebing Yan kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu Xian qin kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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Development of a daily soil moisture product for the period of2002–2011 in Chinese mainland

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Science China Earth Sciences 2020年第8期63卷 1113-1125页

作者： kun YANG Yingying CheN Jie he Long ZHAO Hui LU Jun qin Donghai ZheNG Xin LI Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China National Tibetan Plateau Data Center Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China School of Geographical Sciences Southwest UniversityChongqing 400715China

Soil moisture is an essential climate variable(ECV) concerned widely. Due to its high spatial variability, it is costly to measure soil moisture at tens of kilometers scale. In this study, a ten-year(2002–2011) daily soil moisture dataset at 0.25° spatial resolution for Chinese mainland was produced through assimilating the Advanced Microwave Scanning Radiometer for Earth Observing System(AMSR-E) brightness temperature(TB) data into a land surface model(LSM). The obtained soil moisture data was evaluated against soil moisture-measuring networks deployed in two wet areas and one dry area of the Tibetan *** results show that for the wet areas the accuracy of the soil moisture product obtained from the assimilation is considerably higher than that of both AMSR-E official soil moisture products and land surface simulation results, and for the dry area their accuracy is comparable to each other. The spatial pattern of the soil moisture from the new product is consistent with that of soil porosity from an independent survey-based dataset, further confirming the credibility of the new product. According to this product, the transition regions in China show stronger seasonal variation of soil moisture than dry and wet regions, and drier regions have stronger inter-annual variability of soil moisture than wetter regions, particularly during transitional seasons(spring and autumn). The soil moisture product is accessible at the National Tibetan Plateau Data Center.

关键词： Soil moisture Microwave signal Data assimilation Spatiotemporal variability Tibetan Plateau

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Functional conservation and divergence of miR156 and miR529 during rice development

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The Crop Journal 2023年第3期11卷 692-703页

作者： Yan Li Yizhou he Tian qin Xuelian Guo kun Xu Chunxue Xu Wenya Yuan State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-ResourcesSchool of Life SciencesHubei UniversityWuhan 430062HubeiChina Oil Crops Research Institute of Chinese Academy of Agricultural Sciences Wuhan 430062HubeiChina Wuhan City Vocational College Wuhan 430064HubeiChina

MicroRNAs(miRNAs)are important regulatory elements involved in the regulation of various plant developmental and physiological processes by blocking the expression of target ***156 and miR529 are two combinatorial regulators,which cooperatively target the SQUAMOSA PROMOTER BINDING-LIKE(SPL)family ***,there has been no report about the functional conservation and divergence of miR156 and miR529 during plant development to *** this study,the biological function and relationship of miR156,miR529 and their target Os SPL14 in rice were *** of miR156e or miR529a(miR156e-OE and miR529a-OE)increased the grain size and tiller number but decreased the plant height and panicle length,while an opposite phenotype was observed for their target mimicry(miR156-MIMIC and miR529a-MIMIC)transgenic ***-loop RT-PCR results revealed ubiquitous expression of miR156 in roots,axillary buds and leaves,while miR529 was preferentially expressed in the ***,Os SPL14 could be preferentially and precisely cleaved by miR529a in young panicle but by miR156 in vegetative *** plants generated by the target immune strategy exhibited obvious growth defects upon the blocking of miR156 and/or miR529 function in rice,confirming that both miR156 and miR529 play important roles in controlling rice growth and ***,the miR156/miR529-Os SPL14 module negatively controlled grain size by regulating the genes associated with grain size and cell cycling,and controlled plant height through a more complicated *** together,our results demonstrate that miR156 and miR529 respectively function dominantly in the vegetative stage and reproductive stage to control rice growth and development by regulating the accumulation of Os *** findings facilitate a better understanding of the functional conservation and divergence of miR156 and miR529 family in the miRNA combinatorial regulatory network of plants.

关键词： MiRNA OsSPL14 Tiller number Grain size Oryza sativa

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Computation of Five-Dimensional Grain Boundary Energy

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Acta Metallurgica Sinica(English Letters) 2015年第5期28卷 634-640页

作者： Yong-kun Luo Rong-Shan qin Department of Materials Imperial College London

Abstract A broken-bond type computational method has been developed for the calculation of the five-dimensional grain boundary energy. The model allows quick quantification of the unrelaxed five-dimensionally specified grain boundary energy in arbitrary orientations. It has been validated on some face-centred cubic metals. The stereo projections of grain boundary energy of ∑3,∑5,∑7, ∑9, ∑11, ∑17b and ∑31a have been studied. The results of Ni closely resemble experimentally determined grain boundary energy distribution figures, suggesting that the overall anisotropy of grain boundary energy can be reasonably approximated by the present simple model. Owing to the overlooking of relaxation matter, the absolute values of energy calculated in present model are found to be higher than molecular dynamic-based results by a consistent magnitude, which is 1 J/m2 for Ni. The coverage of present method forms a bridge between atomistic and meso-scale simulations regarding polycrystalline microstructure.

关键词： Boundaries Grain boundary energy Grain boundary structure

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Gapless vortex bound states in superconducting topological semimetals

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National Science Review 2023年第2期10卷 139-145页

作者： Yi Zhang Shengshan qin kun Jiang Jiangping Hu Department of Physics Shanghai University Kavli Institute of Theoretical Sciences University of Chinese Academy of Sciences Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Collaborative Innovation Center of Quantum Matter

We find that the vortex bound states in superconducting topological semimetals are gapless owing to topological massless excitations in their normal *** demonstrate this univers al result in a variety of semimetals,including Dirac and Weyl semimetals,three-fold degenerate spin-1 fermions,spin-3/2Rarita-Schwinger-Weyl fermion semimetals and other exotic fermion *** formation of these gapless bound states is closely related to their Andreev specular refle ction and propagating Andreev modes in π-phase superconductor-normal metal-superconductor *** further demonstrate that these gapless states are topologically protected and can be derived from a topological pumping process.

关键词： superconductivity superconducting vortices topological semimetals Andreev reflection

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Impact of evolution of cathode electrolyte interface of Li(Ni0.8Co0.1Mn0.1)O2 on electrochemical performance during high voltage cycling process

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Journal of Energy Chemistry 2020年第8期29卷 72-78,I0003页

作者： Wei Wang qin Yang kun Qian Baohua Li Engineering Laboratory for Next Generation Power and Energy Storage Batteries Graduate School at ShenzhenTsinghua UniversityShenzhen 518055GuangdongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

In this work, the electrochemical performance of LiNi0.8Co0.1Mn0.1O2(NCM811) has been investigated after cycling with various upper cutoff voltages. Noteworthily, electrochemical impedance of NCM811 declined with the increasing cycle number to high voltages. It was found that the decline of charge transfer impedance could be related to the structural and compositional change of cathode electrolyte interphase(CEI) of NCM811 when charging to high voltages, based on the characterization of electrochemical impedance spectroscopy(EIS), X-ray photoelectron spectroscopy(XPS) and transmission electron microscopy(TEM). The corresponding mechanism has also been proposed in this study. Specifically, due to the increasing roughness of cathode surface, the bottom of CEI film and cubic phase on cathode surface form a transition region mainly at high voltages, leading to the nonobvious boundary. This newly formed transition region at high voltages could promote the Li ion diffusion from electrolyte to cathode, then reducing charge transfer impedance. Additionally, the decrease of Li F on the surface of the cathode could also make a contribution to lower the interface impedance. This study delivers a different evolution of CEI on NCM811, and the impact of CEI evolution on electrochemical performance when charging to a high voltage.

关键词： Cathode electrolyte interface NCM811 Overcharge Rock salt phase

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Calculate Joint Probability Distribution of Steady Directed Cyclic Graph with Local Data and Domain Casual Knowledge

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China Communications 2018年第7期15卷 146-155页

作者： qin Zhang kun Qiu Zhan Zhang School of Computer Science and Engineering Beihang University Tsingrui Intelligence Technology Ltd.

It is desired to obtain the joint probability distribution(JPD) over a set of random variables with local data, so as to avoid the hard work to collect statistical data in the scale of all variables. A lot of work has been done when all variables are in a known directed acyclic graph(DAG). However, steady directed cyclic graphs(DCGs) may be involved when we simply combine modules containing local data together, where a module is composed of a child variable and its parent variables. So far, the physical and statistical meaning of steady DCGs remain unclear and unsolved. This paper illustrates the physical and statistical meaning of steady DCGs, and presents a method to calculate the JPD with local data, given that all variables are in a known single-valued Dynamic Uncertain Causality Graph(S-DUCG), and thus defines a new Bayesian Network with steady DCGs. The so-called single-valued means that only the causes of the true state of a variable are specified, while the false state is the complement of the true state.

关键词： directed cyclic graph probabilistic reasoning parameter learning causality complex network

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Remote sensing of cyanobacterial blooms in inland waters: present knowledge and future challenges

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Science Bulletin 2019年第20期64卷 1540-1556页

作者： kun Shi Yunlin Zhang Boqiang qin Botian Zhou Taihu Laboratory for Lake Ecosystem Research State Key Laboratory of Lake Science and EnvironmentNanjing Institute of Geography and LimnologyChinese Academy ofSciencesNanjing210008China University of Chinese Academy of Sciences Beijing100049China Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing100101China Chongqing Key Laboratory of Big Data and Intelligent Computing Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing400714China

Timely monitoring, detection and quantification of cyanobacterial blooms are especially important for controlling public health risks and understanding aquatic ecosystem dynamics. Due to the advantages of simultaneous data acquisition over large geographical areas and high temporal coverage, remote sensing strongly facilitates cyanobacterial bloom monitoring in inland waters. We provide a comprehensive review regarding cyanobacterial bloom remote sensing in inland waters including cyanobacterial optical characteristics, operational remote sensing algorithms of chlorophyll, phycocyanin and cyanobacterial bloom areas, and satellite imaging applications. We conclude that there have many significant progresses in the remote sensing algorithm of cyanobacterial pigments over the past 30 years. The band ratio algorithms in the red and near-infrared(NIR) spectral regions have great potential for the remote estimation of chlorophyll a in eutrophic and hypereutrophic inland waters, and the floating algae index(FAI) is the most widely used spectral index for detecting dense cyanobacterial blooms. Landsat, MODIS(Moderate Resolution Imaging Spectroradiometer) and MERIS(MEdium Resolution Imaging Spectrometer) are the most widely used products for monitoring the spatial and temporal dynamics of cyanobacteria in inland waters due to the appropriate temporal, spatial and spectral resolutions. Future work should primarily focus on the development of universal algorithms, remote retrievals of cyanobacterial blooms in oligotrophic waters, and the algorithm applicability to mapping phycocyanin at a large spatial-temporal scale. The applications of satellite images will greatly improve our understanding of the driving mechanism of cyanobacterial blooms by combining numerical and ecosystem dynamics models.

关键词： Cyanobacterial blooms Inland waters Bio-optical properties Satellite MODIS

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