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Development and parentage analysis of SNP markers for Chestnut-vented Nuthatch(Sitta nagaensis)based on ddRAD-seq data

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Avian Research 2024年第2期15卷 271-278页

作者： Qingmiao Yuan Xi Lu Ruixin mo Xianyin Xu Xu Luo Yubao Duan Key Laboratory for Conserving Wildlife with Small Populations in Yunnan Southwest Forestry UniversityKunming 650224China Key Laboratory for Forest Resources Conservation and Utilization in the Southwest mountains of China Ministry of EducationSouthwest Forestry UniversityKunming 650224China Key Laboratory of Forest Disaster Warning and Control of Yunnan Province Southwest Forestry UniversityKunming 650224China College of Forestry Southwest Forestry UniversityKunming 650224China Administration of Zixi mountain Provincial Nature Reserve Chuxiong 675008China

Extra-pair paternity(EPP)is commonly found in socially monogamous birds,especially in small passerine birds,and there are interspecific and intraspecific variations in the extent of EPP.The Chestnut-vented Nuthatch(Sitta nagaensis)is a socially monogamous passerine bird,and verifying whether this species has EPP relies on parentage testing-S.nagaensis is not known to have EPP.In this study,we developed SNP markers of this species that are informative for parentage analysis from double digest restriction site-associated DNA sequencing(ddRAD-seq)data.A panel consisting of 50 SNP markers,with a mean heterozygosity of 0.343,was used to resolve 95% of nestlings to fathers.The combined exclusion probabilities for the first parent and second parent were 0.991 and 0.9999,respectively.This panel of SNP markers is a powerful tool for parentage assignments in S.nagaensis.In addition,we found that three offspring(7.9%)from three nests(23.1%)were the result of extra-pair fertilization out of 38 offspring in 13 nests.Our study provided information on parentage analysis that has not been reported before in S.nagaensis.It also supplemented the understudied EPP behavior of birds in Asia,contributing to a general understanding of the EPP behaviors of birds.

关键词： Chestnut-vented Nuthatch ddRAD sequencing Extra-pair paternity Parentage analysis SNPs

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Regulated polarization degree of upconversion luminescence and multiple anti-counterfeit applications

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Rare Metals 2024年第5期43卷 2172-2183页

作者： Dong-Ping Wen Ping Chen Yi liang Xiao-Ming mo Cao-Feng Pan Center On Nanoenergy Research Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and Technology Guangxi University Key Laboratory of Micronano Energy and Sensor CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences

Polarization upconversion luminescence（PUCL） of lanthanide ions (Ln3+) has been widely used in single particle tracking,microfluidics detection,three-dimensional displays,and so on.However,no effective strategy has been developed for modulating PUCL.Here we report a strategy to regulate PUCL in Ho3+-doped NaYF4single nanorods based on the number of upconversion photons.By constructing a multiphoton upconversion system for Ho3+,we regulate the degree of polarization （DOP） of PUCL from 0.590 for two-photon luminescence to 0.929 for three-photon upconversion luminescence （UCL）.Furthermore,our strategy is verified from cross-relaxation between Ho3+and Yb3+,excitation wavelength,excitation power density,and local site symmetry.And this regulation strategy of PUCL has also been achieved in Tm3+,with the DOP ranging from 0.233 for two-photon luminescence to 0.925 for four-photon UCL Besides,multi-dimensional anti-counterfeiting display has been explored with PUCL.This work provides an effective strategy for regulating PUCL and also provides more opportunities for the development of polarization display optical encoding,anti-counterfeiting,and integrated optical devices.

关键词： Polarization upconversion luminescence Degree of polarization Population density of excited state Number of upconversion photons Polarization anti-counterfeiting display

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Reconstruction using artificial intelligence,a promising way to explore the cosmic web

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 179-179页

作者： Houjun mo Department of Astronomy University of MassachusettsAmherst MA 01003USA

One of the most important goals in modern cosmology is to understand the large-scale mass distribution of the universe(the cosmic web),and how galaxies form and evolve in the ecosystem of the cosmic web.Observationally this is done by large redshift surveys of galaxies,which can be used to trace the large-scale structure and to sample the properties of galaxies.

关键词： galaxies cosmic universe

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Bioinspired Closed-loop CPG-based Control of a Robotic Manta for Autonomous Swimming

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Journal of Bionic Engineering 2024年第1期21卷 177-191页

作者： Yiwei Hao Yonghui Cao Yingzhuo Cao Xiong mo qiaogao Huang Lei Gong Guang Pan Yong Cao School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China Unmanned Vehicle Innovation Center Ningbo Institute of NPUNingbo 315103China Key Laboratory of Unmanned Underwater Vehicle Technology of Ministry of Industry and Information Technology Xi'an 710072China

Fish in nature exhibit a variety of swimming modes such as forward swimming,backward swimming,turning,pitching,etc.,enabling them to swim in complex scenes such as coral reefs.It is still difficult for a robotic fish to swim autonomously in a confined area as a real fish.Here,we develop an untethered robotic manta as an experimental platform,which consists of two flexible pectoral fins and a tail fin,with three infrared sensors installed on the front,left,and right sides of the head to sense the surrounding obstacles.To generate multiple swimming modes of the robotic manta and online switching of different modes,we design a closed-loop Central Pattern Generator(CPG)controller based on distance information and use a combination of phase difference and amplitude of the CPG model to achieve stable and rapid adjustment of yaw angle.To verify the autonomous swimming ability of the robotic manta in complex scenes,we design an experimental scenario with a concave obstacle.The experimental results show that the robotic manta can achieve forward swimming,backward swimming,in situ turning within the concave obstacle,and finally exit from the area safely while relying on the perception of external obstacles,which can provide insight into the autonomous exploration of complex scenes by the biomimetic robotic fish.Finally,the swimming ability of the robotic manta is verified by field tests.

关键词： Biomimetic robotic manta Central Pattern Generator Closed-loop control Backward swimming

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Coupling WO_(3-x) dots-encapsulated metal-organic frameworks and template-free branched polymerization for dual signal-amplified electrochemiluminescence biosensing

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Chinese Chemical Letters 2024年第4期35卷 469-474页

作者： Fei Yin Erli Yang Xue Ge Qian Sun Fan mo Guoqiu Wu Yanfei Shen Medical School Southeast UniversityNanjing 210009China Center of Clinical Laboratory Medicine Zhongda HospitalSoutheast UniversityNanjing 210009China Jiangsu Provincial Key Laboratory of Critical Care Medicine Southeast UniversityNanjing 210009China

Developing accurate and sensitive DNA methyltransferase(MTase) analysis methods is essential for early clinical diagnosis and development of antimicrobial drug targets. In this work, by coupling WO_(3-x) dotsencapsulated metal-organic frameworks(moFs) as co-reactants and terminal deoxynucleotidyl transferase(Td T)-mediated template-free branched polymerization, a dual signal-amplified electrochemiluminescent(ECL) biosensor was constructed to detect DNA adenine methylation(Dam) MTase. The employment of WO_(3-x) dots-encapsulated moFs(i.e., NH_(2)-UIO66@WO_(3-x) ) was not only beneficial for biomolecule conjugation because of the abundant amino groups but also led to a 7-fold enhanced ECL response due to the increased loading of WO_(3-x). moreover, Td T-mediated template-free branched polymerization promoted the capture of ECL emitters on the electrode surface, achieving 20-fold enhanced signal amplification. The presented ECL biosensor demonstrated a low detection limit of 2.4 × 10^(-4)U/m L, and displayed high reliability for the detection of Dam MTase in both spiked human serum and E. coli cell samples, and for the screening of potential inhibitors. This study opens a new avenue for designing a dual signal amplificationbased ECL bioassay for Dam MTase and screening inhibitors in the fields of clinical diagnosis and drug development.

关键词： Dual signal-amplified electrochemiluminescence WO_(3-x)dots moFs Template-free branched polymerization DNA methyltransferase

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Sulfated Cyclocarya paliurus polysaccharides exert immunomodulatory potential on macrophages via Toll-like receptor 4 mediated MAPK/NF-κB signaling pathways

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Food Science and Human Wellness 2024年第1期13卷 115-123页

作者： Yue Yu Haibin Zhu Mingyue Shen Qiang Yu Yi Chen Shiru mo Jianhua Xie State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China International Institute of Food Innovation Nanchang UniversityNanchang 330200China

The biological activity of plant polysaccharides can be enhanced by sulfated modification.In this study,the immunomodulatory effect of sulfated Cyclocarya paliurus polysaccharides(SCP3)on macrophages RAW264.7 and its potential molecular mechanism were investigated.Results showed that SCP3 at 25-100μg/m L increased viability and improved phagocytosis of RAW264.7 cells.Meanwhile,SCP3 could activate mitogen-activated protein kinase(MAPK)and nuclear factor kappa B(NF-κB)signaling pathways,which increased the phosphorylation of Erk1/2,JNK,p38 and NF-κB p65,promoting secretion of cytokines tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and nitric oxide(NO)as well as the production of reactive oxygen species(ROS).In addition,Toll-like receptor 4(TLR4)receptor inhibitors were able to block the production of NO and TNF-αby SCP3-stimulated macrophages.Based on Western blot analysis and validation using specific inhibitors against MAPK and NF-κB signaling pathways,the results demonstrated that SCP3 induced macrophages activation and enhanced TNF-αand NO production via TLR4-mediated MAPK and NF-κB pathways.In summary,SCP3 has significant immunomodulatory potential.The underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production,which in turn activates the downstream MAPK/NF-κB signaling pathway and then increases the secretion levels of cytokines and NO.

关键词： Cyclocarya paliurus Sulfated polysaccharides Macrophages Immunomodulatory Mechanism

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Exploring noncoding variants in genetic diseases:from detection to functional insights

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Journal of Genetics and Genomics 2024年第2期51卷 111-132页

作者： Ke Wu Fengxiao Bu Yang Wu Gen Zhang Xin Wang Shunmin He mo-Fang liu Runsheng Chen Huijun Yuan Institute of Rare Diseases West China Hospital of Sichuan UniversityChengduSichuan 610041China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China Key Laboratory of RNA Biology Center for Big Data Research in HealthInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of molecular Biology State Key Laboratory of Cell BiologyShanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China

Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and functional genomics tools has enabled the systematic identification of functional noncoding variants. These variants can impact gene expression, regulation, and chromatin conformation, thereby contributing to disease pathogenesis. Understanding the mechanisms that underlie the impact of noncoding variants on genetic diseases is indispensable for the development of precisely targeted therapies and the implementation of personalized medicine strategies. The intricacies of noncoding regions introduce a multitude of challenges and research opportunities. In this review, we introduce a spectrum of noncoding variants involved in genetic diseases, along with research strategies and advanced technologies for their precise identification and in-depth understanding of the complexity of the noncoding genome. We will delve into the research challenges and propose potential solutions for unraveling the genetic basis of rare and complex diseases.

关键词： Noncoding variation Genetic disease Research approach Challenge

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自回归神经网络的预测值反馈再训练策略及应用

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东南大学学报（自然科学版） 2024年第3期54卷 738-746页

作者：莫正阳李益国东南大学大型发电装备安全运行与智能测控国家工程研究中心南京210096

为提高非线性自回归神经网络(NARX-NN)的多步预测性能,提出了一种预测值反馈再训练(FR)策略.首先采用常规训练策略对NARX-NN进行训练,然后利用模型的单步预测结果替换实测值,得到重构训练集,并指导网络再次训练.为验证FR的有效性,将其... 详细信息

为提高非线性自回归神经网络(NARX-NN)的多步预测性能,提出了一种预测值反馈再训练(FR)策略.首先采用常规训练策略对NARX-NN进行训练,然后利用模型的单步预测结果替换实测值,得到重构训练集,并指导网络再次训练.为验证FR的有效性,将其应用于3种典型的NARX-NN模型:非线性自回归深度神经网络(NARX-DNN)、基于长短期记忆网络的编码器-解码器(LSTMED)和深度自回归网络(DeepAR),以预测燃煤锅炉NO_(x)质量浓度或综合能源系统电负荷.与常规训练策略和计划采样的对比结果表明,采用FR的NARX-NN具有最高的多步预测精度,其中,LSTMED对NO_(x)质量浓度前向15步预测的平均绝对百分比误差(MAPE)为4.01%;DeepAR对电负荷前向24步预测的平均MAPE为4.34%.配对样本T检验结果表明,FR对NARX-NN的多步预测性能提升具有显著性.通过保持训练阶段和预测阶段输入的一致性,FR有效提升了NARX-NN模型的多步预测精度.

关键词：神经网络多步预测训练策略 NO_(x)质量浓度电负荷

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Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study

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Research 2024年第1期2023卷 721-733页

作者： Miao liu Haiqing Zhang Zhichao Wang Tingting mo Xuefeng Lai Yaling He Minghui Jiang Meian He Weijia Kong Tangchun Wu Xiaomin Zhang Department of Occupational and Environmental Health Ministry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was lacking.The present study included 15,827 participants from the Dongfeng–Tongji cohort study.Genetic risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing loss.We conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with PRS.Results showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 p.***.to 10:00 p.***.compared to those with bedtime>10:00 p.***.to 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.

关键词： Middle hearing fen

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北京湿地生态系统服务价值测度及演变分析

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生态与农村环境学报 2024年第6期40卷 749-756页

作者：莫丽春华北科技学院经济管理学院北京065201

湿地生态系统服务价值的精准评估可为决策者平衡生态环境和经济发展之间的关系提供决策依据。该文通过市场价值法、重置成本法、旅行价值法等多种经济评估方法来估算湿地生态系统服务价值。研究结果表明:1984—2020年,北京湿地生态系统... 详细信息

湿地生态系统服务价值的精准评估可为决策者平衡生态环境和经济发展之间的关系提供决策依据。该文通过市场价值法、重置成本法、旅行价值法等多种经济评估方法来估算湿地生态系统服务价值。研究结果表明:1984—2020年,北京湿地生态系统服务价值量呈波段式增长,由1984年的532.66亿元增长到2020年的1856.55亿元,其中20世纪90年代湿地生态系统服务价值快速增加,但随着社会经济发展的影响而大幅下降。2004年后湿地生态系统服务价值开始逐年提升,且维持高位水平。单项价值中北京湿地气候调节和调蓄洪水服务价值最高,休闲旅游服务价值量呈指数形增长,其他各项湿地生态系统服务价值相对稳定。研究结果可为未来城市规划和生态保护提供重要参考。

关键词：湿地生态系统服务价值测度演变变化率

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