检索结果-南通市图书馆

Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis

World Journal of Emergency Medicine 2024年第1期15卷 35-40页

作者： Wei Zhou Maiying Fan Xiang li fang Yu En Zhou Xiaotong Han Department of Emergency Medicine the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China Department of Otolaryngology-head and Neck Surgery the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China

BACKGROUND:Xuebijing(XBJ)can alleviate the inflammatory response,improve organ function,and shorten the intensive care unit(ICU)stay in patients with pyogenic liver abscess(PLA)complicated with sepsis,but the molecular mechanisms have not been *** study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology ***:The active ingredients and targets of XBJ were retrieved from the ETCM *** targets related to PLA and sepsis were retrieved from the GeneCards,PharmGKB,DisGeNet,Online Mendelian Inheritance in Man(OMIM),Therapeutic Targets Database(TTD),and DrugBank *** targets of PLA complicated with sepsis were mapped to the targets of XBJ to identify potential treatment ***-protein interaction networks were analyzed using the STRING *** treatment targets were imported into the Metascape platform for Gene Ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** docking was performed to validate the interactions between active ingredients and core ***:XBJ was found to have 54 potential treatment targets for PLA complicated with ***-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor(TNF)were identifi ed as core *** enrichment analysis revealed important pathways,including the interleukin-17(IL-17)signaling pathway,the TNF signaling pathway,the nuclear factor-kappa B(NF-κB)signaling pathway,and the Toll-like receptor(TLR)signaling *** docking experiments indicated stable binding between XBJ active ingredients and core ***:XBJ may exert therapeutic eff ects on PLA complicated with sepsis by modulating signaling pathways,such as the IL-17,TNF,NF-κB,and TLR pathways,and targeting IL-1β,IL-6,and TNF.

关键词： Xuebijing injection Pyogenic liver abscess Sepsis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research on the identification of the production origin of Angelica dahurica using liBS technology combined with machine learning algorithms

引用

Optoelectronics Letters 2024年第3期20卷 171-176页

作者： SUN Jiaxing li Honglian YAO Yuhang YAN Qiongyan DONG fang College of Quality and Technology Supervising Hebei UniversityBaoding 071000China National and Local Joint Engineering Center of Measuring Instruments and Metrology Systems Baoding 071000China Key Laboratory of Energy Measurement and Safety Detection Technology in Hebei Province Baoding 071000China

The origin of Angelica dahurica medicinal herbs varies, and their pharmacological effects also differ. In order to achieve rapid and accurate identification of the origin of Angelica dahurica medicinal herbs, this study utilizes laser induced breakdown spectroscopy(liBS) technology combined with machine learning algorithms to identify the original source of Angelica dahurica. Sliced samples of Angelica dahurica were taken from four regions: Hebei, Henan, Zhejiang, and Sichuan. The spectral data from the sliced samples were used as features, and different algorithms including support vector machine(SVM), back propagation(BP) neural network, genetic algorithm-back propagation(GA-BP) neural network, particle swarm optimization-back propagation(PSO-BP) neural network, convolutional neural network(CNN), and CNN-SVM were employed to classify the origin of Angelica dahurica samples.

关键词： neural origin network

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laser manufacturing of spatial resolution approaching quantum limit

引用

light(Science & Applications) 2024年第3期13卷 421-428页

作者： Xiao-Jie Wang Hong-Hua fang Zhen-Ze li Dan Wang Hong-Bo Sun State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China

Atomic and close-to-atom scale manufacturing is a promising avenue toward single-photon emitters,single-electron transistors,single-atom memory,and quantum-bit devices for future communication,computation,and sensing *** manufacturing is outstanding to this end for ease of beam manipulation,batch production,and no requirement for *** is,however,suffering from optical diffraction ***,we report a spatial resolution improved to the quantum limit by exploiting a threshold tracing and lock-in method,whereby the two-order gap between atomic point defect complexes and optical diffraction limit is surpassed,and a feature size oflications.

关键词： quantum limit resolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improving flangeability of multiphase steel by increasing microstructural homogeneity

引用

Journal of Iron and Steel Research International 2024年第7期31卷 1736-1745页

作者： Xiao-yu Yang Yong-gang Yang Xing fang Han-long Zhang Zhen-li Mi Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Engineering TechnologyUniversity of Science and Technology BeijingBeijing 100083China Shanghai Baosteel Group Corp.Technology Center Shanghai 201900China

Multiphase microstructure significantly increases the strength,usually at the expense of flangeability because of lacking microstructure *** further improve the strength-flangeability of multiphase steel,the microstructural homogeneity was advanced by adjusting the hard martensite/austenite(M/A)*** strength-flangeability was measured via uniaxial tensile tests and hole expansion *** microstructures were characterized using a scanning electron microscope equipped with an electron backscatter diffraction detector and a transmission electron *** tests were supplementally used to quantitatively reveal the microstructural homogeneity of the *** show that the adjusted multiphase steel achieves an excellent ultimate tensile strength(~800 MPa)and flangeability(~135%hole expansion ratio).A promising homogeneous multiphase microstructure was obtained by controlling undercooled austenite transformed at about 600℃.This microstructure consists of soft polygonal ferrite,blocky bainitic ferrite,and hard M/A *** volume fraction of M/A islands is around 5%,and the average size is less than l *** nanoindentation analysis indicated that the participation of M/A islands impressively influenced the microstructural *** strain partition and better mechanical compatibility were present in the adjusted multiphase steel since the plasticity initiation started late,which resulted in a positive ***,avoiding M/A islands distributed in the chain along the rolling direction on the matrix hindered the possibility of voids coalescing into cracks and stabilized the flanging performance.

关键词： Multiphase steel Flangeability Martensite/austenite island-Microstructural homogeneity-Microstructure Compact strip production process

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quasi-two dimensional Ruddlesden−Popper halide perovskites for laser applications

引用

Frontiers of physics 2024年第2期19卷 53-71页

作者： Kun Chen Qianpeng Zhang Yin liang Jiepeng Song Chun li Shi Chen fang li Qing Zhang School of Mechanical and Electrical Engineering Wuhan Institute of TechnologyWuhan 430205China School of Materials Science and Engineering Peking UniversityBeijing 100871China Institute of Applied Physics and Materials Engineering Macao UniversityMacao 999078China

Quasi-two-dimensional(2D)Ruddlesden‒Popper(RP)halide perovskites,as a kind of emerged two-dimensional layered materials,have recently achieved great attentions in lasing materials field owing to their large exciton binding energy,high emission yield,large optical gain,and wide-range tuning of optical *** review will introduce research progresses of RP halide perovskites for lasing applications in aspects of materials,photophysics,and devices with emphasis on emission and lasing properties tailored by the molecular composition and *** materials,structures and fabrications are introduced in the first ***,the optical transitions and amplified spontaneous emission properties are discussed from the aspects of electronic structure,exciton,gain dynamics,and interface ***,the research progresses on lasing devices are summarized and several types of lasers including VCSEL,DFB lasers,microlasers,random lasers,plasmonic lasers,and polariton lasers are *** last,the challenges and perspectives would be provided.

关键词： two-dimensional materials metal halide perovskite Ruddlesden−Popper halide perovskites lasing emission

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic Effect of Landslides Triggered by Earthquake:A Case Study in Moxi Town of Luding County,China

引用

Journal of Earth Science 2024年第1期35卷 221-234页

作者： Hongfu Zhou Fei Ye Wenxi Fu Bin liu Tian fang Rui li Chengdu Center China Geological SurveyChengdu 610081China State Key Laboratory of Hydraulics and Mountain Rivers Protection Sichuan UniversityChengdu 610065China Sichuan Geological Survey Chengdu610081China Shandong University of Science and Technology Qingdao 266590China

The dynamic effect is a very important issue widely debated by scholars when studying the genetic and disaster-causing mechanisms of earthquake-triggered ***,the dynamic effect mechanism and phenomena of earthquake-triggered landslides were summarized in this ***,the primary types of dynamic effects were further used to interpret the Mogangling landslide in Moxi Town of Luding County,China.A field investigation,remote sensing,numerical calculation and theoretical analysis were carried out to illustrate the failure mechanism of slope rock masses affected by *** interaction between seismic waves and slope rock masses and the induced dynamic effect of slope rock masses were primarily accounted for in the *** slope topography,rock mass weathering and unloading characteristics,river erosion,regional seismogenic structure,and rock mass structure characteristics were also *** results showed that the formation of the Mogangling landslide was mainly related to the high amplification effect of seismic acceleration and back slope effects,interface dynamic stress effects,and double-sided slope effects of seismic waves caused by the catastrophic Ms 7.75 Moxi Earthquake in *** principles for the site and route selection of large-scale infrastructure in the planning stage and the scientific prevention of seismic geological disasters were proposed on the basis of the dynamic effect of earthquake-induced landslides.

关键词： dynamic effect coupling of endogenic and exogenic processes landslides earthquakes disaster prevention

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nitrogen-doped titanium dioxide/schwertmannite nanocomposites as heterogeneous photo-Fenton catalysts with enhanced efficiency for the degradation of bisphenol A

引用

Journal of Environmental Sciences 2024年第9期143卷 1-11页

作者： Xing-Xing qiao Yu-Hang Xu Xiang-Ji liu Sai-Le Chen Zhou Zhong Ya-Feng li Jian Lü Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116China

Potential health risks related to environmental endocrine disruptors(EEDs)have aroused research hotspots at the forefront of water treatment ***,nitrogen-doped titanium dioxide/schwertmannite nanocomposites(N-TiO_(2)/SCH)have been successfully developed as heterogeneous catalysts for the degradation of typical EEDs via photo-Fenton *** to the sustainable Fe(Ⅲ)/Fe(Ⅱ)conversion induced by photoelectrons,as-prepared N-TiO_(2)/SCH nanocomposites exhibit much enhanced efficiency for the degradation of bisphenol A(BPA;ca.100% within 60 min under visible irradiation)in a wide pH range of 3.0-7.8,which is significantly higher than that of the pristine schwertmannite(ca.74.5%)or N-TiO_(2)(ca.10.8%).In this photo-Fenton system,the efficient degradation of BPA is mainly attributed to the oxidation by hydroxyl radical(·OH)and singlet oxygen(^(1)O_(2)).Moreover,the possible catalytic mechanisms and reaction pathway of BPA degradation are systematically investigated based on analytical and photoelectrochemical *** work not only provides a feasible means for the development of novel heterogeneous photo-Fenton catalysts,but also lays a theoretical foundation for the potential application of mineral-based materials in wastewater treatment.

关键词： Titanium dioxide Schwertmannite Fenton reaction Environmental endocrine disruptors Photocatalysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

城市湿地公园景观建设研究

引用

重庆建筑大学学报 2006年第6期28卷 18-23页

作者：张毅川乔丽芳陈亮明河南科技学院园林学院河南新乡453003 中南林业科技大学资源与环境学院湖南长沙410004

通过国内外城市湿地公园建设的实例说明了城市湿地公园的重要作用,并分析了城市湿地公园受到公众和城市建设者普遍欢迎的景观特质,包括自然生态特质———自然特色浓郁、景观丰富多样、生物多样性丰富、生态效益显著和功能复合全面,社... 详细信息

通过国内外城市湿地公园建设的实例说明了城市湿地公园的重要作用,并分析了城市湿地公园受到公众和城市建设者普遍欢迎的景观特质,包括自然生态特质———自然特色浓郁、景观丰富多样、生物多样性丰富、生态效益显著和功能复合全面,社会效益特质———游憩活动性质明确、历史文化内涵丰富和教育功能突出以及经济效益特质。针对我国部分城市湿地公园建设中存在的设置不分地域和条件、景观设计形式化、游憩活动城市化、忽视其它生命、“物种入侵”形势严峻、忽略教育意义等景观建设的误区,提出了城市湿地公园景观建设应遵循严格保护和恢复生物多样性、严格控制人类干扰、建设以生态学理论为指导、游憩活动主题化、建筑自然化生态化等重要原则。最后,对城市湿地公园景观建设中的概念设计和景观分区的构建进行了探讨。希望通过文中研究能对城市湿地公园的景观建设有一定的借鉴意义。

关键词：景观建设湿地公园城市

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cretaceous-Neogene Exhumation of the Daqing Shan,North China Constrained by Apatite Fission Track Thermochronology

引用

Journal of Earth Science 2024年第1期35卷 99-111页

作者： Junlin Zhou Yuhong li Wei Han Yunpeng Zhang Gaochao Chen qiao Zhang Jianshe Wei Yazhuo Niu Xi'an Center of China Geological Survey Xi an 710054China Northwest China Center for Center Geoscience Innovation Xi'an 710054China

The Daqing Shan(DQS)located in the Yinshan-Yanshan Orogenic Belt plays an important role in the Mesozoic to Cenozoic evolution of the North China ***,the cooling and exhumation history since the Cretaceous is still *** the apatite fission track(AFT)data in both this study and previous works,a three-stage exhumation history from Cretaceous to Neogene of the DQS is proposed.(1)The first stage is composed of the early exhumation during Early Cretaceous driven by the collision between the North China and Siberia cratons(ca.148-132 Ma)and the far-field effect of the subduction of the Pacific Plate(ca.132-114 Ma).(2)Due to the subsidence of the Hetao Basin and the subsequent compensation between the DQS and the Hetao Basin,the DQS experienced the second rapid exhumation from Early Eocene to Early Oligocene(ca.54-29 Ma).(3)Since the Late Miocene(ca.13.5 Ma),the third rapid cooling and exhumation of the DQS occurred due to the far-field effect of the uplift of the Tibetan Plateau and the subduction of the Pacific Plate.

关键词： Daqing Shan Hetao Basin Cretaceous-Neogene apatite geochronology apatite fission track cooling and exhumation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metal nanoparticles for cancer therapy:Precision targeting of DNA damage

引用

Acta Pharmaceutica Sinica B 2024年第3期14卷 1132-1149页

作者： Qian Chen Chunyan fang Fan Xia Qiyue Wang fangyuan li Daishun ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China World Laureates Association(WLA)Laboratories Shanghai 201203China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Cancer,a complex and heterogeneous disease,arises from genomic ***,DNA damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clinical ***,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical *** nanoparticles present promising avenues for enhancing each critical aspect of DNA damage-based cancer *** customizable physicochemical properties enable the development of targeted and personalized treatment *** this review,we delve into the design principles and optimization strategies of metal *** shed light on the limitations of DNA damage-based therapy while highlighting the diverse strategies made possible by metal *** encompass targeted drug delivery,inhibition of DNA repair mechanisms,induction of cell death,and the cascading immune ***,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle ***,we present insights into the challenges and future directions of metal nanoparticles in advancing DNA damage-based cancer therapy,paving the way for novel treatment paradigms.

关键词： DNA damage Metal nanoparticles Nucleus-targeting DNA repair inhibition Immune response Size optimization Stimuli-responsiveness Surface modification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：