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Upregulation of miR-345-5p suppresses cell growth of lung adenocarcinoma by regulating ras homolog family member A(RhoA)and Rho/Rho associated protein kinase(Rho/ROCK)pathway

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Chinese Medical Journal 2021年第21期134卷 2619-2628页

作者： qiao-Yun Zhou Shu-Yu Gui Peng zhang Mei Wang Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230011China Department of Respiratory Medicine Anhui No.2 Provincial People’s HospitalClinical College of Anhui Medical UniversityHefeiAnhui 230032China Department of Hyperbaric Oxygen Hefei Hospital Affiliated to Anhui Medical UniversityHefeiAnhui 230032China

Background:Microribose nucleic acids(miRNAs)are implicated in the progression of lung ***-345-5p(miR-345-5p)is a recently identified anti-oncogene in some human cancers,but its functional role and possible molecular mechanism in lung adenocarcinoma remain *** study aimed to identify the biological function and underlying mechanism of miR-345-5p in lung adenocarcinoma ***:In this study,lung adenocarcinoma tissues and adjacent tissues were collected in the First Affiliated Hospital of Anhui Medical University between April 2016 and February *** expression of miR-345-5p and ras homolog family member A(RhoA)in lung adenocarcinoma tissues and human lung adenocarcinoma cell lines(A549,H1650,PC-9,and H441)was detected by reverse transcription quantitative polymerase chain reaction *** assays including colony formation,flow cytometry analysis,wound healing,and transwell assays were performed to assess the proliferation,apoptosis,migration,and invasion of lung adenocarcinoma *** addition,RNA pulldown and luciferase reporter assays were conducted to evaluate the relationship between miR-345-5p and *** between the two groups was analyzed with Student’st test,while that among multiple groups was analyzed with one-way analysis of ***:MiR-345-5p expression displayed lower level in lung adenocarcinoma tissues(0.241±0.095vs.1.000±0.233,t=19.247,P<0.001)and cell lines(F=56.992,P<0.001)than control tissues and *** experiments demonstrated that upregulation of miR-345-5p inhibited the malignant phenotypes of lung adenocarcinoma cells via suppressing cell proliferation,migration,invasion,and facilitating cell ***,RhoA was verified to be the downstream target of *** of RhoA was downregulated by overexpression of miR-345-5p in PC-9(0.321±0.047vs.1.000±0.127,t=8.536,P<0.001)and H1650(0.398±0.054vs.1.000±0.156,t=4.429,P=0.011)*** assays reveal

关键词： MicroRNA-345-5p Lung adenocarcinoma Ras homolog family member A(RhoA) Rho/Rho-associated protein kinase(ROCK)

Parotid metastasis of rare lung adenocarcinoma:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1182-1189页

作者： Ru-Xi Yan Lin-Bo Dou Zi-Jia Wang Xue qiao Hong-Hai Ji Yan-Cong zhang School of Stomatology Weifang Medical UniversityWeifang 261000Shandong ProvinceChina Department of Stomatology Dezhou People’s HospitalDezhou 253000Shandong ProvinceChina Department of Stomatology Dezhou Women and Children's HospitalDezhou 253000Shandong ProvinceChina

BACKGROUND Lung cancer(LC)is the leading cause of malignancy-related deaths *** most common sites of metastasis include the nervous system,bone,liver,respiratory system,and adrenal *** metastasis in the parotid gland is very rare,and its diagnosis presents a ***,we report a case of parotid metastasis in primary *** SUMMARY The patient was a 74-year-old male who was discovered to have bilateral facial asymmetry inadvertently two years *** right earlobe was slightly swollen and without pain or *** tomography(CT)examination showed bilateral lung space-occupying *** biopsy was performed and revealed adenocarcinoma(right-upper-lung nodule tissue).Positron emission tomography-CT examination showed:(1)Two hypermetabolic nodules in the right upper lobe of the lung,enlarged hy-permetabolic lymph nodes in the right hilar and mediastinum,and malignant space-occupying lesion in the right upper lobe of the lung and possible metastasis to the right hilar and mediastinal lymph nodes;and(2)multiple hypermetabolic nodules in bilateral parotid *** puncture biopsy was performed considering lung adenocarcinoma *** detection of lung biopsy specimens revealed an EGFR gene 21 exon L858R *** This case report highlights the challenging diagnosis of parotid metastasis in LC given its rare *** lesions should be differentiated from primary tumors of the parotid *** radiological imaging is unreliable,and puncture biopsy is needed for final diagnosis of this condition.

关键词： Lung cancer Metastasis Parotid gland Pathology Positron emission tomography/computed tomography Case report

Analysis of the clinical efficacy of two-stage revision surgery in the treatment of periprosthetic joint infection in the knee:A retrospective study

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World Journal of Clinical Cases 2022年第36期10卷 13239-13249页

作者： Yong-Jie qiao Feng Li Lv-Dan zhang Xin-Yuan Yu Hao-Qiang zhang Wen-Bin Yang Xiao-Yang Song Rui-Ling Xu Sheng-Hu Zhou Department of Joint Surgery The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Orthopedics The 943rd Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyWuwei 733000Gansu ProvinceChina Department of Respiratory Medicine The 940^(th) Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina

BACKGROUND Periprosthetic joint infection(PJI)is a catastrophic complication that can occur following total knee arthroplasty(TKA).Currently,the treatment for PJI mainly includes the use of antibiotics alone,prosthetic debridement lavage,primary revision,secondary revision,joint fusion,amputation,*** To explore the clinical effect of two-stage revision surgery for the treatment of PJI after *** The clinical data of 27 patients(3 males and 24 females;age range,47–80 years;mean age,66.7±8.0 years;27 knees)with PJI treated with two-stage revision surgery in our hospital between January 1,2010 and December 31,2020 were analyzed *** following outcomes were compared for changes between preoperative and last follow-up results:Erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),visual analogue scale(VAS)scores,Hospital for Special Surgery(HSS)scores,knee range of motion(ROM),and infection cure *** All 27 patients were followed up(range,13–112 mo).The ESR(14.5±6.3 mm/h)and CRP(0.6±0.4 mg/dL)of the patients at the last follow-up were significantly lower than those at admission;the difference was statistically significant(P<0.001).The postoperative VAS score(1.1±0.7),HSS score(82.3±7.1),and knee ROM(108.0°±19.7°)were significantly improved compared with those before the surgery;the difference was statistically significant(P<0.001).Of the 27 patients,26 were cured of the infection,whereas 1 case had an infection recurrence;the infection control rate was 96.3%.CONCLUSION Two-stage revision surgery can effectively relieve pain,control infection,and retain good joint function in the treatment of PJI after TKA.

关键词： Total knee arthroplasty Periprosthetic joint infection Two-stage Revision Antibiotic therapy

Atomic multicast protocol for intrusion-tolerance based on trusted timely computing base

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 97-102页

作者： ZHOU Hua,MENG Xiang-ru,zhang Li,qiao Xiang-dong Telecommunication Engineering Institute,Air Force Engineering University,Xi’an 710077,China [a] Telecommunication Engineering Institute Air Force Engineering University Xi'an 710077 China

Distributed architecture is often adopted for the intrusion-tolerance system ***,this distributed intrusiontolerance system has a consensus *** solve this problem,this article explores a distributed intrusion-tolerance system of hybrid time model based on trusted timely computing base（TTCB） and implement an atomic multicast protocol using TTCB *** TTCB is a trust secure real-time component inside the server,with a well defined interface and separated from the operation *** is in the synchronous communication environment,while the application layer in the server works *** the atomic multicast protocol,it can be achieved that when the servers are over twice the number of faulty servers,the consensus can be *** performance evaluations show that the proposed protocol can yield larger good throughput with a lower unavailability.

关键词： Intrusion-tolerance atomic multicast protocol consensus TTCB network security

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正交多智能体算法求解管网直接优化调度模型

哈尔滨工业大学学报 2008年第4期40卷 644-649页

作者：陈磊张土乔浙江工业大学市政工程系杭州310014 浙江大学市政工程研究所杭州310027

针对传统遗传算法存在高维空间寻优能力较差的问题,提出采用正交多智能体算法求解管网直接优化调度模型.对智能体的随机初始种群进行正交操作,得到较优初始种群,通过智能体的竞争和自学习,找到较优解.结果表明:与正交自适应遗传算法相比... 详细信息

针对传统遗传算法存在高维空间寻优能力较差的问题,提出采用正交多智能体算法求解管网直接优化调度模型.对智能体的随机初始种群进行正交操作,得到较优初始种群,通过智能体的竞争和自学习,找到较优解.结果表明:与正交自适应遗传算法相比,正交多智能体算法具有更强全局搜索能力和更快寻优速度,并且正交多智能体算法优化方案较大提高了水泵运行效率,可节电2.96%.

关键词：正交设计多智能体算法供水系统直接优化调度模型

A new generation M^(pro)inhibitor with potent activity against SARS-CoV-2 Omicron variants

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1970-1982页

作者： Chong Huang Huiping Shuai Jingxin qiao Yuxin Hou Rui Zeng Anjie Xia Lingwan Xie Zhen Fang Yueyue Li Chaemin Yoon qiao Huang Bingjie Hu Jing You Baoxue Quan Xiu Zhao Nihong Guo Shiyu zhang Ronggang Ma Jiahao zhang Yifei Wang Ruicheng Yang Shanshan zhang Jinshan Nan Haixing Xu Falu Wang Jian Lei Hin Chu Shengyong Yang State Key Laboratory of Biotherapy and Cancer Center and National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengduSichuan 610041China State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacySichuan UniversityChengduSichuan 610041China

Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public *** molecule antivirals are an effective treatment strategy to fight against the virus. However, the first-generation antivirals eithershow limited clinical efficacy and/or have some defects in pharmacokinetic (PK) properties. Moreover, with increased use of thesedrugs across the globe, they face great pressure of drug resistance. We herein present the discovery and characterization of a newgeneration antiviral drug candidate (SY110), which is a potent and selective inhibitor of SARS-CoV-2 main protease (Mpro). Thiscompound displayed potent in vitro antiviral activity against not only the predominant SARS-CoV-2 Omicron sublineage BA.5, butalso other highly pathogenic human coronaviruses including SARS-CoV-1 and MERS-CoV. In the Omicron-infected K18-hACE2mouse model, oral treatment with SY110 significantly lowered the viral burdens in lung and alleviated the virus-induced ***, SY110 possesses favorable PK properties with high oral drug exposure and oral bioavailability, and also an outstandingsafety profile. Furthermore, SY110 exhibited sensitivity to several drug-resistance Mpro mutations. Collectively, this investigationprovides a promising new drug candidate against Omicron and other variants of SARS-CoV-2.

关键词： treatment predominant potent

Solid-state synthesis of mesoporous metals via mechanochemical coordination self-assembly

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Science China Chemistry 2024年

作者： Hailong Xiong Chunyu Qi Lantian Xue Ling zhang Hanyu Liu Zhen-An qiao State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China State Key Laboratory of Superhard Materials College of Physics Jilin University State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University

Mesoporous metals with large surface area, high pore volume, and uniform pore structure hold excellent advantages for various applications. However, the state-of-the-art synthesis methods are still limited to wet chemistry, which requires excessive solvents and a time-consuming drying process. Here, we report a facile and general mechanochemical coordination self-assembly strategy to prepare mesoporous metals(e.g., Rh, Ru, Ir, Pt, Pd, Ag, Co, and Ni) with remarkable porous properties by using metal chlorides and cationic polymer interplay. Compared with the wet chemistry process, this method proceeds without solvents and does not need complicated experimental conditions and long synthetic periods, which not only greatly reduces the consumption of cost and energy and environmental pollution, but also improves the synthesis efficiency and yield of target products. We believe the developed approach will provide a general pathway for the scalable preparation of advanced porous materials.

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Application of extracorporeal membrane oxygenation in the endoscopic treatment of severe benign airway stenosis:A case report and literature review

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第2期4卷 48-52页

作者： Yuyuan Liang Jihong Zhu Xing Zheng Qing qiao Yaolin Guan Jisong zhang Enguo Chen Department of Anesthesia Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Anesthesia People's Hospital of Qingyuan CountyLishui 323800China Department of Respiratory Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Ventilation strategies in patients with severe tracheal stenosis should be tailored to the patient according to the underlying cause and narrowing *** report is on a case of a 68-year-old male patient,who was admitted for radiotherapy because of esophageal cancer and then developed severe stenosis at the cervical *** used venovenous extracorporeal membrane oxygenation to secure the airway and ensure adequate *** urgent endoscopic balloon dilation of airway stenosis was successfully performed under general *** case shows that venovenous extracorporeal membrane oxygenation can be used in endoscopic tracheal procedures for patients with severe benign stenosis in the upper-trachea who are unable to tolerate conventional ventilation.

关键词： Severe tracheal stenosis Venovenous extracorporeal membrane oxygenation Ventilation strategy

逆主流射流式旋涡发生器对涡轮流动分离控制数值模拟

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推进技术 2008年第2期29卷 168-173页

作者：张漫乔渭阳西北工业大学航天学院陕西西安710072 西北工业大学动力与能源学院陕西西安710072

通过数值计算,详细研究了射流偏转角与主流夹角大于90°的逆主流小孔稳态射流(Reversed in jectionVG Js)对低雷诺数涡轮流动分离的控制。研究结果发现,逆主流射流对主流的扰动引起射流孔后边界层迅速转捩可抑制流动分离现象。射流作为... 详细信息

通过数值计算,详细研究了射流偏转角与主流夹角大于90°的逆主流小孔稳态射流(Reversed in jectionVG Js)对低雷诺数涡轮流动分离的控制。研究结果发现,逆主流射流对主流的扰动引起射流孔后边界层迅速转捩可抑制流动分离现象。射流作为"湍流发生器"从控制机理上有别于90°偏转角VG Js射流状态。高射流湍流度(10%),135°逆主流VG Js在达到与90°偏转角VG Js基本相同的流动分离控制效果时,可降低射流流量67%。

关键词：低雷诺数逆主流VGJs 湍流发生器数值仿真