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Modes of grain growth and mechanism of dislocation reaction under applied biaxial strain:Atomistic and continuum modeling

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Journal of Materials Science & Technology 2020年第14期47卷 236-250页

作者： Ying-Jun Gao qian-qian deng Zhe-yuan Liu Zong-Ji Huang Yi-Xuan Li Zhi-Rong Luo Guangxi Advanced Key Laboratory of Novel Energy Materials Guangxi Key Laboratory for the Relativistic AstrophysicsSchool of Physics Science and EngineeringGuangxi UniversityNanning530004China Institute of Physics Science and Engineering Technology Yulin Normal UniversityYulin537000China

The phase field crystal method and Continuum Modeling are applied to study the cooperative dislocation motion of the grain boundary(GB)migration,the manner of the nucleation of the grain and of the grain growth in two dimensions(2 D)under the deviatoric deformation at high *** types of the nucleation modes of new finding are observed by the phase field crystal simulation:The first mode of the nucleation is generated by the GB splitting into two sub-GBs;the second mode is of the reaction of the sub-GB dislocations,such as,the generation and annihilation of a pair of partial Frank sessile dislocation in 2 *** process can be considered as the nucleation of dynamic recrystallization;the third mode is caused by two oncoming rows of the dislocations of these sub-GBs,crossing and passing each other to form new gap which is the nucleation place of the new deformed *** research is shown that due to the nucleation of different modes the mechanism of the grain growth by means of the sub-GB migration is different,and therefore,the grain growth rates are also *** the deviatoric deformation of the applied biaxial strain,the grain growth is faster than that of the grain growth without external applied *** is observed that the cooperative dislocation motion of the GB migration under the deviatoric deformation accompanies with local plastic flow and the state of the stress of the system changes *** the system is in the process of recrystallized grain growth,the system energy is in an unstable state due to the release of the strain energy to cause that the reverse movement of the plastic flow *** area growth of the deformed grain is approximately proportional to the strain square and also to the time *** rule of the time square of the deformed grain growth can also be deduced by establishing the continuum dynamic equation of the biaxial strain-driven migration of the *** copper metal is taken as an example of the calcu

关键词： Grain boundary splitting Grain growth Dislocation reaction Atomistic simulation Continuum modeling

Phase field crystal simulation of grain boundary movement and dislocation reaction

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Frontiers of Materials Science 2014年第2期8卷 176-184页

作者： Ying-Jun GAO qian-qian deng Si-Long QUAN Wen-Quan ZHOU Chuang-Gao HUANG College of Physical Science and Engineering Guangxi University Nanning 530004 China Guangxi Key Laboratory for Non-Ferrous Metal and Featured Materials Nanning 530004 China

The phase field crystal （PFC） model is used to simulate the premelting dislocation movement of the symmetric tilt grain boundary （STGB） under strain action when the system temperature is at far from the melting point and close to the melting point, respectively. The results show a local premelting occurs surrounding the dislocations as the premelting temperature is approached to from below temperature. The premelting dislocations of the STGB can glide under strain action, and the premelting region is a companion for dislocation gliding. The process of STGB decay is very similar at the two high temperature conditions. As premelting presents, it diminishes the gliding resistance for the dislocations and leads to a faster movement of dislocations, and also brings about more energy reduction of the system during the decay process of STGB. In spite of applying strain to these premelting samples in whole decay processes of STGB, the premelting dislocation region does not obviously develop and extend. This indicates that the external strain action does not promote the premelting at the high temperature, and cannot induce more premelting dislocation, which can be owed to the premelting phase around the dislocation exhibit fluid-like properties and to the premelting dislocation easily gliding and relaxing the strain energy; this is in agreement with the results of experiments and molecular dynamics.

关键词： phase field crystal (PFC) model grain boundary (GB) premeltingdislocation strain

Structural transformation and energy analysis for pile-up dislocations at triple junction of grain boundary

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Transactions of Nonferrous Metals Society of China 2022年第1期32卷 45-63页

作者： Ying-jun GAO Zong-ji HUANG qian-qian deng Kun LIAO Yi-xuan LI Xiao-Ai YI Zhi-rong LUO Guangxi Key Laboratory of Advanced Energy Materials Guangxi Key Laboratory for the Relativistic AstrophysicsSchool of Physics Science and EngineeringGuangxi UniversityNanning 530004China School of Physics and Telecommunication Engineering Yulin Normal UniversityYulin 537000China

An energy model for the structure transformation of pile-ups of grain boundary dislocations(GBD)at the triple-junction of the grain boundary of ultrafine-grain materials was *** energy of the pile-up of the GBD in the system was calculated by the energy model,the critical geometric and mechanical conditions for the structure transformation of head dislocation of the pile-up were analyzed,and the influence of the number density of the dislocations and the angle between Burgers vectors of two decomposed dislocations on the transformation mode of head dislocation was *** results show when the GBD is accumulated at triple junction,the head dislocation of the GBD is decomposed into two Burgers vectors of these dislocations unless the angle between the two vectors is less than 90°,and the increase of applied external stress can reduce the energy barrier of the dislocation *** mechanism that the ultrafine-grained metal material has both high strength and plasticity owing to the structure transformation of the pile-up of the GBD at the triple junction of the grain boundary is revealed.

关键词： triple junction of grain boundary dislocation pile-up dislocation structural transformation energy model for pile-up ultrafine-grain materials

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng deng Dan Yang Lingxi Qing Yifei Chen Jilian Zou Meiling Jia qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： qian Yin Fan Wen Zhigang Tao Hai Pu Tianci deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

miR-106b及EZH2对HepG2细胞生长的影响及机制

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热带医学杂志 2017年第10期17卷 1279-1284页

作者：桂连张倩倩蔡燕邓小红黄俊琪广东省器官捐献与移植免疫重点实验室广东广州510080 广东省器官移植国际科技合作基地广东广州510080 中山大学中山医学院免疫学研究所广东广州510080

目的探讨miR-106b及核心亚基基因增强子的人同源基因2(EZH2)对HepG2细胞生长的影响及其作用机制。方法 qRT-PCR法检测不同肝癌细胞miR-106b的表达;用miR-106b抑制物(inhibitor)及模拟物(mimic)和siEZH2转染肝癌细胞,CCK8法检测细胞增殖... 详细信息

目的探讨miR-106b及核心亚基基因增强子的人同源基因2(EZH2)对HepG2细胞生长的影响及其作用机制。方法 qRT-PCR法检测不同肝癌细胞miR-106b的表达;用miR-106b抑制物(inhibitor)及模拟物(mimic)和siEZH2转染肝癌细胞,CCK8法检测细胞增殖,细胞凋亡用Annexin V-FITC/PI双染法和WB法检测凋亡蛋白-3(Caspase-3),生物信息学分析并用荧光素酶法证实miR-106b是否靶向结合EZH2。结果与永生化的肝细胞LO2相比,miR-106b在肝癌细胞中表达量增加;miR-106b mimic促进HepG2细胞增殖和抑制凋亡;miR-106b inhibitor能导致Caspase-3全长表达量减少和其活性片段表达量增加;siEZH2抑制HepG2细胞增殖和促进其凋亡,并且能导致Caspase-3全长表达量减少及其活性片段表达量增加。荧光素酶结果表明miR-106b并非直接靶向抑制EZH2,miR-106b促进EZH2的表达。结论抑制miR-106b和EZH2的表达都能有效抑制HepG2细胞增殖和促进其凋亡。

关键词： miR-106b EZH2 HepG2

An Adaptive Collocation Method with Weighted Extended PHT-Splines

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Journal of Systems Science & Complexity 2021年第1期34卷 47-67页

作者： NI qian deng Jiansong WANG Xuhui School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China School of Mathematics Hefei University of TechnologyHefei 230009China

This paper presents an adaptive collocation method with weighted extended *** authors modify the classification rules for basis functions based on the relation between the basis vertices and the computational domain. The Gaussian points are chosen to be collocation points since PHT-splines are C1 continuous. The authors also provide relocation techniques to resolve the mismatch problem between the number of basis functions and the number of interpolation conditions. Compared to the traditional Greville collocation method, the new approach has improved accuracy with fewer oscillations. Several numerical examples are also provided to test our the proposed approach.

关键词： Collocation method Gaussian points PHT-splines weighted extended PHT-splines

淫羊藿苷预处理增强人牙周膜干细胞对M1型巨噬细胞的影响

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中国组织工程研究 2025年第7期29卷 1328-1335页

作者：喻婷吕冬梅邓浩孙涛程钎西南医科大学口颌面修复重建和再生泸州市重点实验室四川省泸州市646000 西南医科大学口腔医学研究所四川省泸州市646000 西南医科大学附属口腔医院正畸科四川省泸州市646000 西南医科大学口腔医学院四川省泸州市646000

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养... 详细信息

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养原代人牙周膜干细胞,并进行鉴定。对THP-1细胞进行诱导,采用免疫荧光染色及PCR进行M1型巨噬细胞鉴定。用含浓度10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷的α-MEM完全培养基培养人牙周膜干细胞1,3,5,7 d,采用CCK-8法筛选合适的淫羊藿苷浓度进行实验。将α-MEM完全培养基、未处理的人牙周膜干细胞α-MEM条件培养基及淫羊藿苷预处理24 h的人牙周膜干细胞α-MEM条件培养基与RPMI-1640完全培养基以1∶1的比例对M1型巨噬细胞进行条件培养,分别为对照组、未处理组及预处理组,24 h后RT-PCR法检测M1型巨噬细胞炎症因子的mRNA表达情况;ELISA法检测M1型巨噬细胞炎症因子的蛋白表达情况;Western blot检测M1/M2型巨噬细胞表面标记物及核转录因子κB通路相关蛋白的表达。结果与结论:(1)CCK-8检测结果显示,10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷对人牙周膜干细胞均无细胞毒性,且从第5天起,各浓度都提高了细胞活力,促进细胞增殖,选择10^(-4)mol/L淫羊藿苷进行后续实验。(2)RT-PCR法及ELISA检测结果显示,与对照组相比,未处理组及预处理组均降低了M1型巨噬细胞白细胞介素1β、白细胞介素6及肿瘤坏死因子α的表达与分泌(P<0.05),且预处理组低于未处理组(P<0.05)。(3)Western blot检测结果显示,与未处理组相比,预处理组CD86的表达明显降低(P<0.05);与对照组相比,未处理组和预处理组M2型巨噬细胞表面标志物CD206的表达均升高(P<0.01),且预处理组明显高于未处理组(P<0.01);M1型巨噬细胞经24 h条件培养后,与对照组相比,核转录因子κB/P65的表达在未处理组和预处理组均有降低(P<0.01),p-IκBα的表达仅在预处理组降低(P<0.01);与未处理组相比,预处理组核转录因子κB/P65和p-IκBα的表达均显著降低(P<0.05),而IκBα在3组中的表达差异无显著性意义。(4)上述结果证实,淫羊藿苷增强了人牙周膜干细胞对M1型巨噬细胞的抑制作用,此作用可能与抑制了巨噬细胞的核转录因子κB信号通路相关。

关键词：人牙周膜干细胞淫羊藿苷巨噬细胞条件培养基共培养表面标志物炎症因子抗炎核转录因子κB信号通路

Design and analysis of firewall-penetrated scheme based on trusted host

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 39-44页

作者： ZHANG deng-yin WANG qian-qian XU Jian Computer Institute Nanjing University of Posts and Telecommunications Nanjing 210003 China

On the basis of various firewall-penetrated technologies, a novel firewall-penetrated technology based on trusted host, which can realize the communication between penetrating host and protected host, is proposed in this paper. Meanwhile, the firewall-penetrated evaluating model and its formalized statement is also proposed by quantizing penetrated level, penetrated quality, and penetrated hiding. Finally, the fuewall-penetrated technology based on trusted host is analyzed under the fuewall-penetrated evaluating model, and the experimental results show that this technology has obvious penetrating effect and high penetrating quality.

关键词： firewall-penetrated trusted host (TH) penetrated host penetrated evaluating model