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Temporal and spatial variations hydrochemical components and driving factors in Baiyangdian Lake in the Northern Plain of China

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Journal of Groundwater Science and Engineering 2024年第3期12卷 293-308页

作者： Tian-lun Zhai qian-qian zhang Long Wang Hui-wei Wang Hebei and China Geological Survey Key Laboratory of Groundwater Remediation Institute of Hydrogeology and Environmental GeologyChinese Academy of Geological SciencesShijiazhuang 050061China

Understanding the temporal and spatial variation of hydrochemical components in large freshwater lakes is crucial for effective management and *** this study,we identify the temporalspatial characteristics and driving factors of the hydrochemical components in Baiyangdian Lake using geochemical methods(Gibbs diagram,Piper diagram and End-element diagram of ion ratio)and multivariate statistical techniques(Principal component analysis and Correlation analysis).16 sets of samples were collected from Baiyangdian Lake in May(normal season),July(flood season),and December(dry season)of *** indicate significant spatial variation in Nat,ci,SO and NO,,suggesting a strong influence of human *** concentrations exhibit greater seasonal variation in the dry season compared to the flood season,while the concentrations of the four anions show inconsistent seasonal changes due to the combined effects of river water chemical composition and human *** hydrochemical type of Baiyangdian Lake is primarily HCO,***,Mg*and HCO,originate mainly from silicate and carbonate rock dissolution,while Kt,Nat and CI originate mainly from sewage and salt dissolution in ***42 may mainly stem from industrial wastewater,while NO,primarily originates from animal feces and domestic *** the use of Principal Component Analysis,it is identified that water-rock interaction(silicate and carbonate rocks dissolution,and dissolution of salt in sediments),carbonate sedimentation,sewage,agricultural fertilizer and manure,and nitrification are the main driving factors of the variation of hydrochemical components of Baiyangdian Lake across three hydrological *** findings suggest the need for effective control of substandard domestic sewage discharge,optimization of agricultural fertilization strategies,and proper management of animal manure to comprehensively improve the water environment in Baiyangdian Lake.

关键词： Hydrochemical variation Sources Human activities Water-rock interaction Multivariate statistical techniques

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Potential Distribution on Random Electrical Networks

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Acta Mathematicae Applicatae Sinica 2011年第3期27卷 549-559页

作者： Da-qian qian Xiao-dong zhang Department of Mathematics Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China

Let N = （G, c） be a random electrical network obtained by assigning a certain resistance for each edge in a random graph G ∈ G（n, p） and the potentials on the boundary vertices. In this paper, we prove that with ... 详细信息

关键词： Electrical network potential distribution random graphs

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Parasitism of Pieris rapae （Lepidoptera： Pieridae） by the endoparasitic wasp Pteromalus puparum （Hymenoptera： Pteromalidae）： Effects of parasitism on differential hemocyte counts, micro- and ultra-structures of host hemocytes

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Insect Science 2012年第4期19卷 485-497页

作者： qian-qian zhang Jia Huang Jia-Ying Zhu Gong-Yin Ye State Key Laboratory of Rice Biology&Key laboratory of Molecular Biology of Crop Pathology and Insects of Ministry of Agriculture Institute of Insect SciencesZhejiang UniversityHangzhouChina

Parasitism by the endoparasitic wasp Pteromalus puparum （Hymenoptera： Pteromalidae） by using only its associated venom, can suppress the immunal responses of Pieris rapae （Lepidoptera： Pieridae）. However, up to now, current knowledge of the mech- anisms has been limited. The response of host hemocytes to parasitism was investigated using a combination of light and transmission electron microscopy （TEM）. Five hemocyte types, prohemocytes （PRs）, granulocytes （GRs）, plasmatocytes （PLs）, oenocytoids （OEs） and coagulocytes （COs）, were observed and characterized from both unparasitized and parasitized Pieris rapae pupae. Light microscopy showed that both GRs and PLs became more round and spread abnormally after parasitism, whereas the shape of other types of hemocytes remained unaffected. In addition, the size of PRs and PLs became larger while OEs became smaller. The proportion of PRs significantly increased after parasitism and that of PLs decreased by 43.9%, but there was no significant increase of GRs and OEs. TEM showed that all types of hemocytes except COs were damaged to various degrees after parasitism, especially resulting in electron opaque cytoplasm and nucleus, fewer cell organelles of rough endoplasmic reticulum, mitochondria and vesicles. Our results indicate that parasitism by P. puparum affects differential hemocyte counts and structures of host hemocytes, particularly for GRs and PLs, which may be the main cause of the parasitoid suppressing host cellular immune responses.

关键词： Key words hemocytes light microscopy parasitism Pieris rapae Pteromaluspuparum,transmission electron microscopy ultrastructure

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Dexmedetomidine as an adjunct to peripheral nerve blocks in pediatric patients

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World Journal of Pediatrics 2022年第4期18卷 251-262页

作者： Jing Yang Yu Cui Rong Cao Qing-Hua Huang qian-qian zhang Department of Anesthesiology The Affiliated HospitalSchool of MedicineUESTC Chengdu Women’s&Children’s Central HospitalNo.1617Riyue AvenueQingyang DistrictChengdu 610091China

Background Combining local anesthetics with dexmedetomidine(DEX)for nerve blocks has been tested and confirmed as an alternative technique to strengthen analgesia in adults,but the evidence supported this proposal in pediatrics was not convincing ***,we intend to conduct a meta-analysis to make an appraisal of the effects of DEX as a local anesthetic adjuvant on peripheral nerve blocks in *** The analysis has been registered on https://***/prospero/with the registration number CRD42021254029 on June 10th,***,Ovid MEDLINE,Embase and Cochrane central register were searched for the randomized controlled trials(RCTs)that are relevant to child/pain/DEX or block up to April 30,*** Eight RCTs were included for data *** pooled results showed a significantly reduced number of patients who required postoperative analgesics within DEX groups[odds ratio=0.1,95%confidence interval(CI)0.03-0.32,P<0.001].And DEX significantly prolonged the duration of analgesia of local anesthetics in the meantime[standardized mean difference(SMD)=4.93,95%CI 3.02-6.83,P<0.001].Nevertheless,adding DEX as an adjunct to local anesthetics would significantly decrease heart rate(SMD=-0.95,95%CI-1.45 to-0.45,P<0.001)and increase sedation score(SMD=1.6,95%CI 0.53-2.66,P=0.003)*** Adding DEX as an adjunct to peripheral nerve blocks can prolong analgesia until postoperative 8 hours in pediatric ***,the benefits should be weighed against the increasing risk of bradycardia and sedation in critical children.

关键词： Block Child Dexmedetomidine Pain

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IGFBPrP1 induces liver fibrosis by inducing hepatic stellate cell activation and hepatocyte apoptosis via Smad2/3 signaling

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World Journal of Gastroenterology 2014年第21期20卷 6523-6533页

作者： Yun zhang qian-qian zhang Xiao-Hong Guo Hai-Yan zhang Li-Xin Liu Department of Gastroenterology and Hepatology First Hospital of Shanxi Medical University Department of Gastroenterology and Hepatology First Hospital of Shanxi Medical University Experimental Centre of Science and Research The First Clinical Hospital of Shanxi Medical University Key Laboratory of Cell Physiology Provincial Department of the Ministry of EducationShanxi Medical University

AIM: To investigate the role and mechanism of insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) in the development of liver fibrosis.

关键词： Insulin-like growth factor binding protein-related protein 1 Liver fibrosis Hepatic stellate cells Hepatocyte apoptosis Smad pathway

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Interaction between insulin-like growth factor binding protein-related protein 1 and transforming growth factor beta 1 in primary hepatic stellate cells

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 395-404页

作者： Xiu-Qing Li qian-qian zhang Hai-Yan zhang Xiao-Hong Guo Hui-Qin Fan Li-Xin Liu Department of Gastroenterology and Hepatology The First Clinical Hospital of Shanxi Medical University Experimental Center of Science and Research The First Clinical Hospital of Shanxi Medical University Key Laboratory of Cell Physiology Provincial Department of the Ministry of EducationShanxi Medical UniversityTaiyuan 030001China

BACKGROUND: We previously showed that insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) is a novel mediator in liver fibrosis. Transforming growth factor beta 1 (TGF beta 1) is known as the strongest effector of liver fibrosis. Therefore, we aimed to investigate the detailed interaction between IGFBPrP1 and TGF beta 1 in primary hepatic stellate cells (HSCs). METHODS: We overexpressed TGF beta 1 or IGFBPrP1 and inhibited TGF beta 1 expression in primary HSCs for 6, 12, 24, 48, 72, and 96 hours to investigate their interaction and observe the accompanying expressions of a-smooth muscle actin (alpha-SMA), collagen I, fibronectin, and phosphorylated-mothers against decapentaplegic homolog 2/3 (p-Smad2/3). RESULTS: We found that the adenovirus vector encoding the TGF beta 1 gene (AdTGF beta 1) induced IGFBPrP1 expression while that of alpha-SMA, collagen I, fibronectin, and TGF beta 1 increased gradually. Concomitantly, AdIGFBPrP1 upregulated TGF beta 1, alpha-SMA, collagen I, fibronectin, and p-Smad2/3 in a time-dependent manner while IGFBPrP1 expression was decreased at 96 hours. Inhibition of TGF beta 1 expression reduced the IGFBPrP1-stimulated expression of alpha-SMA, collagen I, fibronectin, and p-Smad2/3. CONCLUSIONS: These findings for the first time suggest the existence of a possible mutually regulation between IGFBPrP1 and TGF beta 1, which likely accelerates liver fibrosis progression. Furthermore, IGFBPrP1 likely participates in liver fibrosis in a TGF beta 1-depedent manner, and may act as an upstream regulatory factor of TGF beta 1 in the Smad pathway.

关键词： insulin-like growth factor binding protein related protein 1 transforming growth factor in primary hepatic stellate cells alpha-smooth muscle actin extracellular matrix Smad pathway

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Gastrointestinal stromal tumor with multisegmental spinal metastases as first presentation:A case report and review of the literature

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World Journal of Clinical Cases 2021年第6期9卷 1490-1498页

作者： Yan Kong Xiao-Wei Ma qian-qian zhang Yi Zhao He-Lin Feng Department of Medical Oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of Orthopedics The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of Gynecology Hebei Medical University Second Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Gastrointestinal stromal tumor(GIST)usually originates in the stomach,followed by the small intestine,rectum,and other parts of the gastrointestinal *** most common sites of metastasis are the liver and peritoneum,whereas spinal metastases from GIST are extremely *** SUMMARY We found a case of GIST with the first presentation of multilevel spinal metastases involving the thoracic and lumbar vertebrae.A 61-year-old Chinese man presented to our clinic because of pain in his lower back and hip for 10 d without ***,computed tomography(CT)and magnetic resonance imaging(MRI)revealed abnormal signals in the vertebral appendages of T12 and L4 accompanied by spinal canal stenosis,which was considered as tumor *** there were no metastases to vital organs,posterior thoracic and lumbar spinal decompression+adnexal mass resection+pedicle internal fixation was adopted to achieve local cure and prevent nerve *** results of histopathological studies were consistent with the metastasis of *** local recurrence or new metastases were found at the 6-mo follow-up at the surgical *** patient has no neurological symptoms at *** is worth mentioning that a rectal mass was found and surgically removed 1 mo after the patient was discharged from hospital,and the pathological diagnosis of the mass was *** By reviewing 26 previously reported cases of spinal metastasis in GIST,it was found that spinal metastasis of GIST has become more common in recent years,so the possibility of early spinal metastasis should be *** and MRI are of great value in the diagnosis of spinal metastatic tumors,and pathological biopsy is the gold standard for the diagnosis of metastatic *** is safe and feasible to treat isolated spinal metastasis in GIST by excising metastatic masses,decompressing the spinal canal,and stabilizing the spine.

关键词： Spinal metastasectomy Gastrointestinal stromal tumor Multisegmental spinal metastases Magnetic resonance imaging Case report

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BLS-identification:A device fingerprint classification mechanism based on broad learning for Internet of Things

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Digital Communications and Networks 2024年第3期10卷 728-739页

作者： Yu zhang Bei Gong qian Wang Faculty of Information Technology Beijing University of TechnologyBeijing100124China School of Information Science and Technology Zhengzhou Normal UniversityHenan450044China

The popularity of the Internet of Things(IoT)has enabled a large number of vulnerable devices to connect to the Internet,bringing huge security *** a network-level security authentication method,device fingerprint based on machine learning has attracted considerable attention because it can detect vulnerable devices in complex and heterogeneous access ***,flexible and diversified IoT devices with limited resources increase dif-ficulty of the device fingerprint authentication method executed in IoT,because it needs to retrain the model network to deal with incremental features or *** address this problem,a device fingerprinting mechanism based on a Broad Learning System(BLS)is proposed in this *** mechanism firstly characterizes IoT devices by traffic analysis based on the identifiable differences of the traffic data of IoT devices,and extracts feature parameters of the traffic packets.A hierarchical hybrid sampling method is designed at the preprocessing phase to improve the imbalanced data distribution and reconstruct the fingerprint *** complexity of the dataset is reduced using Principal Component Analysis(PCA)and the device type is identified by training weights using *** experimental results show that the proposed method can achieve state-of-the-art accuracy and spend less training time than other existing methods.

关键词： Device fingerprint Traffic analysis Class imbalance Broad learning system Access authentication

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Macrophage-NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes

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Neuroscience Bulletin 2020年第9期36卷 1035-1045页

作者： Hong-Bin Lin Guan-Shan Wei Feng-Xian Li Wen-Jing Guo Pu Hong Ya-qian Weng qian-qian zhang Shi-Yuan Xu Wen-Bin Liang Zhi-Jian You Hong-Fei zhang Department of Anesthesiology Zhujiang Hospital of Southern Medical UniversityGuangzhou 510220China Department of Anesthesiology Shenzhen SAMII Medical CenterShenzhen 518118China Department of Anesthesiology The Second Affiliated HospitalShantou University Medical CollegeShantou 515041China University of Ottawa Heart Institute and Department of Cellular and Molecular Medicine University of OttawaOntarioK1NCanada

Ischemic stroke is one of the leading causes of death *** the post-stroke stage,cardiac dysfunction is common and is known as the brain-heart *** mellitus worsens the post-stroke ***-induced systemic inflammation is the major causative factor for the sequential complications,but the mechanism underlying the brain-heart interaction in diabetes has not been *** NLRP3(NLR pyrin domain-containing 3) inflammasome,an important component of the inflammation after stroke,is mainly activated in M1-polarized *** this study,we found that the cardiac dysfunction induced by ischemic stroke is more severe in a mouse model of type 2 ***,M1-polarized macrophage infiltration and NLRP3 inflammasome activation increased in the cardiac ventricle after diabetic ***,the NLRP3 inflammasome inhibitor CY-09 restored cardiac function,indicating that the Ml-polarized macrophage-NLRP3 inflammasome activation is a pathway underlying the brain-heart interaction after diabetic stroke.

关键词： Ischemic stroke Diabetes mellitus Cardiac dysfunction NLRP3 inflammasome Macrophage

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Existence and asymptotics of normalized solutions for the logarithmic Schrödinger system

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Science China Mathematics 2024年第9期67卷 2019-2048页

作者： qian zhang Wenming Zou Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China

This paper is concerned with the following logarithmic Schrodinger system:{-Δu_(1)+ω_(1)u_(1)=u_(1)u_(1)logu_(1)^(2)+2p/p+q|u_(2)|^(q)|u_(1)|^(p-2)u_(1),-Δu_(2)+ω_(2)u_(2)=u_(2)u_(2)log u_(2)^(2)+2q/p+q|u_(1)|^(p)|u_(2)|^(q-2)u_(2),∫_(Ω)|u_(i)|^(2)dx=ρ_(i),i=1,2,(u_(1),u_(2))∈H_(0)^(1)(Ω;R^(2)),where Ω=R^(N)or Ω■R^(N)(N≥3)is a bounded smooth domain,andω_(i)R,μ_(i),ρ_(i)>0 for i=1,***,p,q≥1,and 2≤p+q≤2^(*),where 2^(*):=2N/*** using a Gagliardo-Nirenberg inequality and a careful estimation of u log u^(2),firstly,we provide a unified proof of the existence of the normalized ground state solution for all 2≤p+q≤2^(*).Secondly,we consider the stability of normalized ground state ***,we analyze the behavior of solutions for the Sobolev-subcritical case and pass to the limit as the exponent p+q approaches 2^(*).Notably,the uncertainty of the sign of u log u^(2)in(0,+∞)is one of the difficulties of this paper,and also one of the motivations we are interested *** particular,we can establish the existence of positive normalized ground state solutions for the Brézis-Nirenberg type problem with logarithmic perturbations(i.e.,p+q=2^(*)).In addition,our study includes proving the existence of solutions to the logarithmic type Bréis-Nirenberg problem with and without the L^(2)-*** ∫_(Ω)|u_(i)|^(2)dx=ρ_(i)(i=1,2)by two different methods,*** results seem to be the first result of the normalized solution of the coupled nonlinear Schrodinger system with logarithmic perturbations.

关键词： logarithmic Schrodinger system Brézis-Nirenberg problem normalized solution existence and stability behavior of solutions

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