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Comprehensive Shape Control Technology for CSP Hot Strip Mills

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International Journal of Automation and computing 2015年第6期12卷 611-619页

作者： Chao-Chao Chen Jian Shao An-Rui He nan-Feng zhang National Engineering Research Center for Advanced Rolling Technology University of Science and Technology Beijing CSP Hot Strip Mill Hunan Valin Lianyuan Iron & Steel Co. Ltd

With the increasing demand on higher strip quality, the profile and flatness of hot rolling strips have become subjects of concern, particularly for compact strip product(CSP) hot strip mills. Based on the roll contour, control model, and rolling process, a comprehensive shape control technology is proposed and applied to CSP hot strip mill of Lianyuan steel, which includes optimization and design of the work roll contour and varying contact back-up roll(VCR) plus backup roll contour, analysis of the flatness feedback control model, as well as improvement of the rolling process control system. The application of the technology has significantly improved the shape control performance. The roll wear is improved and the general roll consumption of the finishing mill is reduced by 29.86%.The percentages that satisfy the control target ranges of the average strip flatness and crown are increased by approximately 15.40%and 14.82%, respectively. The rejection rate of grade Q235 due to shape quality problem is reduced monthly by 39.69%, which creates significant economic benefits for the plant.

关键词： Compact strip product(CSP) hot strip mills roll co

The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1–IRF3 signaling

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Cellular & Molecular Immunology 2019年第10期16卷 800-809页

作者： Hua zhang Chaofeng Han Tianliang Li nan Li Xuetao Cao National Key Laboratory of Medical Immunology&Institute of Immunology Second Military Medical UniversityShanghai 200433China Department of Immunology&Center for Immunotherapy Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100005China

Protein arginine methyltransferases(PRMTs)play diverse biological roles and are specifically involved in immune cell development and ***,their role in antiviral innate immunity has not been *** infection triggers the TBK1–IRF3 signaling pathway to stimulate the production of type-I interferon,which mediates antiviral *** performed a functional screen of the nine mammalian PRMTs for regulators of IFN-βexpression and found that PRMT6 inhibits the antiviral innate immune *** infection also upregulated PRMT6 protein *** generated PRMT6-deficient mice and found that they exhibited enhanced antiviral innate ***6 deficiency promoted the TBK1–IRF3 interaction and subsequently enhanced IRF3 activation and type-I interferon ***,viral infection enhanced the binding of PRMT6 to IRF3 and inhibited the interaction between IRF3 and TBK1;this mechanism was independent of PRMT6 methyltransferase ***,PRMT6 inhibits antiviral innate immunity by sequestering IRF3,thereby blocking TBK1-IRF3 *** work demonstrates a methyltransferase-independent role for *** also identifies a negative regulator of the antiviral immune response,which may protect the host from the damaging effects of an overactive immune system and/or be exploited by viruses to escape immune detection.

关键词： PRMT6 TBK1 IRF3 IFN antiviral innate immunity

Simultaneous denoising and resolution enhancement of seismic data based on elastic convolution dictionary learning

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Petroleum Science 2023年第4期20卷 2127-2140页

作者： nan-Ying Lan Fan-Chang zhang Kai-Heng Sang Xing-Yao Yin School of Geosciences China University of Petroleum(East China)QingdaoShandong266580China

Enhancing seismic resolution is a key component in seismic data processing, which plays a valuable role in raising the prospecting accuracy of oil reservoirs. However, in noisy situations, existing resolution enhancement methods are difficult to yield satisfactory processing outcomes for reservoir characterization. To solve this problem, we develop a new approach for simultaneous denoising and resolution enhancement of seismic data based on convolution dictionary learning. First, an elastic convolution dictionary learning algorithm is presented to efficiently learn a convolution dictionary with stronger representation capability from the noisy data to be processed. Specifically, the algorithm introduces the elastic L1/2 norm as a sparsity constraint and employs a steepest gradient descent strategy to efficiently solve the frequency-domain linear system with substantial computational cost in a half-quadratic splitting framework. Then, based on the learned convolution dictionary, a weighted convolutional sparse representation paradigm is designed to encode the noisy data to acquire an optimal sparse approximation of the effective signal. Subsequently, a high-resolution dictionary with a broadband spectrum is constructed by the proposed parameter scaling strategy and matched filtering technique on the basis of atomic spectrum modeling. Finally, the optimal sparse approximation of the effective signal and the constructed high-resolution dictionary are used for data reconstruction to obtain the seismic signal with high resolution and high signal-to-noise ratio. Synthetic and field dataset examples are executed to check the effectiveness and reliability of the developed method. The results indicate that this method has a more competitive performance in seismic applications compared with the conventional deconvolution and spectral whitening methods.

关键词： Simultaneous denoising and resolution enhancement Elastic convolution dictionary learning Weighted convolutional sparse representation Matched filtering

基于自动升降技术的变电站隔离开关断口安全隔离装置研究

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黑龙江科学 2024年第18期15卷 144-147页

作者：钱聪周秋华张松波冯新民钱林清国网南通供电公司江苏南通226200

为降低变电站隔离开关的检修风险,提高检修效率,采用模块化设计思路,设计了一种由自动移动系统、自动升降系统和绝缘隔离系统组成的自动隔离开关断口安全隔离装置。自动移动系统实现了装置的快速移动,自动升降系统实现了装置高度的调节... 详细信息

为降低变电站隔离开关的检修风险,提高检修效率,采用模块化设计思路,设计了一种由自动移动系统、自动升降系统和绝缘隔离系统组成的自动隔离开关断口安全隔离装置。自动移动系统实现了装置的快速移动,自动升降系统实现了装置高度的调节,绝缘隔离系统则采用高性能绝缘材料实现安全隔离。该装置能够实现在不停电或小范围停电状态下的安全隔离,从而提高检修作业的安全性和经济性,可广泛应用于变电站检修作业中,对保障电网的安全稳定运行具有重要意义。

关键词：隔离开关检修自动化操作安全隔离装置

Compute extremely low-frequency electromagnetic field exposure by 3-D impendance method

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The Journal of China Universities of Posts and Telecommunications 2007年第3期14卷 113-116页

作者： HAN Yu-nan LV Ying-hua zhang Hong-xin Beijing University of Posts and Telecommunications Beijing 100876 ChinaAerospace Science and Technology Group Beijng 100076 China

A 3-D impedance method has been introduced to compute the electric currents induced in a human body exposed to extremely low-frequency electromagnetic field. The 3-D impedance method has been deduced from Maxwell equations and is put into the computation and simulation effectively to the visible human body model, which has 196×114×626 cells and more than 40 types of tissues. As the result, two representative cases are investigated. One is exposure of the human body to 100 μT （1 000 mG）, the limit recommended by the International Commission on Non-Ionizing Radiation Protection for the public and the other one is the exposure of human body to 0.4 laT （4 mG）, the level at which a statistical link appears with a doubled risk of development of childhood leukaemia. The distribution of induced current density can be obtained and the maximum of induced current are found to be 16 mA/m^2 and 0.07 mA/m^2.

关键词： 3-D impedance method induced current magnetic flux density visible human body model extremely low frequency (ELF)

Metallographic sample prepared by ion beam etching

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 282-285页

作者： XU Xiang-yang zhang Kun HAN Jian-min CHEN Guang-nan Institute of Materials Science & Engineering Beijing Jiaotong University Beijing 100044 China Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China Institute of Materials Science & Engineering Beijing Jiaotong University Beijing 100044 China

Ion beam etching technique was used to reveal the metallograhpic microstructure and interface morphology of electroplating chromium coating, in particular, whose substrate surface layer was treated in advance by laser quenching. Chemical etchings were also conducted for comparison. The reveal microstructures were observed and analyzed by scanning electron microscopy. The results show that ion beam etching can reveal well the whole microstructures of composite coating-substrate materials.

关键词： ion beam etching metallography microstructure electroplating chromium

基于转录组学和网络药理学探讨肉豆蔻挥发油干预低氧性肺动脉高压的作用机制

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中草药 2024年第10期55卷 3375-3387页

作者：芦殿香张虹波梁焯森王玉蓉于洋李永芳南星梅青海大学医学部青海西宁810001 成都大学附属医院四川成都610081

目的基于转录组学和网络药理学探讨肉豆蔻挥发油(volatile oil from Myristica fragrans,VOMF)干预低氧性肺动脉高压(hypoxic pulmonary artery hypertension,HPAH)的作用机制。方法通过SwissTargetPrediction数据库获取VOMF活性成分和药物潜在靶点,应用GEO数据库获取HPAH疾病相关靶点,Cytoscape软件构建“成分-靶点-疾病”网络;运用Pymol和MOE软件对VOMF关键活性成分与作用靶点进行分子对接。采用雄性SD大鼠制备肺动脉平滑肌细胞(pulmonary artery smooth muscle cells,PASMCs),低氧处理并给予VOMF干预后,进行转录组学分析获取差异表达基因,采用Western blotting验证VOMF对细胞周期信号通路相关蛋白表达的影响。结果网络药理学分析共得到VOMF潜在作用靶点512个,HPAH疾病相关差异靶点2912个,交集基因80个;转录组学分析共得到40个共同差异表达基因。以P<0.05为筛选条件将转录组学和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集分析结果进行交集,得到交集通路8条,其中与HPAH密切相关的包括细胞周期信号通路、丝裂原活化蛋白激酶信号通路、缺氧诱导因子-1信号通路。结合文献报道和课题组前期研究,选取细胞周期信号通路进行验证。Western blotting结果显示,与对照组比较,模型组细胞周期蛋白依赖性激酶2(cyclin dependent kinase 2,CDK2)、CDK4、细胞周期蛋白D1(cell cycle protein D1,Cyclin D1)、Cyclin A2蛋白表达水平升高(P<0.01、0.001),p27Kip1蛋白表达水平降低(P<0.01);与模型组比较,VOMF组CDK2、CDK4、Cyclin D1、Cyclin A2蛋白表达水平降低(P<0.05、0.01、0.001),p27Kip1蛋白表达水平升高(P<0.05、0.01)。结论从网络药理学和转录组学角度初步阐明了VOMF能够通过干预细胞周期信号通路,进而干预HPAH的发生,可为后续的药理学研究和临床应用提供依据与参考。

关键词：肉豆蔻挥发油低氧肺动脉高压网络药理学转录组学 7,9-二叔丁基-1-氧杂螺[4.5]癸-6,9-二烯-2,8-二酮异榄香脂素乙酸香叶酯细胞周期信号通路

Effect of thermal cycles on microstructure of reduced activation steel fabricated using laser melting deposition

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Journal of Iron and Steel Research International 2021年第3期28卷 316-326页

作者： qian An Zhi-xin Xia Chi zhang Zhi-gang Yang Hao Chen School of Material Science and Engineering Tsinghua UniversityBeijing100084China Shagang School of Iron and Steel Soochow UniversitySuzhou215021JiangsuChina

Reduced activation steel was successfully fabricated by laser melting deposition employing a Gaussian and a ring-shaped *** microstructure evolution of the reduced activation steel was investigated using the scanning electron microscope,transmission electron microscope and electron backscatter *** experimental results showed that the grains close to the substrate were smaller than the grains in the upper *** to those deposited using a Gaussian laser,the samples deposited using a ring-shaped laser showed a more homogeneous ***,a finite element analysis(FEA)model was applied to reveal the thermal history during laser melting *** simulation results were well validated with the experimental *** results indicate that the peak temperature increases and the cooling rate decreases,as the layer gets further from the ***,the temperature and the cooling rate resulting from the Gaussian laser model were higher at the midline of the samples and lower around the edges,whereas those of the ring-shaped laser model were consistent with both at the center and around the edges.

关键词： Laser melting deposition Reduced activation steel Microstructure evolution Thermal cycle Finite element analysis

Field-portable ratiometric fluorescence imaging of dual-color label-free carbon dots for uranyl ions detection with cellphone-based optical platform

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Chinese Chemical Letters 2020年第11期31卷 2925-2928页

作者： Jingjing qian nana Cao Jian zhang Jinjin Hou qian Chen Cheng zhang Yudie Sun Shengjun Liu Lifang He Kui zhang Haibo Zhou Department of Applied Chemistry Anhui Agricultural of UniversityHefei 230036China School of Chemistry and Chemical Engineering Anhui University of TechnologyMa'anshan 243032China Institute of Pharmaceutical Analysis College of PharmacyJinan UniversityGuangzhou 510632China Second Clinical Medical College(Shenzhen People's Hospital) Jinan UniversityShenzhen 518020China

Under the public spotlight,uranyl(UO22+)ions has attracted considerable attention for the extreme radioactive and chemical toxicity to ourselves and our ***,we present a simple and effective ratiometric fluorescence imaging method for the visualizing and quantitative detection UO22+ions by cellphone-based optical *** sensing solution was prepared by mixing label-free red carbon dots(r-CDs)and blue carbon dots(b-CDs)together with a fixed photoluminescence intensity ratio of 4:*** UO22+ions were added,the fluorescence of r-CDs can be selectively quenched,while the fluorescence of b-CDs remains stable without spectral cha *** the gradually increase the amounts of UO22+ions,the different response of dual-color CDs resulted in a signification color evolution from deep red to dark purple under the ultraviolet(UV)light ***,a cellphone-based optical platform was constructed for directly imaging the color change of the samples,and the built-in Colorpicker APP quickly output the red,green and blue(RGB)channel values of these images within one ***,there was a linear relationship between the ratio of red and blue(R/B)channel values and UO22+ions concentration from 0μmol/L to 30.0μmol/L(R^2=0.92804)with the detection limit of^8.15μmol/L(signal-to-noise ratio of 3).In addition,the optical platform has also been applied to the quantification of UO22+ions in tap water and river water *** the advantage of low-cost,portable,easy to operation,we anticipate that this method would greatly improve the accessibility of UO22+ions detection even in resource-limited areas.

关键词： Uranyl ions Carbon dots Ratiometric fluorescence Field-portable Cellphone