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The secretory function of adipose tissues in metabolic regulation

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Life Metabolism 2024年第2期3卷 9-23页

作者： Yang Liu Shu-Wen qian Yan tang qi-qun tang Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan HospitalFudan UniversityShanghai 200032China

In addition to their pivotal roles in energy storage and expenditure,adipose tissues play a crucial part in the secretion of bioactive molecules,including peptides,lipids,metabolites,and extracellular vesicles,in response to physiological stimulation and met-abolic *** secretory factors,through autocrine and paracrine mechanisms,regulate various processes within adipose *** processes include adipogenesis,glucose and lipid metabolism,inflammation,and adaptive thermogenesis,all of which are essential for the maintenance of the balance and functionality of the adipose tissue micro-environment.A subset of these adipose-derived secretory factors can enter the circulation and target the distant tissues to regulate appetite,cognitive function,energy expenditure,insulin secretion and sensitivity,gluconeogenesis,cardiovascular remodeling,and exercise *** this review,we highlight the role of adipose-derived secretory factors and their signaling pathways in modulating meta-bolic ***,we delve into the alterations in both the content and secretion processes of these factors under various physiological and pathological conditions,shedding light on potential pharmacological treatment strategies for related diseases.

关键词： adipokines autocrine paracrine endocrine metabolic regulation

BMP4 facilitates beige fat biogenesis via regulating adipose tissue macrophages

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Journal of Molecular Cell Biology 2019年第1期11卷 14-25页

作者： Shu-Wen qian Meng-Yuan Wu Yi-Na Wang Ya-Xin Zhao Ying Zou Jia-Bao Pan Yan tang Yang Liu Liang Guo qi-qun tang Key Laboratory of Metabolism and Molecular Medicine The Ministry of EducationDepartment of Biochemistry and Molecular BiologyFudan University Shanghai Medical CollegeShanghai 200032China

Thermogenic beige fat improves metabolism and prevents *** evidence shows that the activation of M2 macrophages stimulates beige adipogenesis,whereas the activation of Ml macrophages,which play a major role in inflammation,impedes beige ***,the identification of factors that regulate adipose tissue macrophages(ATMs)will help clarify the mechanism involved in ***,we found that one of the secreted proteins in adipose tissue,namely,BMP4,alters the ATM profile in subcutaneous adipose tissue by activating M2 and inhibiting Ml ***,the BMP4-stimutated p38/MAPK/STAT6/PI3K-AKT signalling pathway is ***,BMP4 improved the potency of M2 macrophages to induce beige fat *** that the overexpression of BMP4 in adipose tissue promotes the beiging of subcutaneous adipose tissue and improves insulin sensitivity,these findings provide evidence that BMP4 acts as an activator of beige fat by targeting immuno-metabolic pathways.

关键词： BMP4 fat browning adipose tissue macrophages

BMP4-stimulated angiogenesis and adipogenesis contribute to adipocytes recruitment in subcutaneous white adipose tissue during beiging

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BMP4-stimulated angiogenesis and adipogenesis contribute to ...

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Shu-wen qian Yan tang qi-qun tang Key Laboratory of Metabolism and Molecular Medicine the Ministry of Education

Adipose tissues are important organs for energy homeostasis. White adipose tissue(WAT)stores energy in the form of triglycerides, whereas brown adipose tissue(BAT) dissipatesenergy in the form of heat. Adipose tissue expands to accommodate changes in energyavailability through hypertrophy of existing adipocytes and by initiating adipogenic differentiationof stem cells. Accumulation of visceral WAT is associated with adverse metabolicoutcomes, whereas increased amounts of subcutaneous WAT has been viewed as beneficialin its metabolic effects. WAT, especially in some subcutaneous depots will undergo‘beiging’- the process of acquiring characteristics of BAT- following cold exposure ortreatment with adrenergic activators or antidiabetic drugs, thiazolidinediones. De novoadipogeneis of subcutaneous WAT is evidenced during ‘beiging’ after cold exposure,which is accompanied by switching on an angiogenesis. However, the mechanisms bywhich adipogenesis is coordinated angiogeneis are largely unknown. Our previous workshowed BMP4 acquires subcutaneous WAT with BAT activity(beiging) along with increasednumber of both stromal vascular cells and mature adipocytes, indicating thatBMP4 both recruits and activates the beige adipocytes. In the present study, we found increasednumber of vascular endothelia in subcutaneous WAT of transgenic mice overexpressingBMP4, and decreased of that in knockouts. In ex vivo angiogenesis assay, sproutingfrom adipose tissue fragement was enhanced in tissues taken from BMP4 transgenicmice, or directly stimulated by BMP4 treatment. EdU labeling study detected EdU positivecells in both stromal vascular and mature adipocyte fraction of subcutaneous WAT, andthat was increased in mature adipocytes from transgenic mice, indicating BMP4 stimulatedstem cells proliferation as well as adipogenic differentiation. PDGFRβ positive pericytesaround blood microvessels were further evidenced to be the cell population regulated byBMP4, as most of the EdU positive SVF c

关键词： BMP4 adipogenesis angiogenesis WAT BAT

C/EBPβ-regulated Autophagy Facilitates Adipogenesis

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C/EBPβ-regulated Autophagy Facilitates Adipogenesis

Taurine-mediated browning of white adipose tissue is involved in its protective role against obesity in mice

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Liang Guo Jia-Xin Huang qi-qun tang Key Laboratory of Molecular Medicine the Ministry of Education Department of Biochemistry and Molecular Biology Fudan University Shanghai Medical College

Autophagy is a highly conserved self-digestion pathway involved in various physiologicaland pathophysiological *** studies have implicated a pivotal role of autophagyin adipocyte differentiation,but the molecular mechanism for its role and how it isregulated during this process is not ***,we show that CCAAT/enhancer-bindingproteinβ(C/EBPβ),an important adipogenic factor,is required for the activation of autophagyduring 3T3-L1 adipocyte *** autophagy-related gene Atg4b is identifiedas a de novo target gene of C/EBPβand plays an important role in ***,autophagy is required for the degradation of Klf2 and Klf3,two negative regulators of adipocyte differentiation,which is mediated by the adaptorprotein p62/***,the regulation of autophagy by C/EBPβand the role ofautophagy in Klf2/3 degradation and in adipogenesis are further confirmed in *** data describe a novel function of C/EBPβin regulating autophagy and revealthe mechanism of autophagy during adipocyte *** new insights into themolecular mechanism of adipose tissue development provide a functional pathway withtherapeutic potential against obesity and its related metabolic disorders.

关键词： 3T3-L1 preadipocytes Adipogenesis C/EBPβ Autophagy Atg4b

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Taurine-mediated browning of white adipose tissue is involve...

中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年

作者： Ying-Ying Guo Liang Guo qi-qun tang Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital Fudan University

Taurine, a nonprotein amino acid, is widely distributed in almost all animal tissues. Ingestion of taurine helps to improve obesity and its related metabolic disorders. However, the molecular mechanism underlying the protective role of taurine against obesity is not completely understood. In this study, it was found that intraperitoneal treatment of the mice with taurine alleviated high-fat diet(HFD)-induced obesity, improved insulin sensitivity, and increased energy expenditure and adaptive thermogenesis of the mice. Meanwhile, administration of the mice with taurine markedly induced the browning of inguinal white adipose tissue(iWAT), with significantly elevated expression of PGC1α, UCP1 and other thermogenic genes in iWAT. In vitro studies indicated that taurine also induced the development of brown-like adipocytes in C3H10T1/2 white adipocytes. Knockdown of PGC1α blunted the role of taurine in promoting the brown-like adipocytes phenotype in C3H10T1/2 cells. Moreover, taurine treatment enhanced AMPK phosphorylation in vitro and in vivo, and knockdown of AMPKα1 prevented taurine-mediated induction of PGC1α in C3H10T1/2 cells. Consistently, specific knockdown of PGC1α in iWAT of the HFDfed mice inhibited taurine-induced browning of iWAT, with the role of taurine in the enhancement of adaptive thermogenesis, the prevention of obesity and the improvement of insulin sensitivity being partially impaired. These results reveal a functional role of taurine in facilitating the browning of white adipose tissue, which is dependent on the induction of PGC1α. Our studies also suggest a potential mechanism for the protective role of taurine against obesity which involves taurine-mediated browning of white adipose tissue.

关键词： Taurine White adipose tissue(WAT) browning Obesity Energy expenditure Adaptive thermogenesis PGC1α AMPK

Critical Role of SENP2 in Development of NAFLD

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Critical Role of SENP2 in Development of NAFLD

中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年

作者： Yang Liu Xin Dou Meng Ding Ling Liu qi-qun tang Key Laboratory of Metabolism and Molecular Medicine the Ministry of Education Department of Biochemistry and Molecular Biology Fudan University Shanghai Medical College

Non-alcoholic fatty liver disease (NAFLD), ranging from hepatic steatosis to non-alcoholic steatohepatitis,liver fibrosis, cirrhosis, and eventually hepatocellular carcinoma, is a major type of metabolic disorders with severe threaten to public health. Aberrant triglycerides (TGs) accumulation in the liver is a hallmark

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Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue

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Stimulation of histamine H4 receptor participates in cold-in...

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Ya-Xin Zhao Jia-Bao Pan Shu-Wen qian qi-qun tang The Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationInstitutes of Biomedical SciencesDepartment of Biochemistry and Molecular BiologyDepartment of Endocrinology and Metabolism of Zhongshan HospitalFudan University

While many studies have shown that histamine and its signaling regulate energy homeostasis through the central nervous system (CNS), their roles in adipose tissues remain poorly understood. We found the HrH4expression was significantly induced in subcutaneous adipose tissue in response to cold exposure by both quantitative PCR and Western blot. Functions of HrH4 in the browning process of white adipose tissue(WAT) and energy expenditure were explored after subcutaneous injection of HrH4 knockdown adenovirus

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RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases

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RPS3A positively regulates the mitochondrial function of hum...

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yan tang Yi He Chen Li Wenjuan Mu Ying Zou Conghui Liu Shuwen qian Ju Mei Rong Zeng qi-qun tang Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences Fudan University Department of Cardiothoracic Surgery Xinhua HospitalShanghai Jiaotong University of Medicine College Key Laboratory of Systems Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences

Pericardial adipose tissue,which comprises both epicardial adipose tissue(EAT) and paracardial adipose tissue(PAT),has recently been recognized as a novel factor in the pathophysiology of cardiovascular diseases,especially coronary artery disease(CAD).The goal of this study was to evaluate differences in the brown-like characteristic and proteome among human EAT,PAT and subcutaneous adipose tissue(SAT) to identify candidate molecules causing *** protein 1(UCP-1) and other brown-related proteins were highly expressed in pericardial adipose tissue but was weakly expressed in SAT from the same non-CAD ***,pericardial adipose tissues displayed a higher thermogenesis than ***,brown-related genes were lower in CAD pericardial ***,there were lower levels of metabolic enzymes involved in glycolysis,tricarboxylic acid cycle and fatty acid metabolism in pericardial adipose tissues of *** is an organ adjacent to aortic root without anatomy barriers,which differs from *** found that the expression of ribosomal protein S3 A(RPS3 A) was decreased in human EAT as well as in mouse perivascular adipose tissue(PVAT).Knockdown of RPS3 A significantly inhibited adipocyte differentiation in preadipocytes and impaired the function of mitochondria in mature ***,RPS3 A knockdown in mouse periaortic adipose tissue impaired browning of PVAT,accelerated vascular inflammation and atherosclerosis ***,RPS3 A can migrate to the mitochondria to maintain the function of brown *** findings provide compelling evidence that RPS3 A was a key factor for modulating the brown fat specific gene UCP-1 and carbon metabolic enzymes in EAT for preventing CAD.

关键词： pericardial adipose tissue coronary artery disease RPS3A mitochondria

中重型颅脑损伤患者继发应激性溃疡机制和防治策略研究进展

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世界华人消化杂志 2024年第2期32卷 97-101页

作者：成杰蔡丽颖唐启群华北理工大学附属医院神经外科河北省唐山市063000 华北理工大学河北省唐山市063210

中重型颅脑损伤是复杂的危重临床疾病,容易继发应激性溃疡(stress ulcer,SU)值得关注.中重型颅脑损伤继发应激性溃疡的机制复杂,多与颅内压增高,迷走神经兴奋,儿茶酚胺分泌增多,胃黏膜灌注减少,H+逆向渗透有关.治疗颅脑损伤的同时,积极... 详细信息

中重型颅脑损伤是复杂的危重临床疾病,容易继发应激性溃疡(stress ulcer,SU)值得关注.中重型颅脑损伤继发应激性溃疡的机制复杂,多与颅内压增高,迷走神经兴奋,儿茶酚胺分泌增多,胃黏膜灌注减少,H+逆向渗透有关.治疗颅脑损伤的同时,积极预防应激性溃疡是改善患者预后的关键.质子泵抑制剂(proton pump inhibitor,PPI)、组胺受体拮抗剂(histamine H2 receptor antagonists,H2RA)被广泛应用于应激性溃疡的预防和治疗,但是其预防效果和药物副作用方面还存在较大争议.应激性溃疡的发生涉及多种因素的综合作用,既往研究为临床提供了一定的参考价值,但是很难精准地指导临床应激性溃疡的科学防治,未来应依据大量循证医学证据制定应激性溃疡防治指南,明确干预时机,预防性用药适应症,形成规范化治疗.

关键词：颅脑损伤应激性溃疡发病机制防治策略