检索结果-南通市图书馆

Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer

引用

Genomics, Proteomics & Bioinformatics 2021年第1期19卷 64-79页

作者： Shuang-Ling Wu Xiaoyi Zhang Mengqi Chang Changcai Huang Jun qian qing Li Fang Yuan Lihong Sun Xinmiao Yu Xinmiao Cui Jiayi Jiang Mengyao Cui Ye Liu Huan-Wen Wu Zhi-Yong Liang Xiaoyue Wang Yamei Niu Wei-Min Tong feng Jin department of Surgical Oncology and Breast Surgery the First Affiliated Hospital of China Medical UniversityShenyang 110000China department of Pathology Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeMolecular Pathology Research CenterChinese Academy of Medical SciencesBeijing 100005China State Key Laboratory of Medical molecular Biology Department of Biochemistry and Center for BioinformaticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China beijing National Laboratory for molecular sciences(BNLMS) MOE Key Laboratory of Bioorganic Chemistry and Molecular EngineeringCollege of ChemistryPeking UniversityBeijing 100871China Center for Experimental Animal Research Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeMolecular Pathology Research CenterChinese Academy of Medical SciencesBeijing 100005China

Although DNA 5-hydroxymethylcytosine(5 hmC)is recognized as an important epigenetic mark in cancer,its precise role in lymph node metastasis remains *** this study,we investigated how 5 hmC associates with lymph node metastasis in breast *** with high expression of TET1 and TET2 proteins,large numbers of genes in the metastasis-positive primary tumors exhibit higher 5 hmC levels than those in the metastasis-negative primary *** contrast,the TET protein expression and DNA 5 hmC decrease significantly within the metastatic lesions in the lymph nodes compared to those in their matched primary *** genomewide analysis of 8 sets of primary tumors,we identified 100 high-confidence metastasis-associated5 hmC signatures,and it is found that increased levels of DNA 5 hmC and gene expression of MAP7 D1 associate with high risk of lymph node ***,we demonstrate that MAP7 D1,regulated by TET1,promotes tumor growth and *** conclusion,the dynamic5 hmC profiles during lymph node metastasis suggest a link between DNA 5 hmC and lymph node ***,the role of MAP7 D1 in breast cancer progression suggests that the metastasis-associated 5 hmC signatures are potential biomarkers to predict the risk for lymph node metastasis,which may serve as diagnostic and therapeutic targets for metastatic breast cancer.

关键词： 5-Hydroxymethylcytosine Breast cancer Lymph node metastasis MAP7D1 Biomarker

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-Assembly of Block Copolymers Containing Azobenzene-Based Liquid Crystalline polymer and Poly(Ionic Liquid) in Bulk

Self-Assembly of Block Copolymers Containing Azobenzene-Base...

引用

2014年两岸三地高分子液晶态与超分子有序结构学术研讨会（暨第十三届全国高分子液晶态与超分子有序结构学术论文报告会）

作者： Yudong Zhang qiwei Wu Xinghe Fan Zhihao Shen qifeng zhou beijing National Laboratory for molecular sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking University

Recently,the self-assembled nanostructures of block copolymers(BCPs)containing poly(ionic liquid)(PIL)domains have attracted considerable attention because of their potential applications toward a range of transport-dependent,energy-based technology.1,2 Compared with the self-assembly of coil-ionic diblock copolymers,the incorporation of the liquid crystalline(LC)block brings two

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics

引用

Journal of molecular Cell Biology 2020年第6期12卷 462-476页

作者： Ruoying Yu Huihui Wu Hazrat Ismail Shihao Du Jun Cao Jianyu Wang Tarsha Ward fengrui Yang Ping Gui Mahboob Ali Lingluo Chu Fei Mo qi Wang Youjun Chu Jianye Zang Yun Zhao Mingliang Ye Guowei Fang Peng RChen Zhen Dou Xinjiao Gao Wenwen Wang Xing Liu Xuebiao Yao MOE Key Laboratory for Cellular Dynamics&Anhui Key Laboratory for Chemical Biology CAS Center for Excellence in Molecular Cell ScienceHefei National Science Center for Physical Sciences at Microscale&University of Science and Technology of ChinaHefei 230027China BUCM-MSM-USTC Joint Program on Global Health Equity Beijing University of Chinese MedicineBeijing 100029China department of Physiology Morehouse School of MedicineAtlantaGA 30310USA Harvard Medical School BostonMA 02115USA Dalian Institute for Physical chemistry Dalian 116023China Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China college of chemistry and molecular engineering Peking UniversityBeijing 100871China

Faithful segregation of mitotic chromosomes requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying PLK1 activation have been extensively studied, the regulatory mechanisms that couple PLK1 activity to accurate chromosome segregation are not well understood. In particular, PLK1 is implicated in stabilizing kinetochore–microtubule attachments, but how kinetochore PLK1 activity is regulated to avoid hyperstabilized kinetochore–microtubules in mitosis remains elusive. Here, we show that kinetochore PLK1 kinase activity is modulated by SET7/9 via lysine methylation during early mitosis. The SET7/9-elicited dimethylation occurs at the Lys191 of PLK1, which tunes down its activity by limiting ATP utilization. Overexpression of the non-methylatable PLK1 mutant or chemical inhibition of SET7/9 methyltransferase activity resulted in mitotic arrest due to destabilized kinetochore–microtubule attachments. These data suggest that kinetochore PLK1 is essential for stable kinetochore–microtubule attachments and methylation by SET7/9 promotes dynamic kinetochore–microtubule attachments for accurate error correction. Our findings define a novel homeostatic regulation at the kinetochore that integrates protein phosphorylation and methylation with accurate chromosome segregation for maintenance of genomic stability.

关键词： mitosis PLK1 kinase SET7/9 methylation kinetochore-microtubule attachment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

“活性”/可控自由基聚合制备两性离子聚合物及其应用

引用

化学进展 2018年第8期30卷 1097-1111页

作者：李智唐后亮冯岸超汤华燊北京化工大学北京市软物质科学与工程高精尖创新研究中心材料科学与工程学院北京100029 南卫理工会大学化学学院美国达拉斯75275

两性离子聚合物是在高分子链段上包含丰富等量阴离子基团与阳离子基团的聚合物,因具备优异的亲水性、生物相容性等独特的性质,近年来在抗污染、生物医药等领域展示了极广阔的应用前景。按照其结构特征,可以大体被分为混合电荷型与甜菜... 详细信息

两性离子聚合物是在高分子链段上包含丰富等量阴离子基团与阳离子基团的聚合物,因具备优异的亲水性、生物相容性等独特的性质,近年来在抗污染、生物医药等领域展示了极广阔的应用前景。按照其结构特征,可以大体被分为混合电荷型与甜菜碱型两性离子聚合物。目前两性离子聚合物的制备方法多种多样,从实际应用的角度出发,使用"活性"/可控自由基聚合制备两性离子聚合物具有独特的优势,如分子量可控、易于制备复杂结构聚合物等,这些特性拓宽了两性离子聚合物的应用领域。本文沿"单体直接聚合"和"聚合物后修饰"两条路径,介绍了使用"活性"/可控自由基聚合制备两性离子聚合物的优势及进展,同时从抗污染材料、生物医药材料、物质检测与分离等方面概述了两性离子聚合物的主要应用,并对其未来发展作出展望。

关键词：两性离子聚合物 “活性”/可控自由基聚合抗污染材料生物医用材料

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel and Convenient Method for the Preparation of Phosphonate Peptides and Phosphonamidate Peptides

引用

有机化学 2003年第Z1期23卷 12-12页

作者： XU Jia-Xi FU Nan-Yan GAO Yuan-He ZHNAG qi-Han DUAN Li-Fang Key Laboratory of Bioorganic chemistry and molecular engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

　　Phosphonate and phosphonamidate peptides are phosphorus analogues of natural peptides. They have been great used as stable mimetics of tetrahedral transition states as enzyme inhibitors and as haptens for catalytic antibody research in recent years. Although several methods are available for the preparation of phosphonate peptides and phosphonamidate peptides, all of them use phosphonic acid derivatives as starting materials. The overall yields from the synthesis of phosphonic acid derivatives to desired peptides are not satisfactory in most cases.……

关键词： phosphonic acid catalytic antibody enzyme inhibitors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tuning SnO_2 surface with CuO for soot particulate combustion: The effect of monolayer dispersion capacity on reaction performance

引用

Chinese Journal of Catalysis 2019年第6期40卷 905-916页

作者： Jiating Shen Xiaohui feng Rui Liu Xianglan Xu Cheng Rao Jianjun Liu Xiuzhong Fang Chao Tan Youchang Xie Xiang Wang Key Laboratory of Jiangxi Province for Environment and Energy Catalysis College of ChemistryNanchang UniversityNanchang 330031JiangxiChina Jiangxi Baoan New Material Technology Corporation LTDPingxiang 337000JiangxiChina Key Laboratory of Process Analysis and Control of Sichuan Universities Yibin UniversityYibin 644000SichuanChina college of chemistry and molecular engineering Peking UniversityBeijing 100871China

With the objective to investigate the structure-reactivity relationship of CuO/SnO2 and eventually design more applicable catalysts for soot combustion,catalysts with different CuO loadings have been prepared by impregnation *** using X-ray diffraction and X-ray photoelectron spectroscopy extrapolation methods,it is disclosed that CuO disperses finely on the SnO2 support to form a monolayer with a capacity of 2.09 mmol 100 m^-2,which equals 4.8 wt%CuO *** the CuO loading is below the capacity,it is in a sub-monolayer ***,when the loading is above the capacity,CuO micro-crystallites will be formed that coexist with the CuO *** soot combustion activity of the catalyst increases with the CuO loading until it reaches the monolayer dispersion capacity.A further increase in the CuO loading has no evident influence on the *** results have testified that with the addition of CuO onto the SnO2 support,a surface-active oxygen species can be formed,the amount of which also increases significantly with the increase in the CuO loading until it reaches the monolayer dispersion *** the CuO loading further has no evident impact on the amount of surface ***,an apparent monolayer dispersion threshold effect is observed for soot combustion over CuO/SnO2 *** is concluded that the amount of surface-active oxygen sites is the major factor determining the activity of the catalyst.

关键词： CuO supported on SnO2 Soot particulate combustion Monolayer dispersion X-ray diffraction and X-ray photoelectron spectroscopy extrapolation Threshold effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

共轭高分子的多级组装

引用

高分子学报 2019年第1期50卷 1-12,I0001页

作者：李其易雷霆姚泽凡王婕妤裴坚北京分子科学国家研究中心生物有机分子工程教育部重点实验室高分子化学与物理教育部重点实验室软物质科学与工程中心北京大学化学与分子工程学院北京100871 北京大学工学院材料科学与工程系北京100871

共轭高分子材料具有质轻、柔软、成本低、性能易于调控且可溶液加工等特点,在有机电致发光二极管、有机光伏、场效应晶体管与传感器件等领域有广泛的应用前景.共轭高分子体系中的多种弱相互作用使其可以形成复杂的多级组装结构,因此深... 详细信息

共轭高分子材料具有质轻、柔软、成本低、性能易于调控且可溶液加工等特点,在有机电致发光二极管、有机光伏、场效应晶体管与传感器件等领域有广泛的应用前景.共轭高分子体系中的多种弱相互作用使其可以形成复杂的多级组装结构,因此深入研究共轭高分子多级组装对于明确高分子功能材料构效关系具有重要意义.本文立足于系统对比共轭高分子多级组装与蛋白质多级组装的相似性,首次划分了共轭高分子多级组装中存在的四级结构:一级结构为通过共价作用形成的一维聚合物链结构,二级结构为通过分子间相互作用如π-π堆积(π-πstacking)、层状堆叠(lamellar packing)和链缠结等形成的一条或多条聚合物链组装结构,三级结构为不同相行为对应的聚集结构,例如结晶、无定形区域(crystalline and amorphous region)和过渡区域等,四级结构为多组分相互作用及相分离的材料体系.多级结构相互关联,共同决定了共轭高分子材料的光、电、热等物理性质.本文总结了近年来共轭高分子多级组装的相关研究工作,为观察和理解并指导高分子多级组装、建立完整的"构效"关系、优化器件性能提供了新视角.

关键词：共轭高分子超分子化学溶液自组装构效关系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

烯碳材料改性有机高性能纤维:制备、性能及应用

引用

物理化学学报 2022年第9期38卷 135-151页

作者：周航焦琨北京大学化学与分子工程学院北京100871 北京石墨烯研究院石墨烯纤维技术研究部北京100095 北京大学材料科学与工程学院北京100871

有机高性能纤维是全球化纤工业的重要发展方向之一。提升现有纤维力学性能的同时研发新型结构功能一体化的纤维对提升我国在航天航空等领域的国际地位具有重要意义。以石墨烯和碳纳米管为代表的烯碳材料具备优异的力、电、热学等性能,... 详细信息

有机高性能纤维是全球化纤工业的重要发展方向之一。提升现有纤维力学性能的同时研发新型结构功能一体化的纤维对提升我国在航天航空等领域的国际地位具有重要意义。以石墨烯和碳纳米管为代表的烯碳材料具备优异的力、电、热学等性能,可用于改性传统有机高性能纤维。通过制备不同物化性质的烯碳材料并设计合理的改性方式,可将烯碳材料优异的性能传递到传统纤维中,形成具备更高力、电、热学等性能的烯碳材料改性有机高性能纤维。本文首先综述了烯碳材料改性有机高性能纤维的制备方式,包括烯碳材料的分散与功能化、烯碳材料对有机高性能纤维的改性方法,阐述了烯碳材料改性有机高性能纤维的力、电、热学等性能以及烯碳材料的增强机理,进而总结了烯碳材料改性有机高性能纤维的应用,并对其现存的挑战和未来的发展做出展望。

关键词：烯碳材料有机高性能纤维制备性能应用

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Nitrogen-doped black titania for high performance supercapacitors

引用

science China Materials 2020年第7期63卷 1227-1234页

作者： Chongyin Yang Xin Wang Wujie Dong I-Wei Chen zhou Wang Jijian Xu Tianquan Lin Hui Gu Fuqiang Huang State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China department of Materials science and engineering University of PennsylvaniaPennsylvaniaPA 19104-6272USA State Key Laboratory of Rare Earth Materials chemistry and Applications and National Laboratory College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China college of chemistry and molecular engineering Zhengzhou UniversityZhengzhou 450001China

For energy storage system,it is still a huge challenge to achieve high energy density and high power density *** potential solution is to fabricate electrochemical capacitors(ECs),which store electric energy through surface ion adsorption or redox *** we report a new electrode material,heavy nitrogen-doped(9.29 at.%)black titania(TiO2-x:N).This unique hybrid material,consisting of conductive amorphous shells supported on nanocrystalline cores,has rapid N-mediated redox reaction(TiO2-xNy+zH++ze■-TiO2-xNyHz),especially in acidic solutions,providing a specific capacitance of 750 Fg-1at 2 m V s-1(707 Fg-1at 1 A g-1),great rate capability(503 F g-1at 20 Ag-1),and maintain stable after initial *** a new developed supercapacitor material,nitrogen-doped black titania may revive the oxide-based supercapacitors.

关键词： black titania supercapacitor nitrogen-dopant N-mediated redox reactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interface modulation of twinned Pt Fe nanoplates branched 3D architecture for oxygen reduction catalysis

引用

science Bulletin 2020年第2期65卷 97-104,87页

作者： Mingchuan Luo Yingnan qin Menggang Li Yingjun Sun Chunji Li Yingjie Li Yong Yang Fan Lv Dong Wu Peng zhou Shaojun Guo department of Materials science&engineering College of EngineeringPeking UniversityBeijing 100871China college of chemistry and molecular engineering Qingdao University of Science and TechnologyQingdao 266042China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China BIC-ESAT College of EngineeringPeking UniversityBeijing 100871China department of Energy and Resources engineering College of EngineeringPeking UniversityBeijing 100871China

Highly-branched dendritic Pt-based nanocrystals possess great potential in catalyzing the oxygen reduction reaction(ORR),but encounter performance ceiling due to their poor thermal and electrochemical ***,we present a novel Pt Fe nanodendrites(NDs)branched with two-dimensional(2 D)twinned nanoplates rather than conventional 1 D nanowires,which breaks the ORR performance ceiling of dendritic catalysts by inducing the unique Pt-skin configuration via rationally thermal *** further hybridizing the Pt-skin Pt Fe NDs/C with amino-functionalized ionic liquids(ILs),we achieve an unprecedented mass activity of 3.15 A/mgPtat 0.9 V versus reversible hydrogen electrode(RHE)in the Pt Fe-based ORR electrocatalytic *** also show excellent electrocatalytic durability for ORR with negligible activity decay and no apparent structural change after 20,000 cycles,in sharp contrast to the nanowires branched Pt Fe NDs *** remarkable catalytic performance is attributed to a combination of several structural features,including 2 D morphology,twin boundary,partially ordered phase and strong coordination with amino *** work highlights the significance of stabilizing electrocatalytic structures via morphology tuning,which thus enables further surface and interface modification for performance breakthrough in ORR electrocatalysis.

关键词： Oxygen reduction reaction PtFe alloy Dendrities Nanoplates Ionic liquid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：