Novel and Convenient Method for the Preparation of Phosphonate Peptides and Phosphonamidate Peptides

作     者：XU Jia-Xi FU Nan-Yan GAO Yuan-He ZHNAG Qi-Han DUAN Li-Fang 

作者机构：Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Peking University Beijing 100871 China 

出 版 物：《有机化学》 (Chinese Journal of Organic Chemistry)

年 卷 期：2003年第23卷第Z1期

页      面：12-12页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Projectp oupported by the National Natural Science Foundation of China (No. 20272002)  Ministry of Education of China (SRF for ROCS and EYTP)  and Peking University (President grant) 

主　　题：phosphonic acid catalytic antibody enzyme inhibitors 

摘      要： Phosphonate and phosphonamidate peptides are phosphorus analogues of natural peptides. They have been great used as stable mimetics of tetrahedral transition states as enzyme inhibitors and as haptens for catalytic antibody research in recent years. Although several methods are available for the preparation of phosphonate peptides and phosphonamidate peptides, all of them use phosphonic acid derivatives as starting materials. The overall yields from the synthesis of phosphonic acid derivatives to desired peptides are not satisfactory in most cases.……