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Preliminary identification of key miRNAs, signaling pathways, and genes associated with Hirschsprung's disease by analysis of tissue microRNA expression profiles

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World Journal of Pediatrics 2017年第5期13卷 489-495页

作者： Zhi-Gang Gao qing-Jiang Chen Min Shao Yun-Zhong qian Li-Feng Zhang Yue-Bin Zhang qi-Xing xiong Pediatric General Surgery Department The Children's HospitalZhejiang University School of MedicineHangzhouChina International Medical Center The First Affiliated HospitalZhejiang UniversitySchool of MedicineHangzhouChina

Background:Hirschsprung's disease (HSCR) is a congenital gut motility disorder of infants,and if left untreated,it is fatal to the affected *** study aimed to identify key microRNAs (miRNAs),signaling pathways and genes involved in the pathogenesis of ***:The miRNA microarray dataset GSE77296 was *** colon tissue samples were available:six from HSCR patients and three matched control *** expressed miRNAs (DEMs) were identified after data *** genes of the selected upregulated and downregulated DEMs were *** addition,functional enrichment analyses for the selected DEMs and target genes were ***,interaction networks between the DEMs and target genes were ***:A total of 162 DEMs (73 upregulated and 89 downregulated) were obtained.A total of 2511 DEM-target gene pairs for the 40 selected DEMs were identified,including 1645 pairs for the upregulated DEMs and 866 pairs for the downregulated *** upregulated DEM miR-141-3p and down-regulated DEM miR-30a-3p were identified as key miRNAs by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and network ***,KEGG pathway enrichment analysis revealed that pathways in cancer and the mitogen-activated protein kinase (MAPK) signaling pathway were key *** key genes frizzled class receptor 3 (FZD3) and docking protein 6 (DOK6) were obtained through the DEM-target gene interaction ***:Two key miRNAs (miR-141-3p and miR-30a-3p),the MAPK signaling pathway and two key genes (FZD3 and DOK6) were implicated in the pathogenesis of HSCR.

关键词： differentially expressed microRNA docking protein 6 frizzled class receptor 3 Hirschsprung's disease mitogen-activated protein kinase signaling pathway

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Congenital duodenal obstruction in neonates:a decade's experience from one center

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World Journal of Pediatrics 2014年第3期10卷 238-244页

作者： qing-Jiang Chen Zhi-Gang Gao Jin-Fa Tou Yun-Zhong qian Min-Ju Li qi-Xing xiong qiang Shu Department of Pediatric General Surgery Children's HospitalZhejiang University Shool of MedicineHangzhou 310003China Department of Pediatric Thoracic Surgery Children's HospitalZhejiang University Shool of MedicineHangzhou 310003China

Background:Congenital duodenal obstruction(CDO)is one of the most common anomalies in newborns,and accounting for nearly half of all cases of neonatal intestinal *** study aimed to review our single-center experience in managing congenital duodenal obstruction while evaluate the ***:We conducted a retrospective analysis of the records of all neonates dianogsed with congenital duodenal obstruction admitted to our center between January 2003 and December *** analyzed demographic criteria,clinical manifestations,associated anomalies,radiologic findings,surgical methods,postoperative complications,and fi nal ***:The study comprised 287 newborns(193 boys and 94 girls).Birth weight ranged from 950 g to 4850 ***-three patients were born prematurely between 28 and 36 weeks'*** was diagnosed in 174 patients,annular pancreas in 66,duodenal web in 55,duodenal atresia or stenosis in 9,preduodenal portal vein in 2,and congenital band compression in *** patients had various combinations of these *** symptoms included bilious vomiting,dehydration,and weight loss.X-rays of the upper abdomen demonstrated the presence of a typical double-bubble sign or air-fluid levels in 68.64%of patients,and confi rmatory upper and/or lower gastrointestinal contrast studies were obtained in 64.11%.Multiple associated abnormalities were observed in 50.52%of the *** surgical approaches were used,including Ladd's procedure,duodenoplasty,duodenoduodenostomy,duodenojejunostomy,or a combination of *** patients died postoperatively and 14 required ***:Congenital duodenal obstruction is a complex entity with various etiologies and often includes multiple concomitant *** diagnosis and aggressive surgery are key to improving *** should be taken to address all of the causes of duodenal obstruction and/or associated alimentary tract anomalies during surge

关键词： congenital duodenal obstruction neonate

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Bimolecular reduction of carbon dioxide: double synthons for alkynes trifunctionalization

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Science China Chemistry 2024年第3期67卷 841-847页

作者： Wenfang xiong Xiaobin Tan Hongjian Liu Baiyao Zhu Jinwu Zhao Jianxiao Li Chaorong qi Huanfeng Jiang School of Pharmacy Guangdong Medical UniversityDongguan 523808China Key Lab of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China

Carbon dioxide reduction, as a sustainable and versatile strategy for the access of chemical fuels, has attracted increasing attention and enormous efforts have been devoted to it in recent years. However, employing carbon dioxide as double synthons via bimolecular reduction remains challenging. Here, by leveraging the bimolecular reduction of carbon dioxide to carbonyl and methyl respectively, we describe a Pd-catalyzed trifunctionalization of alkynes with aryl iodide for the first time and showcase its advantages on the formation of various β-diketones and their application in the constructing of heterocyclic compounds with important biological activity, including pyrimidine, oxazole, pyrazole.

关键词： carbon dioxide bimolecular reduction trifunctionalization double synthons

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Sedimentary-tectonic interaction on the growth sequence architecture within the intraslope basins of deep-water Niger Delta Basin

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Journal of Palaeogeography 2023年第1期12卷 107-128页

作者： Jia-Jia Zhang Sheng-He Wu Guang-Yi Hu Da-Li Yue Cheng Chen Mei Chen Ji-Tao Yu qi-Cong xiong Li-qiong Wang College of Geosciences State Key Laboratory of Petroleum Resource and ProspectingChina University of Petroleum(Beijing)Beijing 102249China Research Institute China National Offshore Oil CorporationBeijing 100028China The Fourth Gas Production Plant Changqing Oilfield CompanyPetroChinaOrdos 017300Inner Mongolia Autonomous RegionChina

This paper presents a 3D seismic-based case study from the deep-water Niger Delta Basin to investigate sedimentary-tectonic interaction on growth sequence architecture within the thrust-related intraslope or piggyback basins. Gravitational contraction in the lower continental slope had yielded a series of thrust faults and associated folds in the study area, which formed several piggyback basins. These basins were filled by a suite of growth sequences with varying stratigraphic architecture. Analysis of the 3D seismic data recognized three primary seismic facies types respectively as: convergent, draping and chaotic, which contain seven subtypes. These facies types are combined to form different filling successions for convergent or chaotic growth sequences. The convergent growth sequences mainly occur in the deep section of basin fills during strong gravitational deformation, and always began with convergent-baselapping strata succeeded by convergent-thinning strata, representing pond-to-bypass transition in the ponded-basin accommodation space. The chaotic growth sequences mainly occur in the shallow section of basin fills in response to weak gravitational deformation, and usually began with debris-flow deposits succeeded by channel-levee complexes, reflecting dominant erosion-bypass processes in the slope accommodation space. A dynamic fill-andspill model considering relationship between episodic sedimentation rate and structural growth rate is proposed to explain the formative mechanisms of growth strata units and associated successions. Interaction between glaciation or deglaciation and sea-level change and gravitational deformation history are suggested to be the factor which resulted in the complex stratal stacking patterns, including progradational or retrogradational stacking patterns within convergent growth sequences, and progradational stacking patterns within chaotic growth sequences.

关键词： Intraslope basin Gravitational deformation Growth sequence Stratigraphic architecture Niger Delta Basin

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Method for identifying effective carbonate source rocks:a case study from Middle-Upper Ordovician in Tarim Basin,China

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Petroleum Science 2020年第6期17卷 1491-1511页

作者： Jun-qing Chen xiong-qi Pang Song Wu Zhuo-Heng Chen Mei-Ling Hu Luo-Fu Liu Kui-You Ma Bo Pang Zhi-Peng Huo State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China Beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of PetroleumBeijing 102249China College of Geoscience China University of PetroleumBeijing 102249China Geological Survey of Canada CalgaryAB T2L 2A7Canada Research Institute of Petroleum Exploration and Development PetroChina Huabei Oilfi eld CompanyRenqiu 062550HebeiChina China University of Geosciences Beijing 100083China

Hydrocarbon expulsion occurs only when pore fluid pressure due to hydrocarbon generation in source rock exceeds the force against migration in the adjacent carrier *** the Middle-Upper Ordovician carbonate source rock of Tarim Basin in China as an example,this paper proposes a method that identifies effective carbonate source rock based on the principles of mass *** from the Well YW2 indicate that the Middle Ordovician Yijianfang Formation contains effective carbonate source rocks with low present-day *** and geochemical analysis suggests that the hydrocarbons in the carbonate interval are likely self-generated and *** steranes from GC-MS analysis of oil extracts in this interval display similar features to those of the crude oil samples in Tabei area,indicating that the crude oil probably was migrated from the effective source *** applying to other wells in the basin,the identified effective carbonate source rocks and non-source rock carbonates can be effectively identified and consistent with the actual exploration results,validating the *** the contribution from the identified effective source rocks with low present-day TOC(TOC_(pd))is considered,the long-standing puzzle between the proved 3 P oil reserves and estimated resources in the basin can be reasonably explained.

关键词： Effective carbonate source rock Mass balance approach Low present-day TOC Ordovician Tarim Basin

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Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity

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Neuroscience Bulletin 2023年第9期39卷 1454-1458页

作者： Mengying Jiang qiwu Xu Can Yang Dan Li Ji-Wei Liu Yuxian Zhang Yong-Chuan Zhu Zhi-qi xiong Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai200030China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai201210China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China

Dear Editor,The X-linked gene cyclin-dependent kinase-like 5(CDKL5)encodes a serine/threonine kinase that is associated with CDKL5-deficiency disorder(CDD),a severe developmental and epileptic encephalopathy characterized by early-onset seizures,gross developmental delay,and motor disabilities[1].The expression of CDKL5 is highly enriched in the brain and is significantly induced during postnatal development[2].

关键词： seizures enriched CDK

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Photo-enhanced uranium recovery from spent fuel reprocessing wastewater via S-scheme 2D/0D C_(3)N_(5)/Fe_(2)O_(3) heterojunctions

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SusMat 2024年第2期4卷 41-50页

作者： qi Meng Linzhen Wu Xiaoyong Yang Ying xiong Fanpeng Kong Tao Duan State Key Laboratory of Environment-friendly Energy Materials NuclearWaste and Environmental Safety Key Laboratory of DefenseSouthwest University of Science and TechnologyMianyangSichuanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage Harbin Institute of TechnologyHarbinHeilongjiangChina Department of Materials Science and Engineering KTH Royal Institute of TechnologyStockholmSweden

Re-extracting environmentally transportable hexavalent uranium from wastew-ater produced by spent fuel reprocessing using the photocatalytic technology is a crucial strategy to avoid uranium pollution and recover nuclear fuel strategic ***,we have designed S-scheme 2D/0D C_(3)N_(5)/Fe_(2)O_(3)heterojunction photocatalysts based on the built-in electric field and the energy band bend-ing theory,and have further revealed the immobilization process of hexavalent uranium conversion into relatively insoluble tetravalent uranium in terms of thermodynamics and *** to the results,the hexavalent uranium removal and recovery ratios in wastewater are as high as 93.38%and 83.58%,***,C_(3)N_(5)/Fe_(2)O_(3)heterojunctions also exhibit satisfactory cat-alytic activity and selectivity even in the presence of excessive impurity cations(including Na^(+),K^(+),Ca^(^(2+)),Mg^(2+),Sr^(2+),and Eu^(3+))or various organics(such as xylene,tributylphosphate,pyridine,tannic acid,citric acid,and oxalic acid).It is believed that this work can provide a potential opportunity for S-scheme heterojunction photocatalysts to re-enrich uranium from spent fuel wastewater.

关键词： nuclear wastewater S-scheme heterostructure uranium recovery

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Treatment of myopic foveoschisis via macular buckling and vitrectomy

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 815-818页

作者： Si-qi xiong Hai-Bo Jiang Fang-Ling Li Yan-Xiu Li Jie Yang Xiao-Bo Xia Hui-Zhuo Xu Department of Ophthalmology Xiangya Hospital Central South University Changsha 410008 Hunan Province China

The aim of the present study was to evaluate the efficacy and safety of the treatment of myopic foveoschisis patients using the macular buckling with L-shaped titanium plate and silicon sponge combined with vitrectomy. The data of the patients who underwent macular buckling combined with vitrectomy was collected. The study recorded the following parameters：best corrected visual acuity（BCVA）, axial length, intraocular pressure, central macular thickness, and the position of the titanium plate. Following the surgery, the BCVA of the included patients were improved, whereas the axial lengths were reduced followed by resolution of the foveoschisis compared with that noted prior to the operations. All patients had orbital CT examination and the results indicated that the titanium plates were appropriately placed and were not in contact with the optic nerve. Therefore, it is effective to treat myopic foveaschisis by macular buckling using the L-shaped titanium plate and silicon sponge in the presence of vitrectomy.

关键词： myopic foveoschisis macular buckling vitrectomy

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Structure,Calculation,Optical Properties and Bioimaging of an Organic Fluorescence Compound

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Chinese Journal of Structural Chemistry 2021年第10期40卷 1291-1297页

作者： JIN Feng xiong qi-Juan LIU Zhuo-Ni XIAO Ya-Ting YANG Fang CHENG Ting-Ting ZHANG Lin TAO Dong-Liang LIAO Rong-Bao LIU Yong College of Chemical and Material Engineering Fuyang Normal UniversityFuyang 236037China College of Biological and Food Engineering Fuyang Normal UniversityFuyang 236037China

A π-conjugated optical functional organic compound comprising an electron donor(D) and acceptor(A) was synthesized. The crystal structure was determined through single-crystal X-ray diffraction analysis. It crystallizes in monoclinic, space group P2_(1) with a = 9.6610(5), b = 8.9093(4), c = 26.303(1)Å, β = 96.262(4)°, V = 2250.5(2)Å^(3), Z = 4, D_(c)= 1.220 Mg/m^(3), F(000) = 872, Μr = 413.50, μ = 0.072 mm^(-1), the final R = 0.0569 and wR = 0.1700 for 8976 observed reflections with I > 2σ(I). Optical properties were studied in detail through theoretical calculation and experimental study. The result reveals that the compound exhibits excellent fluorescence performance and it can be compatible in the cytoplasm of NIH/3T3 cells, showing potential in fluorescence microscopy bioimaging.

关键词： crystal structure theoretical calculation organic fluorescence material bioimaging

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Management of foreign bodies ingestion in children

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World Journal of Pediatrics 2022年第12期18卷 854-860页

作者： qing-Jiang Chen Lin-Yan Wang Yi Chen Jia-Jin Xue Yue-Bin Zhang Li-Feng Zhang Yun-Zhong qian qi-Xing xiong Zhi-Gang Gao Department of Pediatric General Surgery National Center for Clinical Medicine of Children’s Health and DiseaseChildren’s HospitalZhejiang University School of MedicineNational Children’s Regional Medical Center3333 Binsheng RoadBinjiang DistrictHangzhou310052China

Foreign bodies(FBs)ingestion in children is one of the common presentations to the emergency *** majority of FBs ingestion occurs in children younger than 3 years,with males showing a slight predominance[1].Although most FBs pass through the gastrointestinal tract spontaneously,some FBs need urgent medical intervention and even surgical management owing to the complications of obstruction or perforation and a potential risk to children’s health[2].Therefore,timely diagnosis and rational treatment are crucial for reducing FBs ***,optimal indications and/or timing of surgery remain *** this study,we discussed the characteristics of FBs ingestion in children and summarized our experience in its management.

关键词： diagnosis younger children

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