Bimolecular reduction of carbon dioxide: double synthons for alkynes trifunctionalization

作     者：Wenfang Xiong Xiaobin Tan Hongjian Liu Baiyao Zhu Jinwu Zhao Jianxiao Li Chaorong Qi Huanfeng Jiang 

作者机构：School of PharmacyGuangdong Medical UniversityDongguan 523808China Key Lab of Functional Molecular Engineering of Guangdong ProvinceSchool of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2024年第67卷第3期

页      面：841-847页

核心收录：

学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(21971073,22001075,22231002) the Natural Science Foundation of Guangdong Province(2019A1515011468) the Discipline Construction Project of Guangdong Medical University(4SG23231G,4SG23249G) the Ordinary University Characteristic Innovation Project of Guangdong Province(2022KTSCX047) the Key-Area Research and Development Program of Guangdong Province(2020B010188001) 

主　　题：carbon dioxide bimolecular reduction trifunctionalization double synthons 

摘      要：Carbon dioxide reduction, as a sustainable and versatile strategy for the access of chemical fuels, has attracted increasing attention and enormous efforts have been devoted to it in recent years. However, employing carbon dioxide as double synthons via bimolecular reduction remains challenging. Here, by leveraging the bimolecular reduction of carbon dioxide to carbonyl and methyl respectively, we describe a Pd-catalyzed trifunctionalization of alkynes with aryl iodide for the first time and showcase its advantages on the formation of various β-diketones and their application in the constructing of heterocyclic compounds with important biological activity, including pyrimidine, oxazole, pyrazole.