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Mass balance and morphological evolution of the Dokriani Glacier,central Himalaya,India during 1999–2014

Geoscience Frontiers 2022年第1期13卷 255-267页

作者： purushottam kumar garg Jairam Singh Yadav Santosh kumar Rai Aparna Shukla Indian Institute of Technology Indore Khandwa RoadSimrolIndore 453552India Wadia Institute of Himalayan Geology 33GMS RoadDehradun 248001India Ministry of Earth Sciences Prithvi BhavanLodhi RoadNew Delhi 110003India

Glaciological mass balance(MB)is considered the most direct,undelayed and unfiltered response of the glaciers to climatic ***,it may inherit errors associated with stake underrepresentation,averaging over the entire glacier and human ***,proper validation of glaciological MB with geodetic MB is highly recommended by the World Glacier Monitoring Service(WGMS).The present study focuses on the Dokriani Glacier,central Himalaya which is one of the bench-mark glaciers in the region and has glaciological MB records from 1993 to 2013 with intermittent *** the present study,firstly the glaciological MB series is extended to 2014 i.e.,field-based MB for one more year is computed and,to compare with it,the geodetic MB is computed for the 1999–2014 period using high resolution Cartosat-1 digital elevation model(DEM)and SRTM ***,the study assesses the regional representation of the Dokriani Glacier in terms of MB and evaluates the influence of the MB regime on its morphological *** show that the average glaciological MB(-0.34±0.2 m water equivalent(w.e.)y-1)is more negative than the geodetic MB(-0.23±0.1 m w.e.y-1)for the 1999–2014 *** is likely because of the partial representation of glacier margins in the glaciological MB,where melting is strikingly low owing to thick debris cover(>30 cm).In contrast,geodetic MB considers all marginal pixels leading to a comparatively low MB.A comparative assessment shows that the MB of Dokriani Glacier is less negative(possibly due to its huge accumulation area)than most other glacier-specific and regional MBs,restricting it to be a representative glacier in the ***,continuous negative MB has brought a peculiar change in the epiglacial morphology in the lower tongue of the glacier as differential debris thickness-induced differential melting has turned the glacier surface into a concave *** concavity has led to development of a large(10–20 m deep)supraglacial ch

关键词： Glacier mass balance Debris cover Epiglacial morphology Supraglacial channel Dokriani Glacier Central Himalaya

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Assessment of albendazole efficacy against Ascaris lumbricoides at three sites of Andhra Pradesh,Odisha,and Kerala in India

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 310-316页

作者： Vinay garg Ankur garg Shubha garg Sudhir kumar Jain Tanzin Dikid Saurabh Jain Jitendra Manjhi Antonio Montresor Atul Goel Division of Parasitic Diseases National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India National Centre for Disease Control Ministry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Epidemiology Division National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Department of Control of Neglected Tropical Diseases(NTD) World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Department of Community&Family Medicine AIIMS KalyaniIndia Community and Primary Care-based Intervention Department of Control of Neglected Tropical Diseases(NTD)World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Director General of Health Sciences(DGHS)&Director National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India

Objective:To assess efficacy of albendazole against Ascaris(A.)lumbricoides among school-children at three sites of Rajahmundry,Sundergarh and ***:Sites were selected based on soil-transmitted helminths prevalence,different sociocultural-geographical characteristics and operational feasibility.9-12 Years old children from 14 schools were *** study was conducted in two rounds:baseline&follow up *** eligible children found positive for *** at baseline were administered supervised single tablet albendazole 400 mg under the National Deworming Day *** post-treatment follow-up survey,eligible children who provided second stool sample were included in the final *** samples were examined using WHO recommended Kato-Katz *** was estimated based on cure rate(CR)and Fecal Egg Count Reduction Rate(FECRR)among children found positive in baseline and follow-up ***:328 Out of 625(52.5%)were found positive for *** in the baseline survey and 85 out of 178 samples(47.8%)during post-treatment follow-up ***,the estimated CR was 52.2%.FECRR(95%CI)for albendazole was 72.6%(79.2%-66.0%).The FECRR was highest in East Godaveri[89.7%(96.8%-82.6%)],followed by Sundergarh[86.4%(95.3%-77.5%)]and Wayanad[69%(81.7%-56.4%)].Conclusions:Our study confirmed overall reduction in FEC although with varying albendazole efficacy for *** infection at three different locations in ***,these finding may be assessed in context of ongoing MDA under Filaria control program and further studies by in vivo as well as in vitro methods are required to reach to a conclusion on possible resistance if any.

关键词： Soil transmitted helminths Ascaris lumbricoides Albendazole Efficacy

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Cloud‐based video streaming services:Trends,challenges,and opportunities

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 265-285页

作者： Tajinder kumar purushottam Sharma Jaswinder Tanwar Hisham Alsghier Shashi Bhushan Hesham Alhumyani Vivek Sharma Ahmed I.Alutaibi CSE Department JMIETIYamunanagarHaryanaIndia Department of Information Technology ASETAmity University Uttar PradeshNoidaIndia Tata Communications Limited New DelhiIndia Department of Information Technology College of Computer and Information SciencesMajmaah UniversityMajmaahSaudi Arabia Amity School of Engineering and Technology Amity UniversityPatnaBiharIndia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaifSaudi Arabia Department of Computer Engineering College of Computer and Information SciencesMajmaah UniversityMajmaahSaudi Arabia

Cloud computing has drastically changed the delivery and consumption of live streaming *** designs,challenges,and possible uses of cloud computing for live streaming are studied.A comprehensive overview of the technical and business issues surrounding cloudbased live streaming is provided,including the benefits of cloud computing,the various live streaming architectures,and the challenges that live streaming service providers face in delivering high‐quality,real‐time *** different techniques used to improve the performance of video streaming,such as adaptive bit‐rate streaming,multicast distribution,and edge computing are discussed and the necessity of low‐latency and high‐quality video transmission in cloud‐based live streaming is *** such as improving user experience and live streaming service performance using cutting‐edge technology,like artificial intelligence and machine learning are *** addition,the legal and regulatory implications of cloud‐based live streaming,including issues with network neutrality,data privacy,and content moderation are *** future of cloud computing for live streaming is examined in the section that follows,and it looks at the most likely new developments in terms of trends and *** technology vendors,live streaming service providers,and regulators,the findings have major policy‐relevant *** on how stakeholders should address these concerns and take advantage of the potential presented by this rapidly evolving sector,as well as insights into the key challenges and opportunities associated with cloud‐based live streaming are provided.

关键词： cloud computing video analysis video coding

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Recombinant vaccines:Current updates and future prospects

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 338-350页

作者： Vivek kumar Anuj Verma Riddhi Singh Priyanshi garg Santosh kumar Sharma Himanshu Narayan Singh Santosh kumar Mishra Sanjay kumar Department of Allied Medical Sciences School of Allied Medical SciencesLovely Professional UniversityPhagwaraPunjabIndia Bioengineering Division of Department of Bioscience and Biomedical EngineeringIndian Institute of Technology BhilaiChhattisgarhIndia Department of Biotechnology IMS Engineering CollegeGhaziabadU.P.India Department of Chemistry and Biochemistry University of WindsorOntario N9B3P4Canada Biological and Biocomputational Laboratory Department of Life SciencesSharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India Department of System Biology Columbia University Irving Medical CenterNew YorkNY 10032USA Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India

Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of *** technology improved vaccine manufacturing,rendering it more efficient and *** vaccines have multiple advantages compared to conventional *** pandemic has heightened awareness of the advantages of these vaccine technologies;trust and acceptance of these vaccines are steadily growing *** work offers an overview of the prospects and advantages associated with recombinant ***,it discusses some of the challenges likely to arise in the *** ability to target diverse pathogen classes underscores their contributions to preventing previously untreatable diseases(especially vector-borne and emerging diseases)and hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these ***,their compatibility with emerging vaccination platforms of the future like virus-like particles and CRISPR/Cas9 for the production of next-generation vaccines may offer many *** review also reviewed the hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines against vector-borne diseases,emerging diseases,and untreatable diseases with high mortality rates like AIDS as well as cancer.

关键词： Malaria Dengue Emerging diseases Immunoinformatics Virus-like particles CRISPR-Cas9

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Ameliorative Effects of Paclobutrazol via Physio-Biochemical and Molecular Manifestation in Rice under Water Deficit Stress

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Rice science 2024年第5期31卷 603-616,I0065页

作者： Chirag MAHESHWARI Nitin kumar garg Archana SINGH Aruna TYAGI Indian Council of Agricultural Research-Indian Agricultural Research Institute New Delhi 110012India Sri Karan Narendra Agricultural University JobnerRajasthan 303329India

To comprehensively explore the physio-biochemical and molecular changes of paclobutrazol(PBZ) at the ideal dose under water deficit stress(WDS) conditions, we investigated the effects of 100 mg/kg PBZ applied via drenching on various physio-biochemical and molecular parameters in three rice varieties(N22, IR64, and IR64 DTY1.1) under both mild [75%-80% relative water content(RWC)] and severe(60%-65% RWC) WDS conditions. The results showed that PBZ treatment positively influenced the physio-biochemical parameters, significantly increasing dry matter(16.27%-61.91%), RWC(6.48%-16.34%), membrane stability index(4.37%-10.35%), and total chlorophyll content(8.97%-29.09%) in the rice varieties under both mild and severe WDS. Moreover, PBZ treatment reduced drought susceptibility(0.83-0.95) and enhanced drought tolerance efficiency(60.92%-86.78%), indicating its potential as a stress-mitigating agent. Global methylation analysis revealed changes in DNA methylation patterns, indicating the regulatory influence of PBZ on gene expression. The expression analysis of genes involved in the diversification of geranylgeranyl pyrophosphate towards the biosynthesis of abscisic acid, gibberellin acid, and chlorophyll showed alterations in their expression levels, suggesting the involvement of PBZ in the isoprenoid pathway. Overall, this study provides valuable insights into the potential mechanisms by which PBZ modulates physiological and molecular responses in rice plants under WDS. The findings highlight the importance of PBZ as a promising agent for enhancing drought tolerance in rice and offer valuable information for future research in crop stress management.

关键词： rice paclobutrazol drought stress abscisic acid gibberellic acid

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Overlap in oncogenic and pro-inflammatory pathways associated with areca nut and nicotine exposure

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Cancer Pathogenesis and Therapy 2024年第3期2卷 187-194页

作者： Krati garg Anuj kumar Vidisha Kizhakkethil Pramod kumar Shalini Singh Department of Biochemical Engineering and Biotechnology Indian Institute of Technology(IIT)DelhiDelhi 110016India Division of Molecular Biology ICMR-National Institute of Cancer Prevention and Research(ICMR-NICPR)Indian Council of Medical ResearchNoidaUttar Pradesh 201301India Department of Biotechnology Vellore Institute of Technology(VIT)VelloreTamil Nadu 632024India ICMR-National Institute of Cancer Prevention&Research(ICMR-NICPR) Indian Council of Medical ResearchNoidaUttar Pradesh 201301India

Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of *** other psychoactive substances,such as nicotine,the mechanisms underlying addiction to areca nuts and related oncogenesis remain *** reports suggest a possible overlap in the mechanisms of action of nicotine and areca nuts in the human ***,this study aimed to investigate the interactome of human proteins associated with areca nut exposure and the intricate similarities and differences in the effects of the two psychoactive substances on ***:A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings(MeSH).Protein-protein interaction(PPI)networks and functional enrichment were *** results obtained for both psychoactive substances were ***:Given the limited number of common proteins(36/226,16%)in the two sets,a substantial overlap(612/1176 nodes,52%)was observed in the PPI networks,as well as in Gene *** nuts mainly affect signaling pathways through three hub proteins(alpha serine/threonine-protein kinase,tumor protein 53,and interleukin-6),which are common to both psychoactive substances,as well as two unique hub proteins(epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism).Areca nut-related proteins are associated with unique pathways,such as extracellular matrix organization,lipid storage,and metabolism,which are not found in nicotine-associated ***:Areca nuts affect regulatory mechanisms,leading to systemic toxicity and *** nuts also affect unique pathways that can be studied as potential markers of exposure,as well as targets for anticancer therapeutic agents.

关键词： Cancer Areca nut Nicotine Interactome Cell signaling

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Predictors of cerebrospinal fluid GeneXpert MTB/RIF positivity in patients with tuberculous meningitis:A prospective cohort study

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Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 465-472页

作者： Priyanka Gupta Neeraj kumar Ravindra kumar garg Hardeep Singh Malhotra Imran Rizvi Rajesh Verma Praveen kumar Sharma Ravi Uniyal Shweta Pandey Amita Jain Parul Jain Department of Neurology King George’s Medical UniversityLucknowIndia Department of Microbiology King George’s Medical UniversityLucknowIndia

Objective:To identify the clinical,laboratory,and radiological markers that could predict a positive GeneXpert result in patients suspected of tuberculous ***:In this prospective,observational study,patients with tuberculous meningitis were systematically *** clinical,laboratory[including cerebrospinal fluid(CSF)microscopy,culture,and GeneXpert],and neuroimaging factors were *** participants were administered anti-tuberculous treatment and corticosteroids.A six-month follow-up was done to evaluate the ***:Of the 116 patients studied,54(46.6%)tested positive for GeneXpert,while 62(53.4%)were *** cranial nerve involvement(OR 3.71,95%CI 1.052-13.09,P=0.04)and the presence of basal exudates on neuroimaging(OR 5.22,95%CI 2.03-13.42,P=0.001)emerged as independent predictive factors for a positive GeneXpert result.A positive CSF GeneXpert result(P=0.002)and drug resistance(P=0.004)were significantly linked to adverse ***,a high score on the Medical Research Council stageⅢ(OR 5.64,95%CI 1.18-26.87,P=0.03)and elevated CSF cell counts(OR 1.002,95%CI 1.00-1.001,P=0.03)were identified as independent predictors of poor ***:Third cranial nerve involvement and the presence of basal exudates were significant indicators of a positive GeneXpert *** stageⅢdisability and elevated CSF cell counts predicted poor outcomes.

关键词： Tuberculous meningitis Mycobacterium tuberculosis Cerebrospinal fluid Ziehl-Neelsen staining GeneXpert

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In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity:Insights from national inpatient sample 2020

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World Journal of Hepatology 2024年第6期16卷 912-919页

作者： Sashwath Srikanth Vibhor garg Lakshmi Subramanian Jyoti Verma Hansika Sharma Harroop Singh Klair Shrenil A Kavathia Jithin Kolli Teja Nikhil Sai Vasireddy kumar Anmol Dhanush Kolli Shruti Sanjay Bodhankar Sobya Hashmi Shaylika Chauhan Rupak Desai Department of Medicine ECU Health Medical CenterGreenvilleNC 27834United States Department of Medicine Jacobi Medical Center/Albert Einstein College of MedicineBronxNY 10461United States Department of Medicine North Alabama Medical CentreFlorenceAL 35630United States Department of General Medicine Gandhi Medical CollegeSecunderabad 500003TelanganaIndia Department of Medicine Government Medical CollegePatiala 147001PunjabIndia Department of Medicine B.J.Medical CollegeAhmedabad 380016GujaratIndia Department of Medicine JSS Medical CollegeMysore 570015KarnatakaIndia Department of Internal Medicine Gandhi Medical CollegeSecunderabad 500003TelanganaIndia Department of Medicine Kasturba Medical CollegeManipal 575001KarnatakaIndia Clinical Extern Department of Internal MedicineBeaumont HospitalDearbornMI 48124United States Department of Internal Medicine Geisinger Health SystemWilkes-BarrePA 18702United States Independent Researcher AtlantaGA 30079United States

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular diseases independently of other risk ***,data on its effect on cardiovascular outcomes in coronavirus disease 2019(COVID-19)hospitalizations with varied obesity levels is *** management and patient care depend on understanding COVID-19 admission results in NAFLD patients with varying obesity *** To study the in-hospital outcomes in COVID-19 patients with NAFLD by severity of *** COVID-19 hospitalizations with NAFLD were identified using International Classification of Disease-10 CM codes in the 2020 National Inpatient Sample *** and Obesity Classes Ⅰ,Ⅱ,and Ⅲ(body mass index 30-40)were *** adverse cardiac and cerebrovascular events(MACCE)(all-cause mortality,acute myocardial infarction,cardiac arrest,and stroke)were compared between *** regression analyses adjusted for sociodemographic,hospitalization features,and *** Our analysis comprised 13260 hospitalizations,7.3% of which were overweight,24.3% Class Ⅰ,24.1% Class Ⅱ,and 44.3% Class Ⅲ.Class Ⅲ obesity includes younger patients,blacks,females,diabetics,and hypertensive *** multivariable logistic analysis,Class Ⅲ obese patients had higher risks of MACCE,inpatient mortality,and respiratory failure than Class Ⅰ obese *** Ⅱ obesity showed increased risks of MACCE,inpatient mortality,and respiratory failure than Class I,but not *** obesity classes had non-significant risks of MACCE,inpatient mortality,and respiratory failure compared to the overweight *** Class Ⅲ obese NAFLD COVID-19 patients had a greater risk of adverse outcomes than class Ⅰ.Using the overweight group as the reference,unfavorable outcomes were not significantly *** obesity had a greater risk of MACCE regardless of the referent group(overweight or Class Ⅰ obese)compared to overweight NAFLD patients admitte

关键词： Non-alcoholic fatty liver disease Obesity Obese Body mass index Major adverse cardiac and cerebrovascular events Mortality Acute myocardial infarction Cardiac arrest Stroke

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Insights from a Brief Study of Renal Calculi:Recent Diagnostic and Treatment Approaches

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Journal of Bio-X Research 2024年第1期7卷 8-19页

作者： Aashish kumar Rajat Goyal Kajal garg Sumeet Gupta Kashish Wilson Hitesh Chopra MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana 133207India Lal Chand Mal College of Education JhansaKurukshetraHaryana 136130India Department of Biosciences Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennaiTamil Nadu 602105India

Background:Renal calculi,commonly known as kidney stones,is a prevalent urological condition that affects a substantial portion of the population *** formation of kidney stones is a complex process influenced by various factors,including diet,fluid intake,genetics,and metabolic *** pathogenesis of renal calculi involves a complex interplay of multiple factors,including supersaturation of urine with stone-forming constituents,urinary supersaturation,crystallization,and ***:This review aims to provide an overview of the present understanding of renal calculi,their pathophysiology,diagnostic approaches,and available treatment ***:This review discusses the different types of kidney stones,such as calcium oxalate,calcium phosphate,uric acid,and struvite stones,and explores their formation mechanisms and associated risk *** management of renal calculi relies on stone characteristics,patient symptoms,stone size,and ***,counseling and education regarding lifestyle modifications and risk factor management are essential for long-term ***:Accurate diagnosis and appropriate management based on stone characteristics and patient symptoms are essential for successful *** strategies to reduce stone recurrence are vital for long-term management and patient ***,further research is needed to refine diagnostic techniques,improve treatment options,and enhance the understanding of the underlying pathophysiology of renal calculi.

关键词： diagnosis urine treatment

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Comparison of wear behavior of ABS and Nylon6-Fe powder composite parts prepared with fused deposition modelling

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Journal of Central South University 2015年第10期22卷 3705-3711页

作者： Harish kumar garg Rupinder Singh Punjab Technical University Guru Nanak Dev Engineering College

Fused deposition modeling(FDM) is one of the latest rapid prototyping techniques in which parts can be manufactured at a fast pace and are manufactured with a high accuracy. This research work is carried out to study the friction and wear behavior of parts made of newly developed Nylon6-Fe composite material by FDM. This work also involves the comparison of the friction and wear characteristics of the Nylon6-Fe composite with the existing acrylonitrile butadiene styrene(ABS) filament of the FDM machine. This Is carried out on the pin on disk setup by varying the load(5, 10, 15 and 20 N) and speed(200 and 300 r/min). It is concluded that the newly developed composite is highly wear resistant and can be used in industrial applications where wear resistance is of paramount importance. Morphology of the surface in contact with the Nylon6-Fe composite and ABS is also carried out.

关键词： composite material fused deposition modeling(FDM) parts tribology pin on disc iron(Fe) Nylon 6 acrylonitrile butadiene styrene(ABS)

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