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An Adaptive Scalable Data Pipeline for Multiclass Attack Classification in Large-Scale IoT Networks

Big Data Mining and Analytics 2024年第2期7卷 500-511页

作者： selvam Saravanan Uma Maheswari Balasubramanian Department of Computer Science and Engineering Amrita School of ComputingAmrita Vishwa VidyapeethamBengaluru 560035India

The current large-scale Internet of Things(IoT)networks typically generate high-velocity network traffic *** use IoT devices to create botnets and launch attacks,such as DDoS,Spamming,Cryptocurrency mining,Phishing,*** service providers of large-scale IoT networks need to set up a data pipeline to collect the vast network traffic data from the IoT devices,store it,analyze it,and report the malicious IoT devices and types of ***,the attacks originating from IoT devices are dynamic,as attackers launch one kind of attack at one time and another kind of attack at another *** number of attacks and benign instances also vary from time to *** phenomenon of change in attack patterns is called concept ***,the attack detection system must learn continuously from the ever-changing real-time attack patterns in large-scale IoT network *** meet this requirement,in this work,we propose a data pipeline with Apache kafka,Apache Spark structured streaming,and MongoDB that can adapt to the ever-changing attack patterns in real time and classify attacks in large-scale IoT *** concept drift is detected,the proposed system retrains the classifier with the instances that cause the drift and a representative subsample instances from the previous training of the *** proposed approach is evaluated with the latest dataset,IoT23,which consists of benign and several attack instances from various IoT *** classification accuracy is improved from 97.8%to 99.46%by the proposed *** training time of distributed random forest algorithm is also studied by varying the number of cores in Apache Spark environment.

关键词： Internet of Things(IoT) concept drift Apache Spark MongoDB Apache kafka streaming

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Feeding the vasculature with cruciferous vegetables:a secret for organ protection

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Signal Transduction and Targeted Therapy 2024年第3期9卷 828-830页

作者： priya Veluswamy Jens Wippermann Max Wacker Heart Surgery Research Department of Cardiothoracic SurgeryOtto-von-Guericke University HospitalMagdeburgGermany

Two very recent back-to-back papers published in Nature1,2 decipher the holistic role of the aryl hydrocarbon receptor(AHR)/dietary-ligand axis,in enteric and pulmonary vasculature to emphasize tolerance induction and vessel integrity during homeostasis,sterile inflammation and *** studies spectacularly highlight the significance of endothelium in orchestrating tissue tolerance by demonstrating the multifaceted activities of endothelial-expressed AHR that protects the vasculature to maintain organ homeostasis.

关键词： maintain sterile homeostasis

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 319-330页

作者： priya Bhardwaj Swarnabha Sarkar Ritu Mishra Department of Pharmacology All India Institute of Medical SciencesNew Delhi-110029India Department of Physiology All India Institute of Medical SciencesNew Delhi-110029India Department of Zoology University of AllahabadPrayagrajUttar Pradesh-211002India

The recently re-emerged mpox(monkeypox)virus that causes mpox disease is a member of genus Orthopoxvirus and has unprecedentedly spread *** studies have contributed to our understanding of its evolution,pathophysiology,and clinical *** current outbreak of the mpox virus depicts its novel route of transmission as a new ***,the exact reason for its transition from an epidemic to a pandemic remains ***,other poxviruses such as vaccinia virus,variola virus,and cowpox virus,also belong to the same genus,*** the present review,our objective was to summarize the evidence on evolution,pathophysiology,and clinical manifestations of mpox virus and its related *** present review would aid in a better understanding of the current circulating mpox virus and its differences from other *** addition,the shared genetic factors contributing to virulence in these Orthopoxvirus highlight their evolutionary connections and genetic *** they exhibit differences in virulence,studying these genetic relationships is crucial for understanding their biology,pathogenicity,and the development of effective vaccines and antiviral therapeutics to curb mpox disease.

关键词： Evolution Mpox Orthopoxviruses Pathophysiology Poxviruses Transmission

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An improved reverse time migration for subsurface imaging over complex geological structures:A numerical study

Energy Geoscience

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Energy Geoscience 2024年第2期5卷 290-297页

作者： Alok Kumar Routa priya Ranjan Monahty Department of Applied Geophysics IIT(ISM)DhanbadJharkhandIndia

In seismic exploration,it is a critical task to image and interpret different seismic signatures over complex geology due to strong lateral velocity contrast,steep reflectors,overburden strata and dipping *** understand the behavior of these seismic signatures,nowadays Reverse Time Migration(RTM)technique is used extensively by the oil&gas *** the extrapolation phase of RTM,the source wavefield needs to be saved,which needs high storage memory and large computing *** two are the main obstacles of RTM for production *** order to overcome these disadvantages,in this study,a second-generation improved RTM technique is *** this improved form,a shift operator is introduced at the time of imaging condition of RTM algorithm which is performed automatically both in space and time *** effort is made to produce a better-quality image by minimizing the computational time as well as numerical *** proposed method is applied over various benchmark models and validated by implementing over one field data set from the Jaisalmer Basin,*** the analysis,it is observed that the method consumes a minimum of 45%less storage space and reduce the execution time by 20%,as compared to conventional *** proposed RTM is found to work efficiently in comparison to the conventional RTM both in terms of imaging quality and minimization of numerical artefacts for all the benchmark models as well as field data.

关键词： Imaging condition Reverse time migration(RTM) Seismic imaging Velocity-depth model Wave propagation

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High-resolution multi-scale air pollution system:Evaluation of modelling performance and emission control strategies

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Journal of Environmental Sciences 2024年第3期137卷 65-81页

作者： Diogo Lopes Joana Ferreira Sandra Rafael ka In Hoi Xin Li Yuan Liu ka-Veng Yuen kai Meng Mok Ana Isabel Miranda Department of Environment and Planning&CESAM University of AveiroAveiroPortugal Department of Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric *** also allows furthering the design and assessment of air pollution control measures for a specific *** evaluate its performance and suitability,the system was applied to the Macao Special Administrative Region(SAR),China,one of the most densely populated areas on earth,during a winter period when this area is affected by high levels of Particulate Matter(PM).Although the developed system tends to underestimate the PM concentrations,it revealed a good performance in reproducing the temporal and spatial air pollution *** exceedances of the Chinese air quality standards were calculated and high population exposure to PM pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should focus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in Macao *** approach developed in this work can support policymakers in defining new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory Particulate matter Population exposure

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Design,optimization,and characterization of an in-situ pore-forming system for controlled delivery of paliperidone

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Medicine in Novel Technology and Devices 2024年第1期21卷 71-79页

作者： priya Pate Bhumi Ladani Gayatri Patel Ramanbhai Patel College of Pharmacy Charotar University of Science and TechnologyCHARUSAT–CampusChanga388421AnandGujaratIndia

The purpose of the current investigation was to develop a pharmaceutical equivalent osmotic drug delivery formulation of Paliperidone(PLD)in the form of controlled porosity osmotic pump tablets(CPOT)in order to keep the drug's steady state concentration in the *** helps to achieve the greatest therapeutic benefit with the fewest side *** the purpose of identifying various formulation attributes,preliminary trials were *** design was used to study the influence of seven input factors namely drug to polymer ratio,polymer 1(HPMC K100 M)to polymer 2(HPMC K15M),drug to total osmogens,coating level,amount of pore former,concentration of ethyl cellulose and amount of plasticizer on dependent variable similarity factor(f2).Utilizing the Minitab 17,data analysis was *** similarity factor(f2)was computed using the osmotic tablet reference product INVEGA®.The findings demonstrate that each of the seven independent variables significantly affects the similarity *** optimized batch,both core and coated tablets showed acceptable pharmaco-technical *** release profile of the optimized batch tablets was found to be similar to that of reference product with good zero-order release *** release was observed through the channels formed by in-situ pores on tablet surface performed using *** the results it can be concluded that prepared CPOT of PLD was found pharmaceutical equivalent with commercial product which is cost effective and fully compliance with cGMP.

关键词： Controlled release pH-independent release Similarity factor Pharmaceutical equivalent Reference product

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Multi-scale habitat influences sprainting and group size of a freshwater-obligate smooth-coated otter(Lutrogale perspicillata) in Tungabhadra Otter Conservation Reserve, India

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Ecological Processes 2024年第1期13卷 159-175页

作者： Ankit Moun P.Ramesh Kumar M.Malathi priya T.Ramesh Riddhika kalle Sálim Ali Centre for Ornithology and Natural History Deputy Conservator of Forests Bellary Territorial Forest Division Deputy Conservator of Forests Working Plan and Survey and Research WingBellary Territorial Forest Division Centre for Functional Biodiversity University of Kwa Zulu-Natal

Background The impact of changing land-use patterns and associated anthropogenic threats on scale-dependent habitat use of semi-aquatic mustelids in scent-marking and social behaviour can provide important insights into the habitat ecology of smooth-coated otters(Lutrogale perspicillata).Methods We sampled 180 stream segments(100–400 m) as spatial replicates of 60 1-km2 sites to record indirect evidence(i.e. spraints and mass latrine sites) and group sizes of smooth-coated otters along the Tungabhadra Otter Conservation Reserve(TOCR) during the dry season. To quantify habitat, we recorded stream characteristics, riparian vegetation, and anthropogenic disturbances at the local scale, and hydro-environmental characteristics and land uses at the landscape scale. Using Markovian-chain detection and occupancy models, we assessed the multi-scale habitat use of otters in their selection of suitable areas for scent-marking based on repeated presence-absence data on spraint/latrine locations along the TOCR. We further used linear regression techniques to explore relationships between the number of individuals in smooth-coated otter group and hydro-environmental characteristics, spraint/latrine encounter rate, anthropogenic pressure, land cover, topography, and *** At the local scale, the probability of spraint deposition and group size decreased with anthropogenic disturbance while the probability of spraint detections decreased with grass cover. At the landscape scale, the probability of otter site use for spraint deposition and group sizes increased in southeast flowing streams. Spraint deposition increased with the proportion of sugarcane fields, whereas in contrast, group size decreased with proportion of sugarcane *** Our findings highlight the first empirical evidence on multi-scale habitat use of a southern Indian population of smooth-coated otters in an inland freshwater ecosystem surrounded by the scrub jungle–agriculture matrix. We sug

关键词： Presence-absence modelling Inland river Freshwater ecosystem Semi-aquatic mammal Smooth-coated otter

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Serum tumor markers:Can they clinically implicate in type 2 diabetes mellitus?

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World Journal of Diabetes 2024年第7期15卷 1648-1650页

作者： Kotha Sugunakar Reddy Ilakkiya priya Pandiaraj Archana Gaur Sakthivadivel Varatharajan Department of General Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

“Serum tumor markers expression(CA19-9,CA242,and CEA)and its clinical implications in type 2 diabetes mellitus”authored by Meng and Shi presents an observational case-control study investigating the correlation between tumor markers and type 2 diabetes mellitus(T2DM).The study explores the diagnostic accuracy of tumor markers,particularly cancer antigen 19-9(CA19-9),CA242,and carcinoembryonic antigen,in poorly controlled T2DM patients with hemoglobin A1c levels exceeding 9%,employing receiver operating characteristic curve *** study offers valuable insights into the potential utility of tumor markers in clinical practice,caution is advised regarding routine tumor marker testing due to challenges such as limited availability and ***,the study overlooks potential confounding factors like smoking and alcohol *** in CA19-9 and CA242 expression underscore the complex interplay between tumor markers and systemic diseases,warranting further investigation into their diagnostic and prognostic *** Meng and Shi represent a significant contribution to the field,more extensive research is needed to fully elucidate the role of tumor markers in diabetes management and beyond.

关键词： Cancer antigen 19-9 Cancer antigen 242 Carcinoembryonic antigen Tumor markers Type 2 diabetes mellitus

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Anthropogenic noise interacts with the predation risk assessment in a free-ranging bird

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Current Zoology 2024年第3期70卷 277-283页

作者： Piotr Matyjasiak Patrycja Chacińska Piotr Książka Institute of Biological Sciences Cardinal Stefan Wyszyński University in WarsawWóycickiego 1/3PL-01-815 WarsawPoland Department of Environmental Acoustics Institute of Environmental Protection—National Research InstituteKolektorska 4PL-01-692 WarsawPoland

Anthropogenic noise can affect a number of behavioral,physiological,and ecological aspects of animals from major taxonomic groups,raising serious conservation *** example,noise pollution impacts communicative behavior and perception of signals,movements and distribution,as well as predator–prey interactions,such as hunting success or predator detection and predation risk *** have carried out an experimental playback study,in which we investigated whether exposure to anthropogenic noise(sound of a tractor)distracts free-ranging barn swallows Hirundo rustica from paying attention to an approaching human“predator”(the“cognitive distraction”hypothesis),or whether noise leads to increased responsiveness to this“predator”(the“increased threat”hypothesis).The subjects were male barn swallows attending their breeding territories during the time when the females were *** found that barn swallow males initiated fight at signifcantly greater distances to the approaching human“predator”in the noise treatment than during the quiet control *** results suggest that anthropogenic noise causes increased vigilance and reactivity rather than a distraction,enabling birds to avoid the“predator”more *** further discuss the mechanism behind the increased alertness in response to noise and contrast the“increased threat”mechanism,usually tested in previous studies,with an alternative“cognitive sensitization”mechanism.

关键词： anthropogenic noise barn Swallow cognitive distraction flight initiation distance Hirundo rustica predation risk assessment

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Selective deposition of a MOF at the spikes of Au nanostars for SERS detection

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Nano Research 2024年第10期17卷 9166-9173页

作者： Yi Liu ka Kit Chui Xinyue Xia Han Zhang Xiaolu Zhuo Jianfang Wang School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China Department of Physics The Chinese University of Hong KongShatinHong Kong 999077China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310000China

In the pursuit of advancing molecular sensing through surface-enhanced Raman spectroscopy(SERS),the combination of plasmonic nanoparticles and metal-organic frameworks(MOFs)has emerged as a highly effective approach to enhance the sensitivity and selectivity of SERS ***,most prior investigations have predominantly focused on MOF-coated plasmonic nanoparticles in core@shell or layer-by-layer configurations,leaving a notable knowledge gap in exploring alternative *** we present a facile method to construct a particle-on-mirror architecture by selectively coating a MOF,zeolitic imidazolate framework-8(ZIF-8),onto the tips of Au nanostars and subsequently depositing the resultant nanoparticles onto a Au *** design integrates the electric field enhancement at the sharp tips and nanogaps,along with the molecular enrichment function within the porous MOF immobilized at the tips and nanogaps,leading to a substantial boost in the SERS signal *** a unique SERS platform enables consistent and outstanding SERS performance for analytes of different *** work opens up a promising strategy for constructing multifunctional nanostructures for sensitive SERS detection in real-life scenarios.

关键词： electric field enhancement gold nanostars metal-organic frameworks molecular enrichment plasmon coupling surfaceenhanced Raman spectroscopy(SERS)substrates

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