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Role of endoscopic ultrasound guided fine needle aspiration/biopsy in the evaluation of intra-abdominal lymphadenopathy due to tuberculosis

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World Journal of Gastrointestinal Endoscopy 2021年第12期13卷 649-658页

作者： Harshavardhan Rao B priya Nair S krishna priya Archana George Vallonthaiel Dipu T Sathyapalan Anoop K Koshy Rama P Venu Department of Gastroenterology Amrita Institute of Medical SciencesKochi 682041KeralaIndia Department of Pathology Amrita Institute of Medical SciencesKochi 682041KeralaIndia Department of Internal Medicine Amrita Institute of Medical Sciences and Research CentreKochi 682041KeralaIndia

BACKGROUND Intra-abdominal lymphadenopathy due to tuberculosis(TB)poses a diagnostic challenge due to difficulty in tissue *** endoscopic ultrasound guided fine needle aspiration/biopsy(EUS-FNA/B)has shown promise in the evaluation of mediastinal lymph nodes,its role in the evaluation of intra-abdominal lymphadenopathy is not *** To assess the role of EUS-FNA/B in the evaluation of intra-abdominal lymphadenopathy due to *** This was a retrospective study where patients with intra-abdominal lymphadenopathy who underwent evaluation with EUS-FNA/B were *** was diagnosed if the patient had any one of the following:(1)Positive acid fast bacilli(AFB)stain/TB GeneXpert/TB-polymerase chain reaction/AFB culture of tissue sample;and(2)Positive Mantoux test and response to anti-tubercular ***-FNA reports,clinical reports and imaging characteristics of patients were recorded for a detailed analysis of patients with *** A total of 149 patients underwent an EUS-FNA/B from lymph nodes(mean age 51±17 years,M:F=1.2).Benign inflammatory reactive changes were seen in 45 patients(30.2%),while 54 patients(36.2%)showed granulomatous inflammation with/without *** these,51 patients(94.4%)were confirmed to have TB as per pre-defined *** with TB were more likely to have hypoechoic and matted nodes[40 patients(67.7%)].EUS-FNA/B was found to have a sensitivity and specificity of 86%and 93%respectively,with a diagnostic accuracy of 88%in the evaluation of intra-abdominal lymphadenopathy due to *** EUS-FNA/B has a high diagnostic yield with a good sensitivity and specificity in the evaluation of intra-abdominal lymphadenopathy due to ***,the validity of these findings in populations with low prevalence of TB needs further evaluation.

关键词： Endoscopic ultrasound Lymph nodes Tuberculosis Mesenteric Intraabdominal

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布兰妮的香水帝国

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新营销 2016年第12期18卷 18-20页

作者： priya krishna 陈喆

小甜甜布兰妮已经建立了有史以来最能赚钱的香水系列。不知什么时候开始,每年都会有名人推出自己设计的香水,有些大受吹捧,有些被批得一无是处。但似乎很少有哪一款名人香水能够长久屹立于香水行业。偏偏有一个例外。不是碧昂斯,也不是... 详细信息

小甜甜布兰妮已经建立了有史以来最能赚钱的香水系列。不知什么时候开始,每年都会有名人推出自己设计的香水,有些大受吹捧,有些被批得一无是处。但似乎很少有哪一款名人香水能够长久屹立于香水行业。偏偏有一个例外。不是碧昂斯,也不是泰勒·斯威夫特,甚至不是金·卡戴珊。

关键词：布兰妮香水帝国斯威夫特水行业名人

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Feeding the vasculature with cruciferous vegetables:a secret for organ protection

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Signal Transduction and Targeted Therapy 2024年第3期9卷 828-830页

作者： priya Veluswamy Jens Wippermann Max Wacker Heart Surgery Research Department of Cardiothoracic SurgeryOtto-von-Guericke University HospitalMagdeburgGermany

Two very recent back-to-back papers published in Nature1,2 decipher the holistic role of the aryl hydrocarbon receptor(AHR)/dietary-ligand axis,in enteric and pulmonary vasculature to emphasize tolerance induction and vessel integrity during homeostasis,sterile inflammation and *** studies spectacularly highlight the significance of endothelium in orchestrating tissue tolerance by demonstrating the multifaceted activities of endothelial-expressed AHR that protects the vasculature to maintain organ homeostasis.

关键词： maintain sterile homeostasis

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An improved reverse time migration for subsurface imaging over complex geological structures:A numerical study

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Energy Geoscience 2024年第2期5卷 290-297页

作者： Alok Kumar Routa priya Ranjan Monahty Department of Applied Geophysics IIT(ISM)DhanbadJharkhandIndia

In seismic exploration,it is a critical task to image and interpret different seismic signatures over complex geology due to strong lateral velocity contrast,steep reflectors,overburden strata and dipping *** understand the behavior of these seismic signatures,nowadays Reverse Time Migration(RTM)technique is used extensively by the oil&gas *** the extrapolation phase of RTM,the source wavefield needs to be saved,which needs high storage memory and large computing *** two are the main obstacles of RTM for production *** order to overcome these disadvantages,in this study,a second-generation improved RTM technique is *** this improved form,a shift operator is introduced at the time of imaging condition of RTM algorithm which is performed automatically both in space and time *** effort is made to produce a better-quality image by minimizing the computational time as well as numerical *** proposed method is applied over various benchmark models and validated by implementing over one field data set from the Jaisalmer Basin,*** the analysis,it is observed that the method consumes a minimum of 45%less storage space and reduce the execution time by 20%,as compared to conventional *** proposed RTM is found to work efficiently in comparison to the conventional RTM both in terms of imaging quality and minimization of numerical artefacts for all the benchmark models as well as field data.

关键词： Imaging condition Reverse time migration(RTM) Seismic imaging Velocity-depth model Wave propagation

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 319-330页

作者： priya Bhardwaj Swarnabha Sarkar Ritu Mishra Department of Pharmacology All India Institute of Medical SciencesNew Delhi-110029India Department of Physiology All India Institute of Medical SciencesNew Delhi-110029India Department of Zoology University of AllahabadPrayagrajUttar Pradesh-211002India

The recently re-emerged mpox(monkeypox)virus that causes mpox disease is a member of genus Orthopoxvirus and has unprecedentedly spread *** studies have contributed to our understanding of its evolution,pathophysiology,and clinical *** current outbreak of the mpox virus depicts its novel route of transmission as a new ***,the exact reason for its transition from an epidemic to a pandemic remains ***,other poxviruses such as vaccinia virus,variola virus,and cowpox virus,also belong to the same genus,*** the present review,our objective was to summarize the evidence on evolution,pathophysiology,and clinical manifestations of mpox virus and its related *** present review would aid in a better understanding of the current circulating mpox virus and its differences from other *** addition,the shared genetic factors contributing to virulence in these Orthopoxvirus highlight their evolutionary connections and genetic *** they exhibit differences in virulence,studying these genetic relationships is crucial for understanding their biology,pathogenicity,and the development of effective vaccines and antiviral therapeutics to curb mpox disease.

关键词： Evolution Mpox Orthopoxviruses Pathophysiology Poxviruses Transmission

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Design,optimization,and characterization of an in-situ pore-forming system for controlled delivery of paliperidone

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Medicine in Novel Technology and Devices 2024年第1期21卷 71-79页

作者： priya Pate Bhumi Ladani Gayatri Patel Ramanbhai Patel College of Pharmacy Charotar University of Science and TechnologyCHARUSAT–CampusChanga388421AnandGujaratIndia

The purpose of the current investigation was to develop a pharmaceutical equivalent osmotic drug delivery formulation of Paliperidone(PLD)in the form of controlled porosity osmotic pump tablets(CPOT)in order to keep the drug's steady state concentration in the *** helps to achieve the greatest therapeutic benefit with the fewest side *** the purpose of identifying various formulation attributes,preliminary trials were *** design was used to study the influence of seven input factors namely drug to polymer ratio,polymer 1(HPMC K100 M)to polymer 2(HPMC K15M),drug to total osmogens,coating level,amount of pore former,concentration of ethyl cellulose and amount of plasticizer on dependent variable similarity factor(f2).Utilizing the Minitab 17,data analysis was *** similarity factor(f2)was computed using the osmotic tablet reference product INVEGA®.The findings demonstrate that each of the seven independent variables significantly affects the similarity *** optimized batch,both core and coated tablets showed acceptable pharmaco-technical *** release profile of the optimized batch tablets was found to be similar to that of reference product with good zero-order release *** release was observed through the channels formed by in-situ pores on tablet surface performed using *** the results it can be concluded that prepared CPOT of PLD was found pharmaceutical equivalent with commercial product which is cost effective and fully compliance with cGMP.

关键词： Controlled release pH-independent release Similarity factor Pharmaceutical equivalent Reference product

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Multi-scale habitat influences sprainting and group size of a freshwater-obligate smooth-coated otter(Lutrogale perspicillata) in Tungabhadra Otter Conservation Reserve, India

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Ecological Processes 2024年第1期13卷 159-175页

作者： Ankit Moun P.Ramesh Kumar M.Malathi priya T.Ramesh Riddhika Kalle Sálim Ali Centre for Ornithology and Natural History Deputy Conservator of Forests Bellary Territorial Forest Division Deputy Conservator of Forests Working Plan and Survey and Research WingBellary Territorial Forest Division Centre for Functional Biodiversity University of Kwa Zulu-Natal

Background The impact of changing land-use patterns and associated anthropogenic threats on scale-dependent habitat use of semi-aquatic mustelids in scent-marking and social behaviour can provide important insights into the habitat ecology of smooth-coated otters(Lutrogale perspicillata).Methods We sampled 180 stream segments(100–400 m) as spatial replicates of 60 1-km2 sites to record indirect evidence(i.e. spraints and mass latrine sites) and group sizes of smooth-coated otters along the Tungabhadra Otter Conservation Reserve(TOCR) during the dry season. To quantify habitat, we recorded stream characteristics, riparian vegetation, and anthropogenic disturbances at the local scale, and hydro-environmental characteristics and land uses at the landscape scale. Using Markovian-chain detection and occupancy models, we assessed the multi-scale habitat use of otters in their selection of suitable areas for scent-marking based on repeated presence-absence data on spraint/latrine locations along the TOCR. We further used linear regression techniques to explore relationships between the number of individuals in smooth-coated otter group and hydro-environmental characteristics, spraint/latrine encounter rate, anthropogenic pressure, land cover, topography, and *** At the local scale, the probability of spraint deposition and group size decreased with anthropogenic disturbance while the probability of spraint detections decreased with grass cover. At the landscape scale, the probability of otter site use for spraint deposition and group sizes increased in southeast flowing streams. Spraint deposition increased with the proportion of sugarcane fields, whereas in contrast, group size decreased with proportion of sugarcane *** Our findings highlight the first empirical evidence on multi-scale habitat use of a southern Indian population of smooth-coated otters in an inland freshwater ecosystem surrounded by the scrub jungle–agriculture matrix. We sug

关键词： Presence-absence modelling Inland river Freshwater ecosystem Semi-aquatic mammal Smooth-coated otter

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Serum tumor markers:Can they clinically implicate in type 2 diabetes mellitus?

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World Journal of Diabetes 2024年第7期15卷 1648-1650页

作者： Kotha Sugunakar Reddy Ilakkiya priya Pandiaraj Archana Gaur Sakthivadivel Varatharajan Department of General Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

“Serum tumor markers expression(CA19-9,CA242,and CEA)and its clinical implications in type 2 diabetes mellitus”authored by Meng and Shi presents an observational case-control study investigating the correlation between tumor markers and type 2 diabetes mellitus(T2DM).The study explores the diagnostic accuracy of tumor markers,particularly cancer antigen 19-9(CA19-9),CA242,and carcinoembryonic antigen,in poorly controlled T2DM patients with hemoglobin A1c levels exceeding 9%,employing receiver operating characteristic curve *** study offers valuable insights into the potential utility of tumor markers in clinical practice,caution is advised regarding routine tumor marker testing due to challenges such as limited availability and ***,the study overlooks potential confounding factors like smoking and alcohol *** in CA19-9 and CA242 expression underscore the complex interplay between tumor markers and systemic diseases,warranting further investigation into their diagnostic and prognostic *** Meng and Shi represent a significant contribution to the field,more extensive research is needed to fully elucidate the role of tumor markers in diabetes management and beyond.

关键词： Cancer antigen 19-9 Cancer antigen 242 Carcinoembryonic antigen Tumor markers Type 2 diabetes mellitus

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Preparedness,knowledge,and perception of nursing students about climate change and its impact on human health in India

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Regional Sustainability 2024年第1期5卷 107-118页

作者： Ramya Kundayi RAVI priya BABY Nidhin ELIAS Jisa George THOMAS Kathyayani Bidadi VEERABHADRAIAH Bharat PAREEK College of Nursing Medical and Health Sciences UniversityRas Al Khaimah11172United Arab Emirates College of Nursing National Institute of Mental Health and Neuro sciencesBangalore560011India College of Nursing Amrita Institute of Medical SciencesKochi682041India College of Nursing All India Institute of Medical SciencesBhopal462020India Saraswati Professional and Higher Education College of Nursing Mohali140413India

Higher education plays an important role in all aspects of *** climate change and sustainability into the curriculum is important to prepare future health-care professionals for climate change and sustainability actions to build resilient health *** this study,we evaluated the preparedness,knowledge,and perception regarding climate change and its impact on human health among Indian nursing students.A quantitative descriptive survey was conducted among 644 undergraduate nursing students studying in three institutes in the southern,northern,and western parts of *** used a structured online questionnaire with established validity and reliability to collect *** data were analyzed using Statistical Package for the Social Sciences version 26 *** results showed that more than half of the students reported experiencing excessive increase(362;56.2%)and decrease(374;58.1%)in temperature in recent *** more than three quarters of the students(494;76.7%)accepted the general truth that climate change is mainly caused by human activities,only less than half of the students(309;48.0%)perceived the impact of climate change to be *** quarters of the students(483;75.0%)had a high level of knowledge regarding climate *** students who had a high level of knowledge about climate change exerted a high perceived impact of climate change(χ^(2)=75.47;P<0.01).More than half of the students(50.9%)felt that they needed information about climate change to be included in the nursing curriculum,and only one sixth of the students(16.1%)were highly confident about engaging in climate change-related conversation with *** of the students who participated in the study had basic knowledge about climate change and its impact on human ***,there is an observed gap between knowledge and their preparedness and confidence to engage in climate change ***,we propose to strengthen the nursing curriculum by integra

关键词： Climate change Curriculum Nursing students Human health India

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Cancer treatment with biosimilar drugs:A review

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Cancer Innovation 2024年第2期3卷 45-62页

作者： Shilpa Malakar Emmanuel Nuah Gontor Moses YDugbaye Kamal Shah Sakshi Sinha priya Sutaoney Nagendra Singh Chauhan Department of Microbiology Kalinga UniversityRaipurChhattisgarhIndia Institute of Pharmaceutical Research GLA UniversityMathuraUttar PradeshIndia Drug Testing Laboratory Avam Anusandhan KendraRaipurChhattisgarhIndia

Biosimilars are biological drugs created from living organisms or that contain living *** share an identical amino-acid sequence and *** drugs are considered to be cost-effective and are utilized in the treatment of cancer and other endocrine *** primary aim of biosimilars is to predict biosimilarity,efficacy,and treatment costs;they are approved by the Food and Drug Administration(FDA)and have no clinical *** involve analytical studies to understand the similarities and dissimilarities.A biosimilar manufacturer sets up FDA-approved reference products to evaluate *** contribution of next-generation sequencing is evolving to study the organ tumor and its progression with its impactful therapeutic approach on cancer patients to showcase and target rare *** study shall help to understand the future perspectives of biosimilars for use in gastro-entero-logic diseases,colorectal cancer,and thyroid *** also help target specific organs with essential mutational categories and drug prototypes in clinical practices with blood and liquid biopsy,cell treatment,gene therapy,recombinant therapeutic proteins,and personalized *** derivatives such as monoclonal antibodies like trastuzumab and rituximab are common drugs used in cancer *** coli produces more than six antibodies or antibody-derived proteins to treat cancer such as filgrastim,epoetin alfa,and so on.

关键词： biologics biosimilars cancer Escherichia coli monoclonal antibody next-generation sequencing pharmacovigilance

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