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Leukocytoclastic vasculitis caused by hepatitis C virus in a liver transplant recipient: A case report

World Journal of Hepatology 2019年第4期11卷 402-408页

作者： Gustavo de Sousa Arantes Ferreira Andre Luis Conde Watanabe Natalia de Carvalho Trevizoli Fernando Marcus Felippe Jorge Luiz Gustavo Guedes Diaz Milla Carolina Costa Lafeta Araujo Gabriela de campos Araujo Amanda de Castro Machado department of Liver Transplantation Instituto de Cardiologia do Distrito Federal Curso de Medicina Universidade Catolica de Brasilia

BACKGROUND Infection by the hepatitis C virus(HCV) is currently considered to be a global health issue, with a high worldwide prevalence and causing chronic disease in afflicted individuals. The disease largely involves the liver but it can affect other organs, including the skin. While leukocytoclastic vasculitis has been reported as one of the dermatologic manifestations of HCV infection, there are no reports of this condition as the first symptom of HCV recurrence after liver *** SUMMARY We report here a case of leukocytoclastic vasculitis in a liver transplant recipient on maintenance immunosuppression. The condition presented as a palpable purpura in both lower extremities. Blood and urine cultures were negative and all biochemical tests were normal, excepting evidence of anemia and hypocomplementemia. Imaging examination by computed tomography showed a small volume of ascites, diffuse thickening of bowel walls, and a small bilateral pleural effusion. Skin biopsy showed leukocytoclasia and fibrinoid *** biopsy was suggestive of HCV recurrence in the graft, and HCV polymerase chain reaction yielded 11460 copies/mL and identified the genotype as 1 A. Treatment of the virus with a 12-wk direct-acting antiviral regimen of ribavirin, sofosbuvir and daclatasvir led to regression of the symptoms within the first 10 d and subsequent complete resolution of the *** This case highlights the difficulties of diagnosing skin lesions caused by HCVinfection in immunosuppressed patients.

关键词： Hepatitis C Liver transplantation Leukocytoclastic vasculitis Immunosuppression Direct-acting antivirals Case report

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Management of bone metastases in renal cell carcinoma: bone-targeted treatments, systemic therapies, and radiotherapy

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 628-639页

作者： AndréMansinho priscila Nejo Tito Leitão Sandra Casimiro Luís Costa Serviço de Oncologia Médica Centro Hospitalar Universitário Lisboa NorteHospital de Santa MariaLisboa 1649-035Portugal Luis Costa Laboratory Instituto de Medicina MolecularFaculdade de Medicina da Universidade de LisboaLisboa 1649-035Portugal Instituto Português de Oncologia Lisboa Francisco Gentil Lisboa 1649-035Portugal Urology department Centro Hospitalar Universitário Lisboa NorteHospital de Santa MariaLisboa 1649-035Portugal

Metastatic renal cell carcinoma(mRCC)presents with bone metastases in around 20%-30%of patients enrolled in the most recent first-line clinical *** of several new agents in first line,in both monotherapy and combination,has significantly improved patient ***,the activity of such agents on bone metastases is unclear and management of these patients is complex,due to potential complications that can significantly impair quality of *** review addresses mRCC diagnosis and monitoring and summarizes the current evidence on systemic therapy,ablative therapies such as stereotactic ablative radiotherapy and surgery,and supportive therapy with bone-targeting agents for these patients,with the goal of improving their outcomes.

关键词： Bone metastases renal cell carcinoma bone targeted treatments radiotherapy systemic therapy

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Mental Functioning of Workers with Cancer Diagnosis by Brazilian Version of the Work Role Functioning Questionnaire—WRFQ-Br

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Health 2016年第14期8卷 1495-1505页

作者： Cristiane Helena Gallasch Neusa Maria Costa Alexandre Sergio Carlos Barros Esteves Eugenio Fuentes Pérez Júnior Magda Guimarães de Araujo Faria Elias Barbosa de Oliveira priscila Cristina da Silva Thiengo Patricia campos Pavan Baptista Faculty of Nursing Rio de Janeiro State University Rio de Janeiro Brazil Post Graduation Programs Professor Group of Studies and Researches in Occupational Health and Ergonomics Leader Faculty of Nursing State University of Campinas Campinas Brazil CAISM Hospital da Mulher Dr. José Aristodemo Pinotti State University of Campinas Campinas Brazil Post Graduation and Under Graduation Programs Professor Mental Health and Work Study Group Leader (GESMT) Faculty of Nursing Rio de Janeiro State University Rio de Janeiro Brazil Post Graduation and Under graduation Programs Professor Leader of the Group of Studies on the Health of Nursing Worker (GESTE) School of Nursing University of S&atilde o Paulo S&atilde o Paulo Brazil

Aim: To evaluate data related to mental work functioning of workers with cancer diagnosis in radiotherapy in a private service in the city of Campinas, State of São Paulo, Brazil. Method: It consists in a cross-sectional, observational and analytical study with comparison between cancer patients and healthy people, using the Brazilian version of the Work Role Functioning Questionnaire (WRFQ-Br). descriptive and statistical analysis is performed by the Mann-Whitney test. Results: There was a significant difference between the groups in the evaluation of mental demand;however, the population diagnosed with malignant neoplasm submitted to radiotherapy had unexpected higher scores, reflecting lower mental exigency. Conclusions: The observed context may occur due to extensive support of family, government and interdisciplinary team of health care for individuals diagnosed with cancer. This data provide support for new research studies related to the importance of the work to promote mental health, considering aspects related to social interaction and productivity as the support system members. The importance of disseminating these results and limitation is based in the necessity of investments to improve research and actions to promote the permanence and early return to work for cancer survivors in Brazil and Latin America.

关键词： Neoplasms Mental Health Social Support Occupational Health Nursing

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NMS Flows on Three-Dimensional Manifolds with One Saddle Periodic Orbit

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Acta Mathematica Sinica,English Series 2004年第1期20卷 47-56页

作者： B.campos A.CORdeRO J.Martinez ALFARO P.VINdeL department Matemàtiques Universitat Jaume I.CastellóSpain department Matemàtica Aplicada Universitat Politècnica de ValènciaSpain department Matemàtica Aplicada Facultat MatemàtiquesUniversitat de ValènciaSpain

The simplest NMS flow is a polar flow formed by an attractive periodic orbit and a repulsive periodic orbit as limit sets. In this paper we show that the only orientable, simple, compact, 3-dimensional manifolds without boundary that admit an NMS flow with none or one saddle periodic orbit are lens spaces. We also see that when a fattened round handle is a connected sum of tori, the corresponding flow is also a trivial connected sum of flows.

关键词： NMS systems Links of periodic orbits Round handle decomposition Lens spaces

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The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena

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Neuroscience Bulletin 2021年第10期37卷 1493-1509页

作者： priscila Vazquez-Leon Abraham Miranda-Paez Jesus Chavez-Reyes Gonzalo Allende Paulino Barragan-Iglesias Bruno A.Marichal-Cancino departamento de Fisiologia y Farmacologia Centro de Ciencias BasicasUniversidad Autonoma de AguascalientesCiudad Universitaria20131 AguascalientesAgs.Mexico departamento de Fisiologia Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalWilfrido Massieu esq.Manuel Stampa s/n Col.Nueva Industrial Vallejo07738 Gustavo A.MaderoMexico CityMexico

The periaqueductal gray(PAG)is a complex mesencephalic structure involved in the integration and execution of active and passive self-protective behaviors against imminent threats,such as immobility or flight from a *** activity is also associated with the integration of responses against physical discomfort(e.g.,anxiety,fear,pain,and disgust)which occurs prior an imminent attack,but also during withdrawal from drugs such as morphine and *** PAG sends and receives projections to and from other well-documented nuclei linked to the phenomenon of drug addiction including:(i)the ventral tegmental area;(ii)extended amygdala;(iii)medial prefrontal cortex;(iv)pontine nucleus;(v)bed nucleus of the stria terminalis;and(vi)*** models have suggested that the PAG contributes to the modulation of anxiety,fear,and nociception(all of which may produce physical discomfort)linked with chronic exposure to drugs of *** produced by the major pharmacological classes of drugs of abuse is mediated through actions that include participation of the *** support of this,there is evidence of functional,pharmacological,***/or genetic alterations in the PAG during the impulsive/compulsive intake or withdrawal from a *** to its small size,it is difficult to assess the anatomical participation of the PAG when using classical neuroimaging techniques,so its phys-iopathology in drug addiction has been underestimated and poorly *** this theoretical review,we discuss the involvement of the PAG in drug addiction mainly via its role as an integrator of responses to the physical discomfort associated with drug withdrawal.

关键词： Periaqueductal gray Reward circuit Antireward circuit Alcohol Caffeine Cannabis Opioids Stimulants

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Experimental Acoustic determination of the Void Fraction in Two-Phase Flow in Horizontal Pipelines

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Journal of Mechanics Engineering and Automation 2014年第8期4卷 625-631页

作者： Fernando Augusto de Noronha Castro Pinto Thiago de campos Negrelly Alexandre Silva de Lima Mechanical Engineering department UFRJ (Universidade Federal do Rio de Janeiro) Rio de Janeiro 21941-972 Brasil Mechanical Engineering department CEFET/RJ (Centro Federal de Educag6o Tecnologica Celso Suckow da Fonseca) Rio deJaneiro 20271-110 Brasil

In multi-phase flows, the phases can flow and arranged in different spatial configurations in the pipe, which called flow patterns. This type of flow is found in the oil, chemical and nuclear industries. For example, in the production and transport of oil and gas, the identification of the flow patterns are essential for answering those questions which are related to the economic return of the field, such as, measuring the volumetric flow, determining the pressure drop along the flow lines, production management and supervision. In offshore production, these factors are very important. This paper presents a new method for measuring the void fraction in horizontal pipelines, taking the air as gas in water-air two-phase flow. Through acoustic analysis of the frequency response of the pipe, the method gets the parameters to changes in runoff regime, in an experimental arrangement constructed on a small scale. The main advantages are the non-intrusive characteristic and easy to implement. The paper is composed of a qualitative experimental evaluation and transducers （microphone） which are used to analyze variations in the response accompanying variations in void and flow pattern changes. Changes are imposed and controlled by a two-phase flow experimental simulation rig, including a measurement cell constituted of an external casing that can isolate the measurement from the environmental background noise fitted with acoustic pressure transducers radially arranged, and the impact of a monitored excitation mechanism. The signals which captured by the microphones are processed and analyzed by checking their frequency contents changes according to the amount of air in the mixture.

关键词： Experimental method two-phase flow determination of void fraction horizontal pipelines.

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Characterization of goat whey proteins and their bioactivity and toxicity assay

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Food Bioscience 2022年第2期46卷 833-843页

作者： Maria Isabel Ferreira campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha Programa de P´os-Graduaç˜ao em Ciˆencia e Tecnologia de Alimentos Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil departamento de Biologia Molecular Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil Centro de desenvolvimento Tecnol´ogico Universidade Federal de PelotasRio Grande do SulBrazil Programa de P´os-Graduaç˜ao em Ciˆencias da Nutriç˜ao Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil

Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s ***,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute *** proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE *** activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for *** *** activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of *** highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical *** acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout ***,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without *** present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry.

关键词： Goat whey proteins Malignant cells Antimicrobial Antioxidant capacity Whey protein functionality

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Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy

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World Journal of Gastroenterology 2014年第42期20卷 15910-15915页

作者： Letícia de campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro Internal Medicine department Gastroenterology Division Botucatu Medical School UNESP 18 618 970 Botucatu Sao Paulo Brazil Hospital do Cora??o do Instituto de Moléstias Cardiovasculares S?o José do Rio Preto Sao Paulo 15015-210 Brazil department of Internal Medicine Division of Cardiology Botucatu School of Medicine UNESP Univ Estadual Paulista

Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric *** occurs in acute and chronic hepatic disease and also in patients with portosystemic *** presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver ***,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a *** this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic *** report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant *** had a wide portosystemic shunt and also portal vein *** abdominal angiography confirmed the splenorenal shunt and showed other *** larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt *** was a little increase of esophageal and gastric varices,but no endoscopic treatment was *** portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt ***,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE *** conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein *** the patient had other shunts,she was successfully treated by embolization of the larger shunt.

关键词： Recurrent hepatic encephalopathy Liver cirrhosis Port systemic shunt Shunt embolization Portal vein thrombosis

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Mechanical properties and connectivity evaluation of a conductive coated piezoceramic/polymer composite

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Journal of Advanced Dielectrics 2014年第3期4卷 18-22页

作者： Gilberto de campos Fuzari Jr Walter Katsumi Sakamoto Universidade Federal de Mato Grosso(UFMT)Campus do Araguaia Instituto de Ciencias Exatas e da Terra Barra do Garcas(MT)Brasil Faculdade de Engenharia Universidade Estadual PaulistaUNESP Campus de Ilha SolteiraDepto.de Fisica e Quimica Av.Brasil5615.385-000Ilha Solteira(SP)Brasil

In the present work,piezoelectric composite films made of Polyaniline(PAni)coated Lead Zirconate Titanate(PZT)particles immersed into polyvinylidene fluoride(PVDF)matrix were characterized by mechanical tests,and the connectivity of the com-posite sample was determined using dielectric measurements and applying the Poon–Shin *** composite was considered a binary system with coated PZT particles as one phase and the polymer matrix the other *** support the result obtained from theoretical analysis,scanning electron microscopy of the composites were *** was observed a decrease up to 85%on the mechanical resistance when the ceramic volume fraction increases from 0%to 40%.Furthermore,the composite film no longer can be considered with 0–3 connectivity when the ceramic content is 30 vol.%or over.

关键词： Piezoelectric composite mechanical resistance Poon-Shin model 0-3 connectivity

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Diversity of plants and mammals as indicators of the effects of land management types in woodlands

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Forest Ecosystems 2021年第4期8卷 991-1005页

作者： Carolina R.Szymanski Solana Tabeni Juan A.Alvarez Claudia M.campos Instituto Argentino de Nivologia Glaciologia y Ciencias AmbientalesCCT CONICET MendozaAv.Ruiz Leal s/nParque General San Martin5000 MendozaArgentina Facultad de Ciencias Agrarias Universidad Nacional de CuyoAlte.Brown s/nChacras de Coria5505 MendozaArgentina Instituto Argentino de Investigaciones de las Zona Aridas(UNCuyo-Gobierno de Mendoza-CONICET) CCT CONICET MendozaAv.Ruiz Leal s/nParque General San Martin5000 MendozaArgentina

Background:The ecological indicators are useful tools to determine the effects of human disturbances on woodland ***,ecological indicators not always responded in the same way to disturbances,and the responses can differ among *** arid and semiarid woodlands,the use of deadwood associated with cattle raising can affect biodiversity and Nature’s contributions to ***:Our study aimed to assess changes in taxonomic and functional diversity of two assemblages,plants and mammals,in Prosopis woodlands under different land management types:grazed woodlands and a protected *** plants,changes in structural diversity were also *** trees under different land management types were selected and their deadwood characteristics were *** live traps and camera traps,we obtained data on the presence-absence of mammals per tree to estimate diversity *** plants,we measured the abundance of vegetation by species and by cover type through the Line-Intercept Method to estimated ***,we built generalized linear models to assess the responses of diversity of each assemblage to covariables concerning deadwood and different land management ***:We found that all diversity indeces for plants were either negatively affected by the presence of deadwood on the ground,or favored by its *** mammals,removal of deadwood increased taxonomic diversity,while functional diversity increased with deadwood on the *** structural diversity of plants and functional diversity of mammals were greater in grazed ***:The sustainable use of woodland resources is essential for the activities of rural *** study results indicated that land management of grazed woodlands promoted the structural diversity of plant assemblages and the functional diversity of *** presence of deadwood negatively affected plant diversity but it increased mammal functional *** is a

关键词： Central Monte Cattle raising deadwood extraction Taxonomic diversity Functional traits

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