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Recent advances in lung-on-a-chip technology for modeling respiratory disease

生物设计与制造(英文) 2023年第5期6卷 563-585页

作者： Jorge A.Tavares-Negrete prativa das Sahar Najafikhoshnoo Steven Zanganeh Rahim Esfandyarpour Department of Electrical Engineering University of CaliforniaIrvineCA 92697USA Department of Biomedical Engineering University of CaliforniaIrvineCA 92697USA Henry Samueli School of Engineering University of CaliforniaIrvineCA 92697USA Laboratory for Integrated Nano Bio Electronics Innovation Henry Samueli School of EngineeringUniversity of CaliforniaIrvineCA 92697USA Department of Mechanical and Aerospace Engineering University of CaliforniaIrvineCA 92697USA Department of Bioengineering University of Massachusetts DartmouthDartmouthMAUSA

Tissue engineering approaches,including those to functional lung tissues,are finely honed by the inclusion of upgraded devices that mimic biophysical and biochemical features in *** culture is one of these essential biophysical characteristics enabled by the introduction of microfluidic devices in recent *** review links the importance of dynamic culture for in vitro maintenance of functional lung cells to the modeling of respiratory *** identify and discuss different parameters for fabricating the requisite microfluidic models for lung cells,as well as their application in modeling lung diseases caused by external factors such as smoking and *** possibility of creating a multi-organ-on-a-chip to establish a more physiologically relevant model is ***,the focus is on different prospects for the in vitro modeling approach and for lungs-on-a-chip for developing advanced,reliable technology to analyze the pathophysiology of respiratory diseases and screen potential treatments.

关键词： Lung-on-a-chip In vitromodeling Lung pathophysiology Respiratory diseases 3D culturemodel

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Noscapine shows antimalarial activity against Plasmodium falciparum 3D7,its clinical isolate Pf140/SS,and Plasmodium berghei ANKA

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 350-358页

作者： Swaraj Kumar Babu Sameer Maharana Satyaranjan Chhatria Dibya Ranjan Sahoo Ashirbad Nanda Satish Kanhar prativa KBehera Sanjib Mohanty Pradeep Kumar Naik Praveen Kishore Sahu Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyoti ViharSambalpur OdishaIndia Department of Molecular Biology and Infectious Diseases Community Welfare Society HospitalRourkelaOdishaIndia Molecular&Immunology Laboratory Infectious Disease Biology UnitIspat General HospitalRourkelaOdishaIndia Department of Pharmacy Centurion University of Technology and ManagementBhubaneswarOdishaIndia

Objective:To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain(Pf3D7),its clinical isolate(Pf140/SS),and Plasmodium berghei ANKA(PbA).Methods:Using ring-stage survival assay,phenotypic assessments,and SYBR-green-based fluorescence assay,the antimalarial activities of noscapine were assessed compared with dihydroartemisinin(DHA)in in vivo and in vitro *** addition,hemolysis and cytotoxicity tests were carried out to evaluate its ***-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2(PfFP-2).Results:The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA,with IC50 values of(7.68±0.88)and(5.57±0.74)nM/mL,respectively,and>95%inhibition of PbA infected *** also showed a safe profile,as evidenced by low hemolysis and cytotoxicity even at high ***,PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS(P<0.01).Conclusions:Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles,which may be further explored as a therapeutic candidate for the treatment of malaria.

关键词： Malaria Plasmodium falciparum Plasmodium berghei Noscapine Antimalarial Dihydroartemisinin Cytotoxicity Falcipain-2

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评估农林业适应气候变化的潜力:尼泊尔拉姆琼案例研究

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Journal of Resources and Ecology 2024年第2期15卷 280-292页

作者： JOSHI Rajeev TAMANG Gyanu Maya BHANDARI prativa SHARMA Bharat JOSHI Dikshya BHUSAL Shushma 尼泊尔农林大学林学院自然资源管理学院尼泊尔卡塔里56310 特里布万大学林业研究所(博卡拉校区) 尼泊尔博卡拉33700 森林和土壤保护部森林部门办公室尼泊尔久姆拉21200 森林研究所印度德拉敦248001 远西大学农学院尼泊尔提卡波10901

农林系统具有多种效益,包括通过使用肥用树种来提高土壤质量,通过树冠改善小气候,以及生产薪柴和其他医药产品等森林产品以提高经济效益。农林复合经营有助于更好的土地管理、生计多样化和提高土地生产力。然而,政策制定者和其他利益相... 详细信息

农林系统具有多种效益,包括通过使用肥用树种来提高土壤质量,通过树冠改善小气候,以及生产薪柴和其他医药产品等森林产品以提高经济效益。农林复合经营有助于更好的土地管理、生计多样化和提高土地生产力。然而,政策制定者和其他利益相关方在农林业作为气候变化适应战略中作用的争辩却越来越多。本研究的目的是评估农林业作为气候变化适应战略的潜力。数据主要通过问卷调查从拉姆琼县Taksar的120名受访者中收集,采用卡方检验和二元logistic模型分析了影响气候变化适应策略的家庭选择因素。同样,通过访谈、讨论和观察以及后续的文件分析,对所获得的数据进行三角互证和验证。研究表明,农民采取了许多应对气候变化的策略,这些策略包括农牧多样化(71%)、使用改良作物品种、化肥和农药(73%)、农林复合经营(68%)、创收多样化(72%)、改变作物种植日期(57%)和复种措施(67%)等。从卡方检验和二元logistic模型中发现,“耕作经验”、“教育水平”、“农场规模”和“性别”对气候变化适应策略具有显著影响。农林复合经营具有不同的效益,如增加河流汇水(79.2%)、改善小气候(80.8%)、增加木材产品(71.7%)、提高粮食产量(83.3%)、改善牲畜健康和畜产品(77.5%)、提高土壤肥力(84.2%)和多样化生计选择(82.2%)。基于这些发现,该研究得出结论:农林复合经营是一种可以减少气候变化对当地环境影响的农业生产方法,推广和采用农林业可以帮助当地社区减少气候变化的影响。

关键词：气候变化适应策略当地社区复种

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Surgically-induced brain injury:where are we now?

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Chinese Neurosurgical Journal 2020年第1期6卷 45-55页

作者： Travis Zachary D. Sherchan prativa Hayes William K. Zhang John H. Department of Earth and Biological Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92354USA Department of Physiology and Pharmacology School of MedicineLoma Linda UniversityLoma LindaCA 92354USA Department of Anesthesiology School of MedicineLoma Linda UniversityLoma LindaCA 92354USA

Neurosurgical procedures cause inevitable brain damage from the multitude of surgical manipulations ***,retraction,thermal damage from electrocautery,and intraoperative hemorrhage cause immediate and long-term brain injuries that are directly linked to neurosurgical operations,and these types of injuries,collectively,have been termed surgical brain injury(SBI).For the past decade,a model developed to study the underlying brain pathologies resulting from SBI has provided insight on cellular mechanisms and potential therapeutic *** model,as seen in a rat,mouse,and rabbit,mimics a neurosurgical operation and causes commonly encountered post-operative complications such as brain edema,neuroinflammation,and *** this review,we elaborate on SBI and its clinical impact,the SBI animal models and their clinical relevance,the importance of applying therapeutics before neurosurgical procedures(i.e.,preconditioning),and the new direction of applying venom-derived proteins to attenuate SBI.

关键词： Brain injury Cerebral edema Preconditioning Neurotherapeutics Venom therapies

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Synthesis and Characterization of Soy Protein Isolate/MMT Nanocomposite Film for the Control Release of the Drug Ofloxacin

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World Journal of Nano Science and Engineering 2011年第2期1卷 27-36页

作者： Preetishree Nayak Sanjib Kumar Sahoo Anamika Behera prativa Kumari Nanda P.L. Nayak B.C. Guru 不详

Nanocomposites were prepared by blending soy protein isolate with different percentage of MMT by melt extrusion technique. The nanocomposites were characterized by using, XRD, TEM, SEM and TGA methods. The XRD studies indicated the absence of diffraction peaks for the bio-nanocomposites. From the TEM studies it was ascertained that the degree of exfoliation increased with increase in MMT content. The morphology of the nanocomposites was ascertained from the SEM studies. The degradation pattern of the nano-composites was evaluated from the TG analysis. The drug delivery system of the nanocmposites was investigated by blending the nanocomposites with ofloxacin at different pH media. The various kinetic parameters were evaluated and the mechanism of drug delivery has been postulated based on the kinetic data.

关键词： Nanocomposites Soy Protein MMT Drug Delivery Ofloxacin

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