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Alpha-tocopherol supplementation on chromium toxicity: a study on rat liver and kidney cell membrane

Journal of Environmental Sciences 2003年第3期15卷 356-359页

作者： Sankar Kumar Dey prasunpriya nayak Somenath Roy Department of Human Physiology with Community Health Vidyasagar UniversityDepartment of Human Physiology with Community Health Vidyasagar UniversityDepartment of Human Physiology with Community Health Vidyasagar University Midnapore-721 102 West Bengal IndiaMidnapore-721 102 West Bengal IndiaMidnapore-721 102 West Bengal India

Membrane damage is one of the important consequence of chromium, an environmental toxicant, to produce cytotoxicity. α-tocopherol, a membrane protectant can be used to reduce the chromium-induced membrane damage. In the present study, the impact of chromium in presence and absence of α-tocopherol was studied on plasma membrane of liver and kidney in male Wistar rats (80—100 g body weight). Significant increase in membrane cholesterol level as well as significant decrease in membrane phospholipid level in chromium exposed ( 0.8 mg /100 g body weight/d, i.p., for 4 weeks) animals suggest structural alteration of both liver and kidney plasma memebrane. The alkaline phosphatase, total ATPase and Na +-K +-ATPase activities of plasma membrane were significantly decreased in both liver and kidney after chromium treatment. However, α-tocopherol (30 mg/100 g diet) supplementation can restrict the changes in these membrane-bound enzyme activities. Thus, the usefulness of dietary supplementation of α-tocopherol to restrain the chromium-induced membrane damage is suggested.

关键词： chromium liver kidney membrane α-tocopherol

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Chromium-induced membrane damage: protective role of ascorbic acid

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Journal of Environmental Sciences 2001年第3期13卷 272-275页

作者： Sankar Kumar Dey prasunpriya nayak Somenath Roy Department of Human Physiology with Community Health Vidyasagar UniversityMidnapore 721102West BengalIndia

Importance of chromium as environmental toxicant is largely due to impact on the body to produce cellular toxicity. The impact of chromium and their supplementation with ascorbic acid was studied on plasma membrane of liver and kidney in male Wistar rats (80-100g body weight). It has been observed that the intoxication with chromium (i.p.) at the dose of 0.8 mg/100g body weight per day for a period of 28 days causes significant increase in the level of cholesterol and decrease in the level of phospholipid of both liver and kidney. The alkaline phosphatase, total ATPase and Na\++\|K\++\|ATPase activities were significantly decreased in both liver and kidney after chromium treatment, except total ATPase activity of kidney. It is suggested that chromium exposure at the present dose and duration induce for the alterations of structure and function of both liver and kidney plasma membrane. Ascorbic acid (i.p. at the dose of 0.5 mg/100g body weight per day for period of 28 days) supplementation can reduce these structural changes in the plasma membrane of liver and kidney. But the functional changes can not be completely replenished by the ascorbic acid supplementation in response to chromium exposure. So it is also suggested that ascorbic acid (nutritional antioxidant) is useful free radical scavenger to restrain the chromium induced membrane damage.

关键词： chromium liver kidney membrane ascorbic acid

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