Chromium-induced membrane damage: protective role of ascorbic acid

作     者：Sankar Kumar Dey Prasunpriya Nayak Somenath Roy 

作者机构：Department of Human Physiology with Community HealthVidyasagar UniversityMidnapore 721102West BengalIndia 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报(英文版))

年 卷 期：2001年第13卷第3期

页      面：272-275页

核心收录：

学科分类：100405[医学-卫生毒理学] 083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 10[医学] 

主　　题：chromium liver kidney membrane ascorbic acid 

摘      要：Importance of chromium as environmental toxicant is largely due to impact on the body to produce cellular toxicity. The impact of chromium and their supplementation with ascorbic acid was studied on plasma membrane of liver and kidney in male Wistar rats (80-100g body weight). It has been observed that the intoxication with chromium (i.p.) at the dose of 0.8 mg/100g body weight per day for a period of 28 days causes significant increase in the level of cholesterol and decrease in the level of phospholipid of both liver and kidney. The alkaline phosphatase, total ATPase and Na\++\|K\++\|ATPase activities were significantly decreased in both liver and kidney after chromium treatment, except total ATPase activity of kidney. It is suggested that chromium exposure at the present dose and duration induce for the alterations of structure and function of both liver and kidney plasma membrane. Ascorbic acid (i.p. at the dose of 0.5 mg/100g body weight per day for period of 28 days) supplementation can reduce these structural changes in the plasma membrane of liver and kidney. But the functional changes can not be completely replenished by the ascorbic acid supplementation in response to chromium exposure. So it is also suggested that ascorbic acid (nutritional antioxidant) is useful free radical scavenger to restrain the chromium induced membrane damage.