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HbA_(1)c结合神经肌电图在糖尿病周围神经病变早期诊断中的应用价值

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蛇志 2024年第2期36卷 213-216页

作者：饶丹黔西南州人民医院神经电生理科贵州兴义562400

目的研究糖化血红蛋白(HbA_(1)c)结合神经肌电图在糖尿病周围神经病变(DpN)早期诊断中的应用价值。方法选择2022年1月至2023年1月我院收治的45例糖尿病合并DpN患者作为DpN组,选择同期收治的68例非DpN糖尿病患者作为NDpN组。比较两组患者... 详细信息

目的研究糖化血红蛋白(HbA_(1)c)结合神经肌电图在糖尿病周围神经病变(DpN)早期诊断中的应用价值。方法选择2022年1月至2023年1月我院收治的45例糖尿病合并DpN患者作为DpN组,选择同期收治的68例非DpN糖尿病患者作为NDpN组。比较两组患者的HbA_(1)c及神经肌电图,分析HbA_(1)c结合神经肌电图在DpN早期诊断中的价值。结果DpN组患者的HbA_(1)c水平显著高于NDpN组,差异具有统计学意义(ppN组正中神经、腓总神经和尺神经的运动传导速度(MCV)与正中神经、腓浅神经和尺神经的感觉传导速度(SCV)均明显低于NDpN组,差异均有统计学意义(均ppN的ROC曲线下面积(AUC)为0.85,当HbA_(1)c在8.12%时,敏感度与特异度分别为89%、68%。各神经传导速度诊断DpN的AUC均>0.75,但单一指标的敏感度或特异度较低。HbA_(1)c联合各神经传导速度诊断DpN的敏感度和特异度分别为98%和94%(ppN的早期诊断中有极高的准确性和可靠性。

关键词：糖尿病周围神经病变神经肌电图糖化血红蛋白诊断价值

Chemical compositions,cytotoxicity and antioxidant activity of the endophytic fungus Fusarium napiforme isolated from psidium guajava

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Studies in Fungi 2020年第1期5卷 332-352页

作者： Chutulo EC Chalannavar RK pramod Kumar p Department of Studies&Research in Microbiology Mangalore UniversityJnana KaveriP.G.CentreChikka AluvaraKodagu-571232KarnatakaIndia Department of Biosciences Mangalore UniversityMangalagangotri-574199KarnatakaIndia Department of Biology Wolaita Sodo UniversityWolaita SodoEthiopia Department of Applied Botany Mangalore UniversityMangalagangotri-574199KarnatakaIndia Department of Biochemistry CSIR-Central Food Technological Research InstituteMysuru-570020KarnatakaIndia

The bioactive secondary metabolites from the endophytic fungus Fusarium napiforme was evaluated for the cytotoxic effect and antioxidant *** total antioxidant capacity(TAC)of the extract was determined by 2,2-diphenyl-1-picrylhydrazyl(DppH),phosphomolybdate,and reducing power assay *** cytotoxicity of the extract was evaluated against lung adenocarcinoma(A549)cells and mouse embryo fibroblast(NIH3T3)cells by methyl thiazolyl tetrazolium(MTT)*** major composition of the crude extract was identified by the Gas Chromatography-Mass Spectrometry(GC-MS)*** of the endophyte crude extract revealed a high amount of the total flavonoid content(TFC)and total phenolic content(TpC).The extract showed high cytotoxic activity against the A549 cell line with the mean cytotoxicity of 69.74±0.49%.The extract did not show any cytotoxic effect against the NIH3T3 cell *** extract exhibited high antioxidant activity as a function of the *** a test concentration of 1 mg ml-1,the extract showed the highest inhibition against DppH radical at 75.4607%±0.47688,ferric ion reducing power at 0.882±0.0120,and 255.434±21.404 AAE/g of the extract by phosphomolybdenum assay(pMA).There is a significant correlation between TpC and antioxidant activity at ppower and DppH is significant at ppes of bioactive compounds identified by the GC-MS have shown the presence of nine major *** result strongly exhibits that the endophyte *** can be a potential source for the formulation of natural anticancer drugs and protecting the body from oxidative damages.

关键词： flavonoids GC-MS analysis lung adenocarcinoma cells mouse embryo fibroblast cells MTT assay phenolics

超微血管显像在乳腺癌早期诊断、病情判断及疗效评估中的价值

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临床医学研究与实践 2024年第9期9卷 109-112页

作者：付饶安阳市人民医院超声科河南安阳455000

目的探讨超微血管显像(SMI)在乳腺癌早期诊断、病情判断及疗效评估中的价值。方法选取我院2020年4月至2022年3月收治的92例乳腺癌患者作为恶性组,另选取同期114例良性乳腺结节患者作为良性组,均行SMI检查,统计对比两组的血流状况。结果... 详细信息

目的探讨超微血管显像(SMI)在乳腺癌早期诊断、病情判断及疗效评估中的价值。方法选取我院2020年4月至2022年3月收治的92例乳腺癌患者作为恶性组,另选取同期114例良性乳腺结节患者作为良性组,均行SMI检查,统计对比两组的血流状况。结果良性组的血流状况明显优于恶性组(pppp<0.05)。结论SMI技术可为乳腺癌的临床早期诊断、病情判断、疗效评估提供参考依据,便于临床制定针对性治疗方案。

关键词：乳腺癌超微血管显像血流状况

超声造影定量分析参数水平在甲状腺结节性质鉴别诊断中的价值

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中国民康医学 2024年第1期36卷 127-129页

作者：付饶安阳市人民医院超声科河南安阳455000

目的:分析超声造影(CEUS)定量分析参数水平在甲状腺结节性质鉴别诊断中的价值。方法:回顾性分析2020年2月至2022年2月该院收治的124例甲状腺结节患者的临床资料,所有患者均给予CEUS检查,以病理学检查结果为“金标准”,比较不同性质甲状... 详细信息

目的:分析超声造影(CEUS)定量分析参数水平在甲状腺结节性质鉴别诊断中的价值。方法:回顾性分析2020年2月至2022年2月该院收治的124例甲状腺结节患者的临床资料,所有患者均给予CEUS检查,以病理学检查结果为“金标准”,比较不同性质甲状腺结节、不同病理学特征甲状腺恶性结节患者CEUS检查参数[造影剂通过时间(MTT)、峰值强度(peak)、达峰时间(TIp)]水平,采用Spearman相关性分析CEUS定量分析参数水平与不同病理学特征甲状腺恶性结节的相关性。结果:病理学检查结果显示,124例甲状腺结节患者中,良性58例,恶性66例;不同性质甲状腺结节与周围正常组织MTT水平比较,差异均无统计学意义(p>0.05);恶性结节、良性结节peak水平低于周围正常组织,且恶性结节低于良性结节;恶性结节、良性结节TIp水平高于周围正常组织,且恶性结节高于良性结节,差异有统计学意义(pp>0.05);不同病理学特征甲状腺恶性结节peak水平比较,淋巴结转移的低于淋巴结未转移,临床分期Ⅲ~Ⅳ期的低于Ⅰ~Ⅱ期,浸润深度T_(3)~T_(4)的低于T_(1)~T_(2);不同病理学特征甲状腺恶性结节TIp水平比较,淋巴结转移的高于淋巴结未转移,临床分期Ⅲ~Ⅳ期的高于Ⅰ~Ⅱ期,浸润深度T_(3)~T_(4)的高于T_(1)~T_(2),差异有统计学意义(ppearman相关性分析结果显示,peak水平与淋巴结转移、临床分期、浸润深度均呈负相关(rpp水平与淋巴结转移、临床分期、浸润深度均呈正相关(r>0,p<0.05)。结论:CEUS定量分析参数水平可应用于甲状腺结节的性质诊断和病情评估。

关键词：超声造影定量分析参数甲状腺结节性质诊断

The Influence of Systematic Errors on the Asian Summer Monsoon Circulation

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Advances in Atmospheric Sciences 2000年第4期17卷 576-586页

作者： p. L. S. rao IBM India Research Laboratory Indian Institute of Technology

The systematic errors of wind field associated with the prediction of Asian summer monsoon and their impact on the monsoon circulation have been studied in this paper. The daily operational analyses and fore-casts (up to day-5) of the National Centre for Medium Range Weather Forecasting (NCMRWF), India, over the Asian summer monsoon domain for the period June, July and August of 1995 are made use for the purpose. The systematic errors associated with the low level flow delineate, reduction in the strength of trade winds leading to weakening of cross equatorial flow as well as westerly flow over Indian Ocean. The upper level errors connote weakening of Tibetan anticyclone and reduction in the strength of return flow into the Southern Hemisphere. Further, these errors evince growing tendency with increase in the forecast period. Apart from the general underestimation of kinetic energy budget terms, the model forecasts fail to represent the transient eddies. The forecasts show increasing trend in the conversion of eddy to mean kinetic energy. These errors enfeeble Asian summer monsoon circulation with increase in the forecast period. Key words Monsoon - Systematic errors - Kinetic energy budget The author is grateful to the NCMRWF for providing data and computing facilities to carry out the present study.

关键词： Monsoon Systematic errors Kinetic energy budget

Role of autoreactive Tc17 cells in the pathogenesis of experimental autoimmune encephalomyelitis

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Neuroprotection 2024年第1期2卷 49-59页

作者： Yong peng Xiuli Zhang Yandan Tang Shunqing He Guilan rao Quan Chen Yahui Xue Hong Jin Shu Liu Ziyang Zhou Yun Xiang Department of Neurology Affliated First Hospitalof HunanTraditional Chinese Medical CollegeZhuzhouHunanChina Department of Neurology The Third Affiliated Hospital of Hunan University of Chinese MedicineZhuzhouHunanChina Science and Technology Innovation Center HunanUniversityof ChineseMedicineChangshaHunanChina

Background:The pathogenesis of multiple sclerosis(MS)and experimental autoimmune encephalomyelitis(EAE-an animal model of MS)is primarily mediated by T ***,recent studies have only focused on interleukin(IL)-17-secreting CD4^(+)T-helper cells,also known as Th17 *** study aimed to compare Th17 cells and IL-17-secreting CD8^(+)T-cytotoxic cells(Tc17)in the context of MS/***:Female C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein peptides 35-55(MOG35-55),pertussis toxin,and complete Freund's adjuvant to establish the EAE animal model.T cells were isolated from the spleen(12-14 days postimmunization).CD4^(+)and CD8^(+)T cells were purified using isolation kit and then differentiated into Th17 and Tc17,respectively,using MOG35-55 and *** secretion levels of interferon-(IFN-γ)and IL-17 were measured via enzyme-linked immunosorbent assay using cultured CD4^(+)and CD8^(+)T cell *** pathogenicity of Tc17 and Th17 cells was assessed through adoptive transfer(tEAE),with the clinical course assessed using an EAE score(0-5).Hematoxylin and eosin as well as Luxol fast blue staining were used to examine the spinal *** CD8^(+)CD3^(+)and CD4^(+)CD3^(+)cells differentiated into Tc17 and Th17 cells,respectively,were stimulated with MOG35-55 peptide for proliferation ***:The results showed that Tc17 cells(15,951±19855VS.55,709±4196cpm;pponse to highest dose(20μg/mL)MOG35-55 than Th17 ***,this response was not dependent on Th17 *** the 48h stimulation,at the highest dose(20μg/mL)of ***17 cells secreted lower levels of IFN-(280.00±15.00vs.556.67±15.28pg/mL,ppg/mL vs.288.33±12.58 pg/mL;ppatterns were observed for IFN-γsecretion at 96 and ***,Tc17 cell-induced tEAE mice exhibited similar EAE scores to Th17 cell-induced tEAE mice and also showed similar inflammation and demyelinati

关键词： CD8^(+)T cells experimental autoimmune myelitis IFN-y IL-17 multiple sclerosis Tc17 cells

Effect of post Cryorolling Treatments on Microstructural and Mechanical Behaviour of Ultrafine Grained Al-Mg-Si Alloy

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Journal of Materials Science & Technology 2014年第10期30卷 998-1005页

作者： p.Nageswara rao Dharmendra Singh R.Jayaganthan Department of Metallurgical and Materials Engineering Indian Institute of Technology Roorkee

To investigate the effect of post cryorolling treatments on simultaneous enhancement in strength and ductility of ultrafine grained material （UFG）, AI 6061 alloy was subjected to cryorolling followed by warm rolling （CR ＋ WR） and compared with cryorolling followed by short annealing （CR ＋ SA） at the same temperature. Transmission electron microscopy （TEM） was used to characterize the microstructural features of the processed material. The mechanical properties were investigated through Vickers hardness testing and tensile testing at room temperature. TEM, X-ray diffraction （XRD） and differential scanning calorimetry （DSC） were used to investigate the precipitation evolution in UFG material. Results indicated that the alloy subjected to CR ＋ WR has shown improved mechanical properties （114 HV, ultimate tensile strength （UTS）： 350 Mpa） as compared to that in the case of CR ＋ SA （105 HV, UTS： 285 Mpa）. The size of the precipitates observed in CR ＋ WR sample after peak ageing treatment is finer than that of peak aged CR ＋ SA sample. The UTS of peak aged CR ＋ WR sample （UTS： 390 Mpa） was found to be higher than that of peak aged CR ＋ SA sample （UTS： 355 Mpa）, without decrease in ductility.

关键词： Aluminium alloy Cryorolling Warm rolling Short annealing Mechanical properties Differential scanning calorimetry (DSC)

Microstructures and impact toughness behavior of Al 5083 alloy processed by cryorolling and afterwards annealing

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International Journal of Minerals,Metallurgy and Materials 2013年第8期20卷 759-769页

作者： Dharmendra Singh p.Nageswara rao R.Jayaganthan Department of Metallurgical and Materials Engineering Indian Institute of Technology RoorkeeRoorkee-247667India

The influence of rolling at liquid nitrogen temperature and annealing on the microstructure and mechanical properties of Al 5083 alloy was studied in this paper. Cryorolled samples of Al 5083 show significant improvements in strength and hardness. The ultimate tensile strength increases up to 340 Mpa and 390 Mpa for the 30% and 50% cryorolled samples, respectively. The cryorolled samples, with 30% and 50% reduction, were subjected to Charpy impact testing at various temperatures from 190℃ to 100℃. It is observed that increasing the percentage of reduction of samples during cryorolling has significant effect on decreasing impact toughness at all temperatures by increasing yield strength and decreasing ductility. Annealing of samples after cryorolling shows remarkable increment in impact toughness through recovery and recrystallization. The average grain size of the 50% cryorolled sample （14 μm） after annealing at 350℃ for 1 h is found to be finer than that of the 30% cryorolled sample （25 μm）. The scanning electron microscopy （SEM） analysis of fractured surfaces shows a large-size dimpled morphology, resembling the ductile fracture mechanism in the starting material and fibrous structure with very fine dimples in cryorolled samples corresponding to the brittle fracture mechanism.

关键词： aluminum alloys cryorolling annealing microstructure impact toughness recovery recrystallization

托法替布治疗类风湿关节炎发生呼吸道疾病风险的Meta分析

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中国新药与临床杂志 2024年第3期43卷 220-228页

作者：黄洁柔陈亮饶慧湖南省人民医院/湖南师范大学附属第一医院风湿免疫科湖南长沙410005 湖南省人民医院/湖南师范大学附属第一医院感染科湖南长沙410005

目的评估接受托法替布治疗的类风湿关节炎(RA)患者发生呼吸道疾病的风险。方法检索pubMed、Embase、Web of Science、Cochrane Library数据库,搜索关于托法替布在RA患者中的双盲随机对照试验(RCT),检索时限为建库至2022年9月。使用Cochr... 详细信息

目的评估接受托法替布治疗的类风湿关节炎(RA)患者发生呼吸道疾病的风险。方法检索pubMed、Embase、Web of Science、Cochrane Library数据库,搜索关于托法替布在RA患者中的双盲随机对照试验(RCT),检索时限为建库至2022年9月。使用Cochrane偏倚风险工具来评估纳入试验的质量,采用RevMan 5.3软件进行统计学分析,使用Mantel-Haenszel固定效应方法进行相对风险比较以评估结果。结果共纳入14项双盲RCT,合计6372例RA患者。Meta分析结果显示,与对照组相比,托法替布组下呼吸道感染风险显著升高(RR=2.32,95%CI:1.27~4.24,p=0.006),肺栓塞风险显著降低(RR=0.16,95%CI:0.03~0.94,p=0.04)。托法替布组上呼吸道感染、流感、肺炎、机会性呼吸道感染和其他非感染性呼吸道不良事件的发生风险与对照组相比差异无显著意义(p>0.05)。结论托法替布治疗RA会增加下呼吸道感染的发生风险,但与其他呼吸道疾病的发生风险无关。

关键词：托法替布关节炎类风湿呼吸道疾病 Meta分析