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Systems Microbiology and Biomanufacturing 2023年第2期3卷 312-327页

作者： Debanjan Mitra pradeep k.das mohapatra Department of Microbiology Raiganj UniversityRaiganjWBIndia

The current scenario of COVID-19 makes us to think about the devastating diseases that kill so many people every *** of viral proteins contributes many things that are utterly useful in the evolution of therapeutic drugs and *** this study,sequence and structure of fusion glycoproteins and major surface glycoproteins of respiratory syncytial virus(RSV)were analysed to reveal the stability and transmission *** A has the highest abundance of aromatic *** kyte–Doolittle scale indicates the hydrophilic nature of RSV A protein which leads to the higher transmission rate of this ***-protein interactions such as carbonyl interactions,cation-pi,and salt bridges were shown to be greater in RSV A compared to RSV B,which might lead to improved *** study discovered the presence of a network aromatic–sulphur interaction in viral *** of ligand binding pocket of RSV proteins indicated that drugs are performing better on RSV B than RSV *** was also shown that increasing the number of tunnels in RSV A proteins boosts catalytic *** study will be helpful in drug discovery and vaccine development.

关键词： Respiratory syncytial virus Stability Intra-protein interactions Tunnels Drug discovery

Articulating beneficial rhizobacteria-mediated plant defenses through induced systemic resistance:A review

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Pedosphere 2023年第4期33卷 556-566页

作者： Aniruddh RABARI Janki RUPARELIA Chaitanya kumar JHA Riyaz Z.SAYYED Debasis MITRA Ankita PRIYADARSHINI Ansuman SENAPATI Periyasamy PANNEERSELVAM pradeep k.das mohapatra Department of Microbiology and Biotechnology Gujarat UniversityAhmedabadGujarat 380006(India) Microbiology Department Gujarat Arts and Science CollegeEllisbridgeAhmedabadGujarat 380006(India) Department of Microbiology PSGVP Mandal's ArtsScience and Commerce CollegeMaharashtraShahada 425409(India) Department of Microbiology Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India) Crop Production Division Indian Council of Agriculture Research(ICAR)-National Rice Research InstituteCuttackOdisha 753006(India) Professor A.k.B.Environment Conservation Centre Raiganj UniversityRaiganjWest Bengal 733134(India)

Induced systemic resistance(ISR)is a mechanism by which certain plant beneficial rhizobacteria and fungi produce immunity,which can stimulate crop growth and resilience against various phytopathogens,insects,and *** beneficial rhizobacteria and fungi improve plant performance by regulating hormone signaling,including salicylic acid(SA),jasmonic acid(JA),prosystemin,pathogenesis-related gene 1,and ethylene(ET)pathways,which activate the gene expression of ISR,the synthesis of secondary metabolites,various enzymes,and volatile compounds that ultimately induce defense mechanisms in *** protect themselves from disease,plants have various advanced defense mechanisms in which local acquired resistance,systemic gene silencing,systemic wound response,systemic acquired resistance(SAR),and ISR are *** rhizobacteria activate the SA-dependent SAR pathway by producing SA at the root’s *** contrast,other rhizobacteria can activate different signaling pathways independent of SA(SA-independent ISR pathways)such as those dependent on JA and ET *** main objective of this review is to provide insight into the types of induced resistance utilized for plant *** to this,the genetic approaches used to suppress disease-causing genes,i.e.,RNA interference and antisense RNA,which are still underutilized in sustainable agriculture,along with the current vision for virus-induced gene silencing are also discussed.

关键词： biocontrol gene silencing local acquired resistance phytohormone secondary induced resistances signaling pathways systemic acquired resistance

Rice(Oryza sativa L.)plant protection using dual biological control and plant growth-promoting agents:Current scenarios and future prospects

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Pedosphere 2023年第2期33卷 268-286页

作者： Debasis MITRA Sergio DE LOS SANTOS-VILLALOBOS Fannie Isela PARRA-COTA Ana María Garcia MONTELONGO Erika Lorena BLANCO Vanessa L.LIRA Adeyemi N.OLATUNBOSUN Bahman kHOSHRU Rittick MONDAL Parameswaran CHIDAMBARANATHAN Periyasamy PANNEERSELVAM pradeep k.das mohapatra Department of Microbiology Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India) Instituto Tecnológico de Sonora 5 de febrero 818.Col.CentroCd.ObregónSonora 85000(Mexico) Campo Experimental Norman E.Borlaug-Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias(INIFAP)Norman E.Borlaug Km.12C.P.Ciudad ObregónSonora 85000(Mexico) Laboratorio de Investigación en Biotecnología y Química de Polímeros Decanato de InvestigaciónUniversidad Nacional Experimental del TáchiraSan Cristóbal 5001(Venezuela) Departamento de Micologia Federal University of PernambucoRecifePE 50670-901(Brazil) Department of Plant Physiology and Crop Production Federal University of AgricultureAbeokuta 111101(Nigeria) Department of Soil Science Faculty of AgricultureUniversity of TabrizTabriz 51664(Iran) Department of Sericulture Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India) Biotechnology Crop Improvement DivisionIndian Council of Agricultural Research(ICAR)-National Rice Research InstituteCuttackOdisha 753006(India) Microbiology Crop Production DivisionICAR-National Rice Research InstituteCuttackOdisha 753006(India) Professor A.k.Bothra Environment Conservation Centre Raiganj UniversityRaiganjUttar DinajpurWest Bengal 733134(India)

Various microorganisms live in association with different parts of plants and can be harmful,neutral,or beneficial to plant *** microbial inhabitants of plants can control plant diseases by contesting with,predating on,or antagonizing plant pathogens and by inducing systems for plant defense.A range of methods,including plant growth-promoting microorganisms(PGPMs)as biological control agents(BCAs)(BCA-PGPMs)are used for the biological management and control of plant *** BCAs interact with plants by inducing resistance or priming plants without direct interaction with the *** BCAs operate via nutrient competition or other mechanisms to modulate the growth conditions for the ***,PGPMs can be applied alone or together with other chemicals or carriers to control various crop *** review highlights the effective types of BCA-PGPMs and their applications,roles,carrier based-formulations,and responses to rice(Oryza sativa L.)*** plant disease management prospects are promising,and growers’increasing demand for BCA-PGPM products can be exploited as an effective approach to the management of plant diseases,as well as to improve yield,environmental protection,biological resources,and agricultural system sustainability.

关键词： biological control agent plant disease plant growth-promoting microorganism plant health plant pathogen

Actinobacteria-enhanced plant growth, nutrient acquisition, and crop protection:Advances in soil, plant, and microbial multifactorial interactions

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Pedosphere 2022年第1期32卷 149-170页

作者： Debasis MITRA Rittick MONDAL Bahman kHOSHRU Ansuman SENAPATI T.k.RADHA Bhaswatimayee MAHAkUR Navendra UNIYAL Ei Mon MYO Hanane BOUTAJ Beatriz Elena GUERRA SIERRA Periyasamy PANNEERSELVAM Arakalagud Nanjundaiah GANESHAMURTHY Snežana ANÐELkOVIĆ Tanja VASIĆ Anju RANI Subhadeep DUTTA pradeep k.das mohapatra Department of Microbiology Raiganj UniversityRaiganjWest Bengal 733134India Department of Sericulture Raiganj UniversityRaiganjWest Bengal 733134India Department of Soil Science Faculty of AgricultureUniversity of TabrizTabriz 51664Iran Crop Production Division Indian Council of Agricultural Research(ICAR)National Rice Research InstituteCuttackOdisha 753006India Division of Soil Science and Agricultural Chemistry ICAR Indian Institute of Horticultural ResearchBengaluruKarnataka 560089India Department of Botany and Biotechnology Ravenshaw UniversityCuttackOdisha 753003India Genetics and Tree Propagation Division Forest Research InstituteUttarakhand 248003India Biotechnology Research Department Department of Research and InnovationMinistry of EducationKyaukse 05151Myanmar Laboratory of Biotechnology and Molecular Bioengineering Faculty of Sciences and TechnologyCadi Ayyad UniversityMarrakesh 40000Morocco Universidad de Santander Facultad de Ciencias Exactas Naturales y AgropecuariasGrupoMicrobiotaCampus Universitario Lagos del CaciqueBucaramanga 680002Colombia Institute for Forage Crops Kruševac 37251Republic of Serbia Plant Protection Faculty of AgricultureUniversity of NišKosančićeva 4Kruševac 37000Republic of Serbia Department of Life Sciences Graphic Era(Deemed to be University)DehradunUttarakhand 248002India Professor A.k.Bothra Environment Conservation Centre Raiganj UniversityRaiganjWest Bengal 733134India

Agricultural areas of land are deteriorating every day owing to population increase, rapid urbanization, and industrialization. To feed today’s huge populations, increased crop production is required from smaller areas, which warrants the continuous application of high doses of inorganic fertilizers to agricultural land. These cause damage to soil health and, therefore, nutrient imbalance conditions in arable soils. Under these conditions, the benefits of microbial inoculants (such as Actinobacteria) as replacements for harmful chemicals and promoting ecofriendly sustainable farming practices have been made clear through recent technological advances. There are multifunctional traits involved in the production of different types of bioactive compounds responsible for plant growth promotion, and the biocontrol of phytopathogens has reduced the use of chemical fertilizers and pesticides. There are some well-known groups of nitrogen-fixing Actinobacteria, such as Frankia, which undergo mutualism with plants and offer enhanced symbiotic *** addition to nitrogen fixation, increasing availability of major plant nutrients in soil due to the solubilization of immobilized forms of phosphorus and potassium compounds, production of phytohormones, such as indole-3-acetic acid, indole-3-pyruvic acid, gibberellins, and cytokinins, improving organic matter decomposition by releasing cellulases, xylanase, glucanases, lipases, and proteases, and suppression of soil-borne pathogens by the production of siderophores, ammonia, hydrogen cyanide, and chitinase are important features of Actinobacteria useful for combating biotic and abiotic stresses in *** positive influence of Actinobacteria on soil fertility and plant health has motivated us to compile this review of important findings associated with sustaining plant productivity in the long run.

关键词： biocontrol agents microbial inoculant metabolites mitrogen fixation plant growth promoters sustainable agriculture

Intra-protein interactions of SARS-CoV-2 and SARS:a bioinformatic analysis for plausible explanation regarding stability,divergency,and severity

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Systems Microbiology and Biomanufacturing 2022年第4期2卷 653-664页

作者： Debanjan Mitra Aditya k.Pal pradeep kr.das mohapatra Department of Microbiology Raiganj UniversityRaiganjWBIndia

The current nightmare for the whole world is *** occurrence of concentrated pneumonia cases in Wuhan city,Hubei province of China,was first reported on December 30,***-CoV first disclosed in 2002 but had not outspread *** 18 years,in 2020,it reemerged and outspread worldwide as SARS-CoV-2(COVID-19),as the most dangerous virus-creating disease in the *** it possible to create a favorable evolution within the short time(18 years)?If possible,then what are those properties or factors that are changed in SARS-CoV-2 to make it undefeated?What are the fundamental differences between SARS-CoV-2 and SARS?The study is one of the initiatives to find out all those ***,four types of protein sequences from SARS-CoV-2 and SARS were retrieved from the database to study their physicochemical and structural *** showed that charged residues are playing a pivotal role in SARS-CoV-2 evolution and contribute to the helix *** formation of the cyclic salt bridge and other intra-protein interactions specially network aromatic-aromatic interaction also play the crucial role in *** comparative study will help to understand the evolution from SARS to SARS-CoV-2 and helpful in protein engineering.

关键词： COVID-19 Evolution Cyclic salt bridge Intra-protein interactions Protein engineering

Cold adaptation strategy of psychrophilic bacteria:an in-silico analysis of isocitrate dehydrogenase

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Systems Microbiology and Biomanufacturing 2021年第4期1卷 483-493页

作者： Debanjan Mitra pradeep kr.das mohapatra Department of Microbiology Raiganj UniversityRaiganjWBIndia

Non-specific electrostatics is crucial for structure and stability;recently,it has been argued that psychrophilic proteins may also utilize specific electrostatic *** psychrophilic proteins increase the number of salt bridges for cold adaptation?Are there any changes that occur in their sequence,which helps them to adapt in an extreme environment?Do intra-protein interactions affect their stability?Is there any special type of intra-protein interaction present in psychrophilic protein structure?This study will give all those ***(n~100)and structures of psychrophilic isocitrate dehydrogenase and mesophilic isocitrate dehydrogenase extracted from *** had been analyzed in BLOCk and non-BLOCk *** sequences of psychrophiles and mesophiles create two separate *** number of charged and uncharged polar residues is very much high in psychrophilic *** formation of long network aromatic-aromatic interactions and network aromatic-sulfur interactions are very crucial for psychrophilic protein *** of these types of interactions is also a novelty of this *** mutation of charged residues with high-energy contributions affects the protein *** study will help in protein engineering.

关键词： Cold adaptation Aromatic-aromatic interactions Aromatic-sulfur interactions Non-covalent interactions Mutation

Molecular exposition of broad‑spectrum antibacterial efficacy by p‑coumaric acid from an edible mushroom Termitomyces heimii:in vitro and in silico approach

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 750-764页

作者： krishanu Singha Amrita Banerjee Arijit Jana Poushali Bandyopadhyay Smarajit Maiti Bikas Ranjan Pati pradeep kumar das mohapatra Department of Microbiology Vidyasagar UniversityMidnaporeWest Bengal 721102India Department of Biotechnology Oriental Institute of Science and TechnologyMidnaporeWest Bengal 721102India Department of Chemical Engineering IIT RoorkeeUttarakhand 247667India Department of Microbiology Raiganj UniversityRaiganjWest Bengal 733134India

P-Coumaric acid was previously reported to contain antioxidant,antidiabetic,anti-inflammatory,antiplatelet,antiulcer and anticancer *** with these,the present work has been conducted to study the antibacterial activity of p-coumaric *** could be used to control broad-spectrum microbiome-based inflammation or in cancer *** analysis of methanolic extract from the mushroom Termitomyces heimii has exhibited a rich fraction of p-coumaric acid(p-CA),which in the pure form showed significant bactericidal *** predict the molecular interactions associated with the bactericidal mechanism of p-CA,the transmembrane protein sequences of Staphylococcus aureus and Escherichia coli were retrieved from the IMG–JGI database,screened and then aligned using Clustal X2 and PHYLIP 3.69 *** common sequences were subjected to tertiary structure prediction using Phyre2 server,followed by quality assessment through the Ramachandran ***,the 3D molecular structure of p-CA was downloaded from PubChem and docked with the selected tertiary structures using Patchdock and showed higher affinity towards 12 common transmembrane protein structures,amongst which CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyl transferase(PgsA)exhibited best dock-ing with p-CA on the basis of ACE value(–249 kcal/mol).This fact revealed that p-CA can block the normal functioning of membrane-bound enzyme PgsA,consequently leading to the interruption in the synthesis and recycling of an essential membrane component phosphatidylglycerol(PG),resulting in membrane disruption followed by cell ***,for the first time we reported the molecular insights and fundamental biochemical events underlying the bactericidal action by p-CA,to explore new perspective to combat multidrug-resistant bacteria.

关键词： p-Coumaric acid Bactericidal Docking ACE value PgsA Lysis

Early Tumor Diagnosis in Brain MR Images via Deep Convolutional Neural Network Model

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Computers, Materials & Continua 2021年第8期68卷 2413-2429页

作者： Tapan kumar das pradeep kumar Roy Mohy Uddin kathiravan Srinivasan Chuan-Yu Chang Shabbir Syed-Abdul School of Information Technology and Engineering Vellore Institute of TechnologyVellore632014India Department of Computer Science and Engineering Indian Institute of Information TechnologySurat395007India Research Quality Management Section King Abdullah International Medical Research CenterKing Saud bin Abdulaziz University for Health SciencesMinistry of National Guard-Health AffairsRiyadh11426Kingdom of Saudi Arabia Department of Computer Science and Information Engineering National Yunlin University of Science and TechnologyYunlin64002Taiwan Graduate Institute of Biomedical Informatics Taipei Medical UniversityTaipeiTaiwan

Machine learning based image analysis for predicting and diagnosing certain diseases has been entirely trustworthy and even as efficient as a domain expert’s ***,the style of non-transparency functioning by a trained machine learning system poses a more significant impediment for seamless knowledge trajectory,clinical mapping,and delusion *** this proposed study,a deep learning based framework that employs deep convolution neural network(Deep-CNN),by utilizing both clinical presentations and conventional magnetic resonance imaging(MRI)investigations,for diagnosing tumors is *** research aims to develop a model that can be used for abnormality detection over MRI data quite efficiently with high *** research is based on deep learning and Deep-CNN was deployed to examine the MR brain image for tracing the *** system runs on Tensor flow and uses a feature extraction module in DeepCNN to elicit the factors of that part of the image from where underlying issues are identified and subsequently succeeded in prediction of the disease in the MR *** results of this study showed that our model did not have any adverse effect on classification,achieved higher accuracy than the peers in recent years,and attained good detection outcomes including case of *** the future work,further improvement can be made by designing models that can drastically reduce the parameter space without affecting classification accuracy.

关键词： Deep learning convolutional neural network brain tumor magnetic resonance imaging

Identification of optimal composition with superior electrochemical properties along the zero Mn^(3+)line in Na_(0.75)(Mn-Al-Ni)O_(2)pseudo ternary system

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Journal of Energy Chemistry 2024年第9期96卷 206-216页

作者： Hari Narayanan Vasavan Manish Badole Samriddhi Saxena Velaga Srihari Asish kumar das Pratiksha Gami Neha Dagar Sonia Deswal pradeep kumar Himanshu kumar Poswal Sunil kumar Department of Metallurgical Engineering and Materials Science Indian Institute of Technology IndoreSimrol 453552India High Pressure&Synchrotron Radiation Physics Division Bhabha Atomic Research Centre400085 MumbaiIndia School of Physical Sciences Indian Institute of Technology MandiHimachal Pradesh 175005India Center for Electric Vehicle and Intelligent Transport Systems Indian Institute of Technology IndoreSimrol 453552India

Biphasic layered oxide cathodes,known for their superior electrochemical performance,are prime candidates for commercializing in Na-ion ***,we unveil a series of P3/P2 monophasic and biphasic Al-substituted Na_(3/4)Mn_(5-x/8)Al_(2x/8)Ni_(3-x/8)O_(2)layered oxide cathodes that lie along the‘zero Mn^(3+)line’in the Na_(3/4)(Mn-Al-Ni)O_(2)pseudo-ternary *** structural analysis showed a larger Na^(+)conduction bottleneck area in both P3 and P2 structures with a higher Al3+content,which enhanced their rate *** each composition,the P3/P2 biphasic compound with nearly equal fractions of P3 and P2 phases outperformed their monophasic counterparts in almost all electrochemical performance *** synchrotron XRD measurements obtained for the monophasic P3 and biphasic P2/P3 samples revealed the absence of the O3 phase during *** high structure stability and faster Na^(+)transport kinetics in the biphasic samples underpins the enhancement of electrochemical properties in the Al-substituted P3/P2 *** results highlight fixed oxidation state lines as a novel tool to identify and design layered oxide cathodes for Na-ion batteries in pseudo-ternary diagrams involving Jahn-Teller active cations.

关键词： Layered oxides Biphasic cathode Operando Synchrotron XRD Electrochemical behavior Cyclic performance

Cor-triatriatum dexter with pulmonary hypertension in a neonate

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Open Journal of Pediatrics 2013年第4期3卷 337-339页

作者： Bijay kumar Meher pradeep S Leena das Priyadarsi Tripathy Department of Cardiology SCB Medical College Cuttack India PG Department of Paediatrics SVPPGIP SCB Medical College Cuttack India

Cor-triatriatum dexter is an extremely rare congenital anomaly, in which right atrium is divided into 2 halves by a septum giving rise to 3 atrial chambers. We report here a case of cor-triatriatum dexter who presented at 3 days of life with tachypnea and did not respond to antibiotics. Echocardiography revealed ostium secundum atrial septal defect (ASD) with right to left flow, intact interventricular septum (IVS), severe tricuspid regurgitation with pulmonary arterial hypertension and a membranous structure dividing right atrium into 2 halves with good biventricular function. The patient improved with sildenafil and anti-failure medication. This case of cor-triatriatum dexter presenting with pulmonary hypertension, tricuspid regurgitation and ASD added to the new spectrum of cor-triatriatum dexter.

关键词： Cor-Triatriatum Pulmonary Hypertension Neonate