In silico comparative structural and compositional analysis of glycoproteins of RSV to study the nature of stability and transmissibility of RSV A

作     者：Debanjan Mitra Pradeep K.Das Mohapatra 

作者机构：Department of MicrobiologyRaiganj UniversityRaiganjWBIndia 

出 版 物：《Systems Microbiology and Biomanufacturing》 (系统微生物学与生物制造（英文）)

年 卷 期：2023年第3卷第2期

页      面：312-327页

核心收录：

学科分类：08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

主　　题：Respiratory syncytial virus Stability Intra-protein interactions Tunnels Drug discovery 

摘      要：The current scenario of COVID-19 makes us to think about the devastating diseases that kill so many people every *** of viral proteins contributes many things that are utterly useful in the evolution of therapeutic drugs and *** this study,sequence and structure of fusion glycoproteins and major surface glycoproteins of respiratory syncytial virus(RSV)were analysed to reveal the stability and transmission *** A has the highest abundance of aromatic *** Kyte–Doolittle scale indicates the hydrophilic nature of RSV A protein which leads to the higher transmission rate of this ***-protein interactions such as carbonyl interactions,cation-pi,and salt bridges were shown to be greater in RSV A compared to RSV B,which might lead to improved *** study discovered the presence of a network aromatic–sulphur interaction in viral *** of ligand binding pocket of RSV proteins indicated that drugs are performing better on RSV B than RSV *** was also shown that increasing the number of tunnels in RSV A proteins boosts catalytic *** study will be helpful in drug discovery and vaccine development.