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Laboratory response to an infant with suspected measles vaccine associated fever and rash in Sri Lanka

Infectious Medicine 2023年第1期2卷 57-62页

作者： Buddhini Samaraweera Malsha G.Thrimavithana Lakmini Gunathilake prabath gankanda Janitha Nanayakkara Janaki I.Abeynayake The Departement of Virology Teaching Hospital KarapitiyaGalleSri Lanka The Ministry of Heath ColomboSri Lanka The Department of Virology Medical Research InstituteColombo 08Sri Lanka

Background:Measles is a highly contagious *** Lanka(SL)has eliminated the measles in *** coun-try is at risk of importation of measles and there could be vaccine-associated measles like ***,it is important to investigate patients with fever,rash to differentiate the wild-type from vaccine-type exclud-ing other suspected pathogens to direct infection prevention and control *** objective is to describe the laboratory investigation procedure in an immunocompetent child,developed fever,rash following measles containing vaccine in post-measles eliminated period,***:This laboratory based investigation was carried out in National Measles Laboratory,*** and throat swab were received from a patient with fever,rash,cough and coryza developed at tenth day of receiving the measles containing live-attenuated *** were tested for measles,rubella,and other relevant pathogens according to the laboratory testing algorithm for an immunocompetent child with fever,rash and flu like ***:Measles vaccine type A,Edmonston-strain virus was detected after sequencing in throat swab and measles IgM and IgG were positive at sixth-week of *** addition,influenza A RNA was detected in throat swab at day-three with detectable parvoB19 IgM in blood sample received at sixth-week of post-onset ***:Measles like illness of this immunocompetent child who received measles containing vaccine could be due to measles vaccine-type A or influenza *** a measles eliminated,resource-limited setting in SL,there should be a well-defined,testing algorithm to exclude prevalent possible pathogens according to epidemiological and clinical information.

关键词： Measles vaccine Vaccine-type virus Laboratory diagnosis Sequencing Measles elimination

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Low dose oral haloperidol does not prolong QTc interval in older acutely hospitalised adults： a subanalysis of a randomised double-blind placebo-controlled study

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Journal of Geriatric Cardiology 2018年第6期15卷 401-407页

作者： Edmee JM Schrijver Maaike Verstraaten Peter M van de Ven Pierre M Bet Astrid M van Strien Carel de Cock prabath WB Nanayakkara on behalf of all HARPOON Investigators Department of Internal Medicine VU University Medical Centre Amsterdam the Netherlands Department of Cardiology VU University Medical Centre Amsterdam the Netherlands Department of Epidemiology and Biostatistics VU University Medical Centre the Netherlands Department of Clinical Pharmacology and Pharmacy VU University Medical Centre the Netherlands Department of Geriatric Medicine Jeroen Bosch Hospital s-Hertogenbosch the Netherlands

Background Haloperidol is the most frequently prescribed antipsycbotic for delirium symptoms. The risk of QTc prolongation often raises concerns, although the effect of haloperidol on QTc interval has not yet been investigated in a randomised placebo-controlled fixed-dose study. Methods A subanalysis of a randomised double-blind placebo-controlled study was conducted to evaluate the effect of prophylactic haloperidol 1 mg or placebo 1 mg orally twice-daily （maximum of 14 doses） on QTc interval in patients aged 70 years and over. Bedside, 12-lead ECGs were recorded before, during and after the one-week intervention period. Automatic QTc measurements were ob- tained in addition to manual measurements of QT and RR intervals, blinded for treatment status. Manual measurements were corrected （QTc） using Bazett （QTc-B）, Framingham （QTc-Fa）, Fridericia （QTc-Fi） and Hodges （QTc-H） methods. Mixed model analyses were used to test for differences in longitudinal course of QTc between patients receiving haloperidol and placebo. Results ECG recordings of 72 patients （haloperidol n = 38） were analysed, 45.8% male. Median （range） haloperidol serum concentration on day 4 was 0.71 （0.32-1.82） μg/L （n = 23）. Longitudinal course of mean QTc did not significantly differ between treatment arms for any of the automatic or manually derived QTc values. Conclusions Low dose oral haloperidol did not result in QTc prolongation in older acutely hospitalised patients. Results may not be generalizable to patients with existing ECG abnormalities such as atrial fibrillation.

关键词： Haloperidol Prolongation QTc interval The aged

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用一个PWM信号控制一只LM317T

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电子设计技术 EDN CHINA 2011年第9期18卷 69-70页

作者： Aruna prabath Rubasinghe 斯里兰卡莫勒图沃大学

美国国家半导体公司的LM317T是一种常用的可调电压稳压器，能以最大1．5A电流提供125V～37V的输出电压。用一只电位计就可以调节输出电压。图1中的电路用一个模拟电压代替了电位计．模拟电压可以由一个PWM（脉冲宽度调制）信号控制。

关键词：信号控制 PWM 美国国家半导体公司脉冲宽度调制输出电压模拟电压可调电压电位计

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A Study on Pre-Induction Cervical Ripening with PGE2 Vaginal Tablet One (3 mg) vs. Half (1.5 mg) in Low Risk Multi Parous Mothers at 40 Weeks of Gestation

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Open Journal of Obstetrics and Gynecology 2021年第8期11卷 1005-1012页

作者： Naleen Ratnayake Ahangama Arachchige Nilanga Nishad Yahampath Arachchige Gamini Perera Devasuriya Pathinayakalage Lanka Rasanjana Samarakoon Mudiyanselage Sameera Gayanath Gunarathna prabath Kularathna Abeysundara Castle Street Hospital for Women Colombo Sri Lanka Center for Epidemiological and Clinical Research LK Colombo Sri Lanka Worthing Hospital (NHS) Western Sussex UK

Backgrounds: Induction of labor is a common practice. In women with immature cervix, PGE2 is commonly used for pre-induction. We hypothesized that PGE2 1.5 mg may be equally effective to PGE2 3 mg in multiparous women for labor induction. The present effort was an attempt to compare the efficacy and effects of pre-induction cervical ripening with PGE2 3 mg vs. 1.5 mg in multi-parous mothers (2nd and 3rd Pregnancy) at 40 weeks.

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Pseudoainhum Associated With Lepromatous Leprosy:A Very Rare Association in Modern World

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International Journal of Dermatology and Venereology 2023年第2期6卷 110-111页

作者： Ahangama Arachchige Nilanga Nishad Mahathevan Pathman Seyed Ahamed Uwyse Ashan Mendis prabath Kularathne Abeysundara Arjuna P.de Silva Professorial Medical Unit Colombo North Teaching HospitalColombo 11010Sri Lanka Department of Dermatology National Hospital of Sri LankaColombo 01000Sri Lanka Department of Dermatology Colombo North Teaching HospitalColombo 11010Sri Lanka Department of Clinical Medicine General HospitalAmpara 32350Sri Lanka Department of Clinical Medicine Faculty of MedicineUniversity of KelaniyaKelaniya 11300Sri Lanka.

Introduction:Pseudoainhum(dactylolysis spontanea)is characterized by the development of a fibrous band around the digit that gradually leads to *** pain associated with Pseudoainhum may not be evident in patients with neuropathic ***,we present a rare case of pseudoainhum patient,which describes a very rare association of pseudoainhum with *** presentation:A 48 year old male with lepromatous leprosy,with resorption of digits,charcot joints and tropical ulcers was seen in the *** forth digit of the left hand had a narrowing due to a fibrous band at the 2nd inter phalangeal joint with shiny tethering distal *** could not recall the duration of the *** was not suffering from any ***:The current report describes a very rare association of pseudoainhum with *** case involved a 48-year-old man in the dermatology ward with lepromatous leprosy presenting with a ***:This case highlights the possibility of delayed presentation of patients with pseudoainhum to physicians when the patients have underlying neuropathic conditions that prevent feeling finger pain and cause abnormal appearance of the digits,especially in leprosy.

关键词： pseudoainhum leprosy lepromatous leprosy case report

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Preparation of Antimicrobial Iron Oxide Nanostructures from Galvanizing Effluent

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World Journal of Nano Science and Engineering 2022年第1期12卷 1-11页

作者： Rajapakshe Babilage Sanjitha Dilan Rajapakshe Gonapala Deniyage Madhusha Chathurangi Gonapaladeniya Charith Anuruddha Thennakoon prabath Nilan Gunasekara Nirosh Siriwardene Sudath Annasiwatte Sayuri Sammanani Niyangoda Rajapakse Mudiyanselage Gamini Rajapakse Department of Chemistry Faculty of Science University of Peradeniya Peradeniya Sri Lanka Post Graduate Institute of Science University of Peradeniya Peradeniya Sri Lanka LTL Galvanizers Pvt. Ltd. Makola Sri Lanka

Galvanization is the process of applying a protective zinc coating to iron or steel to prevent rusting. In the batch hot-dip galvanizing process, large amounts of wastes originate in liquid, solid and gaseous forms. Acidic waste containing iron and zinc ions is produced due to the cleaning of steel prior to zinc coating, which is considered the galvanizing acid waste. The galvanizing effluent used was collected from LTL Galvanizers Pvt. Ltd., Sapugaskanda, Sri Lanka, and converted into antimicrobial hematite (α-Fe2O3) nanoparticles. These nanoparticles were synthesized using a chemical precipitation method. X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) were used to characterize the nanomaterials produced. Two pathogenic bacteria and one pathogenic fungus were used to analyze the antimicrobial activity of the nanomaterials. All the samples showed excellent antibacterial and antifungal properties. And the material can inhibit the growth of both Gram-positive and Gram-negative bacteria. According to the SEM images, some of the hematite particles were around 100 nm in size or less, which confirms that the describing method is viable in synthesizing hematite nanostructures. As shown in the XRD, the major diffraction peak, located at 2θ of 35.617° (110) in addition to minor peaks at 24.87° (012), 33.07° (104), 42.08° (113), 51.18° (024), 53.52° (116) and, 57.46° (018) confirm the spinel structure of iron oxide (α-Fe2O3). The estimated average crystallite size of the nanomaterial is calculated to be 36.74 nm. The durability of the manufactured nanomaterial is excellent. This method is a time-efficient, environmentally friendly, cost-effective and industrially viable way to manufacture antimicrobial hematite (α-Fe2O3) nanomaterials from a galvanizing effluent.

关键词： Wastewater Treatment Galvanizing Effluent Antimicrobial Hematite Nanomaterials Iron Oxide Nanostructures Coprecipitation

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基于本土大纲的斯里兰卡高考中文写作分析

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现代语文 2021年第10期 91-95页

作者：雷明珍 [斯里兰卡]安喜乐红河学院国际语言文化学院云南蒙自661100 科伦坡大学孔子学院斯里兰卡科伦坡00200

参照斯里兰卡本土高中中文教学大纲,对斯里兰卡近些年来的高考写作要求、写作特点进行了分析,并探讨了学生写作中所存在的主要问题。为满足学生高考中文写作的现实需要,斯里兰卡本土中文教师应紧紧围绕高中中文教学大纲的相关规定,进行... 详细信息

参照斯里兰卡本土高中中文教学大纲,对斯里兰卡近些年来的高考写作要求、写作特点进行了分析,并探讨了学生写作中所存在的主要问题。为满足学生高考中文写作的现实需要,斯里兰卡本土中文教师应紧紧围绕高中中文教学大纲的相关规定,进行专题写作训练;同时,应牢牢把握斯里兰卡高考中文作文评分标准,切实解决学生写作中所遇到的主要问题。

关键词：斯里兰卡高考中文写作高中中文教学大纲

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Forecasting the number of species of asexually reproducing fungi(Ascomycota and Basidiomycota)

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Fungal Diversity 2022年第3期114卷 463-490页

作者： Nalin N.Wijayawardene Alan J.L.Phillips Diana Santos Pereira Dong-Qin Dai AndréAptroot Josiane S.Monteiro Irina S.Druzhinina Feng Cai Xinlei Fan Laura Selbmann Claudia Coleine Rafael F.Castañeda-Ruiz Martin Kukwa Adam Flakus Patricia Oliveira Fiuza Paul M.Kirk Kunhiraman C.Rajesh Kumar Ilesha S.leperuma Arachchi Nakarin Suwannarach Li-Zhou Tang Teun Boekhout Chen Shuhui Tan R.P.prabath K.Jayasinghe Marco Thines Centre for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanPeople’s Republic of China Section of Genetics Institute for Research and Development in Health and Social CareNo:393/3Lily AvenueOff Robert Gunawardane MawathaBattaramulla 10120Sri Lanka Faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal Laboratório de Botânica/Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMS CEP 79070-900Brazil Coordination of Botany Museu Paraense Emílio GoeldiBelémPA 66077830Brazil Fungal Genomics Laboratory(FungiG) College of Resources and Environmental SciencesNanjing Agricultural UniversityWeigang 1Nanjing 210095JiangsuPeople’s Republic of China The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Ecological and Biological Sciences University of TusciaViterboItaly Italian National Antarctic Museum(MNA) Mycological SectionGenoaItaly Alejandro de Humboldt’(INIFAT) Instituto de Investigaciones Fundamentales en AgriculturaTropicalSantiago de Las VegasHavanaCuba Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of GdańskWita Stwosza 5980-308 GdańskPoland W.Szafer Institute of Botany Polish Academy of SciencesLubicz 4631-512 KrakowPoland Universidade Federal do Rio Grande do Norte(UFRN) Programa de Pós-Graduação em Sistemática e EvoluçãoCentro de BiociênciasCampus UniversitárioAv.Senador Salgado Filho3000Lagoa NovaNatalRN 59078-970Brazil Biodiversity Informatics and Spatial Analysis Jodrell LaboratoryRoyal Botanic GardensKewRichmond TW93DSSurreyUK National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.

Asexually reproducing fungi play a significant role in essential processes in managed and wild ecosystems such as nutrients cycling and multitrophic interactions.A large number of such taxa are among the most notorious plant and animal *** addition,they have a key role in food production,biotechnology and *** without or rare sexual reproduction are distinguished based on their sporulating structures and conidiomata in traditional morphology-based *** number,variation and diversity of asexually reproducing taxa are insufficiently known,even though fungi capable of asexual reproduction may provide an untapped,rich biological resource for future ***,ca.30,000 asexual species belonging to ca.3800 genera have been reported(including 1388 coelomycetous and 2265 hyphomycetous genera).Recent reports(2017–2020)reiterate that the number of asexually producing fungi is higher than the number of frequently sexually-reproducing *** the advent of molecular tools and the abandonment of the dual nomenclature system for pleomorphic fungi,priority criteria were established and revisited in the latest outline of fungi and fungus-like ***,species numbers and taxonomic boundaries of pleomorphic taxa and their synanamorphs or synasexual morphs have yet to be *** number of species of speciose genera(***,Aspergillus,Cercospora,Fusarium,Phoma and Pseudocercospora),cryptic species,species of pleomorphic genera,less studied life modes(such as lichenicolous taxa,taxa from extreme environments)and species from biodiversity-rich areas still need evaluation to achieve more reliable estimates of their *** paper discusses the current knowledge on the matter,with diversity estimates,and potential obstacles in several chapters on(1)speciose genera;(2)pleomorphic genera;(3)cryptic species;(4)well-studied but insufficiently resolved taxa,*** inhabiting species,marine fungi,(5)less studied life modes,e.g.

关键词： Cryptic species DNA sequences Morphology Pleomorphism Speciose genera Species identificat

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没有压降的简单反极性保护电路

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电子设计技术 EDN CHINA 2012年第1期19卷 52-52页

作者： Aruna prabath Rubasinghe 莫勒图沃大学

通常反向电压保护方法是使用二极管，防止损坏电路。一个方案是用串联二极管，只允许电流向正确的极性流动（图1）。另外还可以用二极管桥对输入做整流，这样电路就永远有正确的极性（图2）。这些方案的缺点是，二极管上的压降会消耗能... 详细信息

通常反向电压保护方法是使用二极管，防止损坏电路。一个方案是用串联二极管，只允许电流向正确的极性流动（图1）。另外还可以用二极管桥对输入做整流，这样电路就永远有正确的极性（图2）。这些方案的缺点是，二极管上的压降会消耗能量。输入电流为1A时，

关键词：极性保护电路压降串联二极管单反输入电流保护方法反向电压耗能量

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保护倒车摄像头的简单电路

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电子设计技术 EDN CHINA 2012年第1期19卷 49-49页

作者： Aruna prabath Rubasinghe 莫勒图沃大学

本例中的电路使用一个简单的比较器电路做上电时间的延迟，用于汽车倒车摄像头。汽车制造商通常会用倒车灯电路为倒车观察摄像头供电。在自动档汽车中，当从驻车转到行车状态（或相反）时，档位切换要经过倒车档，此时摄像头会加上一个... 详细信息

本例中的电路使用一个简单的比较器电路做上电时间的延迟，用于汽车倒车摄像头。汽车制造商通常会用倒车灯电路为倒车观察摄像头供电。在自动档汽车中，当从驻车转到行车状态（或相反）时，档位切换要经过倒车档，此时摄像头会加上一个短暂的电源脉冲。

关键词：简单电路汽车倒车摄像头保护汽车制造商自动档汽车档位切换比较器

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