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Patient selection and preparation strategies for the use of contrast material in patients with chronic kidney disease

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World Journal of Radiology 2012年第6期4卷 253-257页

作者： poul erik andersen Department of Radiology Odense University HospitalSdr.BoulevardDK-5000 Odense CDenmark

The prevalence of chronic kidney disease and peripheral arterial disease is ***,it is increasingly problematic to image these patients as the number of patients needing a vascular examination is increasing *** high-risk patients with impaired kidney function,intravascular administration of iodinated contrast media can result in contrast-induced acute kidney injury and Gadolinium can induce nephrogenic systemic fibrosis(NSF).It is important to identify these highrisk patients by means of se-creatinine/e glomerular filtration *** indication for contrast examination should counterbalance the increased *** or more alternative examination methods without contrast media,such as CO 2 angiography,Ultrasound/Doppler examination or magnetic resonance angiography without contrast should be considered,but at the same time,allow for a meaningful outcome of the *** contrast is deemed essential,the patient should be well hydrated,the amount of contrast should be restricted,the examination should be focused,metformin and diuretics stopped,and renal function *** bicarbonate and N-acetylcysteine are popular but their efficiency is not *** is no evidence that dialysis protects patients with impaired renal function from contrast-induced nephropathy or NSF.

关键词： Arterial disease Peripheral Radiology Interventional Diabetes complications Nephropathies Diabetic Renal insufficiency Chronic Kidney failure

Endovascular treatment of nonvariceal acute arterial upper gastrointestinal bleeding

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World Journal of Radiology 2010年第7期2卷 257-261页

作者： poul erik andersen Stevo Duvnjak Department of Radiology Odense University Hospital

Transcatheter arterial embolization as treatment of upper nonvariceal gastrointestinal bleeding is increasingly being used after failed primary endoscopic *** results after embolization have become better and surgery still has a high *** is a safe and effective procedure,but its use is has been limited because of relatively high rates of rebleeding and high mortality,both of which are associated with gastrointestinal bleeding and non-gastrointestinal related mortality *** arterial embolization is a valuable minimal invasive method in the treatment of early rebleeding and does not involve a high risk of treatment associated complications.A multidisciplinary approach is necessary in the treatment of these patients and should comprise gastroenterologists,interventional radiologists,anaesthesiologists,and surgeons to achieve the best possible results.

关键词： Gastrointestinal hemorrhage Embolization Upper gastrointestinal tract Endoscopy Gastrointestinal

Interventional treatment of pulmonary arteriovenous malformations

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World Journal of Radiology 2010年第9期2卷 339-344页

作者： poul erik andersen Anette Drφhse Kjeldsen Department of Radiology Odense University Hospital

Pulmonary arteriovenous malformations(PAVM) are congenital vascular communications in the *** act as right to left shunts so that the blood running through these malformations is not oxygenated or *** patients are typically hypoxaemic with exercise intolerance and are at high risk of paradoxical emboli to the brain and other *** malformations are most commonly seen in hereditary haemorrhagic telangiectasia(HHT)(***-Weber-Rendu syndrome).Nowadays,the generally accepted treatment strategy of first choice is embolization of the afferent arteries to the arteriovenous *** is a minimally invasive procedure and at the same time a lung preserving treatment with a very high technical success,high effectiveness and low morbidity and *** prevents cerebral stroke and abscess as well as pulmonary haemorrhage and further raises the functional *** is a well-established method of treating PAVM,with a significant effect on oxygenation of the *** for PAVM in patients at risk is recommended,especially in patients with HHT.

关键词： Pulmonary artery Pulmonary circulation Radiology Interventional Telangiectasia Hereditary hemorrhagic Embolization

Major bridge projects—a multi-disciplinary approach

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Frontiers of Structural and Civil Engineering 2011年第4期5卷 479-495页

作者： Klaus H.OSTENFELD erik Y.andersen COWI Parallelvej 2Kongens LyngbyDK-2800Denmark

Modern bridge building is much more than concrete,steel and *** overall socioeconomic impact,influence on people migration,traffic,use of primary materials,safety of construction impact on the environment,energy,risk scenarios,health,and most relevant now:climate and CO_(2) emissions,are among the parameters which enter into the decision process at the overall holistic conceptual level,the more detailed level of selection of bridge sites,and selection of bridge types as well as construction methods and selection of materials and *** paper illustrates these dilemmas and illustrates by specific examples how this complicated decision process can be managed and structured in order to arrive at an overall satisfactory solution for design,construction and maintenance throughout the lifetime(life cycle)to these sometimes contradictory parameters and requirements.

关键词： bridges materials climate risk safety environment socioeconomics traffic CO_(2) energy life cycle society aesthetics

Characterization of TGFβ-specific CD4+T cells through the modulation of TGFβexpression in malignant myeloid cells

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Cellular & Molecular Immunology 2021年第11期18卷 2575-2577页

作者： Rasmus erik Johansson Mortensen Morten Orebo Holmström Mads Hald andersen National Center for Cancer Immune Therapy Department of OncologyCopenhagen University HospitalHerlevDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor beta(TGFβ)is a pleiotropic cytokine with functions related to angiogenesis,tumor suppression,and immune tolerance[1].TGFβis involved in tumor immune escape and is a target for cancer immune therapy[1].We have reported that healthy donors and cancer patients harbor CD8^(+)cytotoxic T lymphocytes(CTLs)that are specific to TGFβ-derived epitopes and that these CD8^(+)CTLs kill malignant myeloid cells in a TGFβ-dependent manner[2].

关键词： TGFβ malignant myeloid

Postnatal germ cell development in cryptorchid boys

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Asian Journal of Andrology 2020年第3期22卷 258-264页

作者： Li-Hua Dong Simone HildorF erik Clasen-Linde Kolja Kvist Dina Cortes Jorgen Thorup Claus Yding andersen Laboratory of Reproductive Biology Copen hagen University Hospital RigshospitaletCopenhage n 2100Den mark Faculty of Health and Medical Scie nces University of CopenhagenCopenhagen 2200Denmark Department of Pathology Copenhagen University Hospital RigshospitaletCopenhagen 2100Denmark Department of Pediatric Surgery Copenhagen University Hospital RigshospitaletCopenhagen 2100Denmark Department of Pediatrics Copenhagen University Hospital HvidovreCopenhagen 2650Denmark.

Cryptorchidism is associated with infertility in *** orchiopexy is suggested to reduce the *** is lacking on the potential link between infant germ cell maturation and the risk of future *** objective of the study was to evaluate age-related germ cell development in *** for markers of germ cell development(octamerbinding transcription factor 3/4[0CT3/4],placental alkaline phosphatase[PLAP],KIT proto-oncogene[C-KIT],podoplanin[D2-40],Lin-28 homolog A[LIN28],and G antigen 7[GAGE-7])was performed in testicular biopsies from 40 cryptorchid boys aged 4-35 mon *** cell nu mbers and distributi ons were evaluated in cross sectio ns of semi niferous tubules,with and without immuno staini ***3/4,D2-40,and LIN 28 were gen erally expressed in the early stages of germ cell development,as show n by positive expression in germ cells in the central region of seminiferous tubules・In contrast,PLAP and GAGE-7 were expressed in both central and peripheral parts of the tubules in the early stages of development and expressed mainly in a peripheral position with advancing *** cell maturation was delayed in this study population as compared with that observed in our previous study on germ cell markers in a healthy *** number of GAGE-7-positive germ cells per tubular cross section obtained by immunostaining was significantly higher than that obtained by standard hematoxylin and eosin *** immunostaining revealed heterogeneity in germ cell development in cryptorchid *** results shed light on the pathophysiology of germ cell development in boys with cryptorchidism.

关键词： cryptorchidism germ cells immunostaining male fertility preservation reproductive index testis

Quantities of comorbidities affects physical, but not mental health related quality of life in type 1 diabetes with confirmed polyneuropathy

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World Journal of Diabetes 2019年第2期10卷 87-95页

作者： Anne-Marie L Wegeberg Theresa Meldgaard Sofie Hyldahl poul erik Jakobsen Asbjφrn M Drewes Birgitte Brock Christina Brock Mech-Sense Department of Gastroenterology and HepatologyAalborg University Hospital and Clinical InstituteAalborg UniversityAalborg 9000Denmark Steno Diabetes Center North Judland Region NordjyllandAalborg 9000Denmark Steno Diabetes Center Copenhagen Region HovedstadenGentofte 2820Denmark

BACKGROUND A large number of adults with long-term type 1 diabetes are affected by symmetrical peripheral *** complications increase socioeconomic expenses and diminish the individual quality of *** 36-Item Short Form Health Survey(SF-36)is a generic patient reported questionnaire,measuring mental and physical health related quality of *** hypothesized that diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and that clinical appearance may be associated with the *** To investigate if diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and if clinical appearance may be associated with the *** Forty-eight adults[age 50±9 years,10 females,disease duration 32(14-51)years]with verified diabetic symmetrical peripheral neuropathy and 21 healthy participants(age 51±6 years,6 females)underwent standardised nerve conduction testing and completed the SF-36 ***,disease duration,number of comorbidities,both diabetes related and nondiabetes related,vibration perception threshold,number of hypoglycaemic events,HbA1c and administration way of insulin was *** In comparison to healthy subjects,patients’mental composite score was not significantly diminished(51.9±8.9 vs 53.1±5.5,P=0.558),while the physical composite score was(46.3±11.7 vs 54.6±3.3,P=0.002).As expected,the overall physical health related symptoms in patients were associated to total number of comorbidities(P<0.0001),comorbidities relation to diabetes(P=0.0002)and HbA1c(P=0.005)as well as comorbidities not related to diabetes(P=0.0006).CONCLUSION The finding of this study emphasises the importance of focusing on quality of life in adults with diabetes and especially in those with multiple comorbidities as well as the possibility of HbA1c as a biomarker for severe complication.

关键词： Quality of life 36-Item Short Form Health Survey(SF-36) Diabetes mellitus,Type 1 Diabetic neuropathies Comorbidity

SUPPRESSOR OF VARIEGATION4, a New var2 Suppressor Locus, Encodes a Pioneer Protein that Is Required for Chloroplast Biogenesis

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Molecular Plant 2011年第2期4卷 229-240页

作者： Fei Yu ung-Soon Park Xiayan Liu Andrew Foudree Aigen Fu Marta Powikrowska Anastassia Khrouchtchova poul erik Jensen Jillian N. Kriger Gordon RI Gray Steven R. Rodermel College of Life Sciences Northwest A&F University Yangling Shaanxi 712100 People's Republic of China Department of Plant and Microbial Biology University of California Berkeley Berkeley CA 94720 USA Department of Genetics Development and Cell Biology iowa State University 253 Bessey Hall Ames IA 50011 USA Department of Plant Biology and Biotechnology Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg C Denmark Department of Plant Sciences University of Saskatchewan Saskatoon Saskatchewan S7N 5A8 Canada

VAR2 is an integral thylakoid membrane protein and a member of the versatile FtsH class of metalloproteases in prokaryotes and eukaryotes. Recessive mutations in the VAR2 locus give rise to variegated plants （var2） that contain white sectors with abnormal plastids and green sectors with normal-appearing chloroplasts. In a continuing effort to isolate second-site suppressors of var2 variegation, we characterize in this report ems2505, a suppressor strain that has a virescent phenotype due to a missense mutation in At4g28590, the gene for a pioneer protein. We designated this gene SVR4 （for SUPPRESSOR OF VARIEGATION4） and the mutant allele in ems2505 as svr4-1. We demonstrate that SVR4 is located in chloroplasts and that svr4-1 single mutants are normal with respect to chloroplast anatomy and thylakoid membrane protein accumulation. However, they are modestly impaired in several aspects of photochemistry and have enhanced non-photochemical quenching （NPQ） capacity. A T-DNA insertion allele of SVR4, svr4-2, is seedling-lethal due to an early blockage of chloroplast development. We conclude that SVR4 is essential for chloroplast biogenesis, and hypothesize that SVR4 mediates some aspect of thylakoid structure or function that controls NPQ. We propose that in the suppressor strain, photoinhibitory pressure caused by a lack of VAR2 is ameliorated early in chloroplast development by enhanced NPQ capacity caused by reduced SVR4 activity. This would result in an increase in the number of chloroplasts that are able to surmount a threshold necessary to avoid photo-damage and thereby develop into functional chloroplasts.

关键词： Arabidopsis chloroplast biogenesis non-photochemical quenching (NPQ) photo-damage suppressor strain variegation

Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

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Cellular & Molecular Immunology 2021年第2期18卷 415-426页

作者： Morten Orebo Holmström Rasmus erik Johansson Mortensen Angelos Michail Pavlidis Evelina Martinenaite Stine Emilie Weis-Banke Mia Aaboe-Jørgensen Simone Kloch Bendtsen Özcan Met Ayako Wakatsuki Pedersen Marco Donia Inge Marie Svane Mads Hald andersen Department of Oncology National Center for Cancer Immune TherapyCopenhagen University HospitalHerlevDenmark IO Biotech ApS CopenhagenDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor-beta(TGFβ)is a highly potent immunosuppressive *** TGFβis a tumor suppressor in early/premalignant cancer lesions,the cytokine has several tumor-promoting effects in advanced cancer;abrogation of the antitumor immune response is one of the most important tumor-promoting *** several immunoregulatory mechanisms have recently been shown to be targets of specific T cells,we hypothesized that TGFβis targeted by naturally occurring specific T cells and thus could be a potential target for immunomodulatory cancer ***,we tested healthy donor and cancer patient T cells for spontaneous T-cell responses specifically targeting 3820-mer epitopes derived from TGFβ*** identified numerous CD4^(+)and CD8^(+)T-cell responses against several epitopes in TGFβ.Additionally,several ex vivo responses were *** enriching specific T cells from different donors,we produced highly specific cultures specific to several TGFβ-derived *** CD8^(+)T-cell clones specific for both a 20-mer epitope and a 9-mer HLA-A2 restricted killed epitope peptide were pulsed in HLA-A2+target cells and killed the HLA-A2+cancer cell lines THP-1 and ***,stimulation of THP-1 cancer cells with cytokines that increased TGFβexpression increased the fraction of killed *** conclusion,we have shown that healthy donors and cancer patients harbor CD4^(+)and CD8^(+)T cells specific for TGFβ-derived epitopes and that cytotoxic T cells with specificity toward TGFβ-derived epitopes are able to recognize and kill cancer cell lines in a TGFβ-dependent manner.

关键词： Immune regulation TGFbeta cancer T cells adaptive immunity